HRP20110041T1 - Derivati karbazola kao funkcionalni ligandi 5-ht6 - Google Patents
Derivati karbazola kao funkcionalni ligandi 5-ht6 Download PDFInfo
- Publication number
- HRP20110041T1 HRP20110041T1 HR20110041T HRP20110041T HRP20110041T1 HR P20110041 T1 HRP20110041 T1 HR P20110041T1 HR 20110041 T HR20110041 T HR 20110041T HR P20110041 T HRP20110041 T HR P20110041T HR P20110041 T1 HRP20110041 T1 HR P20110041T1
- Authority
- HR
- Croatia
- Prior art keywords
- carbazol
- dimethylamine
- tetrahydro
- compound
- formula
- Prior art date
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- 125000000609 carbazolyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 21
- 150000003839 salts Chemical class 0.000 claims abstract 9
- 108091005435 5-HT6 receptors Proteins 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 3
- 229940079593 drug Drugs 0.000 claims abstract 3
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 22
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 8
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000006529 (C3-C6) alkyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- VXHXQVRVORPRKU-UHFFFAOYSA-N 6-bromo-9-(2,3-dichlorophenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Br)=CC=C1N2S(=O)(=O)C1=CC=CC(Cl)=C1Cl VXHXQVRVORPRKU-UHFFFAOYSA-N 0.000 claims 1
- XHFATGOAAZZKLX-UHFFFAOYSA-N 6-bromo-9-(2-bromophenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Br)=CC=C1N2S(=O)(=O)C1=CC=CC=C1Br XHFATGOAAZZKLX-UHFFFAOYSA-N 0.000 claims 1
- FHTVXPHFFOANMZ-UHFFFAOYSA-N 6-bromo-9-(4-bromophenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Br)=CC=C1N2S(=O)(=O)C1=CC=C(Br)C=C1 FHTVXPHFFOANMZ-UHFFFAOYSA-N 0.000 claims 1
- OCKCNFOQIXKHHQ-UHFFFAOYSA-N 6-bromo-9-(4-fluorophenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Br)=CC=C1N2S(=O)(=O)C1=CC=C(F)C=C1 OCKCNFOQIXKHHQ-UHFFFAOYSA-N 0.000 claims 1
- TVWJLEDPDYVIAF-UHFFFAOYSA-N 6-bromo-9-(4-methoxyphenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=C(Br)C=C2C2=C1CCC(N(C)C)C2 TVWJLEDPDYVIAF-UHFFFAOYSA-N 0.000 claims 1
- FJDBTILNQCEBQX-UHFFFAOYSA-N 6-bromo-n,n-dimethyl-9-(4-propan-2-ylphenyl)sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=CC(C(C)C)=CC=C1S(=O)(=O)N1C2=CC=C(Br)C=C2C2=C1CCC(N(C)C)C2 FJDBTILNQCEBQX-UHFFFAOYSA-N 0.000 claims 1
- OHLIBZZIOZMXIN-UHFFFAOYSA-N 6-bromo-n,n-dimethyl-9-[3-(trifluoromethyl)phenyl]sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Br)=CC=C1N2S(=O)(=O)C1=CC=CC(C(F)(F)F)=C1 OHLIBZZIOZMXIN-UHFFFAOYSA-N 0.000 claims 1
- CHNGIMXRHADLSO-UHFFFAOYSA-N 6-chloro-9-(4-fluorophenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Cl)=CC=C1N2S(=O)(=O)C1=CC=C(F)C=C1 CHNGIMXRHADLSO-UHFFFAOYSA-N 0.000 claims 1
- XJSQPVGIUSJIDS-UHFFFAOYSA-N 6-chloro-n,n-dimethyl-9-(4-methylphenyl)sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Cl)=CC=C1N2S(=O)(=O)C1=CC=C(C)C=C1 XJSQPVGIUSJIDS-UHFFFAOYSA-N 0.000 claims 1
- BBSVXLFIZJQQOV-UHFFFAOYSA-N 6-chloro-n,n-dimethyl-9-[3-(trifluoromethyl)phenyl]sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Cl)=CC=C1N2S(=O)(=O)C1=CC=CC(C(F)(F)F)=C1 BBSVXLFIZJQQOV-UHFFFAOYSA-N 0.000 claims 1
