DE602008003405D1 - Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren - Google Patents

Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren

Info

Publication number
DE602008003405D1
DE602008003405D1 DE602008003405T DE602008003405T DE602008003405D1 DE 602008003405 D1 DE602008003405 D1 DE 602008003405D1 DE 602008003405 T DE602008003405 T DE 602008003405T DE 602008003405 T DE602008003405 T DE 602008003405T DE 602008003405 D1 DE602008003405 D1 DE 602008003405D1
Authority
DE
Germany
Prior art keywords
receptor modulators
glucocorticoid receptor
tricyclic compounds
tricyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008003405T
Other languages
English (en)
Inventor
Hengmiao Cheng
Xiao Hu
Kevin Dewayne Jerome
Mark Gerard Obukowicz
Lisa Olson
Paul Vincent Rucker
Ronald Keith Webber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of DE602008003405D1 publication Critical patent/DE602008003405D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
DE602008003405T 2007-02-02 2008-01-28 Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren Active DE602008003405D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88798107P 2007-02-02 2007-02-02
PCT/IB2008/000249 WO2008093236A1 (en) 2007-02-02 2008-01-28 Tricyclic compounds and their use as glucocorticoid receptor modulators

Publications (1)

Publication Number Publication Date
DE602008003405D1 true DE602008003405D1 (de) 2010-12-23

Family

ID=39887754

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008003405T Active DE602008003405D1 (de) 2007-02-02 2008-01-28 Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren

Country Status (19)

Country Link
EP (1) EP2114888B1 (de)
JP (1) JP4579333B2 (de)
AP (1) AP2411A (de)
AT (1) ATE487700T1 (de)
AU (1) AU2008211622B2 (de)
BR (1) BRPI0807121A2 (de)
CA (1) CA2676907C (de)
DE (1) DE602008003405D1 (de)
DK (1) DK2114888T3 (de)
EA (1) EA016001B1 (de)
HK (1) HK1135094A1 (de)
HR (1) HRP20100726T1 (de)
IL (1) IL200044A (de)
MX (1) MX2009008286A (de)
NZ (1) NZ578661A (de)
PL (1) PL2114888T3 (de)
SI (1) SI2114888T1 (de)
UZ (1) UZ4378C (de)
WO (1) WO2008093236A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY153057A (en) * 2007-02-02 2014-12-31 Pfizer Prod Inc Tryclic compounds,compositions and methods
NZ590559A (en) * 2008-07-28 2011-09-30 Pfizer Phenanthrenone compounds, compositions and methods
CN103732059A (zh) * 2011-03-15 2014-04-16 艾伯维公司 核激素受体调节剂
WO2013040233A1 (en) * 2011-09-13 2013-03-21 New York University Controlling regulatory t cell function
TW201422590A (zh) 2012-09-07 2014-06-16 Abbvie Inc 雜環核激素受體調節劑
WO2014094357A1 (en) 2012-12-21 2014-06-26 Abbvie Inc. Heterocyclic nuclear hormone receptor modulators
DK3350175T3 (da) * 2015-09-15 2020-02-03 Leo Pharma As Ikke-steroidale glucocorticoidreceptormodulatorer til lokal lægemiddelafgivelse
TW202039473A (zh) 2018-12-19 2020-11-01 丹麥商理奧藥品公司 Il-17的小分子調節劑

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE05584B1 (et) * 1999-04-30 2012-10-15 Pfizer Products Inc. Glkokortikoidretseptori modulaatorid
JP4738603B2 (ja) * 2000-11-06 2011-08-03 ライオン株式会社 歯ブラシ
IL146057A (en) * 2000-10-27 2007-09-20 Pfizer Prod Inc A process for the preparation of modulators of a non-steroidal glucocorticoid receptor
ATE327974T1 (de) * 2000-10-28 2006-06-15 Pfizer Prod Inc Modulatoren des glucocorticoid-rezeptors
WO2005047254A1 (en) * 2003-11-13 2005-05-26 Pfizer Products Inc. Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators
JP2009535430A (ja) * 2006-05-02 2009-10-01 コーセプト セラピューティクス， インコーポレイテッド Ｉｌ−２を摂取している患者における抑うつを処置するためのグルココルチコイドレセプターｉｉアンタゴニストの使用

Also Published As

Publication number Publication date
AP2411A (en) 2012-05-30
WO2008093236A1 (en) 2008-08-07
JP2010517991A (ja) 2010-05-27
SI2114888T1 (sl) 2011-02-28
CA2676907A1 (en) 2008-08-07
JP4579333B2 (ja) 2010-11-10
CA2676907C (en) 2012-03-20
ATE487700T1 (de) 2010-11-15
HK1135094A1 (en) 2010-05-28
AP2009004941A0 (en) 2009-08-31
AU2008211622A1 (en) 2008-08-07
EA200970662A1 (ru) 2010-02-26
IL200044A0 (en) 2010-04-15
EP2114888A1 (de) 2009-11-11
HRP20100726T1 (hr) 2011-04-30
EA016001B1 (ru) 2012-01-30
AU2008211622B2 (en) 2012-04-19
PL2114888T3 (pl) 2011-04-29
NZ578661A (en) 2010-12-24
MX2009008286A (es) 2009-08-12
DK2114888T3 (da) 2011-01-24
BRPI0807121A2 (pt) 2014-04-08
UZ4378C (en) 2011-07-29
IL200044A (en) 2015-06-30
EP2114888B1 (de) 2010-11-10

Similar Documents

Publication Publication Date Title
ATE518872T1 (de) Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren
ATE487700T1 (de) Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren
ATE473229T1 (de) Tricyclische verbindungen und deren verwendung als mglur1-antagonisten
ATE537157T1 (de) Substituierte phenoxy-n-alkylierte thiazoledindione als östrogenassoziierte rezeptor-alpha-modulatoren
DE602005023639D1 (de) Chinuclidinderivate und deren verwendung als muscarin-m3-rezeptor-antagonisten
DE112008002275A5 (de) Scheinwerferlampe und deren Verwendung
BRPI0918949A2 (pt) moduladores de receptores de 5-ht2a e piperazina d3
ATE538091T1 (de) Tetrahydrocyclopentaäbüindolverbindungen als androgenrezeptormodulatoren
ATE489389T1 (de) 2 -heteroaryl- pyrrolo ä3, 4-cüpyrrol- derivate und deren verwendung als scd inhibitoren
DE602007012308D1 (de) Bicyclische pyrimidinone und deren verwendung
DE112009000115A5 (de) Polyolefinfolie und Verwendung derselben
DE602007006540D1 (de) Cyclopropancarboxylate und deren verwendung als pestizide
EP2314588A4 (de) Verbindungen östrogenassoziierter rezeptormodulatoren und ihre verwendung
ATE512137T1 (de) Benzoylpiperidinderivate als doppelmodulatoren des 5-ht2a- und des d3-rezeptors
DE602006005138D1 (de) Nichtsteroide glucocorticoid-rezeptormodulatoren
DE602006007976D1 (de) Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes
BRPI0916574A2 (pt) derivados de diazepano e piperazina moduladores de receptores de quiomiocinas
DE112009004836A5 (de) Ecdyson-derivate und deren verwendung
ATE478078T1 (de) Pyridooxazepin-progesteronrezeptor-modulatoren
ATE421516T1 (de) Als modulatoren des glucocorticoidrezeptors geeignete nichtsteroidale verbindungen