HRP20110322T1 - Postupak za pročišćavanje montelukasta - Google Patents
Postupak za pročišćavanje montelukasta Download PDFInfo
- Publication number
- HRP20110322T1 HRP20110322T1 HR20110322T HRP20110322T HRP20110322T1 HR P20110322 T1 HRP20110322 T1 HR P20110322T1 HR 20110322 T HR20110322 T HR 20110322T HR P20110322 T HRP20110322 T HR P20110322T HR P20110322 T1 HRP20110322 T1 HR P20110322T1
- Authority
- HR
- Croatia
- Prior art keywords
- montelukast
- process according
- purification process
- salt
- aqueous phase
- Prior art date
Links
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title claims abstract 25
- 229960005127 montelukast Drugs 0.000 title claims abstract 22
- 238000000746 purification Methods 0.000 title claims abstract 17
- 238000000034 method Methods 0.000 title claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 13
- 239000000203 mixture Substances 0.000 claims abstract 12
- 239000008346 aqueous phase Substances 0.000 claims abstract 11
- 239000003960 organic solvent Substances 0.000 claims abstract 11
- 239000002253 acid Substances 0.000 claims abstract 6
- 238000000638 solvent extraction Methods 0.000 claims abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000012535 impurity Substances 0.000 claims abstract 3
- 239000012453 solvate Substances 0.000 claims abstract 2
- 239000012074 organic phase Substances 0.000 claims 5
- 238000005406 washing Methods 0.000 claims 5
- 238000009835 boiling Methods 0.000 claims 4
- 238000000926 separation method Methods 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 239000012429 reaction media Substances 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 230000020477 pH reduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83687306P | 2006-08-09 | 2006-08-09 | |
| EP06118689A EP1886997A1 (fr) | 2006-08-09 | 2006-08-09 | Procédé de purification de montelukast |
| PCT/EP2007/058176 WO2008017667A1 (fr) | 2006-08-09 | 2007-08-07 | Procédé de purification du montélukast |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110322T1 true HRP20110322T1 (hr) | 2011-06-30 |
Family
ID=37667497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110322T HRP20110322T1 (hr) | 2006-08-09 | 2011-05-03 | Postupak za pročišćavanje montelukasta |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20100029945A1 (fr) |
| EP (2) | EP1886997A1 (fr) |
| JP (1) | JP2010500324A (fr) |
| KR (1) | KR20090037445A (fr) |
| CN (1) | CN101490005B (fr) |
| AT (1) | ATE499345T1 (fr) |
| AU (1) | AU2007283613A1 (fr) |
| CA (1) | CA2657017A1 (fr) |
| DE (1) | DE602007012728D1 (fr) |
| ES (1) | ES2361239T3 (fr) |
| HR (1) | HRP20110322T1 (fr) |
| IL (1) | IL195622A (fr) |
| MX (1) | MX2008015135A (fr) |
| NO (1) | NO20090748L (fr) |
| PL (1) | PL2066638T3 (fr) |
| PT (1) | PT2066638E (fr) |
| RU (1) | RU2009108271A (fr) |
| SI (1) | SI2066638T1 (fr) |
| WO (1) | WO2008017667A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7821421B2 (en) | 2003-07-07 | 2010-10-26 | Sensomatix Ltd. | Traffic information system |
| US7812168B2 (en) | 2005-07-05 | 2010-10-12 | Teva Pharmaceutical Industries Ltd. | Purification of montelukast |
| WO2011121091A1 (fr) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Synthèse efficace pour la préparation de montélukast et nouvelle forme cristalline d'intermédiaires dans celle-ci |
| JP5553096B2 (ja) * | 2012-08-29 | 2014-07-16 | 大日本印刷株式会社 | 高純度モンテルカストの製造法 |
| CN103570619B (zh) * | 2013-11-08 | 2015-12-09 | 南京靖龙药物研发有限公司 | 一种孟鲁司特钠衍生物的制备方法 |
| CN105646344B (zh) * | 2016-02-29 | 2018-08-14 | 山东新时代药业有限公司 | 一种孟鲁司特的纯化方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| US20050187243A1 (en) * | 2004-01-30 | 2005-08-25 | Valerie Niddam-Hildesheim | Montelukast free acid polymorphs |
| BRPI0506610A (pt) * | 2004-02-03 | 2007-05-02 | Chemagis Ltd | montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico |
| US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
| US20080214822A1 (en) * | 2004-11-30 | 2008-09-04 | Medichem, S.A. | Process For the Preparation of a Leukotriene Antagonist |
| WO2006064269A2 (fr) * | 2004-12-17 | 2006-06-22 | Cipla Limited | Sels d'antagoniste de leukotriene |
