HRP20161407T1 - Derivati benzokinona za liječenje mitohondrijskih bolesti oka - Google Patents
Derivati benzokinona za liječenje mitohondrijskih bolesti oka Download PDFInfo
- Publication number
- HRP20161407T1 HRP20161407T1 HRP20161407TT HRP20161407T HRP20161407T1 HR P20161407 T1 HRP20161407 T1 HR P20161407T1 HR P20161407T T HRP20161407T T HR P20161407TT HR P20161407 T HRP20161407 T HR P20161407T HR P20161407 T1 HRP20161407 T1 HR P20161407T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- group
- mitochondrial disease
- treatment
- lhon
- Prior art date
Links
- 150000004057 1,4-benzoquinones Chemical class 0.000 title 1
- 208000030533 eye disease Diseases 0.000 title 1
- 208000001992 Autosomal Dominant Optic Atrophy Diseases 0.000 claims 6
- 208000032087 Hereditary Leber Optic Atrophy Diseases 0.000 claims 6
- 201000000639 Leber hereditary optic neuropathy Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 208000012268 mitochondrial disease Diseases 0.000 claims 5
- 208000009702 Optic Disk Drusen Diseases 0.000 claims 4
- 208000036584 Optic disc drusen Diseases 0.000 claims 4
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 208000002780 macular degeneration Diseases 0.000 claims 3
- 208000002177 Cataract Diseases 0.000 claims 2
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
Claims (5)
1. Spoj predstavljen općom formulom (I)
[image]
i enantiomeri, tautomeri, solvati farmaceutski prihvatljivih soli, naznačen time da je R1 supstituent predstavljen formulom (II):
[image]
gdje su R5 i R6 oba vodikovi atomi ili je R5 atom vodika i R6 je etilna skupina, ili su R5 i R6 oba metilna skupina, R2 je metilna skupina, R3 je metoksi skupina i R4 je metoksi skupina; za upotrebu u liječenju mitohondrijske bolesti, naznačen time da je mitohondrijska bolest izabrana iz skupine koju čini Leberova hereditarna optička neuropatija (LHON), autosomna dominantna optička atrofija (DOA), makularna degeneracija, glaukom, retinopatija, mrena i optički disk druze (ODD).
2. Spoj za upotrebu prema zahtjevu 1, naznačen time, da su R5 i R6 oba atomi vodika.
3. Spoj za upotrebu prema zahtjevu 2, naznačen time, da se spoj primjenjuje oralno.
4. Spoj za upotrebu prema zahtjevu 3, naznačen time, da se mitohondrijska bolest bira iz skupine koju čine Leberova hereditarna optička neuropatija (LHON), autosomna dominantna optička atrofija (DOA), makularna degeneracija i glaukom.
5. Upotreba spoja u skladu s općom formulom (I)
[image]
gdje su R1 do R4 definirani kao u zahtjevu 1 za pripremu lijeka u liječenju mitohondrijske bolesti, naznačen time, da se mitohondrijska bolest bira iz skupine koju čine Leberova hereditarna optička neuropatija (LHON), autosomna dominantna optička atrofija (DOA), makularna degeneracija, glaukom, retinopatija, mrena i optički disk druze (ODD).
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37397210P | 2010-08-16 | 2010-08-16 | |
| EP10008542 | 2010-08-16 | ||
| US201061424978P | 2010-12-20 | 2010-12-20 | |
| EP10015842 | 2010-12-20 | ||
| US201161473835P | 2011-04-11 | 2011-04-11 | |
| EP11003037 | 2011-04-11 | ||
| PCT/EP2011/004123 WO2012022468A2 (en) | 2010-08-16 | 2011-08-16 | Benzoquinone derivatives as modulators of mitchondrial function |
| EP11748898.1A EP2605769B1 (en) | 2010-08-16 | 2011-08-16 | Benzoquinone derivatives for the treatment of mitchondrial eye diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161407T1 true HRP20161407T1 (hr) | 2016-12-02 |
Family
ID=45605465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161407TT HRP20161407T1 (hr) | 2010-08-16 | 2016-10-27 | Derivati benzokinona za liječenje mitohondrijskih bolesti oka |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2605769B1 (hr) |
| CY (1) | CY1118134T1 (hr) |
| DK (1) | DK2605769T3 (hr) |
| ES (1) | ES2588770T3 (hr) |
| HR (1) | HRP20161407T1 (hr) |
| HU (1) | HUE030595T2 (hr) |
| PL (1) | PL2605769T3 (hr) |
| PT (1) | PT2605769T (hr) |
| RS (1) | RS55173B1 (hr) |
| SI (1) | SI2605769T1 (hr) |
| SM (1) | SMT201600345B (hr) |
