WO2012022468A3 - Benzoquinone derivatives as modulators of mitchondrial function - Google Patents

Benzoquinone derivatives as modulators of mitchondrial function Download PDF

Info

Publication number
WO2012022468A3
WO2012022468A3 PCT/EP2011/004123 EP2011004123W WO2012022468A3 WO 2012022468 A3 WO2012022468 A3 WO 2012022468A3 EP 2011004123 W EP2011004123 W EP 2011004123W WO 2012022468 A3 WO2012022468 A3 WO 2012022468A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
function
mitchondrial
benzoquinone derivatives
benzoquinone
Prior art date
Application number
PCT/EP2011/004123
Other languages
French (fr)
Other versions
WO2012022468A2 (en
Inventor
Achim Feurer
Nuri Gueven
Barbara Hoffmann-Enger
Michael Erb
Holger Deppe
Robert Dallmann
Roman Haefeli
Fabrice Heitz
Original Assignee
Santhera Pharmaceuticals (Schweiz) Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santhera Pharmaceuticals (Schweiz) Ag filed Critical Santhera Pharmaceuticals (Schweiz) Ag
Priority to RS20160776A priority Critical patent/RS55173B1/en
Priority to ES11748898.1T priority patent/ES2588770T3/en
Priority to EP11748898.1A priority patent/EP2605769B1/en
Priority to DK11748898.1T priority patent/DK2605769T3/en
Priority to SI201130942A priority patent/SI2605769T1/en
Publication of WO2012022468A2 publication Critical patent/WO2012022468A2/en
Publication of WO2012022468A3 publication Critical patent/WO2012022468A3/en
Priority to SM201600345T priority patent/SMT201600345B/en
Priority to CY20161101059T priority patent/CY1118134T1/en
Priority to HRP20161407TT priority patent/HRP20161407T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure

Abstract

The present invention relates to benzoquinone derivatives which are efficient as modulators of mitochondrial function and as such are useful for the treatment of pathological conditions where mitochondrial function is impaired.
PCT/EP2011/004123 2010-08-16 2011-08-16 Benzoquinone derivatives as modulators of mitchondrial function WO2012022468A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
RS20160776A RS55173B1 (en) 2010-08-16 2011-08-16 Benzoquinone derivatives for the treatment of mitchondrial eye diseases
ES11748898.1T ES2588770T3 (en) 2010-08-16 2011-08-16 Benzoquinone derivatives for the treatment of mitochondrial eye diseases
EP11748898.1A EP2605769B1 (en) 2010-08-16 2011-08-16 Benzoquinone derivatives for the treatment of mitchondrial eye diseases
DK11748898.1T DK2605769T3 (en) 2010-08-16 2011-08-16 Benzoquinonderivater for the treatment of mitochondrial diseases of the eye
SI201130942A SI2605769T1 (en) 2010-08-16 2011-08-16 Benzoquinone derivatives for the treatment of mitchondrial eye diseases
SM201600345T SMT201600345B (en) 2010-08-16 2016-10-03 BENZOCHINONIC DERIVATIVES AS MODULATORS OF THE MITOCHONDRIAL FUNCTION
CY20161101059T CY1118134T1 (en) 2010-08-16 2016-10-21 Benzokinone derivatives for the treatment of mitochondrial ocular diseases
HRP20161407TT HRP20161407T1 (en) 2010-08-16 2016-10-27 Benzoquinone derivatives for the treatment of mitchondrial eye diseases

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US37397210P 2010-08-16 2010-08-16
EP10008542 2010-08-16
EP10008542.2 2010-08-16
US61/373,972 2010-08-16
US201061424978P 2010-12-20 2010-12-20
EP10015842.7 2010-12-20
EP10015842 2010-12-20
US61/424,978 2010-12-20
US201161473835P 2011-04-11 2011-04-11
US61/473,835 2011-04-11
EP11003037 2011-04-11
EP11003037.6 2011-04-11

Publications (2)

