HRP20150959T1 - Emulzija ulje-u-vodi koja sadrži mometazon i propilen glikol - Google Patents
Emulzija ulje-u-vodi koja sadrži mometazon i propilen glikol Download PDFInfo
- Publication number
- HRP20150959T1 HRP20150959T1 HRP20150959TT HRP20150959T HRP20150959T1 HR P20150959 T1 HRP20150959 T1 HR P20150959T1 HR P20150959T T HRP20150959T T HR P20150959TT HR P20150959 T HRP20150959 T HR P20150959T HR P20150959 T1 HRP20150959 T1 HR P20150959T1
- Authority
- HR
- Croatia
- Prior art keywords
- oil
- water emulsion
- mometasone
- emulsion according
- propylene glycol
- Prior art date
Links
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title claims 24
- 239000007764 o/w emulsion Substances 0.000 title claims 20
- 229960001664 mometasone Drugs 0.000 title claims 8
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 title claims 8
- 229960002744 mometasone furoate Drugs 0.000 claims 8
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 8
- 239000003995 emulsifying agent Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 5
- 239000008158 vegetable oil Substances 0.000 claims 5
- 239000000839 emulsion Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 239000003002 pH adjusting agent Substances 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 229960003511 macrogol Drugs 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 235000019198 oils Nutrition 0.000 claims 2
- -1 polyoxyethylene Polymers 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- 235000019484 Rapeseed oil Nutrition 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 1
- 239000003240 coconut oil Substances 0.000 claims 1
- 235000019864 coconut oil Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 229960004063 propylene glycol Drugs 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Claims (17)
1. Emulzija ulje-u-vodi koja sadrži mometazon ili mometazon furoat i propilen glikol, te je koncentracija propilen glikola od 20 do 45% w/w, naznačena time da je udio mometazona ili mometazon furoata sadržan u neotopljenom obliku.
2. Emulzija ulje-u-vodi prema zahtjevu 1, naznačena time da težinski omjer između propilen glikola i vode sadržane u emulziji ulje-u-vodi je od 1:1 do 1:3.
3. Emulzija ulje-u-vodi prema bilo kojem od prethodnih zahtjeva, naznačena time da mometazon ili mometazon furoat je jedini terapeutski aktivni sastojak.
4. Emulzija ulje-u-vodi prema bilo kojem od prethodnih zahtjeva, naznačena time da je mometazon ili mometazon furoat prisutan u emulziji u mikroniziranom obliku.
5. Emulzija ulje-u-vodi prema bilo kojem od prethodnih zahtjeva naznačena time da ulje je biljno ulje.
6. Emulzija ulje-u-vodi prema zahtjevu 5, naznačena time da biljno ulje je kokosovo ulje, maslinovo ulje, suncokretovo ulje i/ili repičino ulje.
7. Emulzija ulje-u-vodi prema bilo kojem od zahtjeva 5 do 6, naznačena time da je koncentracija ulja u emulziji ulje-u-vodi od oko 3 do 30% w/w.
8. Emulzija ulje-u-vodi prema bilo kojem od prethodnih zahtjeva naznačena time da dodatno sadrži jedan ili više emulgatora.
9. Emulzija ulje-u-vodi prema zahtjevu 8, naznačena time da je jedan ili više emulgatora odabran iz skupine koju čine glicerol alkil esteri, makrogol alkil esteri, polioksietilenglikol alkil esteri, masne kiseline, polioksietilen sorbitan esteri, polioksietilen alkil eteri, galaktolipidi.
10. Emulzija ulje-u-vodi prema zahtjevima 8 do 9, naznačena time da su jedan ili više emulgatora glicerol monostearat 40-55, makrogol stearat, ili stearinska kiselina.
11. Emulzija ulje-u-vodi prema prethodnim zahtjevima naznačena time da dodatno sadrži sredstvo koje povećava viskoznost.
12. Emulzija ulje-u-vodi prema zahtjevu 11, naznačena time da jedno ili više sredstava koja povećavaju viskoznost je cetostearil alkohol.
13. Emulzija ulje-u-vodi prema bilo kojem od prethodnih zahtjeva naznačena time da sadrži:
0.05-0.2 % w/w mometazona ili mometazon furoata
20-45 % w/w propilen glikola,
3-30 % w/w biljnog ulja,
1-15 % w/w jednog ili više emulgatora,
proizvoljno 0.1-1% w/w sredstva za podešavanje pH,
proizvoljno 5-15% w/w sredstva za povećanje viskoznosti,
do 100% w/w vode.