-
2006
- 2006-08-09 EP EP06118689A patent/EP1886997A1/fr not_active Withdrawn
-
2007
- 2007-08-07 EP EP07788278A patent/EP2066638B8/fr active Active
- 2007-08-07 US US12/376,773 patent/US20100029945A1/en not_active Abandoned
- 2007-08-07 SI SI200730588T patent/SI2066638T1/sl unknown
- 2007-08-07 PL PL07788278T patent/PL2066638T3/pl unknown
- 2007-08-07 ES ES07788278T patent/ES2361239T3/es active Active
- 2007-08-07 CA CA002657017A patent/CA2657017A1/fr not_active Abandoned
- 2007-08-07 AU AU2007283613A patent/AU2007283613A1/en not_active Abandoned
- 2007-08-07 RU RU2009108271/04A patent/RU2009108271A/ru not_active Application Discontinuation
- 2007-08-07 DE DE602007012728T patent/DE602007012728D1/de active Active
- 2007-08-07 KR KR1020097002300A patent/KR20090037445A/ko not_active Application Discontinuation
- 2007-08-07 PT PT07788278T patent/PT2066638E/pt unknown
- 2007-08-07 AT AT07788278T patent/ATE499345T1/de not_active IP Right Cessation
- 2007-08-07 WO PCT/EP2007/058176 patent/WO2008017667A1/fr active Application Filing
- 2007-08-07 MX MX2008015135A patent/MX2008015135A/es active IP Right Grant
- 2007-08-07 JP JP2009523275A patent/JP2010500324A/ja active Pending
- 2007-08-07 CN CN2007800263787A patent/CN101490005B/zh not_active Expired - Fee Related
-
2008
- 2008-12-01 IL IL195622A patent/IL195622A/en not_active IP Right Cessation
-
2009
- 2009-02-17 NO NO20090748A patent/NO20090748L/no not_active Application Discontinuation
-
2011
- 2011-05-03 HR HR20110322T patent/HRP20110322T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090037445A (ko) | 2009-04-15 |
| EP2066638A1 (fr) | 2009-06-10 |
| CN101490005B (zh) | 2011-08-31 |
| AU2007283613A1 (en) | 2008-02-14 |
| PL2066638T3 (pl) | 2011-07-29 |
| IL195622A0 (en) | 2009-09-01 |
| AU2007283613A8 (en) | 2009-01-22 |
| CN101490005A (zh) | 2009-07-22 |
| SI2066638T1 (sl) | 2011-06-30 |
| WO2008017667A1 (fr) | 2008-02-14 |
| ES2361239T3 (es) | 2011-06-15 |
| IL195622A (en) | 2011-03-31 |
| JP2010500324A (ja) | 2010-01-07 |
| US20100029945A1 (en) | 2010-02-04 |
| EP1886997A1 (fr) | 2008-02-13 |
| MX2008015135A (es) | 2008-12-15 |
| ATE499345T1 (de) | 2011-03-15 |
| DE602007012728D1 (de) | 2011-04-07 |
| NO20090748L (no) | 2009-03-09 |
| PT2066638E (pt) | 2011-05-16 |
| CA2657017A1 (fr) | 2008-02-14 |
| EP2066638B1 (fr) | 2011-02-23 |
| EP2066638B8 (fr) | 2011-10-12 |
| RU2009108271A (ru) | 2010-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20110322T1 (hr) | Postupak za pročišćavanje montelukasta | |
| HRP20110575T1 (hr) | Postupak pročišćavanja montelukasta i njegovih soli amina | |
| CN105531245A (zh) | 用于纯化包含2-甲酰基-呋喃-5-羧酸和2,5-呋喃二羧酸的酸组合物的方法 | |
| CN107488139B (zh) | 一种含硫3-芳亚甲基异吲哚啉酮衍生物制备方法 | |
| DK2681192T3 (en) | Synthesis of 2-carboxamide-cycloamino-urea derivatives | |
| JP2013542174A5 (fr) | ||
| CN104817422A (zh) | 一种己内酰胺生产工艺反萃取工序中粗苯残液的处理方法 | |
| AR013051A1 (es) | Aislacion y purificacion de esteroles a partir de fracciones neutras de resina de tallol mediante cristalizacion de decantacion unica | |
| HK1087109A1 (en) | Process for isolation and purification of paclitaxel from natural sources | |
| RU2016112932A (ru) | Способ удаления серы из метанола-сырца | |
| Vallejo et al. | N-Demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus | |
| CN102199442B (zh) | 胺类质子型离子液体萃取剂用于油品脱硫及萃取剂回收方法 | |
| CN106008316B (zh) | 一种合成雷迪帕韦手性中间体的方法 | |
| RU2009115852A (ru) | Способ получения абакавира | |
| KR20080071841A (ko) | 조효소 ｑ10의 분리 및 정제 방법 | |
| BR0007649A (pt) | Processo para produção de solução aquosa, isenta essencialmente de alcanol | |
| CN106883227B (zh) | 通过麦角菌发酵废料制备麦角新碱的方法 | |
| EP3666756B1 (fr) | Procédé de préparation de lévétiracétam | |
| CN105348256B (zh) | 一种药用级盐酸氟哌噻吨的制备方法 | |
| CN103360463A (zh) | 一种达福普汀及其中间体的分离纯化方法 | |
| CN103012188A (zh) | 一种龙胆酸乙醇胺的制备方法 | |
| CN105272854A (zh) | 一种吉法酯的制备方法 | |
| KR20210028665A (ko) | 일종(1r,3s)-3-아미노기-1-사이클로펜탄올 및 그 염의 제조방법 | |
| Vieira et al. | 1. Separation and Purification of Mixtures | |
| TWI242599B (en) | Process for separating aromatics from hydrocarbon mixtures by extractive distillation and composite solvent therefor |