HRP20120218T1 - Proizvodnja homogenog preparata cjepiva za liječenje raka - Google Patents
Proizvodnja homogenog preparata cjepiva za liječenje raka Download PDFInfo
- Publication number
- HRP20120218T1 HRP20120218T1 HR20120218T HRP20120218T HRP20120218T1 HR P20120218 T1 HRP20120218 T1 HR P20120218T1 HR 20120218 T HR20120218 T HR 20120218T HR P20120218 T HRP20120218 T HR P20120218T HR P20120218 T1 HRP20120218 T1 HR P20120218T1
- Authority
- HR
- Croatia
- Prior art keywords
- hregf
- rp64k
- vaccine
- protein
- conjugated
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract 19
- 206010028980 Neoplasm Diseases 0.000 title claims 2
- 201000011510 cancer Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract 21
- 102000004169 proteins and genes Human genes 0.000 claims abstract 13
- 108090000623 proteins and genes Proteins 0.000 claims abstract 13
- 238000000034 method Methods 0.000 claims 9
- 230000021615 conjugation Effects 0.000 claims 7
- 239000008240 homogeneous mixture Substances 0.000 claims 6
- 230000001939 inductive effect Effects 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 238000000108 ultra-filtration Methods 0.000 claims 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- 238000011026 diafiltration Methods 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00113—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070154A CU23652A1 (es) | 2007-06-29 | 2007-06-29 | Composición vacunal homogénea para el tratamiento del cáncer y su método de obtención |
| PCT/CU2008/000005 WO2009003425A1 (es) | 2007-06-29 | 2008-06-26 | Obtención de un preparado vacunal homogéneo para el tratamiento del cáncer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120218T1 true HRP20120218T1 (hr) | 2012-04-30 |
Family
ID=40225717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120218T HRP20120218T1 (hr) | 2007-06-29 | 2012-03-07 | Proizvodnja homogenog preparata cjepiva za liječenje raka |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8778879B2 (es) |
| EP (1) | EP2184072B1 (es) |
| JP (1) | JP5368437B2 (es) |
| KR (1) | KR20100039372A (es) |
| CN (1) | CN101790383B (es) |
| AR (1) | AR067085A1 (es) |
| AT (1) | ATE536885T1 (es) |
| AU (1) | AU2008271798B2 (es) |
| BR (1) | BRPI0813662B8 (es) |
| CA (1) | CA2692340C (es) |
| CL (1) | CL2008001936A1 (es) |
| CO (1) | CO6251274A2 (es) |
| CU (1) | CU23652A1 (es) |
| CY (1) | CY1112476T1 (es) |
| DK (1) | DK2184072T3 (es) |
| EA (1) | EA021905B1 (es) |
| ES (1) | ES2379130T3 (es) |
| HK (1) | HK1145979A1 (es) |
| HR (1) | HRP20120218T1 (es) |
| JO (1) | JO2777B1 (es) |
| MY (1) | MY149136A (es) |
| NZ (1) | NZ582829A (es) |
| PE (2) | PE20131037A1 (es) |
| PL (1) | PL2184072T3 (es) |
| PT (1) | PT2184072E (es) |
| RS (1) | RS52196B (es) |
| SI (1) | SI2184072T1 (es) |
| TW (1) | TWI409080B (es) |
| UY (1) | UY31184A1 (es) |
| WO (1) | WO2009003425A1 (es) |
| ZA (1) | ZA201000609B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU20200032A7 (es) * | 2020-06-09 | 2022-01-13 | Ct Inmunologia Molecular | Composiciones vacunales basadas en nano-partículas de fosfatos de calcio para el tratamiento del cáncer |
| CN114594257B (zh) * | 2022-05-09 | 2022-08-05 | 北京生物制品研究所有限责任公司 | 含CpG ODN的吸附型疫苗的解吸附组合物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2137639C (en) | 1993-12-09 | 1999-01-26 | Agustin B. L. Davila | Vaccine composition comprising autologous epidermal growth factor or a fragment or a derivate thereof having anti-tumor activity and use thereof in the therapy of malignant diseases |