Publication Number Publication Date
WO2012022468A2 WO2012022468A2 (en) 2012-02-23
WO2012022468A3 true WO2012022468A3 (en) 2012-06-28

Family

ID=45605465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/004123 WO2012022468A2 (en) 2010-08-16 2011-08-16 Benzoquinone derivatives as modulators of mitchondrial function

Country Status (12)

Country Link
EP (1) EP2605769B1 (en)
CY (1) CY1118134T1 (en)
DK (1) DK2605769T3 (en)
ES (1) ES2588770T3 (en)
HR (1) HRP20161407T1 (en)
HU (1) HUE030595T2 (en)
PL (1) PL2605769T3 (en)
PT (1) PT2605769T (en)
RS (1) RS55173B1 (en)
SI (1) SI2605769T1 (en)
SM (1) SMT201600345B (en)
WO (1) WO2012022468A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6393684B2 (en) 2012-09-07 2018-09-19 バイオエレクトロン テクノロジー コーポレイション Quinone derivatives for use in regulating the redox state of individuals
WO2018078922A1 (en) * 2016-10-24 2018-05-03 国立大学法人福井大学 Preventive agent and therapeutic agent for cataracts, and use of hat inhibitor for production thereof
ES2961580T3 (en) 2017-01-13 2024-03-12 Cellular Res Inc Hydrophilic coating of fluid channels
MX2019008542A (en) 2017-01-18 2019-11-05 Schlumberger Technology Bv Non-stop circulation system for maintaining bottom hole pressure.
US11584728B2 (en) 2019-10-04 2023-02-21 Stealth Biotherapeutics Inc. Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
WO2021211436A1 (en) * 2020-04-13 2021-10-21 Travecta Therapeutics Pte. Ltd. Idebenone compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5877839A (en) * 1981-11-02 1983-05-11 Takeda Chem Ind Ltd Stable fine crystal and its preparation
EP0201196A2 (en) * 1985-04-08 1986-11-12 Takeda Chemical Industries, Ltd. Benzoquinone derivatives, their production and use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5919930B2 (en) 1974-05-02 1984-05-09 武田薬品工業株式会社 Method for producing quinonic acid derivatives
JPS51128932A (en) 1975-04-30 1976-11-10 Takeda Chem Ind Ltd Organic compounds
JPS56150014A (en) 1980-04-21 1981-11-20 Takeda Chem Ind Ltd Antiallergic agent
EP0788793A1 (en) * 1996-02-01 1997-08-13 Takeda Chemical Industries, Ltd. Idebenone for the treatment of dementia
US6271266B1 (en) * 1996-07-11 2001-08-07 Takeda Chemical Industries, Ltd. Use of idebenone and analogues against β amyloid induced cytotoxicity
TWI246421B (en) 1998-12-03 2006-01-01 Alcon Mfg Ltd Use of neurotrophic factor stimulators for the treatment of ophthalmic neurodegenerative diseases
EP1861080B1 (en) 2005-03-21 2010-05-26 Santhera Pharmaceuticals (Schweiz) AG Idebenone for the treatment of muscular dystrophies
DK1888059T3 (en) 2005-06-01 2015-03-30 Edison Pharmaceuticals Inc Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers
EP1891946A1 (en) 2006-08-14 2008-02-27 Santhera Pharmaceuticals (Schweiz) AG Transmucosal administration of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone
US20100099775A1 (en) 2008-10-17 2010-04-22 Alpharx Inc. Method for ameliorating of post-anesthetic recovery
US20100129431A1 (en) 2008-11-24 2010-05-27 Alpharx Inc. Idebenone composition for the treatment of neurological disorders
US20100130619A1 (en) 2008-11-24 2010-05-27 Joseph Schwarz Pharmaceutical composition for parenteral administration of idebenone
US20100215725A1 (en) 2009-02-20 2010-08-26 Joseph Schwarz Pharmaceutical composition containing idebenone for the treatment of liver disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5877839A (en) * 1981-11-02 1983-05-11 Takeda Chem Ind Ltd Stable fine crystal and its preparation
EP0201196A2 (en) * 1985-04-08 1986-11-12 Takeda Chemical Industries, Ltd. Benzoquinone derivatives, their production and use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DANIEL JAROVSKY ET AL: "Mitochondrial Diseases: A review", REVIEWING BASIC SCIENCES, 1 January 2006 (2006-01-01), pages 343 - 350, XP055018708, Retrieved from the Internet <URL:http://apps.einstein.br/REVISTA/arquivos/PDF/Einstein_vol4_n4_2006_p343.pdf> [retrieved on 20120208] *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; "Stable 6-(10-hydroxydodecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone microcrystals", XP002668984, retrieved from STN Database accession no. 1983:476854 *
DATABASE WPI Week 198325, Derwent World Patents Index; AN 1983-59523K *
DUVEAU D Y ET AL: "Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 18, no. 17, 4 August 2010 (2010-08-04), pages 6429 - 6441, XP027218831, ISSN: 0968-0896, [retrieved on 20100804] *
KAYOKO OKAMOTO ET AL: "Synthesis, Metabolism, and in Vitro Biological Activities of 6-(10-Hydroxydecyl)-2, 3-dimethoxy-5-methyl-1, 4-benzoquinone (CV-2619)-Related Compounds", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 36, no. 1, 1 January 1988 (1988-01-01), pages 178 - 189, XP009143726, ISSN: 0009-2363 *