- LZILBCGLADWRRO-UHFFFAOYSA-N 6-fluoro-9-(4-fluorophenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(F)=CC=C1N2S(=O)(=O)C1=CC=C(F)C=C1 LZILBCGLADWRRO-UHFFFAOYSA-N 0.000 claims 1
- QHQSBPRWLHRWAQ-UHFFFAOYSA-N 6-fluoro-n,n-dimethyl-9-(4-methylphenyl)sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(F)=CC=C1N2S(=O)(=O)C1=CC=C(C)C=C1 QHQSBPRWLHRWAQ-UHFFFAOYSA-N 0.000 claims 1
- ZLSXIXYITXPSOC-UHFFFAOYSA-N 6-fluoro-n,n-dimethyl-9-(4-propan-2-ylphenyl)sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=CC(C(C)C)=CC=C1S(=O)(=O)N1C2=CC=C(F)C=C2C2=C1CCC(N(C)C)C2 ZLSXIXYITXPSOC-UHFFFAOYSA-N 0.000 claims 1
- VKSRBIPXHKGXHU-UHFFFAOYSA-N 6-methoxy-9-(4-methoxyphenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=C(OC)C=C2C2=C1CCC(N(C)C)C2 VKSRBIPXHKGXHU-UHFFFAOYSA-N 0.000 claims 1
- ALWRRUFJVQDOPL-UHFFFAOYSA-N 6-methoxy-n,n-dimethyl-9-(4-methylphenyl)sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=2CCC(N(C)C)CC=2C2=CC(OC)=CC=C2N1S(=O)(=O)C1=CC=C(C)C=C1 ALWRRUFJVQDOPL-UHFFFAOYSA-N 0.000 claims 1
- ADGNYVSGEVQHLZ-UHFFFAOYSA-N 6-methoxy-n,n-dimethyl-9-[3-(trifluoromethyl)phenyl]sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=2CCC(N(C)C)CC=2C2=CC(OC)=CC=C2N1S(=O)(=O)C1=CC=CC(C(F)(F)F)=C1 ADGNYVSGEVQHLZ-UHFFFAOYSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- SRCUGVUYMUSXIR-UHFFFAOYSA-N 9-(3-chlorophenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC=CC=C1N2S(=O)(=O)C1=CC=CC(Cl)=C1 SRCUGVUYMUSXIR-UHFFFAOYSA-N 0.000 claims 1
- BYIPSJSCVXORRR-UHFFFAOYSA-N 9-(4-bromophenyl)sulfonyl-6-chloro-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Cl)=CC=C1N2S(=O)(=O)C1=CC=C(Br)C=C1 BYIPSJSCVXORRR-UHFFFAOYSA-N 0.000 claims 1
- SZOUKQKLAZNOSX-UHFFFAOYSA-N 9-(4-bromophenyl)sulfonyl-6-fluoro-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(F)=CC=C1N2S(=O)(=O)C1=CC=C(Br)C=C1 SZOUKQKLAZNOSX-UHFFFAOYSA-N 0.000 claims 1
- JDJZZFHUUVRNHZ-UHFFFAOYSA-N 9-(4-bromophenyl)sulfonyl-6-methoxy-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=2CCC(N(C)C)CC=2C2=CC(OC)=CC=C2N1S(=O)(=O)C1=CC=C(Br)C=C1 JDJZZFHUUVRNHZ-UHFFFAOYSA-N 0.000 claims 1
- INOVOZTXOHBWOI-UHFFFAOYSA-N 9-(4-fluorophenyl)sulfonyl-6-methoxy-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=2CCC(N(C)C)CC=2C2=CC(OC)=CC=C2N1S(=O)(=O)C1=CC=C(F)C=C1 INOVOZTXOHBWOI-UHFFFAOYSA-N 0.000 claims 1
- UZKROYHPNXXRML-UHFFFAOYSA-N 9-(4-methoxyphenyl)sulfonyl-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=CC=C2C2=C1CCC(N(C)C)C2 UZKROYHPNXXRML-UHFFFAOYSA-N 0.000 claims 1
- BPDIPISJQZBBJL-UHFFFAOYSA-N 9-(benzenesulfonyl)-6-bromo-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Br)=CC=C1N2S(=O)(=O)C1=CC=CC=C1 BPDIPISJQZBBJL-UHFFFAOYSA-N 0.000 claims 1
- UQXLBDBXJGUYAE-UHFFFAOYSA-N 9-(benzenesulfonyl)-6-chloro-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(Cl)=CC=C1N2S(=O)(=O)C1=CC=CC=C1 UQXLBDBXJGUYAE-UHFFFAOYSA-N 0.000 claims 1
- TYJYBRVLMVDOMJ-UHFFFAOYSA-N 9-(benzenesulfonyl)-6-fluoro-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC(F)=CC=C1N2S(=O)(=O)C1=CC=CC=C1 TYJYBRVLMVDOMJ-UHFFFAOYSA-N 0.000 claims 1
- WJGHDFLJHZUCKM-UHFFFAOYSA-N 9-(benzenesulfonyl)-6-methoxy-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=2CCC(N(C)C)CC=2C2=CC(OC)=CC=C2N1S(=O)(=O)C1=CC=CC=C1 WJGHDFLJHZUCKM-UHFFFAOYSA-N 0.000 claims 1