14. Emulzija ulje-u-vodi prema bilo kojem od prethodnih zahtjeva naznačena time da sadrži:
0.06-0.15 % w/w mometazona ili mometazon furoata
20-40 % w/w propilen glikola,
5-15 % w/w biljnog ulja,
1-10 % w/w jednog ili više emulgatora,
0.1-1% w/w sredstva za podešavanje pH za podešavanje pH emulzije na oko 4-6,
proizvoljno 5-15% w/w sredstva za povećanje viskoznosti,
do 100% w/w vode.
15. Emulzija ulje-u-vodi prema bilo kojem od prethodnih zahtjeva naznačena time da sadrži:
0.1 % w/w mometazona ili mometazon furoata
od 20 do 30 % w/w propilen glikola,
od 5 do 10 % w/w biljnog ulja,
od 5-10 % w/w jednog ili više emulgatora,
0.1-1% w/w sredstva za podešavanje pH za podešavanje pH emulzije na oko 4-6,
5-10% w/w sredstva za povećanje viskoznosti,
do 100% w/w vode.
16. Emulzija ulje-u-vodi prema bilo kojem od prethodnih zahtjeva uz uvjet da emulzija ne sadrži jedan ili više konzervansa osim bilo kojeg učinka konzervansa koji se odnosi na propilen glikol.
17. Emulzija ulje-u-vodi koja sadrži:
[image]
naznačena time da je udio mometazon furoata sadržan u neotopljenom obliku.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200900601 | 2009-05-12 | ||
| PCT/EP2010/002921 WO2010130428A1 (en) | 2009-05-12 | 2010-05-12 | Oil-in-water emulsion of mometasone and propylene glycol |
| EP10721697.0A EP2429510B1 (en) | 2009-05-12 | 2010-05-12 | Oil-in-water emulsion of mometasone and propylene glycol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150959T1 true HRP20150959T1 (hr) | 2015-11-06 |
Family
ID=42352732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150959TT HRP20150959T1 (hr) | 2009-05-12 | 2015-09-11 | Emulzija ulje-u-vodi koja sadrži mometazon i propilen glikol |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8728497B2 (hr) |
| EP (2) | EP2962688B1 (hr) |
| JP (2) | JP5833541B2 (hr) |
| CN (1) | CN102458382B (hr) |
| AU (1) | AU2010246613B2 (hr) |
| BR (1) | BRPI1010907B8 (hr) |
| CA (1) | CA2761739C (hr) |
| CY (1) | CY1116667T1 (hr) |
| DK (1) | DK2429510T3 (hr) |
| ES (2) | ES2813400T3 (hr) |
| HR (1) | HRP20150959T1 (hr) |
| HU (1) | HUE027718T2 (hr) |
| MX (1) | MX345888B (hr) |
| NZ (1) | NZ596429A (hr) |
| PL (2) | PL2429510T3 (hr) |
| PT (1) | PT2429510E (hr) |
| RU (1) | RU2526911C2 (hr) |
| SI (1) | SI2429510T1 (hr) |
| SM (1) | SMT201500297B (hr) |
| WO (1) | WO2010130428A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX345888B (es) | 2009-05-12 | 2017-02-22 | Galenica Ab * | Emulsion aceite en agua de mometasona y propilenglicol. |
| PT105982B (pt) * | 2011-11-03 | 2014-07-29 | Laboratório Edol Produtos Farmac Uticos S A | Composição e método de preparação a frio de uma emulsão utilizada como veículo de fármacos anti-inflamatórios |
| WO2019082873A1 (ja) * | 2017-10-23 | 2019-05-02 | マルホ株式会社 | 被膜形成外用剤 |
| US20190282465A1 (en) * | 2018-03-19 | 2019-09-19 | Essential Lipid Technologies, LLC | Topical Phospholipid Formulations and Methods for Preparing the Same |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4282216A (en) * | 1977-04-20 | 1981-08-04 | Johnson & Johnson | Topical anti-inflammatory drug therapy |
| US4808610A (en) | 1986-10-02 | 1989-02-28 | Schering Corporation | Mometasone furoate anti-inflammatory cream composition using hexylene glycol |
| US5422361A (en) * | 1989-12-20 | 1995-06-06 | Schering Corporation | Stable cream and lotion bases for lipophilic drug compositions |
| US6127353A (en) | 1991-09-06 | 2000-10-03 | Schering Corporation | Mometasone furoate monohydrate, process for making same and pharmaceutical compositions |
| WO1994013257A1 (en) * | 1992-12-16 | 1994-06-23 | Creative Products Resource Associates, Ltd. | Occlusive/semi-occlusive lotion for treatment of a skin disease or disorder |
| US5696105A (en) * | 1996-03-14 | 1997-12-09 | Hackler; Walter A. | Antifungal nail composition |
| US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
| US6075056A (en) | 1997-10-03 | 2000-06-13 | Penederm, Inc. | Antifungal/steroid topical compositions |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| US7030203B2 (en) * | 2001-09-28 | 2006-04-18 | 3M Innovative Properties Company | Water-in-oil emulsions with ethylene oxide groups, compositions, and methods |
| PE20030828A1 (es) * | 2002-03-04 | 2003-11-04 | Novartis Ag | Composicion oftalmica que comprende ascomicina |
| TR200201343A2 (tr) | 2002-05-17 | 2003-12-22 | Orva İlaç Sanayi̇ Ve Ti̇caret A. Ş. | Kortikosteroid ve antiseptik içeren farmasötik bileşim |
| DE60318727T2 (de) | 2002-08-27 | 2009-01-08 | Schering Corp. | Verfahren zur herstellung von dosierinhalatorformulierungen |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US20060104968A1 (en) * | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| EP1624861A2 (en) | 2003-05-23 | 2006-02-15 | Taro Pharmaceuticals Industries Ltd. | Novel topical steroid cream formulations |
| US20070179152A1 (en) | 2003-05-23 | 2007-08-02 | Lee Margaret S | Combination therapy for the treatment of neoplasms |
| US20050196462A1 (en) * | 2003-12-30 | 2005-09-08 | Oculus Innovative Sciences, Inc. | Topical formulation containing oxidative reductive potential water solution and method for using same |
| US20070099883A1 (en) * | 2005-10-07 | 2007-05-03 | Cheryl Lynn Calis | Anhydrous mometasone furoate formulation |
| DE102006034883A1 (de) | 2006-07-25 | 2008-01-31 | Hermal Kurt Herrmann Gmbh & Co. Ohg | Pharmazeutische Zusammensetzung enthaltend Mometasonfuroat |
| WO2008126076A2 (en) * | 2007-04-11 | 2008-10-23 | Perrigo Israel Pharmaceuticals Ltd. | Low-dose mometasone formulations |
| DK2429490T3 (en) | 2009-05-12 | 2017-02-20 | Galenica Ab | OIL-IN-WATER EMULSION OF MOMETASON |
| MX345888B (es) | 2009-05-12 | 2017-02-22 | Galenica Ab * | Emulsion aceite en agua de mometasona y propilenglicol. |
-
2010
- 2010-05-12 MX MX2011011959A patent/MX345888B/es active IP Right Grant
- 2010-05-12 HU HUE10721697A patent/HUE027718T2/en unknown
- 2010-05-12 PL PL10721697T patent/PL2429510T3/pl unknown
- 2010-05-12 ES ES15172934T patent/ES2813400T3/es active Active
- 2010-05-12 AU AU2010246613A patent/AU2010246613B2/en active Active
- 2010-05-12 CN CN201080030169.1A patent/CN102458382B/zh active Active
- 2010-05-12 DK DK10721697.0T patent/DK2429510T3/en active
- 2010-05-12 WO PCT/EP2010/002921 patent/WO2010130428A1/en active Application Filing
- 2010-05-12 PL PL15172934T patent/PL2962688T3/pl unknown
- 2010-05-12 PT PT107216970T patent/PT2429510E/pt unknown
- 2010-05-12 CA CA2761739A patent/CA2761739C/en active Active
- 2010-05-12 JP JP2012510162A patent/JP5833541B2/ja active Active
- 2010-05-12 EP EP15172934.0A patent/EP2962688B1/en active Active
- 2010-05-12 RU RU2011150246/15A patent/RU2526911C2/ru active
- 2010-05-12 SI SI201031007T patent/SI2429510T1/sl unknown
- 2010-05-12 NZ NZ596429A patent/NZ596429A/xx not_active IP Right Cessation
- 2010-05-12 ES ES10721697.0T patent/ES2547556T3/es active Active
- 2010-05-12 EP EP10721697.0A patent/EP2429510B1/en active Active
- 2010-05-12 US US13/319,758 patent/US8728497B2/en active Active
- 2010-05-12 BR BRPI1010907A patent/BRPI1010907B8/pt active IP Right Grant
-
2014
- 2014-02-24 US US14/187,997 patent/US11395827B2/en active Active
-
2015
- 2015-07-16 JP JP2015142118A patent/JP2015227354A/ja active Pending
- 2015-09-03 CY CY20151100770T patent/CY1116667T1/el unknown
- 2015-09-11 HR HRP20150959TT patent/HRP20150959T1/hr unknown
- 2015-11-30 SM SM201500297T patent/SMT201500297B/it unknown
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