HRP20150685T1 - Postupak za pripremu mehaniäśki strukturiranog sedefa pomoä†u mehanosinzete, mehaniäśki strukturiran sedef proizveden istom, i primjene istoga - Google Patents
Postupak za pripremu mehaniäśki strukturiranog sedefa pomoä†u mehanosinzete, mehaniäśki strukturiran sedef proizveden istom, i primjene istoga Download PDFInfo
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- HRP20150685T1 HRP20150685T1 HRP20150685TT HRP20150685T HRP20150685T1 HR P20150685 T1 HRP20150685 T1 HR P20150685T1 HR P20150685T T HRP20150685T T HR P20150685TT HR P20150685 T HRP20150685 T HR P20150685T HR P20150685 T1 HRP20150685 T1 HR P20150685T1
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- mechanosynthesis
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- 238000000034 method Methods 0.000 title claims 17
- 238000000133 mechanosynthesis reaction Methods 0.000 title claims 11
- 238000000227 grinding Methods 0.000 claims 30
- 239000000843 powder Substances 0.000 claims 21
- 239000002245 particle Substances 0.000 claims 9
- 239000000463 material Substances 0.000 claims 4
- 238000005507 spraying Methods 0.000 claims 4
- 210000000988 bone and bone Anatomy 0.000 claims 3
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims 2
- 238000007598 dipping method Methods 0.000 claims 2
- 238000005868 electrolysis reaction Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- -1 5H2O) Chemical compound 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 241000195493 Cryptophyta Species 0.000 claims 1
- 241000490567 Pinctada Species 0.000 claims 1
- 241001464019 Pinctada margaritifera Species 0.000 claims 1
- 241001490476 Pinctada maxima Species 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 230000001133 acceleration Effects 0.000 claims 1
- 229920001222 biopolymer Polymers 0.000 claims 1
- 229910000365 copper sulfate Inorganic materials 0.000 claims 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000004053 dental implant Substances 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 230000002045 lasting effect Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 235000015170 shellfish Nutrition 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Marine Sciences & Fisheries (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Prostheses (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Dental Prosthetics (AREA)
- Farming Of Fish And Shellfish (AREA)
Claims (16)
1. Postupak za primjenu mehanički strukturiranog sedefa pomoću mehanosinteze mikrometrijskog praha sedefa, naznačen time da se temperatura sedefa održava ispod 40°C, po mogućnosti ispod 20°C, a čak prikladnije ispod ili jednako 0°C, te da se čestice sedefa za tretiranje dobivaju iz sedefnog testa, na primjer unutarnjeg oklopa školjkaša.
2. Postupak za primjenu mehanički strukturiranog sedefa pomoću mehanosinteze mikrometrijskog praha sedefa sukladno Zahtjevu 1, naznačen time da se čestice sedefa za tretiranje dobivaju iz sedefnog testa, na primjer unutarnjeg oklopa školjkaša odabranih iz skupine koja sadrži: Pinctada maxima, Pinctada margaritifera ili druge Pinctade, Tridacnae gigas, te mješavine navedenih.
3. Postupak za primjenu mehanički strukturiranog sedefa pomoću mehanosinteze mikrometrijskog praha sedefa sukladno Zahtjevu 1 ili 2 koji sadrži sljedeće postupne faze:
a) sedefni prah koji će se obrađivati smješta se u posudu za mljevenje planetarnog mlina, zatim
b) Ni kuglice za mljevenje (s i integerom sadržanim između 1 i 20, najbolje 3 i 15, a radije između 5 i 14; Ni je integer sadržan između 2 i 150, najbolje između 10 i 100 te preferencijalno između 20 i 85) promjera Di smještene su u posudu za mljevenje,
c) Planetarni mlin se pokreće brzinom rotacije V sadržanom između 800 i 1400 rpm, preferencijalno 1100rpm, s ubrzanjem od 90 do 110 G, preferencijalno 90 do 100 G, a najbolje od 95 G,
d) planetarni mlin zaustavljen je u uklanjaju se kuglice za mljevenje promjera Di,
Faze b,c i d ponavljaju se s Ni+1 (s Ni+1 > Ni) s kuglicama za mljevenje promjera Di+1 (s Di+1 < Di), sve dok se ne dobiju čestice sedefa željene veličine;
Kada se postigne željena veličina čestica, završetkom faze d), dobiva se mehanostrukturirani sedef.
