HRP20110845T1 - Antitumorski dihidropiran-2-onski spojevi - Google Patents

Antitumorski dihidropiran-2-onski spojevi Download PDF

Info

Publication number
HRP20110845T1
HRP20110845T1 HR20110845T HRP20110845T HRP20110845T1 HR P20110845 T1 HRP20110845 T1 HR P20110845T1 HR 20110845 T HR20110845 T HR 20110845T HR P20110845 T HRP20110845 T HR P20110845T HR P20110845 T1 HRP20110845 T1 HR P20110845T1
Authority
HR
Croatia
Prior art keywords
image
tautomer
pharmaceutically acceptable
stereoisomer
acceptable salt
Prior art date
Application number
HR20110845T
Other languages
English (en)
Croatian (hr)
Inventor
Jes�s Mart�n L�pez Ma
Coello Molinero Laura
Fernando Reyes Ben�tez Jos�
Rodr�guez Vicente Alberto
Garranzo Garc�a-Ibarrola Mar�a
Murcia P�rez Carmen
Francesch Solloso Andr�s
S�nchez Sancho Francisco
del Carmen Cuevas Marchante Mar�a
Fern�ndez Rodr�guez Rogelio
Original Assignee
Pharma Mar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar filed Critical Pharma Mar
Publication of HRP20110845T1 publication Critical patent/HRP20110845T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
HR20110845T 2006-06-16 2007-06-15 Antitumorski dihidropiran-2-onski spojevi HRP20110845T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06380173 2006-06-16
PCT/EP2007/055959 WO2007144423A1 (en) 2006-06-16 2007-06-15 Antitumoral dihydropyran-2-one compounds

Publications (1)

Publication Number Publication Date
HRP20110845T1 true HRP20110845T1 (hr) 2011-12-31

Family

ID=38508885

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110845T HRP20110845T1 (hr) 2006-06-16 2007-06-15 Antitumorski dihidropiran-2-onski spojevi

Country Status (29)

Country Link
US (2) US8324406B2 (enExample)
EP (3) EP2404913A3 (enExample)
JP (2) JP5117491B2 (enExample)
KR (1) KR101474031B1 (enExample)
CN (2) CN102336730A (enExample)
AR (1) AR061506A1 (enExample)
AT (1) ATE522514T1 (enExample)
AU (1) AU2007259257B8 (enExample)
BR (2) BRPI0713031B8 (enExample)
CA (1) CA2654334C (enExample)
CY (1) CY1112103T1 (enExample)
DK (1) DK2032551T3 (enExample)
ES (1) ES2371942T3 (enExample)
HR (1) HRP20110845T1 (enExample)
IL (1) IL195676A (enExample)
MX (1) MX2008015754A (enExample)
MY (1) MY145788A (enExample)
NO (2) NO341508B1 (enExample)
NZ (1) NZ573706A (enExample)
PL (1) PL2032551T3 (enExample)
PT (1) PT2032551E (enExample)
RS (1) RS52034B (enExample)
RU (2) RU2444519C2 (enExample)
SG (1) SG174830A1 (enExample)
SI (1) SI2032551T1 (enExample)
TW (2) TWI373469B (enExample)
UA (1) UA97369C2 (enExample)
WO (1) WO2007144423A1 (enExample)
ZA (1) ZA200810315B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2597091B1 (en) 2007-12-20 2016-04-20 Pharma Mar, S.A. Antitumoral Compounds
MX2010008922A (es) 2008-02-20 2010-09-07 Actelion Pharmaceuticals Ltd Compuestos antibioticos azatriciclicos.
ES2398939T3 (es) 2008-02-22 2013-03-22 Actelion Pharmaceuticals Ltd. Derivados de oxazolidinona
MY158520A (en) 2008-10-07 2016-10-14 Actelion Pharmaceuticals Ltd Tricyclic oxazolidinone antibiotic compounds
BRPI0920870A2 (pt) 2008-10-10 2018-06-26 Actelion Pharmaceuticals Ltd antibióticos de oxazolidinila.
WO2010149688A2 (en) 2009-06-24 2010-12-29 Pharma Mar, S.A. Antitumoral compounds
GB201309807D0 (en) * 2013-05-31 2013-07-17 Pharma Mar Sau Antibody drug conjugates
CN108467378A (zh) * 2017-02-23 2018-08-31 复旦大学 一种二氢吡喃酮类化合物及其制备方法和用途
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN110790737B (zh) * 2019-11-07 2022-07-22 河南中烟工业有限责任公司 一种2,3-二氢-3,5-二羟基-6-乙基-4h-吡喃-4-酮的制备方法
TW202330486A (zh) 2021-10-22 2023-08-01 西班牙商瑪製藥股份有限公司 抗腫瘤化合物
CN117510448A (zh) * 2023-11-13 2024-02-06 贵州中医药大学 一种二氢吡喃酮衍生物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
PT1142887E (pt) * 1993-11-19 2004-08-31 Parke Davis & Co Derivados de 5,6-di-hidropirona como inibidores de protease e agentes antivirais
US7446196B2 (en) * 2004-06-03 2008-11-04 Kosan Biosciences, Incorporated Leptomycin compounds