- DXPHMVPLORWBKA-UHFFFAOYSA-N 9-(benzenesulfonyl)-n,n-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC=CC=C1N2S(=O)(=O)C1=CC=CC=C1 DXPHMVPLORWBKA-UHFFFAOYSA-N 0.000 claims 1
- VFIXEEIIZUMLIG-UHFFFAOYSA-N 9-(benzenesulfonyl)-n,n-dimethyl-6-methylsulfanyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=2CCC(N(C)C)CC=2C2=CC(SC)=CC=C2N1S(=O)(=O)C1=CC=CC=C1 VFIXEEIIZUMLIG-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- LYGXTKJBXJMAQL-UHFFFAOYSA-N n,n-dimethyl-9-(4-methylphenyl)sulfonyl-6-methylsulfanyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=2CCC(N(C)C)CC=2C2=CC(SC)=CC=C2N1S(=O)(=O)C1=CC=C(C)C=C1 LYGXTKJBXJMAQL-UHFFFAOYSA-N 0.000 claims 1
- IAMTYBROQNVCMZ-UHFFFAOYSA-N n,n-dimethyl-9-(4-propan-2-ylphenyl)sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1=CC(C(C)C)=CC=C1S(=O)(=O)N1C2=CC=CC=C2C2=C1CCC(N(C)C)C2 IAMTYBROQNVCMZ-UHFFFAOYSA-N 0.000 claims 1
- XNHXAWXVLOOHSD-UHFFFAOYSA-N n,n-dimethyl-9-[3-(trifluoromethyl)phenyl]sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine Chemical compound C1C(N(C)C)CCC2=C1C1=CC=CC=C1N2S(=O)(=O)C1=CC=CC(C(F)(F)F)=C1 XNHXAWXVLOOHSD-UHFFFAOYSA-N 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- -1 pyrrolopyridinyl Chemical group 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Indole Compounds (AREA)
- Structures Or Materials For Encapsulating Or Coating Semiconductor Devices Or Solid State Devices (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1504CH2005 | 2005-10-19 | ||
| PCT/IN2006/000195 WO2007046111A1 (en) | 2005-10-19 | 2006-06-09 | Carbazole derivatives as functional 5-ht6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110041T1 true HRP20110041T1 (hr) | 2011-02-28 |
Family
ID=37054637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110041T HRP20110041T1 (hr) | 2005-10-19 | 2011-01-20 | Derivati karbazola kao funkcionalni ligandi 5-ht6 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8143303B2 (pt) |
| EP (1) | EP1948166B1 (pt) |
| JP (1) | JP2009512681A (pt) |
| KR (1) | KR101125820B1 (pt) |
| CN (1) | CN101291670B (pt) |
| AT (1) | ATE485040T1 (pt) |
| AU (1) | AU2006305502B2 (pt) |
| BR (1) | BRPI0619308A2 (pt) |
| CA (1) | CA2626646C (pt) |
| CY (1) | CY1111560T1 (pt) |
| DE (1) | DE602006017722D1 (pt) |
| DK (1) | DK1948166T3 (pt) |
| EA (1) | EA014694B1 (pt) |
| ES (1) | ES2354455T3 (pt) |
| HK (1) | HK1120424A1 (pt) |
| HR (1) | HRP20110041T1 (pt) |
| NO (1) | NO341252B1 (pt) |
| NZ (1) | NZ567865A (pt) |
| PL (1) | PL1948166T3 (pt) |
| PT (1) | PT1948166E (pt) |
| RS (1) | RS51627B (pt) |
| SI (1) | SI1948166T1 (pt) |
| WO (1) | WO2007046111A1 (pt) |
| ZA (1) | ZA200803118B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013055386A2 (en) * | 2011-10-03 | 2013-04-18 | The University Of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
| CN106045972B (zh) * | 2016-06-03 | 2018-11-16 | 中山大学 | 咔唑-利凡斯的明二联体及其药物组合物和应用 |
| CN106749184B (zh) * | 2016-11-15 | 2020-07-17 | 中山大学 | 8-氨基喹啉-羟基咔唑杂联体，其制备方法及其药物组合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01005905A (es) * | 1998-12-11 | 2002-09-18 | Univ Virginia Commonwealth | Ligandos selectivos de receptores de 5-ht6. |
