HRP20120085T1 - Pripravak zibotentana koji sadrži manitol i mikrokristalnu celulozu - Google Patents
Pripravak zibotentana koji sadrži manitol i mikrokristalnu celulozu Download PDFInfo
- Publication number
- HRP20120085T1 HRP20120085T1 HR20120085T HRP20120085T HRP20120085T1 HR P20120085 T1 HRP20120085 T1 HR P20120085T1 HR 20120085 T HR20120085 T HR 20120085T HR P20120085 T HRP20120085 T HR P20120085T HR P20120085 T1 HRP20120085 T1 HR P20120085T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutical preparation
- weight
- amount
- preparation according
- cancer
- Prior art date
Links
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 title claims abstract 6
- 229930195725 Mannitol Natural products 0.000 title claims abstract 6
- FJHHZXWJVIEFGJ-UHFFFAOYSA-N N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide Chemical compound COC1=NC(C)=CN=C1NS(=O)(=O)C1=CC=CN=C1C1=CC=C(C=2OC=NN=2)C=C1 FJHHZXWJVIEFGJ-UHFFFAOYSA-N 0.000 title claims abstract 6
- 239000000594 mannitol Substances 0.000 title claims abstract 6
- 235000010355 mannitol Nutrition 0.000 title claims abstract 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 title claims abstract 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 title claims abstract 5
- 239000008108 microcrystalline cellulose Substances 0.000 title claims abstract 5
- 229940016286 microcrystalline cellulose Drugs 0.000 title claims abstract 5
- 229950003684 zibotentan Drugs 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 238000005550 wet granulation Methods 0.000 claims 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 229940069328 povidone Drugs 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- 239000001034 iron oxide pigment Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97973607P | 2007-10-12 | 2007-10-12 | |
| US8911808P | 2008-08-15 | 2008-08-15 | |
| PCT/GB2008/050928 WO2009047565A2 (en) | 2007-10-12 | 2008-10-09 | Composition 064 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120085T1 true HRP20120085T1 (hr) | 2012-02-29 |
Family
ID=40534840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120085T HRP20120085T1 (hr) | 2007-10-12 | 2012-01-24 | Pripravak zibotentana koji sadrži manitol i mikrokristalnu celulozu |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US8168221B2 (ko) |
| EP (2) | EP2209501B1 (ko) |
| JP (1) | JP2011500548A (ko) |
| KR (1) | KR20100099113A (ko) |
| CN (1) | CN101896210A (ko) |
| AR (1) | AR068845A1 (ko) |
| AT (1) | ATE536893T1 (ko) |
| AU (1) | AU2008309385B2 (ko) |
| BR (1) | BRPI0818323A2 (ko) |
| CA (1) | CA2701385A1 (ko) |
| CL (1) | CL2008003022A1 (ko) |
| CO (1) | CO6270344A2 (ko) |
| CR (1) | CR11363A (ko) |
| CU (1) | CU20100064A7 (ko) |
| CY (1) | CY1112433T1 (ko) |
| DK (1) | DK2209501T3 (ko) |
| DO (1) | DOP2010000105A (ko) |
| EA (1) | EA201000545A1 (ko) |
| ES (1) | ES2377426T3 (ko) |
| HK (1) | HK1143095A1 (ko) |
| HR (1) | HRP20120085T1 (ko) |
| IL (1) | IL204953A0 (ko) |
| MX (1) | MX2010003989A (ko) |
| NI (1) | NI201000052A (ko) |
| NZ (1) | NZ585310A (ko) |
| PE (1) | PE20091032A1 (ko) |
| PL (1) | PL2209501T3 (ko) |
| PT (1) | PT2209501E (ko) |
| SG (1) | SG182138A1 (ko) |
| SI (1) | SI2209501T1 (ko) |
| SV (1) | SV2010003529A (ko) |
| TW (1) | TW200924768A (ko) |
| UY (1) | UY31385A1 (ko) |
| WO (1) | WO2009047565A2 (ko) |
| ZA (1) | ZA201002477B (ko) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102977016B (zh) | 2003-06-06 | 2015-01-14 | 菲布罗根有限公司 | 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途 |
| EP2209501B1 (en) | 2007-10-12 | 2011-12-14 | AstraZeneca AB | Zibotentan composition containing mannitol and microcrystalline cellulose |
| CN101822796B (zh) * | 2010-03-17 | 2012-01-04 | 山西仟源制药有限公司 | 一种银冰含片及制备方法和应用 |
| US9492395B2 (en) * | 2010-05-11 | 2016-11-15 | Sensient Colors Llc | Film coating composition and methods of making and using the same |
| JO3753B1 (ar) | 2011-10-14 | 2021-01-31 | Otsuka Pharma Co Ltd | قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه |
| ES2784134T3 (es) * | 2012-04-27 | 2020-09-22 | Merck Patent Gmbh | Comprimidos con cubierta y producción de los mismos |
| DK2872488T3 (en) | 2012-07-16 | 2018-10-29 | Fibrogen Inc | CRYSTALLINIC FORMS OF A PROLYL HYDROXYLASE INHIBITOR |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| JP6604941B2 (ja) * | 2013-06-06 | 2019-11-13 | フィブロジェン インコーポレイテッド | Ｈｉｆプロリルヒドロキシラーゼ阻害剤の医薬製剤 |
