CL2011001060A1 - Compuestos derivados de 4-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil]-piridina, 3-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil)-fenilo, 3-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil)-fenilo; procedimiento de preparacion; composicion farmaceutica; utiles para tratar enfermedades cancerosas o tumorales. - Google Patents
Compuestos derivados de 4-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil]-piridina, 3-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil)-fenilo, 3-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil)-fenilo; procedimiento de preparacion; composicion farmaceutica; utiles para tratar enfermedades cancerosas o tumorales.Info
- Publication number
- CL2011001060A1 CL2011001060A1 CL2011001060A CL2011001060A CL2011001060A1 CL 2011001060 A1 CL2011001060 A1 CL 2011001060A1 CL 2011001060 A CL2011001060 A CL 2011001060A CL 2011001060 A CL2011001060 A CL 2011001060A CL 2011001060 A1 CL2011001060 A1 CL 2011001060A1
- Authority
- CL
- Chile
- Prior art keywords
- oxadiazol
- methyl
- pyrazol
- phenyl
- pharmaceutical composition
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004505 1,2,4-oxadiazol-5-yl group Chemical group O1N=CN=C1* 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos derivados de heteroarilos; procedimiento de preparación; composición farmacéutica; y su uso para el tratamiento y/o prevención de enfermedades cancerosas o tumorales, enfermedades cardiovasculares isquémicas, insuficiencia cardíaca, arritmia, artritis reumatoide, entre otras.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008057343A DE102008057343A1 (de) | 2008-11-14 | 2008-11-14 | Heterocyclisch substituierte Aryl-Verbindungen und ihre Verwendung |
DE102009041242A DE102009041242A1 (de) | 2009-09-11 | 2009-09-11 | Heterocyclisch substituierte Aryl-Verbindungen und ihre Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2011001060A1 true CL2011001060A1 (es) | 2011-09-16 |
Family
ID=41445560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011001060A CL2011001060A1 (es) | 2008-11-14 | 2011-05-10 | Compuestos derivados de 4-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil]-piridina, 3-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil)-fenilo, 3-[3-{3-(1,2,4-oxadiazol-5-il)-1h-pirazol-1-il}-metil)-fenilo; procedimiento de preparacion; composicion farmaceutica; utiles para tratar enfermedades cancerosas o tumorales. |
Country Status (36)
Country | Link |
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US (1) | US20130196964A1 (es) |
EP (1) | EP2356113B1 (es) |
JP (1) | JP5829915B2 (es) |
KR (1) | KR20110082569A (es) |
CN (1) | CN102282143A (es) |
AR (1) | AR074336A1 (es) |
AU (1) | AU2009316019A1 (es) |
BR (1) | BRPI0921257A2 (es) |
CA (1) | CA2743536A1 (es) |
CL (1) | CL2011001060A1 (es) |
CO (1) | CO6361923A2 (es) |
CR (1) | CR20110248A (es) |
CU (1) | CU24067B1 (es) |
DK (1) | DK2356113T3 (es) |
DO (1) | DOP2011000132A (es) |
EA (1) | EA022271B1 (es) |
EC (1) | ECSP11011042A (es) |
ES (1) | ES2538301T3 (es) |
GT (1) | GT201100118A (es) |
HN (1) | HN2011001280A (es) |
HR (1) | HRP20150341T1 (es) |
IL (1) | IL212142A0 (es) |
MA (1) | MA32784B1 (es) |
MX (1) | MX2011005025A (es) |
MY (1) | MY160004A (es) |
NZ (1) | NZ592792A (es) |
PE (1) | PE20110906A1 (es) |
PL (1) | PL2356113T3 (es) |
PT (1) | PT2356113E (es) |
SA (1) | SA109300677B1 (es) |