| MXPA04003419A (es) * | 2001-10-09 | 2004-07-08 | Upjohn Co | Tetrahidro y hexahidro-carbazoles sustituidos con arilsulfonilo como ligandos del receptor 5-ht-6. |
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2006
- 2006-06-09 DE DE602006017722T patent/DE602006017722D1/de active Active
- 2006-06-09 EP EP06766266A patent/EP1948166B1/en active Active
- 2006-06-09 NZ NZ567865A patent/NZ567865A/en not_active IP Right Cessation
- 2006-06-09 CA CA2626646A patent/CA2626646C/en not_active Expired - Fee Related
- 2006-06-09 US US12/083,707 patent/US8143303B2/en not_active Expired - Fee Related
- 2006-06-09 PT PT06766266T patent/PT1948166E/pt unknown
- 2006-06-09 CN CN2006800390082A patent/CN101291670B/zh not_active Expired - Fee Related
- 2006-06-09 BR BRPI0619308-0A patent/BRPI0619308A2/pt not_active Application Discontinuation
- 2006-06-09 ES ES06766266T patent/ES2354455T3/es active Active
- 2006-06-09 EA EA200801114A patent/EA014694B1/ru not_active IP Right Cessation
- 2006-06-09 RS RS20110017A patent/RS51627B/en unknown
- 2006-06-09 DK DK06766266.8T patent/DK1948166T3/da active
- 2006-06-09 PL PL06766266T patent/PL1948166T3/pl unknown
- 2006-06-09 AT AT06766266T patent/ATE485040T1/de active
- 2006-06-09 KR KR1020087010404A patent/KR101125820B1/ko active IP Right Grant
- 2006-06-09 WO PCT/IN2006/000195 patent/WO2007046111A1/en active Application Filing
- 2006-06-09 AU AU2006305502A patent/AU2006305502B2/en not_active Ceased
- 2006-06-09 JP JP2008536206A patent/JP2009512681A/ja active Pending
- 2006-06-09 SI SI200630873T patent/SI1948166T1/sl unknown
-
2008
- 2008-04-09 NO NO20081739A patent/NO341252B1/no not_active IP Right Cessation
- 2008-04-09 ZA ZA2008/03118A patent/ZA200803118B/en unknown
- 2008-12-03 HK HK08113183.2A patent/HK1120424A1/xx not_active IP Right Cessation
-
2011
- 2011-01-20 CY CY20111100064T patent/CY1111560T1/el unknown
- 2011-01-20 HR HR20110041T patent/HRP20110041T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009512681A (ja) | 2009-03-26 |
| CA2626646C (en) | 2011-03-01 |
| CA2626646A1 (en) | 2007-04-26 |
| DE602006017722D1 (de) | 2010-12-02 |
| NZ567865A (en) | 2010-07-30 |
| US20100189646A1 (en) | 2010-07-29 |
| KR20080064848A (ko) | 2008-07-09 |
| ZA200803118B (en) | 2011-11-30 |
| CN101291670B (zh) | 2012-07-04 |
| EP1948166A1 (en) | 2008-07-30 |
| EP1948166B1 (en) | 2010-10-20 |
| PL1948166T3 (pl) | 2011-04-29 |
| RS51627B (en) | 2011-08-31 |
| US8143303B2 (en) | 2012-03-27 |
| DK1948166T3 (da) | 2011-01-31 |
| KR101125820B1 (ko) | 2012-03-28 |
| NO341252B1 (no) | 2017-09-25 |
| HK1120424A1 (en) | 2009-04-03 |
| CN101291670A (zh) | 2008-10-22 |
| NO20081739L (no) | 2008-07-09 |
| WO2007046111A1 (en) | 2007-04-26 |
| CY1111560T1 (el) | 2015-10-07 |
| SI1948166T1 (sl) | 2011-02-28 |
| ATE485040T1 (de) | 2010-11-15 |
| AU2006305502A1 (en) | 2007-04-26 |
| EA014694B1 (ru) | 2010-12-30 |
| PT1948166E (pt) | 2011-01-19 |
| ES2354455T3 (es) | 2011-03-15 |
| BRPI0619308A2 (pt) | 2013-03-05 |
| EA200801114A1 (ru) | 2009-02-27 |
| AU2006305502B2 (en) | 2009-11-26 |
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