| US20230105591A1 (en) * | 2020-03-31 | 2023-04-06 | Eisai R&D Management Co., Ltd. | Tablet, medicine, methods for producing these, and kit |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3674794A (en) * | 1970-03-18 | 1972-07-04 | Ciba Geigy Corp | Certain-3-pyridine-sulfonamide derivatives |
| UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
| BR9812258A (pt) * | 1997-04-28 | 2000-07-25 | Texas Biotechnology Corp | Sulfonamidas para tratamento de distúrbios mediados por endotelina |
| US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| AU5248900A (en) * | 1999-06-18 | 2001-01-09 | Takeda Chemical Industries Ltd. | Quickly disintegrating solid preparations |
| JP2001058944A (ja) * | 1999-06-18 | 2001-03-06 | Takeda Chem Ind Ltd | 速崩壊性固形製剤 |
| KR20050044459A (ko) | 2001-11-13 | 2005-05-12 | 파마시아 코포레이션 | 파레콕시브 등의 설폰아미드 선구약물의 경구 투여 형태 |
| GB0219660D0 (en) * | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
| JP2006504696A (ja) * | 2002-09-20 | 2006-02-09 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体アンタゴニストのマンニトール製剤 |
| GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
| GB0320806D0 (en) | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
| US7772232B2 (en) | 2004-04-15 | 2010-08-10 | Bristol-Myers Squibb Company | Quinazolinyl compounds as inhibitors of potassium channel function |
| GB0425854D0 (en) | 2004-11-25 | 2004-12-29 | Astrazeneca Ab | Therapeutic treatment |
| CN101032464A (zh) * | 2007-04-01 | 2007-09-12 | 杨喜鸿 | 含有利莫那班和聚乙烯吡咯烷酮的组合物、固体分散体及其制备和药物应用 |
| EP2209501B1 (en) | 2007-10-12 | 2011-12-14 | AstraZeneca AB | Zibotentan composition containing mannitol and microcrystalline cellulose |
-
2008
- 2008-10-09 EP EP08806744A patent/EP2209501B1/en not_active Not-in-force
- 2008-10-09 PT PT08806744T patent/PT2209501E/pt unknown
- 2008-10-09 AU AU2008309385A patent/AU2008309385B2/en not_active Ceased
- 2008-10-09 PL PL08806744T patent/PL2209501T3/pl unknown
- 2008-10-09 SG SG2012039327A patent/SG182138A1/en unknown
- 2008-10-09 ES ES08806744T patent/ES2377426T3/es active Active
- 2008-10-09 KR KR1020107010484A patent/KR20100099113A/ko not_active Application Discontinuation
- 2008-10-09 CA CA2701385A patent/CA2701385A1/en not_active Abandoned
- 2008-10-09 AT AT08806744T patent/ATE536893T1/de active
- 2008-10-09 MX MX2010003989A patent/MX2010003989A/es active IP Right Grant
- 2008-10-09 TW TW097139020A patent/TW200924768A/zh unknown
- 2008-10-09 CN CN2008801210391A patent/CN101896210A/zh active Pending
- 2008-10-09 NZ NZ585310A patent/NZ585310A/en not_active IP Right Cessation
- 2008-10-09 EA EA201000545A patent/EA201000545A1/ru unknown
- 2008-10-09 SI SI200830529T patent/SI2209501T1/sl unknown
- 2008-10-09 JP JP2010528486A patent/JP2011500548A/ja active Pending
- 2008-10-09 EP EP11187017A patent/EP2433620A1/en not_active Withdrawn
- 2008-10-09 BR BRPI0818323A patent/BRPI0818323A2/pt not_active IP Right Cessation
- 2008-10-09 WO PCT/GB2008/050928 patent/WO2009047565A2/en active Application Filing
- 2008-10-09 DK DK08806744.2T patent/DK2209501T3/da active
- 2008-10-10 PE PE2008001750A patent/PE20091032A1/es not_active Application Discontinuation
- 2008-10-10 UY UY31385A patent/UY31385A1/es not_active Application Discontinuation
- 2008-10-10 AR ARP080104448A patent/AR068845A1/es not_active Application Discontinuation
- 2008-10-10 CL CL2008003022A patent/CL2008003022A1/es unknown
- 2008-10-10 US US12/249,157 patent/US8168221B2/en not_active Expired - Fee Related
-
2010
- 2010-04-08 ZA ZA2010/02477A patent/ZA201002477B/en unknown
- 2010-04-08 IL IL204953A patent/IL204953A0/en unknown
- 2010-04-12 SV SV2010003529A patent/SV2010003529A/es not_active Application Discontinuation
- 2010-04-12 NI NI201000052A patent/NI201000052A/es unknown
- 2010-04-12 CU CU20100064A patent/CU20100064A7/es unknown
- 2010-04-12 DO DO2010000105A patent/DOP2010000105A/es unknown
- 2010-04-12 CR CR11363A patent/CR11363A/es not_active Application Discontinuation
- 2010-05-07 CO CO10054830A patent/CO6270344A2/es not_active Application Discontinuation
- 2010-10-13 HK HK10109702.8A patent/HK1143095A1/xx not_active IP Right Cessation
-
2012
- 2012-01-24 HR HR20120085T patent/HRP20120085T1/hr unknown
- 2012-02-09 CY CY20121100136T patent/CY1112433T1/el unknown
- 2012-03-21 US US13/425,474 patent/US20120177705A1/en not_active Abandoned
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