Also Published As

Publication number Publication date
SMT201600345B (en) 2016-11-10
ES2588770T3 (en) 2016-11-04
WO2012022468A2 (en) 2012-02-23
PL2605769T3 (en) 2017-01-31
CY1118134T1 (en) 2017-06-28
HRP20161407T1 (en) 2016-12-02
HUE030595T2 (en) 2017-05-29
RS55173B1 (en) 2017-01-31
DK2605769T3 (en) 2016-10-24
EP2605769B1 (en) 2016-07-27
SI2605769T1 (en) 2016-10-28
PT2605769T (en) 2016-11-02
EP2605769A2 (en) 2013-06-26

Similar Documents

Publication Publication Date Title
WO2012022467A3 (en) Novel benzoquinone derivatives and use thereof as modulators of mitochondrial function
WO2012022468A3 (en) Benzoquinone derivatives as modulators of mitchondrial function
WO2014031928A3 (en) Heterocyclic modulators of hif activity for treatment of disease
EP2533783B8 (en) COMPOUNDS AND METHODS for the inhibition of HDAC
IN2014KN01517A (en)
WO2013134336A3 (en) Inhibition of adaptor associated kinase 1 for the treatment of pain
MY165579A (en) Synthetic methods for spiro-oxindole compounds
WO2011129936A3 (en) Compositions and methods for the prevention and treatment of cancer
WO2014031933A3 (en) Heterocyclic modulators of hif activity for treatment of disease
WO2014015210A3 (en) Microorganisms and processes for the conversion of glycerol to isoprene
AU2010306870A8 (en) Reducing the risk of pathological effects of traumatic brain injury
WO2014031936A3 (en) Heterocyclic modulators of hif activity for treatment of disease
WO2011126852A9 (en) Treatment of gout
WO2013108105A3 (en) Novel solvates of darunavir
BR112012016894A2 (en) lactobacilli with antioxidant action.
WO2012051599A3 (en) Modulation neural pathways
EP2557919A4 (en) Stabilized statin formulations
WO2012082862A3 (en) Androgen receptor inhibitors and methods of use thereof
WO2014086453A8 (en) Azaheterobicyclic compounds
WO2011153429A9 (en) Methods of treatment
MX339361B (en) Alternan derivatives.
WO2011073370A3 (en) Use of 2,3-dihydroxypropyl dodecanoate for treating seborrhea
WO2011116351A3 (en) Methods and compositions for the treatment of cancer
WO2012004073A3 (en) Use of beta-isophorone as solvent
WO2014004178A3 (en) Compositions comprising substituted phenols and topical application thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11748898

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2011748898

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2011748898

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: P-2016/0776

Country of ref document: RS