PL2215071T3 - Proleki tetrahydrokannabinolu, kompozycje zawierające proleki tetrahydrokannabinolu i sposoby ich stosowania - Google Patents

Proleki tetrahydrokannabinolu, kompozycje zawierające proleki tetrahydrokannabinolu i sposoby ich stosowania

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Publication number
PL2215071T3
PL2215071T3 PL08855829T PL08855829T PL2215071T3 PL 2215071 T3 PL2215071 T3 PL 2215071T3 PL 08855829 T PL08855829 T PL 08855829T PL 08855829 T PL08855829 T PL 08855829T PL 2215071 T3 PL2215071 T3 PL 2215071T3
Authority
PL
Poland
Prior art keywords
tetrahydrocannabinol
prodrugs
compositions
methods
same
Prior art date
Application number
PL08855829T
Other languages
English (en)
Polish (pl)
Inventor
Audra Lynn Stinchcomb
Miroslaw Jerzy Golinski
Dana Carmel Hammell
Jeffry Lynn Howard
Original Assignee
Zynerba Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zynerba Pharmaceuticals Inc filed Critical Zynerba Pharmaceuticals Inc
Publication of PL2215071T3 publication Critical patent/PL2215071T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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PL08855829T 2007-11-30 2008-12-01 Proleki tetrahydrokannabinolu, kompozycje zawierające proleki tetrahydrokannabinolu i sposoby ich stosowania PL2215071T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99155507P 2007-11-30 2007-11-30
US3756808P 2008-03-18 2008-03-18
PCT/US2008/085201 WO2009073633A1 (en) 2007-11-30 2008-12-01 Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same
EP08855829.1A EP2215071B1 (en) 2007-11-30 2008-12-01 Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same

Publications (1)

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PL2215071T3 true PL2215071T3 (pl) 2015-12-31

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Family Applications (2)

Application Number Title Priority Date Filing Date
PL08855829T PL2215071T3 (pl) 2007-11-30 2008-12-01 Proleki tetrahydrokannabinolu, kompozycje zawierające proleki tetrahydrokannabinolu i sposoby ich stosowania
PL15172043T PL2963031T3 (pl) 2007-11-30 2008-12-01 Proleki tetrahydrokannabinolu, kompozycje zawierające proleki tetrahydrokannabinolu i sposoby ich stosowania

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PL15172043T PL2963031T3 (pl) 2007-11-30 2008-12-01 Proleki tetrahydrokannabinolu, kompozycje zawierające proleki tetrahydrokannabinolu i sposoby ich stosowania

Country Status (16)

