AR081638A1 - Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del vih - Google Patents

Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del vih

Info

Publication number
AR081638A1
AR081638A1 ARP110101945A ARP110101945A AR081638A1 AR 081638 A1 AR081638 A1 AR 081638A1 AR P110101945 A ARP110101945 A AR P110101945A AR P110101945 A ARP110101945 A AR P110101945A AR 081638 A1 AR081638 A1 AR 081638A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
group
coor2
cycloalkyl
Prior art date
Application number
ARP110101945A
Other languages
English (en)
Spanish (es)
Inventor
Alicia Regueiro-Ren
Zheng Liu
Jacob Swidorski
Nicholas A Meanwell
Sing-Yuen Sit
Jie Yuen-Chen
Yan Chen
Ny Sin
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR081638A1 publication Critical patent/AR081638A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ARP110101945A 2010-06-04 2011-06-03 Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del vih AR081638A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35133210P 2010-06-04 2010-06-04

Publications (1)

Publication Number Publication Date
AR081638A1 true AR081638A1 (es) 2012-10-10

Family

ID=44627254

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110101945A AR081638A1 (es) 2010-06-04 2011-06-03 Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del vih

Country Status (20)

Country Link
US (1) US8802661B2 (enExample)
EP (1) EP2576586B1 (enExample)
JP (1) JP5755731B2 (enExample)
CN (1) CN102985438B (enExample)
AR (1) AR081638A1 (enExample)
BR (1) BR112012030810A2 (enExample)
CA (1) CA2801491C (enExample)
DK (1) DK2576586T3 (enExample)
EA (1) EA026140B1 (enExample)
ES (1) ES2548905T3 (enExample)
HR (1) HRP20150977T1 (enExample)
HU (1) HUE026662T2 (enExample)
MX (1) MX2012013628A (enExample)
PL (1) PL2576586T3 (enExample)
PT (1) PT2576586E (enExample)
RS (1) RS54239B1 (enExample)
SI (1) SI2576586T1 (enExample)
SM (1) SMT201500272B (enExample)
TW (1) TW201201792A (enExample)
WO (1) WO2011153319A1 (enExample)

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CN103339141B (zh) * 2011-01-31 2016-08-24 百时美施贵宝公司 作为hiv成熟抑制剂的c-3修饰的桦木酸衍生物的c-28胺
ES2653847T3 (es) * 2011-01-31 2018-02-09 Viiv Healthcare Uk (No. 4) Limited Triterpenoides C-17 y C-3 modificados con actividad inhibitoria contra maduración del VIH
ES2611727T3 (es) 2011-09-21 2017-05-10 VIIV Healthcare UK (No.5) Limited Derivados de ácido betulínico novedosos con actividad antivírica
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
JP6186010B2 (ja) * 2013-02-06 2017-08-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｈｉｖ成熟阻害活性を有するｃ−１９修飾トリテルペノイド類
KR20150121712A (ko) * 2013-02-25 2015-10-29 브리스톨-마이어스 스큅 컴퍼니 Hiv의 치료에 유용한 c-3 알킬 및 알케닐 개질된 베툴린산 유도체
MA39374A1 (fr) 2014-04-11 2018-06-29 Viiv Healthcare Uk No 4 Ltd Triterpénoïdes présentant une activité d'inhibition de la maturation du vih, substitués en 3ème position par un cycle non aromatique portant un substituant halogénoalkyle
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
RU2017118576A (ru) 2014-11-14 2018-12-14 ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД C-17-арил-замещённые аналоги бетулиновой кислоты
BR112017009850A2 (pt) * 2014-11-14 2018-01-16 Viiv Healthcare Uk No 5 Ltd composto, composição, e, uso de uma quantidade melhoradora de hiv de um composto
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
RU2018105352A (ru) 2015-07-28 2019-08-29 ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед Производные бетулина для предупреждения или лечения ВИЧ-инфекций
KR20180028534A (ko) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체
CN108368071A (zh) * 2015-09-24 2018-08-03 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的化合物
CN108699103A (zh) 2016-01-20 2018-10-23 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的羽扇烷类的胺衍生物
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478703A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
WO2019207460A1 (en) 2018-04-24 2019-10-31 VIIV Healthcare UK (No.5) Limited Compounds with hiv maturation inhibitory activity
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
US10343997B1 (en) 2018-12-04 2019-07-09 King Saud University Ursolic acid derivatives

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US5962527A (en) 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5679828A (en) * 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
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WO2009114083A2 (en) 2008-03-03 2009-09-17 Panacos Pharmaceuticals, Inc. Determinants of antiviral response
SI2271658T1 (sl) * 2008-04-18 2017-03-31 Reata Pharmaceuticals, Inc. Antioksidantni modulatorji vnetja: C-17 homologirani derivati oleanolne kisline
KR20120138761A (ko) * 2010-02-11 2012-12-26 글락소스미스클라인 엘엘씨 베툴린의 유도체

Also Published As

Publication number Publication date
EP2576586B1 (en) 2015-08-12
MX2012013628A (es) 2012-12-17
EA026140B1 (ru) 2017-03-31
BR112012030810A2 (pt) 2019-09-24
HRP20150977T1 (hr) 2015-10-09
CN102985438B (zh) 2016-05-18
PT2576586E (pt) 2015-10-23
WO2011153319A1 (en) 2011-12-08
PL2576586T3 (pl) 2016-01-29
CN102985438A (zh) 2013-03-20
JP2013527243A (ja) 2013-06-27
EP2576586A1 (en) 2013-04-10
CA2801491A1 (en) 2011-12-08
SMT201500272B (it) 2016-01-08
RS54239B1 (sr) 2015-12-31
DK2576586T3 (en) 2015-11-23
US8802661B2 (en) 2014-08-12
SI2576586T1 (sl) 2015-11-30
ES2548905T3 (es) 2015-10-21
US20120142653A1 (en) 2012-06-07
JP5755731B2 (ja) 2015-07-29
TW201201792A (en) 2012-01-16
EA201270800A1 (ru) 2013-04-30
CA2801491C (en) 2018-01-23
HUE026662T2 (en) 2016-06-28

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