HRP20110405T1 - Mimetička tijela koja vezuju receptore melanokortina, smjese, postupci i upotrebe - Google Patents
Mimetička tijela koja vezuju receptore melanokortina, smjese, postupci i upotrebe Download PDFInfo
- Publication number
- HRP20110405T1 HRP20110405T1 HR20110405T HRP20110405T HRP20110405T1 HR P20110405 T1 HRP20110405 T1 HR P20110405T1 HR 20110405 T HR20110405 T HR 20110405T HR P20110405 T HRP20110405 T HR P20110405T HR P20110405 T1 HRP20110405 T1 HR P20110405T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- polypeptide
- polypeptide according
- polynucleotide
- melanocortin receptor
- Prior art date
Links
- 102000004378 Melanocortin Receptors Human genes 0.000 title claims abstract 7
- 108090000950 Melanocortin Receptors Proteins 0.000 title claims abstract 7
- 238000000034 method Methods 0.000 title claims abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims abstract 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 18
- 102000040430 polynucleotide Human genes 0.000 claims abstract 8
- 108091033319 polynucleotide Proteins 0.000 claims abstract 8
- 239000002157 polynucleotide Substances 0.000 claims abstract 8
- 210000004027 cell Anatomy 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 102000008316 Type 4 Melanocortin Receptor Human genes 0.000 claims 1
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Polipeptid prema formuli (I): (Mp-Lk-v2-Hg- CH 2- CH3) (t) (I) gdje Mp je molekula koja veže receptor melanokortina, Lk je polipeptid ili kemijska veza, V2 je dio na
Claims (18)
1. Polipeptid prema formuli (I):
(Mp-Lk-v2-Hg- CH 2- CH3) (t) (I)
gdje Mp je molekula koja veže receptor melanokortina, Lk je polipeptid ili kemijska veza, V2 je dio na C-terminalnom dijelu imunoglobulinskog promjenjivog područja, Hg je barem dio imunoglobulinskog promjenjivog spojnog područja, CH2 je konstantno područje imunoglobulinskog teškog lanca CH2 i CH3 konstantno područje imunoglobulinskog teškog lanca CH3 i t je nezavisno cijeli broj od 1 do 10.
2. Polipeptid prema zahtjevu 1 naznačen time da Mp je biološki aktivni dio iz SEQ ID NO: 2, 4, 6, 8, 10, 12, 14, 16, ili 18; ili Mp ima amino kiselinsku sekvencu prikazanu u SEQ ID NO: 2, 4, 6, 8, 10, 12, 14, 16, ili 18.
3. Polipeptid prema zahtjevu 1 naznačen time da se polipeptid veže na barem jedan receptor melanokortina.
4. Polipeptid prema zahtjevu 3 naznačen time da receptor melanokortina je melanokortin 4 receptor.
5. Polipeptid naznačen time da sadrži SEQ ID NO: 60 ili 62.
6. Polinukleotid naznačen time da kodira polipeptid prema bilo kojem od zahtjeva 1 do 5.
7. Polinukleotid naznačen time da sadrži SEQ ID NO: 59 ili SEQ ID NO: 61 ili polinukleotid komplementaran sa SEQ ID NO: 59 ili SEQ ID NO: 61.
8. Polinukleotid naznačen time da sadrži polinukleotid koji kodira polipeptid prema SEQ ID NO: 60 ili SEQ ID NO: 62.
9. Vektor naznačen time da sadrži polinukleotid prema zahtjevu 7 ili 8.
10. Vektor prema zahtjevu 9 naznačen time da sadrži SEQ ID NO: 63.
11. Stanica naznačena time da eksprimira polipeptid prema bilo kojem od zahtjeva 1 do 5.
12. Stanica naznačena time da sadrži vektor prema zahtjevu 9.
13. Stanica prema zahtjevu 12 naznačena time da stanica je HEK293 derivirana stanica.
14. Postupak za dobivanje polipeptida naznačen time da sadrži korake uzgoja stanice prema zahtjevu 11 i pročišćavanja eksprimiranog polipeptida.
