HRP20150977T1 - C-28 amidi modificiranih derivata c-3 betulinske kiseline kao inhibitori sazrijevanja hiv-a - Google Patents

C-28 amidi modificiranih derivata c-3 betulinske kiseline kao inhibitori sazrijevanja hiv-a Download PDF

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Publication number
HRP20150977T1
HRP20150977T1 HRP20150977TT HRP20150977T HRP20150977T1 HR P20150977 T1 HRP20150977 T1 HR P20150977T1 HR P20150977T T HRP20150977T T HR P20150977TT HR P20150977 T HRP20150977 T HR P20150977T HR P20150977 T1 HRP20150977 T1 HR P20150977T1
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HR
Croatia
Prior art keywords
image
group
substituted
alkyl
compound according
Prior art date
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HRP20150977TT
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English (en)
Croatian (hr)
Inventor
Alicia Regueiro-Ren
Zheng Liu
Jacob Swidorski
Nicholas A. Meanwell
Sing-Yuen Sit
Jie Chen
Yan Chen
Ny Sin
Original Assignee
Bristol-Myers Squibb Company
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Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HRP20150977T1 publication Critical patent/HRP20150977T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HRP20150977TT 2010-06-04 2011-06-02 C-28 amidi modificiranih derivata c-3 betulinske kiseline kao inhibitori sazrijevanja hiv-a HRP20150977T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35133210P 2010-06-04 2010-06-04
PCT/US2011/038884 WO2011153319A1 (en) 2010-06-04 2011-06-02 C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors
EP11726564.5A EP2576586B1 (en) 2010-06-04 2011-06-02 C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number Publication Date
HRP20150977T1 true HRP20150977T1 (hr) 2015-10-09

Family

ID=44627254

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20150977TT HRP20150977T1 (hr) 2010-06-04 2011-06-02 C-28 amidi modificiranih derivata c-3 betulinske kiseline kao inhibitori sazrijevanja hiv-a

Country Status (20)

Country Link
US (1) US8802661B2 (enExample)
EP (1) EP2576586B1 (enExample)
JP (1) JP5755731B2 (enExample)
CN (1) CN102985438B (enExample)
AR (1) AR081638A1 (enExample)
BR (1) BR112012030810A2 (enExample)
CA (1) CA2801491C (enExample)
DK (1) DK2576586T3 (enExample)
EA (1) EA026140B1 (enExample)
ES (1) ES2548905T3 (enExample)
HR (1) HRP20150977T1 (enExample)
HU (1) HUE026662T2 (enExample)
MX (1) MX2012013628A (enExample)
PL (1) PL2576586T3 (enExample)
PT (1) PT2576586E (enExample)
RS (1) RS54239B1 (enExample)
SI (1) SI2576586T1 (enExample)
SM (1) SMT201500272B (enExample)
TW (1) TW201201792A (enExample)
WO (1) WO2011153319A1 (enExample)

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* Cited by examiner, † Cited by third party
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HUE026371T2 (en) * 2011-01-31 2016-05-30 Bristol Myers Squibb Co C-28 amines from modified C-3 betulinic acid derivatives as anti-HIV matrices
EP2670765B1 (en) * 2011-01-31 2017-10-18 Viiv Healthcare Uk (No. 4) Limited C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
EA023463B1 (ru) 2011-09-21 2016-06-30 Бристол-Майерс Сквибб Компани Производные бетулиновой кислоты с противовирусной активностью
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
BR112015018491A2 (pt) * 2013-02-06 2017-07-18 Bristol Myers Squibb Co triterpenoides c-19-modificados com atividade inibidora de maturação de hiv
EA027861B1 (ru) * 2013-02-25 2017-09-29 Бристол-Майерс Сквибб Компани C-3 алкил- и алкенилмодифицированные производные бетулиновой кислоты или их фармацевтические соли, противовирусная фармацевтическая композиция и фармацевтическая композиция для лечения вич на их основе
UA120927C2 (uk) 2014-04-11 2020-03-10 Віів Гелскер Юк (Но.4) Лімітед Тритерпеноїди, заміщені в положенні 3 неароматичним кільцем, яке несе галогеналкільний замісник, з інгібуючою активністю щодо дозрівання віл
US9920090B2 (en) 2014-06-19 2018-03-20 VIIV Healthcare UK (No.5) Limited Betulinic acid derivatives with HIV maturation inhibitory activity
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
RU2017118489A (ru) 2014-11-14 2018-12-14 ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД Оксолупеновые производные
US10047118B2 (en) 2014-11-14 2018-08-14 VIIV Healthcare UK (No.5) Limited C17-aryl substituted betulinic acid analogs
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
JP2018521093A (ja) 2015-07-28 2018-08-02 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ感染を予防または治療するためのベツイン誘導体
KR20180028535A (ko) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체
KR20180054826A (ko) 2015-09-24 2018-05-24 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 성숙 억제 활성을 갖는 화합물
AU2017208874A1 (en) 2016-01-20 2018-08-02 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with HIV maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018002849A1 (en) * 2016-06-30 2018-01-04 VIIV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
US20210347813A1 (en) 2018-04-24 2021-11-11 Viiv Healthcare Uk (No. 5) Limited Compounds with hiv maturation inhibitory activity
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
US10343997B1 (en) 2018-12-04 2019-07-09 King Saud University Ursolic acid derivatives

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Also Published As

Publication number Publication date
US8802661B2 (en) 2014-08-12
RS54239B1 (sr) 2015-12-31
CA2801491C (en) 2018-01-23
CN102985438A (zh) 2013-03-20
DK2576586T3 (en) 2015-11-23
EP2576586B1 (en) 2015-08-12
EA201270800A1 (ru) 2013-04-30
TW201201792A (en) 2012-01-16
PT2576586E (pt) 2015-10-23
CN102985438B (zh) 2016-05-18
HUE026662T2 (en) 2016-06-28
ES2548905T3 (es) 2015-10-21
JP5755731B2 (ja) 2015-07-29
EP2576586A1 (en) 2013-04-10
WO2011153319A1 (en) 2011-12-08
AR081638A1 (es) 2012-10-10
SMT201500272B (it) 2016-01-08
EA026140B1 (ru) 2017-03-31
CA2801491A1 (en) 2011-12-08
MX2012013628A (es) 2012-12-17
US20120142653A1 (en) 2012-06-07
SI2576586T1 (sl) 2015-11-30
PL2576586T3 (pl) 2016-01-29
BR112012030810A2 (pt) 2019-09-24
JP2013527243A (ja) 2013-06-27

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