Also Published As

Publication number Publication date
US20090186938A1 (en) 2009-07-23
NO20111248L (no) 2008-12-16
HK1130052A1 (en) 2009-12-18
EP2404912A3 (en) 2012-07-25
NZ573706A (en) 2011-09-30
CA2654334A1 (en) 2007-12-21
WO2007144423A1 (en) 2007-12-21
AU2007259257A8 (en) 2012-04-05
JP5117491B2 (ja) 2013-01-16
KR101474031B1 (ko) 2014-12-17
AR061506A1 (es) 2008-09-03
JP2012021023A (ja) 2012-02-02
SG174830A1 (en) 2011-10-28
BRPI0713031B1 (pt) 2020-10-06
UA97369C2 (ru) 2012-02-10
EP2404913A2 (en) 2012-01-11
KR20090024261A (ko) 2009-03-06
NO20090054L (no) 2009-01-06
ATE522514T1 (de) 2011-09-15
CN101679340B (zh) 2013-06-05
MX2008015754A (es) 2009-01-12
RU2011133128A (ru) 2013-02-10
IL195676A0 (en) 2009-09-01
TW200811128A (en) 2008-03-01
US8501968B2 (en) 2013-08-06
PT2032551E (pt) 2011-12-06
CN102336730A (zh) 2012-02-01
DK2032551T3 (da) 2012-01-02
US20120190870A1 (en) 2012-07-26
TWI373469B (en) 2012-10-01
RU2009101150A (ru) 2010-07-27
ES2371942T3 (es) 2012-01-11
US20100048690A2 (en) 2010-02-25
EP2032551B1 (en) 2011-08-31
AU2007259257A1 (en) 2007-12-21
SI2032551T1 (sl) 2012-01-31
BRPI0722429A2 (pt) 2013-11-26
US8324406B2 (en) 2012-12-04
AU2007259257B8 (en) 2012-04-05
BRPI0713031A2 (pt) 2013-03-12
CA2654334C (en) 2014-06-10
PL2032551T3 (pl) 2012-01-31
MY145788A (en) 2012-04-30
EP2404912A2 (en) 2012-01-11
EP2404913A3 (en) 2012-06-06
EP2032551A1 (en) 2009-03-11
ZA200810315B (en) 2010-02-24
BRPI0713031B8 (pt) 2021-05-25
TW201213316A (en) 2012-04-01
EP2032551B9 (en) 2012-02-29
RS52034B (sr) 2012-04-30
IL195676A (en) 2012-06-28
CN101679340A (zh) 2010-03-24
CY1112103T1 (el) 2015-11-04
RU2444519C2 (ru) 2012-03-10
NO341508B1 (no) 2017-11-27
JP2009539943A (ja) 2009-11-19
AU2007259257B2 (en) 2011-12-08

Similar Documents

Publication Publication Date Title
HRP20110845T1 (hr) Antitumorski dihidropiran-2-onski spojevi
HRP20130942T1 (hr) Aminodiazepini kao modulatori toll-u sliäśnih receptora
AR080878A1 (es) Derivados heterociclicos de ariletinilo, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos en el tratamiento de la esquizofrenia y trastornos cognitivos.
ME02373B (me) Biciklična heterociklična jedinjenja kao inhibitori protein tirozin kinaze
JP2009504764A5 (enExample)
RU2015117267A (ru) Замещенные соединения амида
ATE427949T1 (de) 4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung
JP2015537020A5 (enExample)
ME02875B (me) Inhibitori hcv polimeraze
AR036874A1 (es) Derivados de fenetanolina, procedimiento de preparacion, uso en la fabricacion de medicamentos para enfermedades respiratorias
HRP20160852T1 (hr) Biciklični heterociklični spojevi kao inhibitori protein tirozin kinaze
HRP20160623T1 (hr) Inhibitori proteinske kinaze
EA200870196A1 (ru) Индолсульфонамидные модуляторы рецепторов прогестерона
AR069490A1 (es) Agonistas de los receptores de glucocorticoides
EA200970928A1 (ru) Антагонисты рецептора гонадотропин-рилизин-фактора и способы их применения
JP2009539943A5 (enExample)
EA200970704A1 (ru) ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ АНТАГОНИСТЫ NK1 РЕЦЕПТОРА И БЛОКАТОРЫ Na КАНАЛОВ
EA201201414A8 (ru) КОМБИНАЦИИ, СОДЕРЖАЩИЕ ЗАМЕЩЕННЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИНЫ
CO6430439A2 (es) Agonistas del receptor de esfingosina -1- fosfato
AR109714A1 (es) Derivados de cromano, isocromano y dihidroisobenzofuranos como moduladores alostéricos negativos de mglur2, composiciones y su uso
PE20081703A1 (es) Nuevos derivados triciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
HRP20120464T1 (hr) Antitumorski spojevi
RU2006146215A (ru) Производные аминопропанола
ATE484502T1 (de) Neue verbindungen
RU2007125660A (ru) Фенилпиперазиновые производные с сочетанием свойств неполного агонизма к рецепторам дофамина-d2 и ингибирования повторного поглощения серотонина