15. Farmaceutski pripravak naznačen time da sadrži učinkovitu količinu barem jednog polipeptida prema bilo kojem od zahtjeva 1 do 5 i farmaceutski prihvatljiv nosač ili razrjeđivač.
16. Polipeptid prema bilo kojem od zahtjeva 1 do 5 naznačen time da je za uporabu u medicini.
17. Polipeptid prema bilo kojem od zahtjeva 1 do 5 naznačen time da je za modulaciju barem jednog stanja posredovanog receptorom melanokortina.
18. Polipeptid prema zahtjevu 17 naznačen time da stanje posredovano receptorom melanokortina je pretilost.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62196004P | 2004-10-25 | 2004-10-25 | |
| PCT/US2005/038431 WO2006047535A2 (en) | 2004-10-25 | 2005-10-25 | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110405T1 true HRP20110405T1 (hr) | 2011-06-30 |
Family
ID=36228385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110405T HRP20110405T1 (hr) | 2004-10-25 | 2011-05-31 | Mimetička tijela koja vezuju receptore melanokortina, smjese, postupci i upotrebe |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20060105951A1 (hr) |
| EP (1) | EP1812046B1 (hr) |
| JP (1) | JP2008517605A (hr) |
| KR (1) | KR101255140B1 (hr) |
| CN (1) | CN101437540B (hr) |
| AT (1) | ATE501731T1 (hr) |
| AU (1) | AU2005299440B2 (hr) |
| BR (1) | BRPI0518411A2 (hr) |
| CA (1) | CA2585287A1 (hr) |
| CY (1) | CY1111486T1 (hr) |
| DE (1) | DE602005026970D1 (hr) |
| DK (1) | DK1812046T3 (hr) |
| EA (1) | EA200700944A1 (hr) |
| EC (1) | ECSP077416A (hr) |
| ES (1) | ES2363023T3 (hr) |
| HK (1) | HK1106445A1 (hr) |
| HR (1) | HRP20110405T1 (hr) |
| IL (1) | IL182683A0 (hr) |
| MA (1) | MA28943B1 (hr) |
| ME (1) | ME01234B (hr) |
| MX (1) | MX2007004974A (hr) |
| NO (1) | NO20072499L (hr) |
| PL (1) | PL1812046T3 (hr) |
| PT (1) | PT1812046E (hr) |
| RS (1) | RS51789B (hr) |
| SI (1) | SI1812046T1 (hr) |
| TN (1) | TNSN07157A1 (hr) |
| WO (1) | WO2006047535A2 (hr) |
| ZA (1) | ZA200704260B (hr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7910101B2 (en) * | 2004-10-25 | 2011-03-22 | Centocor, Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
| US7790671B2 (en) * | 2005-10-07 | 2010-09-07 | Codman & Shurtleff, Inc. | Implantable pump for protein delivery for obesity control by drug infusion into the brain |
| NZ590254A (en) * | 2008-06-09 | 2012-07-27 | Palatin Technologies Inc | Melanocortin receptor-specific cyclic peptides for treatment of sexual dysfunction |
| WO2009151383A1 (en) * | 2008-06-09 | 2009-12-17 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptides for the treatment of obesity and other diseases associated with melanocortin receptor function |
| US8614185B2 (en) * | 2009-05-04 | 2013-12-24 | Centocor Ortho Biotech Inc. | Fusion proteins of alpha-MSH derivatives and Fc |
| UY32690A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
| WO2010144341A2 (en) | 2009-06-08 | 2010-12-16 | Palatin Technologies, Inc. | Lactam-bridged melanocortin receptor-specific peptides |
| CN102458436B (zh) | 2009-06-08 | 2015-06-03 | 帕拉丁科技公司 | 黑皮质素受体特异性肽 |
