HRP20100726T1 - Triciklički spojevi i njihova upotreba kao modulatora glukokortikoidnih receptora - Google Patents
Triciklički spojevi i njihova upotreba kao modulatora glukokortikoidnih receptora Download PDFInfo
- Publication number
- HRP20100726T1 HRP20100726T1 HR20100726T HRP20100726T HRP20100726T1 HR P20100726 T1 HRP20100726 T1 HR P20100726T1 HR 20100726 T HR20100726 T HR 20100726T HR P20100726 T HRP20100726 T HR P20100726T HR P20100726 T1 HRP20100726 T1 HR P20100726T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- salt
- image
- formula
- receptor modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88798107P | 2007-02-02 | 2007-02-02 | |
| PCT/IB2008/000249 WO2008093236A1 (en) | 2007-02-02 | 2008-01-28 | Tricyclic compounds and their use as glucocorticoid receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100726T1 true HRP20100726T1 (hr) | 2011-04-30 |
Family
ID=39887754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100726T HRP20100726T1 (hr) | 2007-02-02 | 2008-01-28 | Triciklički spojevi i njihova upotreba kao modulatora glukokortikoidnih receptora |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2114888B1 (enExample) |
| JP (1) | JP4579333B2 (enExample) |
| AP (1) | AP2411A (enExample) |
| AT (1) | ATE487700T1 (enExample) |
| AU (1) | AU2008211622B2 (enExample) |
| BR (1) | BRPI0807121A2 (enExample) |
| CA (1) | CA2676907C (enExample) |
| DE (1) | DE602008003405D1 (enExample) |
| DK (1) | DK2114888T3 (enExample) |
| EA (1) | EA016001B1 (enExample) |
| HR (1) | HRP20100726T1 (enExample) |
| IL (1) | IL200044A (enExample) |
| MX (1) | MX2009008286A (enExample) |
| NZ (1) | NZ578661A (enExample) |
| PL (1) | PL2114888T3 (enExample) |
| SI (1) | SI2114888T1 (enExample) |
| UZ (1) | UZ4378C (enExample) |
| WO (1) | WO2008093236A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101107949B1 (ko) * | 2007-02-02 | 2012-02-08 | 화이자 프로덕츠 인코포레이티드 | 트라이사이클릭 화합물 및 글루코코르티코이드 수용체 조절자로서의 이들의 용도 |
| DK2307375T3 (en) * | 2008-07-28 | 2014-12-08 | Pfizer | Phenanthrenonforbindelser, compositions and methods |
| AU2012229952A1 (en) * | 2011-03-15 | 2013-04-18 | Abbvie Inc. | Nuclear hormone receptor modulators |
| US20140350078A1 (en) * | 2011-09-13 | 2014-11-27 | New York University | Controlling regulatory t cell function |
| TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| EP2935284A4 (en) | 2012-12-21 | 2016-04-27 | Abbvie Inc | HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS |
| PL3350175T3 (pl) * | 2015-09-15 | 2020-07-27 | Leo Pharma A/S | Niesteroidowe modulatory receptora glukokortykoidowego do miejscowego dostarczania leku |
| MX2021006421A (es) | 2018-12-19 | 2021-08-16 | Leo Pharma As | Anilidas de aminoácidos como moduladores de moléculas pequeñas de interleucinas-17 (il-17). |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0201243A3 (en) * | 1999-04-30 | 2002-11-28 | Pfizer Prod Inc | Glucocorticoid receptor modulators, pharmaceutical compositions containing them and their use |
| JP4738603B2 (ja) * | 2000-11-06 | 2011-08-03 | ライオン株式会社 | 歯ブラシ |
| IL180679A0 (en) * | 2000-10-27 | 2009-02-11 | Pfizer Prod Inc | Process for the preparation of non-steroidal glucocorticoid receptor modulators |
| JP2002193911A (ja) * | 2000-10-28 | 2002-07-10 | Pfizer Prod Inc | グルココルチコイドレセプターモジュレーター |
| EP1685110A1 (en) * | 2003-11-13 | 2006-08-02 | Pfizer Products Inc. | Octahydrophenanthrene hydrazide derivatives useful as glucocorticoid receptor modulators |
| EP2012796A4 (en) * | 2006-05-02 | 2010-08-11 | Corcept Therapeutics Inc | USE OF GLUCOCORTICOID TYPE II RECEPTOR ANTAGONISTS TO TREAT PATIENT DEPRESSION WITH IL-2 |
-
2008
- 2008-01-28 EA EA200970662A patent/EA016001B1/ru not_active IP Right Cessation
- 2008-01-28 AU AU2008211622A patent/AU2008211622B2/en not_active Ceased
- 2008-01-28 AP AP2009004941A patent/AP2411A/xx active
- 2008-01-28 AT AT08702358T patent/ATE487700T1/de active
- 2008-01-28 PL PL08702358T patent/PL2114888T3/pl unknown
- 2008-01-28 MX MX2009008286A patent/MX2009008286A/es active IP Right Grant
- 2008-01-28 DK DK08702358.6T patent/DK2114888T3/da active
- 2008-01-28 HR HR20100726T patent/HRP20100726T1/hr unknown
- 2008-01-28 UZ UZ0900241A patent/UZ4378C/xx unknown
