BRPI0807121A2 - Compostos tricíclicos e seu uso como moduladores de receptor glicocorticóide - Google Patents
Compostos tricíclicos e seu uso como moduladores de receptor glicocorticóideInfo
- Publication number
- BRPI0807121A2 BRPI0807121A2 BRPI0807121-7A2A BRPI0807121A BRPI0807121A2 BR PI0807121 A2 BRPI0807121 A2 BR PI0807121A2 BR PI0807121 A BRPI0807121 A BR PI0807121A BR PI0807121 A2 BRPI0807121 A2 BR PI0807121A2
- Authority
- BR
- Brazil
- Prior art keywords
- glucocorticid
- receptor modulators
- tricyclic compounds
- tricyclic
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88798107P | 2007-02-02 | 2007-02-02 | |
| PCT/IB2008/000249 WO2008093236A1 (en) | 2007-02-02 | 2008-01-28 | Tricyclic compounds and their use as glucocorticoid receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0807121A2 true BRPI0807121A2 (pt) | 2014-04-08 |
Family
ID=39887754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0807121-7A2A BRPI0807121A2 (pt) | 2007-02-02 | 2008-01-28 | Compostos tricíclicos e seu uso como moduladores de receptor glicocorticóide |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2114888B1 (enExample) |
| JP (1) | JP4579333B2 (enExample) |
| AP (1) | AP2411A (enExample) |
| AT (1) | ATE487700T1 (enExample) |
| AU (1) | AU2008211622B2 (enExample) |
| BR (1) | BRPI0807121A2 (enExample) |
| CA (1) | CA2676907C (enExample) |
| DE (1) | DE602008003405D1 (enExample) |
| DK (1) | DK2114888T3 (enExample) |
| EA (1) | EA016001B1 (enExample) |
| HR (1) | HRP20100726T1 (enExample) |
| IL (1) | IL200044A (enExample) |
| MX (1) | MX2009008286A (enExample) |
| NZ (1) | NZ578661A (enExample) |
| PL (1) | PL2114888T3 (enExample) |
| SI (1) | SI2114888T1 (enExample) |
| UZ (1) | UZ4378C (enExample) |
| WO (1) | WO2008093236A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY153057A (en) * | 2007-02-02 | 2014-12-31 | Pfizer Prod Inc | Tryclic compounds,compositions and methods |
| CN102112446B (zh) * | 2008-07-28 | 2012-10-31 | 美国辉瑞有限公司 | 菲酮化合物、组合物及方法 |
| US20120238549A1 (en) * | 2011-03-15 | 2012-09-20 | Abbott Laboratories | Nuclear Hormone Receptor Modulators |
| WO2013040233A1 (en) * | 2011-09-13 | 2013-03-21 | New York University | Controlling regulatory t cell function |
| TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| WO2014094357A1 (en) | 2012-12-21 | 2014-06-26 | Abbvie Inc. | Heterocyclic nuclear hormone receptor modulators |
| CN108368094B (zh) * | 2015-09-15 | 2021-07-02 | 利奥制药有限公司 | 用于局部药物递送的非甾体类糖皮质激素受体调节剂 |
| JP7515481B2 (ja) | 2018-12-19 | 2024-07-12 | レオ ファーマ アクティーゼルスカブ | Ｉｌ－１７の小分子調節物質としてのアミノ酸アニリド |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA007483B1 (ru) * | 1999-04-30 | 2006-10-27 | Пфайзер Продактс Инк. | Применение модулятора рецепторов глюкокортикоидов и агониста рецепторов глюкокортикоидов при получении лекарственного средства |
| JP4738603B2 (ja) * | 2000-11-06 | 2011-08-03 | ライオン株式会社 | 歯ブラシ |
| IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
| ATE327974T1 (de) * | 2000-10-28 | 2006-06-15 | Pfizer Prod Inc | Modulatoren des glucocorticoid-rezeptors |
| AU2004289532A1 (en) * | 2003-11-13 | 2005-05-26 | Pfizer Products Inc. | Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators |
| EP2012796A4 (en) * | 2006-05-02 | 2010-08-11 | Corcept Therapeutics Inc | USE OF GLUCOCORTICOID TYPE II RECEPTOR ANTAGONISTS TO TREAT PATIENT DEPRESSION WITH IL-2 |
-
2008
- 2008-01-28 PL PL08702358T patent/PL2114888T3/pl unknown
- 2008-01-28 SI SI200830124T patent/SI2114888T1/sl unknown
- 2008-01-28 UZ UZ0900241A patent/UZ4378C/xx unknown
- 2008-01-28 AU AU2008211622A patent/AU2008211622B2/en not_active Ceased
- 2008-01-28 HR HR20100726T patent/HRP20100726T1/hr unknown
- 2008-01-28 JP JP2009547779A patent/JP4579333B2/ja not_active Expired - Fee Related
- 2008-01-28 NZ NZ578661A patent/NZ578661A/en not_active IP Right Cessation
- 2008-01-28 BR BRPI0807121-7A2A patent/BRPI0807121A2/pt not_active Application Discontinuation