Country Link
US (13) US8227627B2 (hr)
EP (2) EP2963031B1 (hr)
JP (3) JP5551604B2 (hr)
CA (3) CA2977722C (hr)
CY (2) CY1116927T1 (hr)
DK (2) DK2963031T3 (hr)
ES (2) ES2547880T3 (hr)
HK (1) HK1219733A1 (hr)
HR (2) HRP20151029T1 (hr)
HU (2) HUE043555T2 (hr)
LT (1) LT2963031T (hr)
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Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2963031T1 (sl) * 2007-11-30 2019-04-30 Zynerba Pharmaceuticals, Inc. Predzdravila tetrahidrokanabinola, sestavki, ki obsegajo predzdravila tetrahidrokanabinola in postopki njihove uporabe
WO2009099670A2 (en) * 2008-02-08 2009-08-13 Nektar Therapeutics Al, Corporation Oligomer-cannabinoid conjugates
JP5739344B2 (ja) * 2008-10-31 2015-06-24 ザ ユニヴァーシティー オブ ミシシッピ Δ−９−ｔｈｃ−アミノ酸エステルを含む組成物及び調製方法
JP5941038B2 (ja) 2010-04-02 2016-06-29 ジネルバ ファーマシューティカルズ， インコーポレイティド 経皮送達可能なオピオイドプロドラッグ、乱用抵抗性組成物及びオピオイドプロドラッグを使用する方法
ES2592277T3 (es) 2010-04-02 2016-11-29 Buzzz Pharmaceuticals Limited Formulaciones transdérmicas disuasorias del abuso de agonistas y agonistas-antagonistas opiáceos
US9254272B2 (en) * 2011-11-30 2016-02-09 Sutter West Bay Hospitals Resorcinol derivatives
US9776014B2 (en) 2012-05-03 2017-10-03 Magdent Ltd. Bone enhancement device and method
KR101629077B1 (ko) * 2013-04-03 2016-06-09 차이나 메디칼 유니버시티 편평세포 암종 및 간암에 대한 억제제인 스틸베노이드 화합물 및 그의 용도
CA2952934A1 (en) 2014-06-26 2015-12-30 Island Breeze Systems Ca, Llc Mdi related products and methods of use
US9539295B2 (en) 2014-12-05 2017-01-10 Bradley Michael Bohus Cannabidiol (CBD) enriched alcohol
EP3277260B1 (en) 2015-04-01 2021-05-12 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) Erodium crassifolium l'her plant extracts and uses thereof
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
CN108136208B (zh) 2015-09-22 2022-07-15 统帅青凤蝶生物科学公司 大麻素糖苷前药以及合成方法
WO2021173130A1 (en) 2020-02-26 2021-09-02 Vitality Biopharma, Inc. Novel cannabinoid glycosides and uses thereof
WO2017132526A1 (en) 2016-01-29 2017-08-03 University Of Mississippi Biologically active cannabidiol analogs
US10596130B2 (en) 2017-12-19 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use
US10245242B1 (en) 2017-11-22 2019-04-02 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US11103470B2 (en) 2017-11-22 2021-08-31 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US10596131B2 (en) 2017-11-22 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US10973786B2 (en) 2016-03-11 2021-04-13 Axcess Global Sciences, Llc R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions
US11185518B2 (en) 2017-12-19 2021-11-30 Axcess Global Sciences, Llc S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer
US10973792B2 (en) 2019-02-13 2021-04-13 Axcess Global Sciences, Llc Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use
US10245243B1 (en) 2017-12-19 2019-04-02 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
US10736861B2 (en) 2016-03-11 2020-08-11 Axcess Global Sciences, Llc Mixed salt compositions for producing elevated and sustained ketosis
US10596129B2 (en) 2017-11-22 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
JP2019513422A (ja) * 2016-04-15 2019-05-30 ティーウィノット テクノロジーズ リミテッド カンナビノイドプロドラッグの生合成法
CN109475586A (zh) 2016-06-29 2019-03-15 康纳塞斯创新公司 脱羧的大麻树脂、其用途和制备其的方法
US10278951B1 (en) * 2016-09-29 2019-05-07 Jon Newland Method of treating opiate dependency using tetrahydrocannabinol extracts
IL269158B2 (en) 2017-03-05 2024-04-01 The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo Cannabis preparations enriched with THCA and their use for the treatment of inflammatory diseases
US11207291B2 (en) 2017-05-09 2021-12-28 Graphium Biosciences, Inc. Antimicrobial compositions comprising cannabinoids and methods of using the same
US10925843B2 (en) 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
US11129802B2 (en) 2018-08-27 2021-09-28 Axcess Global Sciences, Llc Compositions and methods for delivering cannabidiol and ketone bodies
US11419836B2 (en) 2019-02-13 2022-08-23 Axcess Global Sciences, Llc Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
US20200061023A1 (en) * 2018-08-27 2020-02-27 Axcess Global Sciences, Llc Compositions and methods for delivering tetrahydrocannabinol and ketone bodies
US10980772B2 (en) 2018-08-27 2021-04-20 Axcess Global Sciences, Llc Compositions and methods for delivering tetrahydrocannabinol and ketone bodies
US11241401B2 (en) 2020-02-06 2022-02-08 Axcess Global Sciences, Llc Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions
GB201807942D0 (en) 2018-05-16 2018-06-27 Klaria Pharma Holding Ab Pharmaceutical formulation
US10912806B2 (en) * 2018-09-26 2021-02-09 Michael MCGOWAN Composition comprising an essential oil and its packaging thereof
US11033553B2 (en) 2019-06-21 2021-06-15 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11950616B2 (en) 2019-06-21 2024-04-09 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
CA3152752A1 (en) 2019-10-01 2021-04-08 Thomas Henley Genetic engineering of fungi to modulate tryptamine expression
EP4089081A4 (en) * 2020-01-08 2024-02-21 Chengdu Baiyu Pharmaceutical Co., Ltd. TETRAHYDROCANNABINOL DERIVATIVE AND ITS PREPARATION METHOD AND ITS MEDICAL USE
US11746113B2 (en) 2020-03-19 2023-09-05 Alexandros Makriyannis Labelled cannabinergic ligands and related analogs
WO2022072031A1 (en) 2020-10-01 2022-04-07 Tobacco Technology, Inc. Shisha, heat-not-burn, or combustion casing, product, and method of making the same