4. Postupak za primjenu mehanički strukturiranog sedefa pomoću mehanosinteze mikrometrijskog praha sedefa sukladno bilo kojem Zahtjevu 1 do 3, naznačen činjenicom da su broj i promjer kuglica takvi da postoji odnos od 2/5 po težini čestica sedefa koje će se obrađivati do 3/5 po težini čestica.
5. Postupak za primjenu mehanički strukturiranog sedefa pomoću mehanosinteze mikrometrijskog praha sedefa sukladno bilo kojem Zahtjevu 1 do 4, naznačen time da su posuda za mljevenje, sedefni prah koji će se obrađivati i/ili kuglice za mljevenje ohlađeni prije upotrebe na temperaturu između -30°C i 5°C, po mogućnosti između -20°C i -15°C te po izboru prije svakog ponavljanja faza b), c) i d).
6. Postupak za primjenu mehanički strukturiranog sedefa pomoću mehanosinteze mikrometrijskog praha sedefa sukladno bilo kojem Zahtjevu 1 do 5, naznačen time da su ciklusi mljevenja c) provedeni na temperaturi hlađenja ili ispresijecani ciklusima hlađenja.
7. Postupak za primjenu mehanički strukturiranog sedefa pomoću mehanosinteze mikrometrijskog praha sedefa sukladno bilo kojem Zahtjevu 1 do 6, naznačen time da:
- Sedefni prah koji će se tretirati smješta se u posudu za mljevenje, kuglice za mljevenje smještaju se u posudu za mljevenje, a sustav koji sadrži sedefni prah koji će se tretirati, kuglice za mljevenje i posuda za mljevenje ohlađeni su na temperaturu između -30°C i 5°C, po mogućnosti između -20°C i -15°C,
- Ohlađeni sedefni prah koji će se tretirati zatim se podvrgava:
a) Ciklusima mljevenja pomoću kuglica za mljevenje promjera 10 mm sve dok čestice sedefa srednjeg volumena nisu promjera između 5 i 15 mikrona, zatim
b) Ciklusima mljevenja pomoću kuglica za mljevenje promjera 5 mm sve dok čestice sedefa srednjeg volumena nisu promjera između 800 nm i 2 mm, zatim
c) Ciklusima mljevenja pomoću kuglica za mljevenje promjera 2 mm sve dok čestice sedefa srednjeg volumena nisu promjera manjeg od 500 nm, po mogućnosti manjeg od 250 nm te po mogućnosti promjera manjeg od 100 nm, zatim je dobiven nanostrukturirani sedef.
8. Postupak za primjenu mehanički strukturiranog sedefa pomoću mehanosinteze mikrometrijskog praha sedefa sukladno bilo kojem Zahtjevu 1 do 7, naznačen time da:
Sedefni prah koji će se tretirati smješta se u posudu za mljevenje, kuglice za mljevenje smještaju se u posudu za mljevenje, a sustav koji sadrži sedefni prah koji će se tretirati, kuglice za mljevenje i posuda za mljevenje ohlađeni su na temperaturu između -30°C i 5°C, po mogućnosti između -20°C i -15°C,
Ohlađeni sedefni prah zatim se podvrgava:
5 do 15, po mogućnosti 7 do 13 ciklusa, najbolje 8 do 11 ciklusa mljevenja, svaki ciklus traje 1 do 10 minuta, po mogućnosti 2 do 8 minuta te najbolje 6 minuta, proveden pomoću kuglica za mljevenje promjera 10 mm, zatim
5 do 15 ciklusa mljevenja, po mogućnosti 10 ciklusa, od 1 do 10 minuta, po mogućnosti 6 minuta, proveden pomoću kuglica za mljevenje promjera 5 mm, zatim
5 do 15 ciklusa mljevenja, po mogućnosti 10 ciklusa, od 1 do 10 minuta, po mogućnosti 6 minuta, proveden pomoću kuglica za mljevenje promjera 2 mm, zatim se dobiva nanostrukturirani sedef.