- 2008-01-28 JP JP2009547779A patent/JP4579333B2/ja not_active Expired - Fee Related
- 2008-01-28 WO PCT/IB2008/000249 patent/WO2008093236A1/en not_active Ceased
- 2008-01-28 EP EP08702358A patent/EP2114888B1/en active Active
- 2008-01-28 NZ NZ578661A patent/NZ578661A/en not_active IP Right Cessation
- 2008-01-28 BR BRPI0807121-7A2A patent/BRPI0807121A2/pt not_active Application Discontinuation
- 2008-01-28 CA CA2676907A patent/CA2676907C/en not_active Expired - Fee Related
- 2008-01-28 DE DE602008003405T patent/DE602008003405D1/de active Active
- 2008-01-28 SI SI200830124T patent/SI2114888T1/sl unknown
-
2009
- 2009-07-23 IL IL200044A patent/IL200044A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AP2009004941A0 (en) | 2009-08-31 |
| DE602008003405D1 (de) | 2010-12-23 |
| IL200044A (en) | 2015-06-30 |
| JP2010517991A (ja) | 2010-05-27 |
| WO2008093236A1 (en) | 2008-08-07 |
| AU2008211622B2 (en) | 2012-04-19 |
| CA2676907A1 (en) | 2008-08-07 |
| HK1135094A1 (en) | 2010-05-28 |
| MX2009008286A (es) | 2009-08-12 |
| AP2411A (en) | 2012-05-30 |
| AU2008211622A1 (en) | 2008-08-07 |
| EA200970662A1 (ru) | 2010-02-26 |
| EP2114888A1 (en) | 2009-11-11 |
| NZ578661A (en) | 2010-12-24 |
| DK2114888T3 (da) | 2011-01-24 |
| EA016001B1 (ru) | 2012-01-30 |
| ATE487700T1 (de) | 2010-11-15 |
| PL2114888T3 (pl) | 2011-04-29 |
| SI2114888T1 (sl) | 2011-02-28 |
| BRPI0807121A2 (pt) | 2014-04-08 |
| JP4579333B2 (ja) | 2010-11-10 |
| CA2676907C (en) | 2012-03-20 |
| UZ4378C (en) | 2011-07-29 |
| IL200044A0 (en) | 2010-04-15 |
| EP2114888B1 (en) | 2010-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20110702T1 (hr) | Triciklički spojevi i njihova uporaba kao modulatora glukokortikoidnih receptora | |
| HRP20100726T1 (hr) | Triciklički spojevi i njihova upotreba kao modulatora glukokortikoidnih receptora | |
| EA201170251A1 (ru) | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 1,2,3,4-ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛ-3-ИЛ)УКСУСНОЙ КИСЛОТЫ, ПРИМЕНИМЫЕ В ЛЕЧЕНИИ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ РАССТРОЙСТВ | |
| EA201170374A1 (ru) | Производные замещенных трициклических кислот в качестве агонистов рецептора s1p1, применимые при лечении аутоиммунных и воспалительных заболеваний | |
| RU2014112319A (ru) | Соединения и фармацевтические композиции для лечения вирусных инфекций | |
| HRP20090235A2 (hr) | Karbonilirani (aza) cikloheksani kao ligandi dopaminskog receptora d<sub>3</sub> | |
| HRP20170403T1 (hr) | SUPSTITUIRANI BENZOAZEPINI KAO MODULATORI TOLL-u SLIČNIH RECEPTORA | |
| WO2009069032A3 (en) | Novel glucocorticoid receptor agonists | |
| MX347706B (es) | Derivados de triazol y su uso para trastornos neurologicos. | |
| WO2007085451A3 (en) | 3,5-di (aryl or heteroaryl) isoxazoles and 1, 2, 4-oxadiazoles as s1p1 receptor agonists, immunosuppresssive and anti -inflammatory agents | |
| BRPI0406762A (pt) | Derivados de n-(1-benzil-2-oxo-2-(1-piperazinil)etil)-1-piperidincarb oxamida e compostos relacionados como antagonistas de cgrp, para tratamento de dores de cabeça | |
| EA201101672A1 (ru) | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина | |
| JO3327B1 (ar) | تركيبات قرص تحتوي على المركب (z)- 2- سيانو- 3- هيدروكسي- بيوت- 2- حمض ينويك- (4'- ثالث فلورو مثيل فنيل)- أميد بمستوى ثبات محسن | |
| HRP20140394T1 (hr) | Tri-aril spojevi i sastavi koji ih ukljuäśuju | |
| MX2011007772A (es) | Derivados de isoxazol/o-piridina con enlazador etilo y etenilo. | |
| MX2011011484A (es) | Derivados de isoxazol-piridina como moduladores del acido gamma-aminobutirico. | |
| MA28598B1 (fr) | Combinaisons de glycopyrrolate et d'agonistes de recepteur beta2-adrenergique | |
| MX2011007737A (es) | Derivados de hidroximetil isoxazol como moduladores de acido gamma-aminobutirico a. | |
| NO20055376L (no) | Benzoksazinyl-amidosyklopentyl-heterosykliske modulatorer av chemokin-reseptorer | |
| WO2011005295A8 (en) | Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto | |
| MX391445B (es) | Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato. | |
| MX2011012669A (es) | Nuevos agonistas del receptor de glucocorticoides. | |
| HRP20140589T1 (hr) | Derivati pirazinooksazepina | |
| MX2011011303A (es) | Derivados de isoxazol. | |
| JP2010517991A5 (enExample) |