US11058142B1 (en) 2020-10-01 2021-07-13 Tobacco Technology, Inc. Shisha, heat-not-burn, or combustion casing with active ingredient, product and casing with active ingredient, and method of making the same
CN116964064A (zh) * 2021-03-03 2023-10-27 伦敦制药与研究公司 协同大麻素酯、其盐和用途
WO2023082003A1 (en) * 2021-11-10 2023-05-19 London Pharmaceuticals And Research Corporation New cannabinoid-gabapentinoid conjugates and uses thereof
US11660348B1 (en) 2022-02-01 2023-05-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
US11883499B2 (en) 2022-02-01 2024-01-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
US11969430B1 (en) 2023-03-10 2024-04-30 Axcess Global Sciences, Llc Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5518709B2 (hr) * 1970-02-13 1980-05-21
US3941782A (en) 1972-04-27 1976-03-02 Sharps Associates Heterocyclic esters of benzopyrans
US4327028A (en) * 1978-08-17 1982-04-27 Calcol, Inc. Composition of matter
US4933363A (en) 1988-08-16 1990-06-12 Elsohly Mahmoud A Method for effecting systemic delivery of delta-9-tetrahydrocannabinol
US5389375A (en) 1993-05-21 1995-02-14 University Of Mississippi Stable suppository formulations effecting bioavailability of Δ9 -thc
CA2189297C (en) 1995-11-02 2004-09-21 Masahiro Imoto Process for preparing 1-substituted pyrrole-3-carboxylic acid derivatives
WO2000045813A1 (en) 1999-02-04 2000-08-10 New Millennium Pharmaceutical Research, Inc. Method for enhancement of delivery of thc by the administration of its prodrugs via the nasal route
US20020111377A1 (en) 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
KR100828982B1 (ko) 2000-12-28 2008-05-14 시오노기세이야쿠가부시키가이샤 칸나비노이드 2형 수용체 친화 작용을 갖는 피리돈 유도체
GB0112752D0 (en) * 2001-05-25 2001-07-18 Johnson Matthey Plc Synthesis of cannabinoids
US7109216B2 (en) 2001-09-21 2006-09-19 Solvay Pharmaceuticals B.V. 1H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
HUP0402113A3 (en) 2001-09-21 2012-05-29 Solvay Pharm Bv 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity, preparation and use thereof
PL368441A1 (en) 2001-09-21 2005-03-21 Solvay Pharmaceuticals B.V. Novel 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
TWI231757B (en) 2001-09-21 2005-05-01 Solvay Pharm Bv 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
JP2006506366A (ja) 2002-10-18 2006-02-23 ファイザー・プロダクツ・インク カンナビノイド受容体リガンドおよびその使用方法
GB0230088D0 (en) 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0230087D0 (en) 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
PL1637527T3 (pl) 2003-06-26 2013-09-30 Takeda Pharmaceuticals Co Modulator receptora kanabinoidowego
US7326706B2 (en) 2003-08-15 2008-02-05 Bristol-Myers Squibb Company Pyrazine modulators of cannabinoid receptors
US20050143441A1 (en) 2003-10-27 2005-06-30 Jochen Antel Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
US7524867B2 (en) 2004-05-28 2009-04-28 Solvay Pharmaceuticals, B.V. Tetrasubstituted imidazole derivatives as cannabinoid CB1 receptor modulators with a high CB1/CB2 receptor subtype selectivity
CA2573859A1 (en) * 2004-07-19 2006-01-26 Cilag Ltd. Method for obtaining pure tetrahydrocannabinol
US20060051824A1 (en) * 2004-09-03 2006-03-09 Haoyun An Tetrahydrocannabinoid antigens and method of use
US7517991B2 (en) 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
WO2006049880A1 (en) 2004-10-27 2006-05-11 Janssen Pharmaceutica, N.V. Tetrahydro pyridinyl pyrazole cannabinoid modulators
US7321047B2 (en) * 2005-05-19 2008-01-22 Alphora Research Inc. Separation of tetrahydrocannabinols
US7452892B2 (en) 2005-06-17 2008-11-18 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
TW200726765A (en) 2005-06-17 2007-07-16 Bristol Myers Squibb Co Triazolopyridine cannabinoid receptor 1 antagonists
US20060287342A1 (en) 2005-06-17 2006-12-21 Mikkilineni Amarendra B Triazolopyrimidine heterocycles as cannabinoid receptor modulators
US7632837B2 (en) 2005-06-17 2009-12-15 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid-1 receptor modulators
US7629342B2 (en) 2005-06-17 2009-12-08 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
US7829581B2 (en) 2005-07-15 2010-11-09 Laboratorios Del Dr. Esteve, S.A. Prodrugs of pyrazoline compounds, their preparation and use as medicaments
GB0516379D0 (en) 2005-08-09 2005-09-14 Glaxo Group Ltd Compounds
WO2007020502A2 (en) 2005-08-16 2007-02-22 Pharmacia & Upjohn Company Llc Cannabinoid receptor ligands and uses thereof
WO2007026215A1 (en) 2005-08-29 2007-03-08 Glenmark Pharmaceuticals S.A. Pyrazole derivatives as cannabinoid receptor ligands, pharmaceutical compositions containing? them, and processes for their preparation
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
ATE458480T1 (de) 2005-09-23 2010-03-15 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl-pyrazol-cannabinoid- modulatoren
BRPI0616263A2 (pt) 2005-09-23 2011-06-14 Janssen Pharmaceutica Nv moduladores canabinàides do tipo tetrahidro-ciclopentil pirazol
EP1928853A4 (en) 2005-09-29 2011-02-16 Amr Technology Inc PROCESS FOR THE PRODUCTION OF DELTA-9-TETRAHYDROCANNABINOL
WO2008134668A2 (en) * 2007-04-27 2008-11-06 Alexza Pharmaceuticals, Inc. Heat-labile prodrugs
SI2963031T1 (sl) * 2007-11-30 2019-04-30 Zynerba Pharmaceuticals, Inc. Predzdravila tetrahidrokanabinola, sestavki, ki obsegajo predzdravila tetrahidrokanabinola in postopki njihove uporabe

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