CY1118134T1 - Παραγωγα βενζοκινονης για την αγωγη μιτοχονδριακων ασθενειων των οφθαλμων - Google Patents

Παραγωγα βενζοκινονης για την αγωγη μιτοχονδριακων ασθενειων των οφθαλμων

Info

Publication number
CY1118134T1
CY1118134T1 CY20161101059T CY161101059T CY1118134T1 CY 1118134 T1 CY1118134 T1 CY 1118134T1 CY 20161101059 T CY20161101059 T CY 20161101059T CY 161101059 T CY161101059 T CY 161101059T CY 1118134 T1 CY1118134 T1 CY 1118134T1
Authority
CY
Cyprus
Prior art keywords
benzokinone
derivatives
treatment
mitochondrial
ocular diseases
Prior art date
Application number
CY20161101059T
Other languages
English (en)
Inventor
Achim Feurer
Nuri Gueven
Barbara Hoffmann-Enger
Michael Erb
Holger Deppe
Robert Dallmann
Roman Haefeli
Fabrice Heitz
Original Assignee
Santhera Pharmaceuticals (Schweiz) Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santhera Pharmaceuticals (Schweiz) Ag filed Critical Santhera Pharmaceuticals (Schweiz) Ag
Publication of CY1118134T1 publication Critical patent/CY1118134T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε παράγωγα βενζοκινόνης τα οποία είναι αποτελεσματικά ως ρυθμιστές της μιτοχονδριακής λειτουργίας και ως τέτοια είναι χρήσιμα για την αγωγή παθολογικών καταστάσεων όπου η μιτοχονδριακή λειτουργία έχει διαταραχθεί.
CY20161101059T 2010-08-16 2016-10-21 Παραγωγα βενζοκινονης για την αγωγη μιτοχονδριακων ασθενειων των οφθαλμων CY1118134T1 (el)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US37397210P 2010-08-16 2010-08-16
EP10008542 2010-08-16
US201061424978P 2010-12-20 2010-12-20
EP10015842 2010-12-20
US201161473835P 2011-04-11 2011-04-11
EP11003037 2011-04-11
EP11748898.1A EP2605769B1 (en) 2010-08-16 2011-08-16 Benzoquinone derivatives for the treatment of mitchondrial eye diseases
PCT/EP2011/004123 WO2012022468A2 (en) 2010-08-16 2011-08-16 Benzoquinone derivatives as modulators of mitchondrial function

Publications (1)

Publication Number Publication Date
CY1118134T1 true CY1118134T1 (el) 2017-06-28

Family

ID=45605465

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161101059T CY1118134T1 (el) 2010-08-16 2016-10-21 Παραγωγα βενζοκινονης για την αγωγη μιτοχονδριακων ασθενειων των οφθαλμων

Country Status (12)

Country Link
EP (1) EP2605769B1 (el)
CY (1) CY1118134T1 (el)
DK (1) DK2605769T3 (el)
ES (1) ES2588770T3 (el)
HR (1) HRP20161407T1 (el)
HU (1) HUE030595T2 (el)
PL (1) PL2605769T3 (el)
PT (1) PT2605769T (el)
RS (1) RS55173B1 (el)
SI (1) SI2605769T1 (el)
SM (1) SMT201600345B (el)
WO (1) WO2012022468A2 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014039917A1 (en) * 2012-09-07 2014-03-13 Edison Pharmaceuticals, Inc. Benzoquinone derivatives for treating oxidative stress disorders
WO2018078922A1 (ja) * 2016-10-24 2018-05-03 国立大学法人福井大学 白内障の予防剤、治療剤、およびこれらを製造するためのｈａｔ阻害剤の使用
US10722880B2 (en) 2017-01-13 2020-07-28 Cellular Research, Inc. Hydrophilic coating of fluidic channels
MX2019008542A (es) 2017-01-18 2019-11-05 Schlumberger Technology Bv Sistema de circulacion ininterrumpida para mantener la presion de fondo de pozo.
EP4038076A1 (en) 2019-10-04 2022-08-10 Stealth BioTherapeutics Inc. Chinone-, hydrochinome- and naphthochinone-analogues of vatiquione for treatment of mitochondrial disorder diseases
WO2021211436A1 (en) * 2020-04-13 2021-10-21 Travecta Therapeutics Pte. Ltd. Idebenone compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5919930B2 (ja) 1974-05-02 1984-05-09 武田薬品工業株式会社 キノン酸誘導体の製造法
JPS51128932A (en) 1975-04-30 1976-11-10 Takeda Chem Ind Ltd Organic compounds
JPS56150014A (en) 1980-04-21 1981-11-20 Takeda Chem Ind Ltd Antiallergic agent
JPS5877839A (ja) * 1981-11-02 1983-05-11 Takeda Chem Ind Ltd 安定な微細結晶およびその製造法
EP0201196B1 (en) * 1985-04-08 1991-07-03 Takeda Chemical Industries, Ltd. Benzoquinone derivatives, their production and use
EP0788793A1 (en) * 1996-02-01 1997-08-13 Takeda Chemical Industries, Ltd. Idebenone for the treatment of dementia
US6271266B1 (en) * 1996-07-11 2001-08-07 Takeda Chemical Industries, Ltd. Use of idebenone and analogues against β amyloid induced cytotoxicity
TWI246421B (en) 1998-12-03 2006-01-01 Alcon Mfg Ltd Use of neurotrophic factor stimulators for the treatment of ophthalmic neurodegenerative diseases
WO2006100017A1 (en) 2005-03-21 2006-09-28 Santhera Pharmaceuticals (Schweiz) Ag Quinone derivative 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1 ,4- benzoquinone for the treatment of muscular dystrophies
CA2610152C (en) 2005-06-01 2018-04-10 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EP1891946A1 (en) 2006-08-14 2008-02-27 Santhera Pharmaceuticals (Schweiz) AG Transmucosal administration of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone
US20100099775A1 (en) 2008-10-17 2010-04-22 Alpharx Inc. Method for ameliorating of post-anesthetic recovery
US20100130619A1 (en) 2008-11-24 2010-05-27 Joseph Schwarz Pharmaceutical composition for parenteral administration of idebenone
US20100129431A1 (en) 2008-11-24 2010-05-27 Alpharx Inc. Idebenone composition for the treatment of neurological disorders
US20100215725A1 (en) 2009-02-20 2010-08-26 Joseph Schwarz Pharmaceutical composition containing idebenone for the treatment of liver disorders

Also Published As

Publication number Publication date
HUE030595T2 (en) 2017-05-29
RS55173B1 (sr) 2017-01-31
HRP20161407T1 (hr) 2016-12-02
WO2012022468A3 (en) 2012-06-28
EP2605769A2 (en) 2013-06-26
SMT201600345B (it) 2016-11-10
WO2012022468A2 (en) 2012-02-23
EP2605769B1 (en) 2016-07-27
PL2605769T3 (pl) 2017-01-31
ES2588770T3 (es) 2016-11-04
PT2605769T (pt) 2016-11-02
SI2605769T1 (sl) 2016-10-28
DK2605769T3 (en) 2016-10-24

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