SV (1) | SV2011003901A (es) |
TN (1) | TN2011000234A1 (es) |
TW (1) | TW201031656A (es) |
UY (1) | UY32237A (es) |
WO (1) | WO2010054763A1 (es) |
ZA (1) | ZA201103476B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2718723C (en) * | 2008-03-19 | 2018-05-08 | Aurimmed Pharma, Inc. | Novel compounds advantageous in the treatment of central nervous system diseases and disorders |
US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
RU2560729C2 (ru) | 2010-01-11 | 2015-08-20 | АСТРАЕА ТЕРАПЕУТИКС, ЭлЭлСи | Модуляторы никотиновых ацетилхолиновых рецепторов |
JP2013530139A (ja) * | 2010-05-08 | 2013-07-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ヒドロキシアルキルベンジルピラゾール類およびその使用 |
PE20130228A1 (es) * | 2010-05-08 | 2013-03-15 | Bayer Ip Gmbh | Heterociclilbencilpirazoles sustituidos |
CA2803292C (en) | 2010-06-30 | 2016-06-14 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
NZ609955A (en) | 2010-11-09 | 2015-05-29 | Ironwood Pharmaceuticals Inc | Sgc stimulators |
UY34200A (es) | 2011-07-21 | 2013-02-28 | Bayer Ip Gmbh | 3-(fluorovinil)pirazoles y su uso |
WO2013057101A1 (de) | 2011-10-17 | 2013-04-25 | Bayer Intellectual Property Gmbh | Substituierte oxadiazolylpyridinone und - pyridazinone als hif - hemmer |
EP3112363A1 (en) | 2011-12-27 | 2017-01-04 | Ironwood Pharmaceuticals, Inc. | 2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1h-pyrazol-3-yl]-pyrimidine derivatives and related compounds as soluble guanylate cyclase (sgc) stimulators for the treatment of pulmonary hypertension |
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HUE040025T2 (hu) * | 2012-08-24 | 2019-02-28 | Univ Texas | A HIF aktivitás heterociklusos modulátorai betegség kezelésére |
EP2888253A4 (en) * | 2012-08-24 | 2016-01-06 | Univ Texas | HETEROCYCLIC MODULATORS OF HIF FACTOR ACTIVITY USED FOR THE TREATMENT OF DISEASES |
EP2948447B1 (en) * | 2013-01-23 | 2016-09-21 | Astrazeneca AB | Chemical compounds |
US9663504B2 (en) | 2014-02-25 | 2017-05-30 | Board Of Regents, The University Of Texas System | Salts of heterocyclic modulators of HIF activity for treatment of disease |
EA201990109A1 (ru) | 2016-06-30 | 2019-07-31 | Базилеа Фармацойтика Интернациональ Аг | Митохондриальные ингибиторы для лечения пролиферативных нарушений |
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US7226941B2 (en) * | 2003-06-30 | 2007-06-05 | Hif Bio, Inc. | Compound for treating angiogenesis |
WO2007040565A2 (en) * | 2004-11-22 | 2007-04-12 | King Pharmaceuticals Research & Development, Inc. | Enhancing treatment of cancer and hif-1 mediated disoders with adenosine a3 receptor antagonists |
ITMI20042475A1 (it) * | 2004-12-23 | 2005-03-23 | Cell Therapeutics Europe Srl | Uso di derivati tiazolidinonici come agenti terapeutici |
JP2009506068A (ja) * | 2005-08-25 | 2009-02-12 | エモリー・ユニバーシティ | Hif阻害剤 |
WO2007065010A2 (en) * | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Anti-angiogenesis compounds |
RU2009146851A (ru) * | 2007-05-18 | 2011-06-27 | Байер Шеринг Фарма Акциенгезельшафт (DE) | Гетероарил-замещенные пиразольные производные, которые могут использоваться для лечения гиперпролиферативных нарушений и заболеваний, связанных с ангиогенезом |
DE102008057344A1 (de) * | 2008-11-14 | 2010-05-20 | Bayer Schering Pharma Aktiengesellschaft | Aminoalkyl-substituierte Aryl-Verbindungen und ihre Verwendung |
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