| EP2504351A4 (en) | 2009-11-23 | 2013-10-30 | Palatin Technologies Inc | MELANOCORTIN-1 RECEPTOR-SPECIFIC LINEAR PEPTIDE |
| BR112012011787B1 (pt) | 2009-11-23 | 2022-03-03 | Palatin Technologies, Inc | Peptídeo cíclico e composição farmacêutica |
| JP2020141710A (ja) * | 2011-07-06 | 2020-09-10 | ゲンマブ エー／エス | 抗体重鎖のｃ末端の修飾による補体依存性細胞傷害の調節 |
| CN113272330A (zh) * | 2019-03-02 | 2021-08-17 | 上海一宸医药科技有限公司 | 一种双特异抗体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1137340A4 (en) * | 1998-12-09 | 2005-12-21 | Eleanor Roosevelt Inst | COMPOSITION AND METHOD FOR REGULATING BODY WEIGHT AND ASSOCIATED CONDITIONS |
| AU7593001A (en) * | 2000-07-14 | 2002-01-30 | Zycos Inc | Alpha-msh related compounds and methods of use |
| EP1575499A2 (en) * | 2002-06-28 | 2005-09-21 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
| EP1545608A4 (en) * | 2002-06-28 | 2006-09-13 | Centocor Inc | CH1-DELETED MAMMED MUICETIC BODIES, COMPOSITIONS, METHODS AND APPLICATIONS |
| JP2008537873A (ja) * | 2004-03-31 | 2008-10-02 | セントカー・インコーポレーテツド | ヒトｇｌｐ−１ミメティボディ、組成物、方法および用途 |
-
2005
- 2005-10-25 ES ES05819741T patent/ES2363023T3/es active Active
- 2005-10-25 PL PL05819741T patent/PL1812046T3/pl unknown
- 2005-10-25 MX MX2007004974A patent/MX2007004974A/es unknown
- 2005-10-25 CA CA002585287A patent/CA2585287A1/en not_active Abandoned
- 2005-10-25 EA EA200700944A patent/EA200700944A1/ru unknown
- 2005-10-25 AU AU2005299440A patent/AU2005299440B2/en not_active Ceased
- 2005-10-25 CN CN2005800447902A patent/CN101437540B/zh not_active Expired - Fee Related
- 2005-10-25 DE DE602005026970T patent/DE602005026970D1/de active Active
- 2005-10-25 KR KR1020077011487A patent/KR101255140B1/ko not_active IP Right Cessation
- 2005-10-25 PT PT05819741T patent/PT1812046E/pt unknown
- 2005-10-25 SI SI200531295T patent/SI1812046T1/sl unknown
- 2005-10-25 RS RS20110230A patent/RS51789B/en unknown
- 2005-10-25 JP JP2007538172A patent/JP2008517605A/ja active Pending
- 2005-10-25 WO PCT/US2005/038431 patent/WO2006047535A2/en active Application Filing
- 2005-10-25 BR BRPI0518411-8A patent/BRPI0518411A2/pt not_active IP Right Cessation
- 2005-10-25 DK DK05819741.9T patent/DK1812046T3/da active
- 2005-10-25 AT AT05819741T patent/ATE501731T1/de active
- 2005-10-25 US US11/257,851 patent/US20060105951A1/en not_active Abandoned
- 2005-10-25 EP EP05819741A patent/EP1812046B1/en active Active
- 2005-10-25 ME MEP-2011-85A patent/ME01234B/me unknown
-
2007
- 2007-04-19 IL IL182683A patent/IL182683A0/en unknown
- 2007-04-23 MA MA29843A patent/MA28943B1/fr unknown
- 2007-04-24 TN TNP2007000157A patent/TNSN07157A1/fr unknown
- 2007-04-25 EC EC2007007416A patent/ECSP077416A/es unknown
- 2007-05-15 NO NO20072499A patent/NO20072499L/no not_active Application Discontinuation
- 2007-05-24 ZA ZA200704260A patent/ZA200704260B/xx unknown
- 2007-11-05 HK HK07112011.3A patent/HK1106445A1/xx not_active IP Right Cessation
-
2011
- 2011-05-23 CY CY20111100502T patent/CY1111486T1/el unknown
- 2011-05-31 HR HR20110405T patent/HRP20110405T1/hr unknown
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