HRP20120165T1 - Novi pripravci na bazi taksoida - Google Patents
Novi pripravci na bazi taksoida Download PDFInfo
- Publication number
- HRP20120165T1 HRP20120165T1 HR20120165T HRP20120165T HRP20120165T1 HR P20120165 T1 HRP20120165 T1 HR P20120165T1 HR 20120165 T HR20120165 T HR 20120165T HR P20120165 T HRP20120165 T HR P20120165T HR P20120165 T1 HRP20120165 T1 HR P20120165T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparations according
- acid
- lecithin
- chosen
- preparations
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 6
- 238000002360 preparation method Methods 0.000 claims abstract 18
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract 6
- 239000000787 lecithin Substances 0.000 claims abstract 6
- 229940067606 lecithin Drugs 0.000 claims abstract 6
- 235000010445 lecithin Nutrition 0.000 claims abstract 6
- 239000000839 emulsion Substances 0.000 claims abstract 5
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims abstract 4
- 239000003945 anionic surfactant Substances 0.000 claims abstract 3
- 229940123237 Taxane Drugs 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims 5
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical group CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 3
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 3
- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 2
- LHCZDUCPSRJDJT-UHFFFAOYSA-N dilauroyl phosphatidylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCC LHCZDUCPSRJDJT-UHFFFAOYSA-N 0.000 claims 2
- 229960005160 dimyristoylphosphatidylglycerol Drugs 0.000 claims 2
- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 235000019198 oils Nutrition 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000008344 egg yolk phospholipid Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 239000008347 soybean phospholipid Substances 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0707092A FR2922107B1 (fr) | 2007-10-10 | 2007-10-10 | Nouvelles compositions a base de taxoides |
| PCT/FR2008/001410 WO2009083664A1 (fr) | 2007-10-10 | 2008-10-09 | Nouvelles compositions a base de taxoides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120165T1 true HRP20120165T1 (hr) | 2012-03-31 |
Family
ID=39356621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120165T HRP20120165T1 (hr) | 2007-10-10 | 2012-02-20 | Novi pripravci na bazi taksoida |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US8481589B2 (ja) |
| EP (1) | EP2197492B1 (ja) |
| JP (1) | JP5574965B2 (ja) |
| KR (1) | KR20100075490A (ja) |
| CN (1) | CN101820918A (ja) |
| AR (1) | AR072333A1 (ja) |
| AT (1) | ATE534406T1 (ja) |
| AU (1) | AU2008345527A1 (ja) |
| BR (1) | BRPI0818597A2 (ja) |
| CA (1) | CA2701789A1 (ja) |
| CL (1) | CL2008003002A1 (ja) |
| CO (1) | CO6260107A2 (ja) |
| CR (1) | CR11335A (ja) |
| CY (1) | CY1112388T1 (ja) |
| DK (1) | DK2197492T3 (ja) |
| DO (1) | DOP2010000098A (ja) |
| EA (1) | EA016619B1 (ja) |
| ES (1) | ES2377352T3 (ja) |
| FR (1) | FR2922107B1 (ja) |
| GT (1) | GT201000075A (ja) |
| HR (1) | HRP20120165T1 (ja) |
| IL (1) | IL204950A0 (ja) |
| MA (1) | MA31840B1 (ja) |
| MX (1) | MX2010003914A (ja) |
| NI (1) | NI201000048A (ja) |
| NZ (1) | NZ584544A (ja) |
| PA (1) | PA8798101A1 (ja) |
| PE (1) | PE20090962A1 (ja) |
| PL (1) | PL2197492T3 (ja) |
| PT (1) | PT2197492E (ja) |
| RS (1) | RS52131B (ja) |
| SI (1) | SI2197492T1 (ja) |
| TN (1) | TN2010000129A1 (ja) |
| TW (1) | TW200922552A (ja) |
| UA (1) | UA97418C2 (ja) |
| UY (1) | UY31386A1 (ja) |
| WO (1) | WO2009083664A1 (ja) |
| ZA (1) | ZA201002504B (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120065255A1 (en) * | 2009-10-19 | 2012-03-15 | Nagesh Palepu | Cabazitaxel formulations and methods of preparing thereof |
| PE20121429A1 (es) | 2009-10-29 | 2012-11-06 | Aventis Pharma Sa | Nuevo uso antitumoral de cabazitaxel |
| BR112012028037A2 (pt) | 2010-05-03 | 2016-08-02 | Teikoku Pharma Usa Inc | formulação de pró-emulsão líquida de taxano não aquosa, métodos para administrar um taxano a um paciente e para fabricar uma formulação de pró-emulsão de taxano, composição de emulsão de taxano, e, kit |
| JP2012051823A (ja) * | 2010-08-31 | 2012-03-15 | Fujifilm Corp | 難容性薬物含有水中油型乳化組成物及びその製造方法 |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| CN104225615B (zh) * | 2014-09-24 | 2017-02-01 | 东南大学 | 一种紫杉醇类磷脂化合物、其药物组合物及应用 |