| WO (1) | WO2012022468A2 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014039862A1 (en) * | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Quinone derivatives for use in the modulation of redox status of individuals |
| WO2018078922A1 (ja) * | 2016-10-24 | 2018-05-03 | 国立大学法人福井大学 | 白内障の予防剤、治療剤、およびこれらを製造するためのｈａｔ阻害剤の使用 |
| JP7104048B2 (ja) | 2017-01-13 | 2022-07-20 | セルラー リサーチ， インコーポレイテッド | 流体チャネルの親水性コーティング |
| MX2019008542A (es) * | 2017-01-18 | 2019-11-05 | Schlumberger Technology Bv | Sistema de circulacion ininterrumpida para mantener la presion de fondo de pozo. |
| KR20220078644A (ko) | 2019-10-04 | 2022-06-10 | 스텔스 바이오테라퓨틱스 인코포레이티드 | 미토콘드리아 질환 치료를 위한 바티퀴논의 퀴논-, 히드로퀴논- 및 나프토퀴논-유사체 |
| WO2021211436A1 (en) * | 2020-04-13 | 2021-10-21 | Travecta Therapeutics Pte. Ltd. | Idebenone compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5919930B2 (ja) | 1974-05-02 | 1984-05-09 | 武田薬品工業株式会社 | キノン酸誘導体の製造法 |
| JPS51128932A (en) | 1975-04-30 | 1976-11-10 | Takeda Chem Ind Ltd | Organic compounds |
| JPS56150014A (en) | 1980-04-21 | 1981-11-20 | Takeda Chem Ind Ltd | Antiallergic agent |
| JPS5877839A (ja) * | 1981-11-02 | 1983-05-11 | Takeda Chem Ind Ltd | 安定な微細結晶およびその製造法 |
| ATE64921T1 (de) * | 1985-04-08 | 1991-07-15 | Takeda Chemical Industries Ltd | Benzochinonderivate, ihre herstellung und verwendung. |
| EP0788793A1 (en) * | 1996-02-01 | 1997-08-13 | Takeda Chemical Industries, Ltd. | Idebenone for the treatment of dementia |
| CA2252519A1 (en) * | 1996-07-11 | 1998-01-22 | Keisuke Hirai | Use of idebenone and analogues against beta amyloid induced cytotoxicity |
| TWI246421B (en) | 1998-12-03 | 2006-01-01 | Alcon Mfg Ltd | Use of neurotrophic factor stimulators for the treatment of ophthalmic neurodegenerative diseases |
| US7977388B2 (en) | 2005-03-21 | 2011-07-12 | Santhera Pharmaceuticals (Schweiz) Ag | Quinone derivative 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone for the treatment of muscular dystrophies |
| EP2471530B1 (en) | 2005-06-01 | 2017-01-11 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| EP1891946A1 (en) | 2006-08-14 | 2008-02-27 | Santhera Pharmaceuticals (Schweiz) AG | Transmucosal administration of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone |
| US20100099775A1 (en) | 2008-10-17 | 2010-04-22 | Alpharx Inc. | Method for ameliorating of post-anesthetic recovery |
| US20100130619A1 (en) | 2008-11-24 | 2010-05-27 | Joseph Schwarz | Pharmaceutical composition for parenteral administration of idebenone |
| US20100129431A1 (en) | 2008-11-24 | 2010-05-27 | Alpharx Inc. | Idebenone composition for the treatment of neurological disorders |
| US20100215725A1 (en) | 2009-02-20 | 2010-08-26 | Joseph Schwarz | Pharmaceutical composition containing idebenone for the treatment of liver disorders |
-
2011
- 2011-08-16 WO PCT/EP2011/004123 patent/WO2012022468A2/en active Application Filing
- 2011-08-16 HU HUE11748898A patent/HUE030595T2/en unknown
- 2011-08-16 PL PL11748898T patent/PL2605769T3/pl unknown
- 2011-08-16 SI SI201130942A patent/SI2605769T1/sl unknown
- 2011-08-16 RS RS20160776A patent/RS55173B1/sr unknown
- 2011-08-16 DK DK11748898.1T patent/DK2605769T3/en active
- 2011-08-16 ES ES11748898.1T patent/ES2588770T3/es active Active
- 2011-08-16 PT PT117488981T patent/PT2605769T/pt unknown
- 2011-08-16 EP EP11748898.1A patent/EP2605769B1/en active Active
-
2016
- 2016-10-03 SM SM201600345T patent/SMT201600345B/it unknown
- 2016-10-21 CY CY20161101059T patent/CY1118134T1/el unknown
- 2016-10-27 HR HRP20161407TT patent/HRP20161407T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1118134T1 (el) | 2017-06-28 |
| WO2012022468A2 (en) | 2012-02-23 |
| EP2605769B1 (en) | 2016-07-27 |
| SMT201600345B (it) | 2016-11-10 |
| DK2605769T3 (en) | 2016-10-24 |
| PL2605769T3 (pl) | 2017-01-31 |
| ES2588770T3 (es) | 2016-11-04 |
| HUE030595T2 (en) | 2017-05-29 |
| SI2605769T1 (sl) | 2016-10-28 |
| PT2605769T (pt) | 2016-11-02 |
| EP2605769A2 (en) | 2013-06-26 |
| WO2012022468A3 (en) | 2012-06-28 |
| RS55173B1 (sr) | 2017-01-31 |
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