| CA2261433A1 (en) * | 1993-12-09 | 1995-06-10 | Belinda Sanchez Ramirez | Composition comprising autologous epidermal growth factor |
| CU23077A1 (es) * | 2000-12-06 | 2005-08-17 | Centro Inmunologia Molecular | Composicion vacunal que contiene factor de crecimiento transformante (tgf-alfa). su uso en la terapia de enfermedades malignas |
| CU22979A1 (es) * | 2000-12-08 | 2004-09-09 | Centro Inmunologia Molecular | Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina |
| CU22999A1 (es) * | 2001-12-04 | 2004-10-12 | Centro Inmunologia Molecular | Método de tratamiento de enfermedades malignas e infecciosas crónicas |
| GB0109297D0 (en) * | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
| FR2844514B1 (fr) * | 2002-09-16 | 2007-10-19 | Neovacs | Produit immunogene stable comprenant des heterocomplexes antigeniques, compositions les contenant et procede de preparation |
| GB0405787D0 (en) * | 2004-03-15 | 2004-04-21 | Chiron Srl | Low dose vaccines |
-
2007
- 2007-06-29 CU CU20070154A patent/CU23652A1/es unknown
-
2008
- 2008-06-20 AR ARP080102638A patent/AR067085A1/es not_active Application Discontinuation
- 2008-06-26 DK DK08757902.5T patent/DK2184072T3/da active
- 2008-06-26 MY MYPI20095626A patent/MY149136A/en unknown
- 2008-06-26 AU AU2008271798A patent/AU2008271798B2/en active Active
- 2008-06-26 JP JP2010513634A patent/JP5368437B2/ja active Active
- 2008-06-26 SI SI200830563T patent/SI2184072T1/sl unknown
- 2008-06-26 TW TW097123928A patent/TWI409080B/zh active
- 2008-06-26 PT PT08757902T patent/PT2184072E/pt unknown
- 2008-06-26 RS RS20120101A patent/RS52196B/en unknown
- 2008-06-26 KR KR1020107002173A patent/KR20100039372A/ko active Search and Examination
- 2008-06-26 BR BRPI0813662A patent/BRPI0813662B8/pt active IP Right Grant
- 2008-06-26 ES ES08757902T patent/ES2379130T3/es active Active
- 2008-06-26 EA EA201070080A patent/EA021905B1/ru not_active IP Right Cessation
- 2008-06-26 CA CA2692340A patent/CA2692340C/en active Active
- 2008-06-26 PL PL08757902T patent/PL2184072T3/pl unknown
- 2008-06-26 WO PCT/CU2008/000005 patent/WO2009003425A1/es active Application Filing
- 2008-06-26 NZ NZ582829A patent/NZ582829A/en active IP Right Revival
- 2008-06-26 CN CN200880021856XA patent/CN101790383B/zh active Active
- 2008-06-26 US US12/664,545 patent/US8778879B2/en active Active
- 2008-06-26 EP EP08757902A patent/EP2184072B1/en active Active
- 2008-06-26 PE PE2013000227A patent/PE20131037A1/es not_active Application Discontinuation
- 2008-06-26 AT AT08757902T patent/ATE536885T1/de active
- 2008-06-26 PE PE2008001089A patent/PE20090426A1/es not_active Application Discontinuation
- 2008-06-26 UY UY31184A patent/UY31184A1/es unknown
- 2008-06-27 CL CL2008001936A patent/CL2008001936A1/es unknown
- 2008-06-29 JO JO2008307A patent/JO2777B1/en active
-
2009
- 2009-12-18 CO CO09145155A patent/CO6251274A2/es active IP Right Grant
-
2010
- 2010-01-27 ZA ZA201000609A patent/ZA201000609B/xx unknown
-
2011
- 2011-01-10 HK HK11100165.6A patent/HK1145979A1/xx unknown
-
2012
- 2012-01-10 US US13/346,831 patent/US8841251B2/en active Active
- 2012-03-07 HR HR20120218T patent/HRP20120218T1/hr unknown
- 2012-03-09 CY CY20121100245T patent/CY1112476T1/el unknown
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