9. Sedefni prah koji je moguće dobiti postupkom određenim bilo kojim od Zahtjeva od 1 do 8 te srednjeg volumena promjera između 0.01 i 500 nanometara, po mogućnosti između 0.01 i 250 nanometara, nadalje preferencijalno između 0.01 i 100 nanometara.
10. Postupak pripreme nanostrukturiranog sedefa mehanosintezom mikrometrijskog sedefnog praha sukladno bilo kojem od Zahtjeva 1 do 8, naznačen time da je sedefni prah koji će se obrađivati samljeven zajedno s barem još jednim materijalom različitim od sedefa.
11. Postupak pripreme nanostrukturiranog sedefa mehanosintezom mikrometrijskog sedefnog praha sukladno Zahtjevu 10, naznačen time da je materijal odabran iz skupine koja sadrži više od 90%-tni deacetilirani hitozan prah, hitin, alge, netopljive i topljive biopolimere ekstrahirane iz sedefnog testa i vanjskog oklopa navedenih školjkaša, bakar sulfat (CuSO4, 5H2O), cink oksid, zlato ili srebro i mješavine istih.
12. Upotreba mehanostrukturiranog sedefa sukladno Zahtjevu 9 ili dobivenog sukladno postupku određenom bilo kojim od Zahtjeva 1 do 8 i 10 do 11, u primjenama u kozmetici.
13. Upotreba mehanostrukturiranog sedefa sukladno Zahtjevu 9 ili dobivenog sukladno postupku određenom bilo kojim od Zahtjeva 1 do 8 i 10 do 11 za prekrivanje kosti i dentalnih implantanata, te dijelova koji zamjenjuju kosti.
14. Implantat koji sadrži jezgru strukturalnog materijala, po izboru od sedefa, površina kojeg je prekrivena raspršivanjem, prskanjem, presvlačenjem, elektrolizom ili uranjanjem sedefa sukladno Zahtjevu 9 ili dobivenog sukladno postupku opisanom bilo kojim od Zahtjeva 1 do 8 i 10 do 11.
15. Dio za popunjavanje kosti koji sadrži jezgru strukturalnog materijala, po izboru od sedefa, površina kojeg je prekrivena raspršivanjem, prskanjem, presvlačenjem, elektrolizom ili uranjanjem sedefa sukladno Zahtjevu 9 ili dobivenog sukladno postupku opisanom bilo kojim od Zahtjeva 1 do 8 i 10 do 11.
16. Mehanostrukturirani sedef sukladno Zahtjevu 9 ili dobiven sukladno postupku opisanom bilo kojim od Zahtjeva 1 do 8 i 10 do 11, za medicinsku ili veterinarsku upotrebu.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0954066A FR2946888B1 (fr) | 2009-06-17 | 2009-06-17 | Procede de preparation de nacre mecanostructuree par mecano-synthese, nacre mecanostructuree ainsi obtenue et ses applications |
| PCT/FR2010/051201 WO2010146308A1 (fr) | 2009-06-17 | 2010-06-16 | Procédé de préparation de nacre mécanostructurée par mécano-synthèse, nacre mécanostructurée ainsi obtenue et ses applications |
| EP10734250.3A EP2442838B1 (fr) | 2009-06-17 | 2010-06-16 | Procédé de préparation de nacre mécanostructurée par mécano-synthèse, nacre mécanostructurée ainsi obtenue et ses applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150685T1 true HRP20150685T1 (hr) | 2015-08-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150685TT HRP20150685T1 (hr) | 2009-06-17 | 2015-06-26 | Postupak za pripremu mehaniäśki strukturiranog sedefa pomoä†u mehanosinzete, mehaniäśki strukturiran sedef proizveden istom, i primjene istoga |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8485458B2 (hr) |
