AU2008211622B2 - Tricyclic compounds and their use as glucocorticoid receptor modulators - Google Patents

Tricyclic compounds and their use as glucocorticoid receptor modulators Download PDF

Info

Publication number
AU2008211622B2
AU2008211622B2 AU2008211622A AU2008211622A AU2008211622B2 AU 2008211622 B2 AU2008211622 B2 AU 2008211622B2 AU 2008211622 A AU2008211622 A AU 2008211622A AU 2008211622 A AU2008211622 A AU 2008211622A AU 2008211622 B2 AU2008211622 B2 AU 2008211622B2
Authority
AU
Australia
Prior art keywords
receptor
compound
compounds
kinase
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008211622A
Other languages
English (en)
Other versions
AU2008211622A1 (en
Inventor
Hengmiao Cheng
Xiao Hu
Kevin Dewayne Jerome
Mark Gerard Obukowicz
Lisa Olson
Paul Vincent Rucker
Ronald Keith Webber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of AU2008211622A1 publication Critical patent/AU2008211622A1/en
Application granted granted Critical
Publication of AU2008211622B2 publication Critical patent/AU2008211622B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
AU2008211622A 2007-02-02 2008-01-28 Tricyclic compounds and their use as glucocorticoid receptor modulators Ceased AU2008211622B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88798107P 2007-02-02 2007-02-02
US60/887,981 2007-02-02
PCT/IB2008/000249 WO2008093236A1 (en) 2007-02-02 2008-01-28 Tricyclic compounds and their use as glucocorticoid receptor modulators

Publications (2)

Publication Number Publication Date
AU2008211622A1 AU2008211622A1 (en) 2008-08-07
AU2008211622B2 true AU2008211622B2 (en) 2012-04-19

Family

ID=39887754

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008211622A Ceased AU2008211622B2 (en) 2007-02-02 2008-01-28 Tricyclic compounds and their use as glucocorticoid receptor modulators

Country Status (18)

Country Link
EP (1) EP2114888B1 (enExample)
JP (1) JP4579333B2 (enExample)
AP (1) AP2411A (enExample)
AT (1) ATE487700T1 (enExample)
AU (1) AU2008211622B2 (enExample)
BR (1) BRPI0807121A2 (enExample)
CA (1) CA2676907C (enExample)
DE (1) DE602008003405D1 (enExample)
DK (1) DK2114888T3 (enExample)
EA (1) EA016001B1 (enExample)
HR (1) HRP20100726T1 (enExample)
IL (1) IL200044A (enExample)
MX (1) MX2009008286A (enExample)
NZ (1) NZ578661A (enExample)
PL (1) PL2114888T3 (enExample)
SI (1) SI2114888T1 (enExample)
UZ (1) UZ4378C (enExample)
WO (1) WO2008093236A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008093227A1 (en) * 2007-02-02 2008-08-07 Pfizer Products Inc. Tricyclic compounds and their use as glucocorticoid receptor modulators
ES2527137T3 (es) * 2008-07-28 2015-01-21 Pfizer Inc. Compuestos de fenantrenona, composiciones y procedimientos
WO2012125797A1 (en) * 2011-03-15 2012-09-20 Abbott Laboratories Nuclear hormone receptor modulators
US20140350078A1 (en) * 2011-09-13 2014-11-27 New York University Controlling regulatory t cell function
TW201422590A (zh) 2012-09-07 2014-06-16 Abbvie Inc 雜環核激素受體調節劑
EP2935284A4 (en) 2012-12-21 2016-04-27 Abbvie Inc HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS
KR20180050408A (ko) * 2015-09-15 2018-05-14 레오 파마 에이/에스 국부 약물 전달용의 비스테로이드성 글루코코르티코이드 수용체 조절제
CN113164448A (zh) 2018-12-19 2021-07-23 利奥制药有限公司 作为il-17的小分子调节剂的氨基酸苯胺类化合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066522A1 (en) * 1999-04-30 2000-11-09 Pfizer Products Inc. Glucocorticoid receptor modulators
EP1201649A1 (en) * 2000-10-28 2002-05-02 Pfizer Products Inc. Glucocorticoid receptor modulators
EP1201655A2 (en) * 2000-10-27 2002-05-02 Pfizer Products Inc. Process for the preparation of non-steroidal glucocorticoid receptor modulators
WO2005047254A1 (en) * 2003-11-13 2005-05-26 Pfizer Products Inc. Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4738603B2 (ja) * 2000-11-06 2011-08-03 ライオン株式会社 歯ブラシ
AU2007248059A1 (en) * 2006-05-02 2007-11-15 Corcept Therapeutics, Inc. The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066522A1 (en) * 1999-04-30 2000-11-09 Pfizer Products Inc. Glucocorticoid receptor modulators
EP1201655A2 (en) * 2000-10-27 2002-05-02 Pfizer Products Inc. Process for the preparation of non-steroidal glucocorticoid receptor modulators
EP1201649A1 (en) * 2000-10-28 2002-05-02 Pfizer Products Inc. Glucocorticoid receptor modulators
WO2005047254A1 (en) * 2003-11-13 2005-05-26 Pfizer Products Inc. Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators

Also Published As

Publication number Publication date
JP2010517991A (ja) 2010-05-27
UZ4378C (en) 2011-07-29
DK2114888T3 (da) 2011-01-24
ATE487700T1 (de) 2010-11-15
CA2676907A1 (en) 2008-08-07
IL200044A (en) 2015-06-30
IL200044A0 (en) 2010-04-15
WO2008093236A1 (en) 2008-08-07
JP4579333B2 (ja) 2010-11-10
SI2114888T1 (sl) 2011-02-28
HRP20100726T1 (hr) 2011-04-30
EP2114888B1 (en) 2010-11-10
BRPI0807121A2 (pt) 2014-04-08
HK1135094A1 (en) 2010-05-28
CA2676907C (en) 2012-03-20
AP2411A (en) 2012-05-30
NZ578661A (en) 2010-12-24
DE602008003405D1 (de) 2010-12-23
EA016001B1 (ru) 2012-01-30
EP2114888A1 (en) 2009-11-11
PL2114888T3 (pl) 2011-04-29
AP2009004941A0 (en) 2009-08-31
MX2009008286A (es) 2009-08-12
AU2008211622A1 (en) 2008-08-07
EA200970662A1 (ru) 2010-02-26

Similar Documents

Publication Publication Date Title
AU2008211613B2 (en) Tricyclic compounds and their use as glucocorticoid receptor modulators
CA2676907C (en) Tricyclic compounds and their use as glucocorticoid receptor modulators
HK1135108B (en) Tricyclic compounds and their use as glucocorticoid receptor modulators
HK1135094B (en) Tricyclic compounds and their use as glucocorticoid receptor modulators

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired