HRP20120231T1 - Upotreba derivata indola kao aktivatora nurr-1 u liječenju parkinsonove bolesti - Google Patents
Upotreba derivata indola kao aktivatora nurr-1 u liječenju parkinsonove bolesti Download PDFInfo
- Publication number
- HRP20120231T1 HRP20120231T1 HR20120231T HRP20120231T HRP20120231T1 HR P20120231 T1 HRP20120231 T1 HR P20120231T1 HR 20120231 T HR20120231 T HR 20120231T HR P20120231 T HRP20120231 T HR P20120231T HR P20120231 T1 HRP20120231 T1 HR P20120231T1
- Authority
- HR
- Croatia
- Prior art keywords
- group
- formula
- compound
- disease
- compound according
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title claims abstract 5
- 201000010099 disease Diseases 0.000 title claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 2
- 239000012190 activator Substances 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- -1 useful in therapy Chemical class 0.000 claims abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 238000002560 therapeutic procedure Methods 0.000 claims abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 2
- 239000013543 active substance Substances 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0854712A FR2933609B1 (fr) | 2008-07-10 | 2008-07-10 | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
| PCT/FR2009/051372 WO2010004221A2 (fr) | 2008-07-10 | 2009-07-09 | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120231T1 true HRP20120231T1 (hr) | 2012-04-30 |
Family
ID=40297845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120231T HRP20120231T1 (hr) | 2008-07-10 | 2012-03-13 | Upotreba derivata indola kao aktivatora nurr-1 u liječenju parkinsonove bolesti |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8575210B2 (zh) |
| EP (1) | EP2300424B1 (zh) |
| JP (1) | JP5396650B2 (zh) |
| KR (1) | KR101606184B1 (zh) |
| CN (1) | CN102112441B (zh) |
| AR (1) | AR072718A1 (zh) |
| AT (1) | ATE541831T1 (zh) |
| AU (1) | AU2009269842B2 (zh) |
| BR (1) | BRPI0915627A8 (zh) |
| CA (1) | CA2730302C (zh) |
| CY (1) | CY1112638T1 (zh) |
| DK (1) | DK2300424T3 (zh) |
| EA (1) | EA018079B1 (zh) |
| ES (1) | ES2381180T3 (zh) |
| FR (1) | FR2933609B1 (zh) |
| HK (1) | HK1154852A1 (zh) |
| HR (1) | HRP20120231T1 (zh) |
| IL (1) | IL210386A (zh) |
| MX (1) | MX2011000353A (zh) |
| MY (1) | MY155959A (zh) |
| PL (1) | PL2300424T3 (zh) |
| PT (1) | PT2300424E (zh) |
| SA (1) | SA109300453B1 (zh) |
| SI (1) | SI2300424T1 (zh) |
| TW (1) | TWI414289B (zh) |
| UA (1) | UA102397C2 (zh) |
| WO (1) | WO2010004221A2 (zh) |
| ZA (1) | ZA201100041B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2955108B1 (fr) * | 2010-01-08 | 2012-03-16 | Fournier Lab Sa | Utilisation de derives de pyrrolopyridine comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| EP2487159A1 (en) * | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| WO2013029338A1 (en) * | 2011-09-01 | 2013-03-07 | Glaxo Group Limited | Novel compounds |
| CA3084139C (en) | 2017-11-15 | 2023-02-28 | Korea Research Institute Of Bioscience And Biotechnology | Composition for preventing or treating neurodegenerative diseases, containing diterpene-based compound |
| KR102059160B1 (ko) | 2017-11-15 | 2019-12-24 | 한국생명공학연구원 | 다프난 또는 포볼 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물 |
| KR101964889B1 (ko) | 2017-11-17 | 2019-04-02 | 한국생명공학연구원 | 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물 |
| KR20240020098A (ko) | 2022-08-05 | 2024-02-14 | 엠테라파마 주식회사 | 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7348359B2 (en) * | 2001-03-14 | 2008-03-25 | Eli Lilly And Company | Retinoid X receptor modulators |
| GB0119911D0 (en) * | 2001-08-15 | 2001-10-10 | Novartis Ag | Organic Compounds |
| GB0303503D0 (en) | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| CN1886133B (zh) * | 2003-12-04 | 2010-12-01 | 财团法人卫生研究院 | 吲哚化合物 |
| FR2890071B1 (fr) * | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
| FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2903106B1 (fr) * | 2006-07-03 | 2010-07-30 | Sanofi Aventis | Utilisations de 2-benzoyl-imidazopyridines en therapeutique |
| FR2903105A1 (fr) * | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
| FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
-
2008
- 2008-07-10 FR FR0854712A patent/FR2933609B1/fr not_active Expired - Fee Related
-
2009
- 2009-07-08 SA SA109300453A patent/SA109300453B1/ar unknown
- 2009-07-08 AR ARP090102577A patent/AR072718A1/es unknown
- 2009-07-09 WO PCT/FR2009/051372 patent/WO2010004221A2/fr active Application Filing
- 2009-07-09 DK DK09784501.0T patent/DK2300424T3/da active
- 2009-07-09 MY MYPI2011000084A patent/MY155959A/en unknown
- 2009-07-09 EP EP09784501A patent/EP2300424B1/fr not_active Not-in-force
- 2009-07-09 CA CA2730302A patent/CA2730302C/fr not_active Expired - Fee Related
- 2009-07-09 CN CN2009801269277A patent/CN102112441B/zh not_active Expired - Fee Related
- 2009-07-09 EA EA201170150A patent/EA018079B1/ru not_active IP Right Cessation
- 2009-07-09 US US13/003,554 patent/US8575210B2/en not_active Expired - Fee Related
- 2009-07-09 AT AT09784501T patent/ATE541831T1/de active
- 2009-07-09 MX MX2011000353A patent/MX2011000353A/es active IP Right Grant
- 2009-07-09 KR KR1020117000129A patent/KR101606184B1/ko not_active IP Right Cessation
- 2009-07-09 PL PL09784501T patent/PL2300424T3/pl unknown
- 2009-07-09 UA UAA201100224A patent/UA102397C2/ru unknown
- 2009-07-09 PT PT09784501T patent/PT2300424E/pt unknown
- 2009-07-09 AU AU2009269842A patent/AU2009269842B2/en not_active Ceased
- 2009-07-09 JP JP2011517215A patent/JP5396650B2/ja not_active Expired - Fee Related
- 2009-07-09 ES ES09784501T patent/ES2381180T3/es active Active
- 2009-07-09 SI SI200930209T patent/SI2300424T1/sl unknown
- 2009-07-09 BR BRPI0915627A patent/BRPI0915627A8/pt not_active IP Right Cessation
- 2009-07-10 TW TW098123503A patent/TWI414289B/zh not_active IP Right Cessation
-
2010
- 2010-12-30 IL IL210386A patent/IL210386A/en not_active IP Right Cessation
-
2011
- 2011-01-03 ZA ZA2011/00041A patent/ZA201100041B/en unknown
- 2011-08-29 HK HK11109072.9A patent/HK1154852A1/xx not_active IP Right Cessation
-
2012
- 2012-03-13 HR HR20120231T patent/HRP20120231T1/hr unknown
- 2012-03-14 CY CY20121100267T patent/CY1112638T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20120231T1 (hr) | Upotreba derivata indola kao aktivatora nurr-1 u liječenju parkinsonove bolesti | |
| MX2011012628A (es) | Derivados amino-propionicos sustituidos como inhibidores de neprilisina. | |
| PT2323972E (pt) | Compostos de tetraciclina substituídos com c7-flúor | |
| EA201101672A1 (ru) | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина | |
| TN2012000125A1 (en) | Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors | |
| SG151260A1 (en) | 5-substituted-2-phenylamino-benzamides as mek inhibitors | |
| ATE540932T1 (de) | Hydantoin-derivate als antibakterielle wirkstoffe | |
| EA200800147A1 (ru) | Способ получения олмесартан медоксомила | |
| MA30821B1 (fr) | Derives de pyrazoline utiles comme antagonistes des recepteurs de mineralocorticoïdes | |
| MX2011008910A (es) | Derivados de azol sustituidos, composicion farmaceutica que comprende los derivados, y uso de los derivados para tratar enfermeda de parkinson. | |
| MY151295A (en) | Pyrimidyl indoline compound | |
| NO20092535L (no) | Fumaratsalt av (alfa S, beta R)-6-brom-alfa-[2-(dimetylamino)etyl]-2-metoksy-alfa-1-naftalenyl-beta-fenyl-3-kinolinetanol | |
| EP2639229A3 (en) | Thiazole Derivative and use thereof as VAP-1 Inhibitor | |
| UA96575C2 (en) | Process for the preparation of olmesartan medoxomil | |
| TW200745097A (en) | 4-Phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors | |
| IN2012DN02502A (zh) | ||
| MX2009009445A (es) | Derivados novedosos de benzamida y proceso para la preparacion de los mismos. | |
| NO20083058L (no) | Cykloheksylsulfonamidderivater med H3 reseptor aktivitet | |
| MX2021010046A (es) | Nueva composicion terapeutica que contiene ingrediente activo de apomorfinas. | |
| WO2010129057A8 (en) | Tetracycline compounds | |
| ATE399164T1 (de) | Antagonisten des opioidrezeptors | |
| WO2011037833A3 (en) | Novel n-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents | |
| MY153733A (en) | Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same | |
| WO2008099781A1 (ja) | アミノアルコール誘導体を有効成分とする脱髄性疾患の治療剤又は予防剤 | |
| TW200740428A (en) | Substituted propanamide derivatives and pharmaceutical compositions thereof |