| EP (1) | EP2442838B1 (hr) |
| JP (2) | JP6246467B2 (hr) |
| KR (1) | KR101699914B1 (hr) |
| CN (1) | CN102802687B (hr) |
| AU (1) | AU2010261594B2 (hr) |
| BR (1) | BRPI1015555B1 (hr) |
| CA (1) | CA2765930C (hr) |
| DK (1) | DK2442838T3 (hr) |
| ES (1) | ES2540808T3 (hr) |
| FR (1) | FR2946888B1 (hr) |
| HR (1) | HRP20150685T1 (hr) |
| HU (1) | HUE026050T2 (hr) |
| IL (1) | IL216935A (hr) |
| MX (1) | MX2012000030A (hr) |
| PL (1) | PL2442838T3 (hr) |
| PT (1) | PT2442838E (hr) |
| RU (1) | RU2555766C2 (hr) |
| WO (1) | WO2010146308A1 (hr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10167564A (ja) * | 1996-12-05 | 1998-06-23 | Toray Ind Inc | 炭素繊維パッケージおよび炭素繊維梱包体 |
| US8205623B2 (en) * | 2010-04-05 | 2012-06-26 | Rovcal, Inc. | Coatings for personal grooming apparatus containing calcium carbonate derived from mollusk shells or pearls |
| CN102274243B (zh) * | 2011-09-16 | 2012-08-22 | 无锡市西施美日化有限公司 | 瓷球滚碾水磨法生产珍珠粉的方法 |
| CN103665187A (zh) * | 2013-11-22 | 2014-03-26 | 徐广苓 | 一种壳聚糖的制备方法 |
| US10478309B2 (en) | 2014-01-10 | 2019-11-19 | Mbp (Mauritius) Ltd | Method for producing osteosynthesis devices, osteosynthesis devices and implants made of semi-synthetic hybrid material obtained by structural modification of the components of a natural marine biomaterial |
| FR3016293B1 (fr) * | 2014-01-10 | 2019-12-20 | Mbp (Mauritius) Ltd | Procede de fabrication de dispositifs d'osteosynthese, dispositifs d'osteosynthese et implants en materiau hybride semi-synthetique obtenu par modification structurale des composants d'un biomateriau naturel marin |
| CN104135708B (zh) * | 2014-08-14 | 2017-08-25 | 陈宏乔 | 玉化砗磲珍珠质纳米粉及扬声器振膜的制作方法 |
| US10342895B2 (en) * | 2015-06-23 | 2019-07-09 | Mbp (Mauritius) Ltd | Pulverulent semisynthetic material obtained by modifying the composition of a natural marine biomaterial, method of manufacture thereof, and applications thereof |
| FR3037801B1 (fr) * | 2015-06-23 | 2017-08-11 | Jd Invest | Materiau semi-synthetique pulverulent, obtenu par modification de la composition d'un biomateriau naturel marin, son procede de fabrication, ses applications |
| CN105056209A (zh) * | 2015-07-16 | 2015-11-18 | 中山大学深圳研究院 | 珍珠母蛋白n16在制备促成骨活性药物中的应用 |
| CN105056210A (zh) * | 2015-07-16 | 2015-11-18 | 中山大学深圳研究院 | 珍珠母蛋白n16在制备抑制破骨活性药物中的应用 |
| CN109851690B (zh) * | 2019-03-14 | 2021-11-02 | 福州大学 | 一种贝壳珍珠层几丁质的制备方法 |
| CN112237648B (zh) * | 2020-09-29 | 2022-10-11 | 上海理工大学 | 一种含磷珍珠质涂层及其制备方法 |
| CN112843328B (zh) * | 2021-02-25 | 2022-05-13 | 山东大学 | 一种具有抑菌作用的鲍鱼壳粉/ZnO复合材料掺杂的智能水凝胶伤口敷料的制备方法 |