- 2008-01-28 DK DK08702358.6T patent/DK2114888T3/da active
- 2008-01-28 CA CA2676907A patent/CA2676907C/en not_active Expired - Fee Related
- 2008-01-28 AT AT08702358T patent/ATE487700T1/de active
- 2008-01-28 EA EA200970662A patent/EA016001B1/ru not_active IP Right Cessation
- 2008-01-28 AP AP2009004941A patent/AP2411A/xx active
- 2008-01-28 DE DE602008003405T patent/DE602008003405D1/de active Active
- 2008-01-28 EP EP08702358A patent/EP2114888B1/en active Active
- 2008-01-28 MX MX2009008286A patent/MX2009008286A/es active IP Right Grant
- 2008-01-28 WO PCT/IB2008/000249 patent/WO2008093236A1/en not_active Ceased
-
2009
- 2009-07-23 IL IL200044A patent/IL200044A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL200044A0 (en) | 2010-04-15 |
| HK1135094A1 (en) | 2010-05-28 |
| AP2009004941A0 (en) | 2009-08-31 |
| JP2010517991A (ja) | 2010-05-27 |
| EP2114888B1 (en) | 2010-11-10 |
| DK2114888T3 (da) | 2011-01-24 |
| DE602008003405D1 (de) | 2010-12-23 |
| AP2411A (en) | 2012-05-30 |
| EP2114888A1 (en) | 2009-11-11 |
| EA016001B1 (ru) | 2012-01-30 |
| AU2008211622B2 (en) | 2012-04-19 |
| IL200044A (en) | 2015-06-30 |
| SI2114888T1 (sl) | 2011-02-28 |
| UZ4378C (en) | 2011-07-29 |
| WO2008093236A1 (en) | 2008-08-07 |
| ATE487700T1 (de) | 2010-11-15 |
| JP4579333B2 (ja) | 2010-11-10 |
| HRP20100726T1 (hr) | 2011-04-30 |
| MX2009008286A (es) | 2009-08-12 |
| AU2008211622A1 (en) | 2008-08-07 |
| EA200970662A1 (ru) | 2010-02-26 |
| CA2676907C (en) | 2012-03-20 |
| CA2676907A1 (en) | 2008-08-07 |
| NZ578661A (en) | 2010-12-24 |
| PL2114888T3 (pl) | 2011-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0720003A2 (pt) | pirimidinas substituídas e seu uso como moduladores de jnk | |
| BRPI0920448A2 (pt) | compostos spiro-oxindol e seu uso como agentes terapêuticos | |
| BRPI0720866A2 (pt) | Derivados de oxindol substituídos e seu uso como ligandos de receptor de vasopressina | |
| AP2455A (en) | Tricyclic compounds and their use as glucocorticoid receptor modulators | |
| BRPI0810679A2 (pt) | Derivados de 4-aza indol e seu uso como fungicidas | |
| BRPI0813831A2 (pt) | Compostos de heteroarila bicíclica e seu uso como inibidores de quinase | |
| ATE537157T1 (de) | Substituierte phenoxy-n-alkylierte thiazoledindione als östrogenassoziierte rezeptor-alpha-modulatoren | |
| BRPI0717023A2 (pt) | Tiazol pirazolopirimidina como antagonistas do receptor de crf1 | |
| BRPI1012870A2 (pt) | derivados de 1,2,4-triazolo[4,3-a]piridina e seu uso como moduladores alostéricos positivos de recpetores de mglur2 | |
| BRPI0911563A2 (pt) | uso de antagonista da progesterona | |
| BRPI0908225A2 (pt) | derivados de piridazina e seu uso como agentes terapêuticos | |
| BRPI0913885A8 (pt) | tiadiazoliloxifenilamidinas e seu uso como fungicidas | |
| BRPI0906444A2 (pt) | Compostos de 4-piridinona e seu uso para câncer | |
| DK2297100T3 (da) | Tetrahydrocyclopenta[b]indol-androgenreceptor-modulatorer | |
| BRPI0814231A2 (pt) | Derivados de pleuromutilina e seu uso como antimicrobianos | |
| BRPI1015145A2 (pt) | derivados de tiazol e seu uso como receptores antagonistas de p2y12 | |
| BRPI0807121A2 (pt) | Compostos tricíclicos e seu uso como moduladores de receptor glicocorticóide | |
| BR112013004662A2 (pt) | agonistas de receptores de neurotrofina e o uso destes como medicamentos | |
| BRPI0717937A2 (pt) | Compostos de pirazona como antagonistas do receptor mineralocorticóide | |
| CU23870B1 (es) | Derivados de ciclopropilamida como moduladores h3 | |
| BRPI0808846A2 (pt) | fenoxifenilamidinas 3-substituídas e seu uso como fungicidas | |
| BRPI0810733A2 (pt) | Uso do modulador do receptor s1p | |
| BRPI0920502A2 (pt) | compostos cicloundecadepsipeptídeos e seu uso como medicamento | |
| CU23899B1 (es) | Benzotiazoles como moduladores del receptor de grelina | |
| BRPI0809641A2 (pt) | Pirimidinil-piperazinas úteis como ligantes do receptor d3/d2hu |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |