HRP20140071T1 - Derivat piperidinila kao modulator aktivnosti receptora kemokina - Google Patents
Derivat piperidinila kao modulator aktivnosti receptora kemokina Download PDFInfo
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- HRP20140071T1 HRP20140071T1 HRP20140071AT HRP20140071T HRP20140071T1 HR P20140071 T1 HRP20140071 T1 HR P20140071T1 HR P20140071A T HRP20140071A T HR P20140071AT HR P20140071 T HRP20140071 T HR P20140071T HR P20140071 T1 HRP20140071 T1 HR P20140071T1
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- acid
- additional active
- compound
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- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 125000003386 piperidinyl group Chemical group 0.000 title 1
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Landscapes
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Claims (19)
1. Spoj Formule (I):
[image]
ili njegov stereoizomer ili farmaceutski prihvatljiv oblik soli.
2. Farmaceutska smjesa sastavljena od farmaceutski prihvatljivog nosača i terapijski učinkovite količine spoja prema zahtjevu 1.
3. Farmaceutska smjesa koja sadrži spoj prema zahtjevu 1 te jednu ili više dodatnih djelatnih tvari.
4. Farmaceutska smjesa prema zahtjevu 3 gdje se jedna ili više dodatnih djelatnih tvari izabire između protu-upalnog sredstva, analgetika, sredstva protiv bolova, potencijatora, dekongestiva, sredstva protiv kašlja, diuretika te antihistaminika s ili bez sedativnog svojstva.
5. Farmaceutska smjesa prema zahtjevu 3 gdje se jedna ili više dodatnih djelatnih tvari izabire između antagonista integrina, steroida, imunosupresiva, antihistaminika, ne-steroidnih anti-astmatika, ne-steroidnih protu-upalnih lijekova (NSAIDS), inhibitora ciklo-oksigenaze-2 (COX-2), inhibitora fosfodiesteraze tip IV (PDE-IV), antagonista receptora kemokina, sredstava za snižavanje kolesterola, antidijabetika, pripravaka interferona, antivirusnih spojeva, antimetabolita i citotoksičnih kemoterapijskih sredstava protiv raka.
6. Farmaceutska smjesa prema zahtjevu 3 gdje se jedna ili više dodatnih djelatnih tvari izabire između opioidnog agonista, inhibitora lipo-oksigenaze, inhibitora ciklo-oksigenaze -2, inhibitora interleukina, inhibitora faktora nekroze tumora, antagonista NMDA, inhibitora dušikovog oksida ili inhibitora sinteze dušikovog oksdia, ne-steroidnih protu-upalnih lijekova, inhibitora fosfodiesteraze, protu-upalnih lijekova koji suprimiraju citokin, steroidnog analgetika i H2-antagonista.
7. Farmaceutska smjesa prema zahtjevu 6 gdje je jedna ili više dodatnih djelatnih tvari inhibitor interleukina.
8. Farmaceutska smjesa prema zahtjevu 6 gdje je jedna ili više dodatnih djelatnih tvari inhibitor faktora nekroze tumora.
9. Farmaceutska smjesa prema zahtjevu 3 gdje se jedna ili više dodatnih djelatnih tvari izabire između antagonista za selektine, ICAM i VLA-4; FK-506 tip imunosupresiva; H1-histamin antagonista; ne-steroidnih anti-astmatika izabranih između b2-agonista, antagonista leukotriena, i inhibitora sinteze leukotriena; ne-steroidnih protu-upalnih lijekova (NSAIDS) izabranih između derivata propionske kiseline, derivata octene kiseline, derivata fenaminske kiseline, derivata bifenilkarboksilne kiseline, oksikama, salicilata i pirazolona; sredstava za snižavanje kolesterola izabranih između inhibitora reduktaze HMG-COA, sekvestranata, nikotinske kiseline, derivata fenofibrične kiseline; antidijabetika izabranih između sulfonilurea, bigvanida, inhibitora a-glukozidase i glitazona; i pripravaka interferona izabranih između interferona alfa-2a, interferona-2B, interferona alfa-N3, interferona beta-1a, interferona beta-1b i interferona gama-1b.
10. Farmaceutska smjesa prema zahtjevu 9 gdje je jedna ili više dodatnih djelatnih tvari ICAM antagonist.
11. Farmaceutska smjesa prema zahtjevu 3 gdje se jedna ili više dodatnih djelatnih tvari izabire između acetaminofena, aspirina, kodeina, fentanila, ibuprofena, indometacina, ketorolaka, morfija, naproksena, fenacetina, piroksikama, sufentanila, sunlindaka, interferona alfa, kofeina, simetikona, aluminijevog ili magnezijevog hidroksida, fenilefrina, fenilpropanolamina, pseudofedrina, oksimetazolina, efinefrina, nafazolina, ksilometazolina, propilheksedrina, levodeoksi-efedrina, kodeina, hidrokodona, karamifena, karbetapentana i dekstrametorfana.
12. Farmaceutska smjesa prema zahtjevu 3 gdje se jedna ili više dodatnih djelatnih tvari izabire između beklometazona, metilprednizolona, betametazona, prednizona, deksametazona, hidrokortizona; ciklosporina, takrolimusa, rapamicina; bromofeniramina, klorfeniramina, deksklorfeniramina, triprolidina, klemastina, difenhidramina, difenilpiralina, tripelenamina, hidroksizina, metdilazina, prometazina, trimeprazina, azatadina, ciproheptadina, antazolina, feniramin pirilamina, astemizola, terfenadina, loratadina, cetirizina, feksofenadina, dekarboetoksiloratadina, terbutalina, metaproterenola, fenoterola, izoetarina, albuterala, bitolterola, pirbuterola, teofillina, kromolin natrija, atropina, ipratropij bromida, zafirlukasta, montelukasta, pranlukasta, iralukasta, pobilukasta, SKB-102,203, zileutona, BAY-1005, alminoprofena, benksaprofena, bukloksične kiseline, karprofena, fenbufena, fenoprofena, fluprofena, flurbiprofena, ibuprofena, indoprofena, ketoprofena, miroprofena, naproksena, oksaprozina, pirprofena, pranoprofena, suprofena, tiaprofenainske kiseline, tioksaprofena, indometacina, acemetacina, alklofenaka, klidanaka, diklofenaka, fencklofenaka, fenklozatne kiseline, fentiazaka, furofenaka, ibufenaka, izoksepaka, okspinaka, sulindaka, tiopinaka, tolmetina, zidometacina, zomepiraka, flufenaminske kiseline, meklofenaminske kiseline, mefenaminske kiseline, nifluminske kiseline, tolfenaminske kiseline, diflunisala, flufenisala, izoksikama, piroksikama, sudoksikama, tenoksikama, acetil salicilne kiseline, sulfasalazina, apazona, bezpiperilona, feprazona, mofebutazona, oksifenbutazona, fenilbutazona, lovastatina, simvastatina, pravastatina, fluvastatina, atorvastatina, kolestiramina, kolestipola, gemfibrozila, klofibrata, fenofibrata, benzafibrata, probukola, inzulina, metformina, akarboze, troglitazona i pioglitazona, efavirenca, nevirapina, indinavira, ganciklovira, lamivudina, famciklovira, zalcitabina, 5-aminosalicilne kiseline, azatioprina i 6-merkaptopurina.
13. Spoj prema zahtjevu 1 ili smjesa prema bilo kojem od zahtjeva 2 do 12 za uporabu u liječenju.
14. Spoj prema zahtjevu 1 za uporabu u liječenju u kombinaciji s jednom ili više dodatnih djelatnih tvari, gdje je jedna ili više dodatnih djelatnih tvari kako je definirano u bilo kojem od zahtjeva 3 do 12.
15. Spoj za uporabu prema zahtjevu 13 ili zahtjevu 14, ili smjesa za uporabu prema zahtjevu 13, za uporabu u liječenju poremećaja izabranog između spondiloartropatija, osteoartritisa, aneurizme, vrućice, kardiovaskularnih događaja, Crohnove bolesti, kongestivnog zatajenja srca, autoimunih bolesti, HIV-infekcije, HIV-povezane demencije, psorijaze, idiopatske plućne fibroze, fibroze bubrega, cistične fibroze, arterioskleroze transplantanta, fizički ili kemijski inducirane traume mozga, neuropatske boli, upalne bolesti crijeva, alveolitisa, ulceroznog kolitisa, sistemskog lupus eritematosus, nefrotoksičnog serumskog nefritisa, glomerulonefritisa, astme, multiple skleroze, artroskleroze, reumatoidnog artritisa, restenoze, odbacivanja transplantata, multiplog mijeloma, kolorektalnog raka, hepatocelularnog raka i drugih vrsta raka.
16. Spoj za uporabu prema zahtjevu 13 ili zahtjevu 14, ili smjesa za uporabu prema zahtjevu 13, za uporabu u liječenju upalnih bolesti.
17. Spoj za uporabu prema zahtjevu 13 ili zahtjevu 14, ili smjesa za uporabu prema zahtjevu 13, za uporabu u liječenju reumatoidnog artritisa, sistemskog lupus eritematosus, nefrotoksičnog serumskog nefritisa, glomerulonefritisa, multiple skleroze, odbacivanja transplantanta i multiplog mijeloma.
18. Spoj za uporabu prema zahtjevu 13 ili zahtjevu 14, ili smjesa za uporabu prema zahtjevu 13, za uporabu u liječenju cistične fibroze.
19. Spoj za uporabu prema zahtjevu 13 ili zahtjevu 14, ili smjesa za uporabu prema zahtjevu 13, za uporabu u liječenju intersticijske bolesti pluća.
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| PCT/US2009/048564 WO2009158452A1 (en) | 2008-06-25 | 2009-06-25 | Piperidinyl derivative as a modulator of chemokine receptor activity |
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| US8877749B2 (en) * | 2009-10-07 | 2014-11-04 | Bristol-Myers Squibbs Company | Spirocyclic compounds as modulators of chemokine receptor activity |
| US8410139B2 (en) * | 2009-10-07 | 2013-04-02 | Bristol-Myers Squibb Company | Prodrugs of a piperidinyl derivative as modulators of chemokine receptor activity |
| US8642622B2 (en) * | 2010-06-16 | 2014-02-04 | Bristol-Myers Squibb Company | Piperidinyl compound as a modulator of chemokine receptor activity |
| US9095585B2 (en) | 2011-07-21 | 2015-08-04 | Bristol-Myers Squibb Company | Bioavailable compositions of amorphous piperidinyl compounds |
| US20150225790A1 (en) | 2012-04-25 | 2015-08-13 | Bristol-Myers Squibb Company | Methods for identifying subjects with an increased likelihood of responding to ccr1 antagonist |
| US9257178B1 (en) * | 2014-11-26 | 2016-02-09 | Taiwan Semiconductor Manufacturing Company Limited | Devices and methods for writing to a memory cell of a memory |
| US10079235B2 (en) * | 2016-08-31 | 2018-09-18 | Micron Technology, Inc. | Memory cells and memory arrays |
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- 2010-12-14 CO CO10157214A patent/CO6321247A2/es active IP Right Grant
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2011
- 2011-08-08 HK HK11108273.8A patent/HK1154003A1/xx not_active IP Right Cessation
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2012
- 2012-09-27 US US13/628,180 patent/US8633226B2/en active Active
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2014
- 2014-01-21 HR HRP20140071AT patent/HRP20140071T1/hr unknown
- 2014-03-28 CY CY20141100231T patent/CY1114994T1/el unknown
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