| CN112999142A (zh) * | 2021-03-03 | 2021-06-22 | 优牌智能科技(上海)有限公司 | 一种益健康牙膏及其制备工艺 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62298507A (ja) * | 1986-06-18 | 1987-12-25 | Mikimoto Seiyaku Kk | 化粧品 |
| FR2647334A1 (fr) | 1989-05-23 | 1990-11-30 | Cazprasse Serge | Produits de remplacement de structures osseuses et radiculo-dentaires en nacre |
| CN1067224C (zh) * | 1995-08-11 | 2001-06-20 | 林其溪 | 珍珠、鲨鱼骨、牡蛎壳、乌贼骨软化蜜及制备方法 |
| JPH11209225A (ja) * | 1998-01-21 | 1999-08-03 | Leap:Kk | 貝の利用方法 |
| FR2777190B1 (fr) | 1998-04-14 | 2001-07-27 | Georges Camprasse | Procede d'extraction, identification des principes actifs contenus dans la coquille interne et externe des mollusques marins, leur utilisation dans des preparations a visee thera peutique,diagnostic et cosmetique |
| JP2001278793A (ja) * | 2000-03-29 | 2001-10-10 | Choya:Kk | 易吸収性カルシウム剤の製法 |
| FR2808657B1 (fr) * | 2000-05-11 | 2003-06-13 | Pharma Futura | Composition commestible comprenant de la poudre de nacre micronisee |
| FR2827478B1 (fr) * | 2001-07-18 | 2003-10-24 | Jean Louis Montero | Procede de preparation d'une poudre a base de nacre, proteine isolee de ladite poudre et leurs utilisations en chirurgie osseuse et dans diverses pathologies osteoarticulaires |
| JP3799279B2 (ja) * | 2002-02-28 | 2006-07-19 | 遠赤青汁株式会社 | 真珠貝貝殻の処理方法 |
| CN101062060A (zh) * | 2006-04-28 | 2007-10-31 | 海南京润珍珠生物技术有限公司 | 纳米珍珠粉的制备方法 |
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- 2010-06-16 PT PT107342503T patent/PT2442838E/pt unknown
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- 2010-06-16 HU HUE10734250A patent/HUE026050T2/en unknown
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|---|---|
| PT2442838E (pt) | 2015-08-20 |
| IL216935A (en) | 2015-05-31 |
| IL216935A0 (en) | 2012-02-29 |
| JP2012529949A (ja) | 2012-11-29 |
| PL2442838T3 (pl) | 2015-08-31 |
| RU2555766C2 (ru) | 2015-07-10 |
| EP2442838A1 (fr) | 2012-04-25 |
| CA2765930A1 (fr) | 2010-12-23 |
| JP2018038809A (ja) | 2018-03-15 |
| MX2012000030A (es) | 2012-04-19 |
| CA2765930C (fr) | 2017-09-05 |
| CN102802687A (zh) | 2012-11-28 |
| KR101699914B1 (ko) | 2017-02-08 |
| CN102802687B (zh) | 2017-08-15 |
| RU2012101418A (ru) | 2013-07-27 |
| KR20120089624A (ko) | 2012-08-13 |
| HUE026050T2 (en) | 2016-05-30 |
| AU2010261594A1 (en) | 2012-01-19 |
| ES2540808T3 (es) | 2015-07-13 |
| BRPI1015555A2 (pt) | 2016-04-26 |
| DK2442838T3 (en) | 2015-07-06 |
| WO2010146308A1 (fr) | 2010-12-23 |
| FR2946888B1 (fr) | 2011-07-29 |
| FR2946888A1 (fr) | 2010-12-24 |
| BRPI1015555B1 (pt) | 2018-07-03 |
| AU2010261594B2 (en) | 2013-11-28 |
| US20110004218A1 (en) | 2011-01-06 |
| EP2442838B1 (fr) | 2015-04-08 |
| BRPI1015555A8 (pt) | 2018-01-02 |
| JP6246467B2 (ja) | 2017-12-13 |
| US8485458B2 (en) | 2013-07-16 |
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