| EP3384961B1 (en) * | 2017-04-05 | 2021-10-13 | RaySearch Laboratories AB | System and method for modelling of dose calculation in radiotherapy treatment planning |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750561A (en) * | 1991-07-08 | 1998-05-12 | Rhone-Poulenc Rorer, S.A. | Compositions containing taxane derivatives |
| FR2678833B1 (fr) | 1991-07-08 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes. |
| US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| JP3208517B2 (ja) * | 1992-07-01 | 2001-09-17 | ブリストル−マイヤーズ スクイブ カンパニー | ７，８−シクロプロパタキサン類 |
| FR2698543B1 (fr) | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
| US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| US5616330A (en) * | 1994-07-19 | 1997-04-01 | Hemagen/Pfc | Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same |
| US6372780B2 (en) * | 1995-03-27 | 2002-04-16 | Aventis Pharma S.A. | Methods of treating cell lines expressing multidrug resistance P-glycoprotein |
| EP1105119A2 (en) * | 1998-08-20 | 2001-06-13 | Aventis Pharma S.A. | New use of taxoid derivatives |
| US20020001613A1 (en) * | 2000-02-08 | 2002-01-03 | Susan Niemiec | Method of manufacturing liposomes |
| US20030099674A1 (en) * | 2001-08-11 | 2003-05-29 | Chen Andrew X. | Lyophilized injectable formulations containing paclitaxel or other taxoid drugs |
| EP1617818A1 (en) * | 2003-04-29 | 2006-01-25 | Baxter International Inc. | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
| EP1498120A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Semi-solid formulations for the oral administration of taxoids |
| EP1498143A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Self-emulsifying and self-microemulsifying formulations for the oral administration of taxoids |
| US8557861B2 (en) * | 2004-09-28 | 2013-10-15 | Mast Therapeutics, Inc. | Low oil emulsion compositions for delivering taxoids and other insoluble drugs |
| JP5089887B2 (ja) * | 2006-01-23 | 2012-12-05 | 日本精化株式会社 | 生理活性物質含有複合体 |
-
2007
- 2007-10-10 FR FR0707092A patent/FR2922107B1/fr not_active Expired - Fee Related
-
2008
- 2008-09-24 TW TW097136649A patent/TW200922552A/zh unknown
- 2008-10-07 PE PE2008001737A patent/PE20090962A1/es not_active Application Discontinuation
- 2008-10-08 PA PA20088798101A patent/PA8798101A1/es unknown
- 2008-10-08 AR ARP080104386A patent/AR072333A1/es not_active Application Discontinuation
- 2008-10-09 CA CA2701789A patent/CA2701789A1/fr not_active Abandoned
- 2008-10-09 UA UAA201005592A patent/UA97418C2/ru unknown
- 2008-10-09 DK DK08868434.5T patent/DK2197492T3/da active
- 2008-10-09 CN CN200880110996A patent/CN101820918A/zh active Pending
- 2008-10-09 AT AT08868434T patent/ATE534406T1/de active
- 2008-10-09 WO PCT/FR2008/001410 patent/WO2009083664A1/fr active Application Filing
- 2008-10-09 PT PT08868434T patent/PT2197492E/pt unknown
- 2008-10-09 BR BRPI0818597 patent/BRPI0818597A2/pt not_active IP Right Cessation
- 2008-10-09 JP JP2010528443A patent/JP5574965B2/ja active Active
- 2008-10-09 ES ES08868434T patent/ES2377352T3/es active Active
- 2008-10-09 CL CL2008003002A patent/CL2008003002A1/es unknown
- 2008-10-09 EA EA201070448A patent/EA016619B1/ru not_active IP Right Cessation
- 2008-10-09 SI SI200830554T patent/SI2197492T1/sl unknown
- 2008-10-09 AU AU2008345527A patent/AU2008345527A1/en not_active Abandoned
- 2008-10-09 KR KR1020107007728A patent/KR20100075490A/ko not_active Application Discontinuation
- 2008-10-09 EP EP08868434A patent/EP2197492B1/fr active Active
- 2008-10-09 MX MX2010003914A patent/MX2010003914A/es active IP Right Grant
- 2008-10-09 RS RS20120058A patent/RS52131B/en unknown
- 2008-10-09 PL PL08868434T patent/PL2197492T3/pl unknown
- 2008-10-09 NZ NZ584544A patent/NZ584544A/en not_active IP Right Cessation
- 2008-10-10 UY UY31386A patent/UY31386A1/es unknown
-
2010
- 2010-03-22 TN TNP2010000129A patent/TN2010000129A1/fr unknown
- 2010-03-24 CR CR11335A patent/CR11335A/es not_active Application Discontinuation
- 2010-04-06 GT GT201000075A patent/GT201000075A/es unknown
- 2010-04-08 DO DO2010000098A patent/DOP2010000098A/es unknown
- 2010-04-08 IL IL204950A patent/IL204950A0/en unknown
- 2010-04-08 NI NI201000048A patent/NI201000048A/es unknown
- 2010-04-09 CO CO10041381A patent/CO6260107A2/es not_active Application Discontinuation
- 2010-04-09 ZA ZA2010/02504A patent/ZA201002504B/en unknown
- 2010-04-09 US US12/757,255 patent/US8481589B2/en active Active
- 2010-05-10 MA MA32825A patent/MA31840B1/fr unknown
-
2012
- 2012-02-20 HR HR20120165T patent/HRP20120165T1/hr unknown
- 2012-02-23 CY CY20121100186T patent/CY1112388T1/el unknown
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