HRP20090505T1 - Homogemcitabini - Google Patents
Homogemcitabini Download PDFInfo
- Publication number
- HRP20090505T1 HRP20090505T1 HR20090505T HRP20090505T HRP20090505T1 HR P20090505 T1 HRP20090505 T1 HR P20090505T1 HR 20090505 T HR20090505 T HR 20090505T HR P20090505 T HRP20090505 T HR P20090505T HR P20090505 T1 HRP20090505 T1 HR P20090505T1
- Authority
- HR
- Croatia
- Prior art keywords
- general formula
- represents hydrogen
- group
- represent
- compound according
- Prior art date
Links
- 238000000034 method Methods 0.000 claims abstract 11
- 239000003814 drug Substances 0.000 claims abstract 5
- 238000004519 manufacturing process Methods 0.000 claims abstract 5
- 239000013543 active substance Substances 0.000 claims abstract 3
- 201000010099 disease Diseases 0.000 claims abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 3
- 230000002062 proliferating effect Effects 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims 25
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 13
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 10
- 125000006239 protecting group Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 150000002431 hydrogen Chemical group 0.000 claims 7
- 239000000126 substance Substances 0.000 claims 7
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 125000000468 ketone group Chemical group 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 125000003172 aldehyde group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- CSJLBAMHHLJAAS-UHFFFAOYSA-N diethylaminosulfur trifluoride Substances CCN(CC)S(F)(F)F CSJLBAMHHLJAAS-UHFFFAOYSA-N 0.000 claims 1
- 239000012025 fluorinating agent Substances 0.000 claims 1
- 238000003682 fluorination reaction Methods 0.000 claims 1
- 150000004678 hydrides Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- RXXXGJINTARBNA-UHFFFAOYSA-N n-ethyl-n-(trichloro-$l^{4}-sulfanyl)ethanamine Chemical compound CCN(CC)S(Cl)(Cl)Cl RXXXGJINTARBNA-UHFFFAOYSA-N 0.000 claims 1
- 238000005580 one pot reaction Methods 0.000 claims 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 1
- 239000012279 sodium borohydride Substances 0.000 claims 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0122405A AT502221A1 (de) | 2005-07-20 | 2005-07-20 | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
PCT/AT2006/000308 WO2007009147A2 (fr) | 2005-07-20 | 2006-07-20 | Homogemcitabines |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20090505T1 true HRP20090505T1 (hr) | 2009-10-31 |
Family
ID=37669151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090505T HRP20090505T1 (hr) | 2005-07-20 | 2009-09-23 | Homogemcitabini |
Country Status (17)
Country | Link |
---|---|
US (1) | US20080249119A1 (fr) |
EP (1) | EP1904511B1 (fr) |
KR (1) | KR20080043312A (fr) |
CN (1) | CN101243101A (fr) |
AT (2) | AT502221A1 (fr) |
AU (1) | AU2006272424A1 (fr) |
BR (1) | BRPI0614004A2 (fr) |
CA (1) | CA2615356A1 (fr) |
DE (1) | DE502006004194D1 (fr) |
DK (1) | DK1904511T3 (fr) |
ES (1) | ES2328855T3 (fr) |
HR (1) | HRP20090505T1 (fr) |
PL (1) | PL1904511T3 (fr) |
PT (1) | PT1904511E (fr) |
RU (1) | RU2008106480A (fr) |
SI (1) | SI1904511T1 (fr) |
WO (1) | WO2007009147A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110128947A (ko) * | 2009-03-20 | 2011-11-30 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오시드 및 뉴클레오티드 유사체 |
BR112015010941A2 (pt) | 2012-11-13 | 2017-07-11 | Boyen Therapeutics Inc | pró-fármacos de gemcitabina e suas utilizações |
JP6505388B2 (ja) * | 2013-07-31 | 2019-04-24 | 株式会社半導体エネルギー研究所 | ジオキソラン誘導体、液晶組成物及び液晶表示装置 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
CZ123493A3 (en) * | 1992-06-22 | 1994-02-16 | Lilly Co Eli | Stereoselective anionic glycosylation process |
MX9303713A (es) * | 1992-06-22 | 1994-05-31 | Lilly Co Eli | Proceso estereoselectivo para preparar un derivadoribofuranosilo enriquecido con alfa anomero. |
US5401861A (en) * | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
US5256798A (en) * | 1992-06-22 | 1993-10-26 | Eli Lilly And Company | Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
US5256797A (en) * | 1992-06-22 | 1993-10-26 | Eli Lilly And Company | Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
US5252756A (en) * | 1992-06-22 | 1993-10-12 | Eli Lilly And Company | Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates |
TW466112B (en) * | 1998-04-14 | 2001-12-01 | Lilly Co Eli | Novel use of 2'-deoxy-2',2'-difluorocytidine for immunosuppressive therapy and pharmaceutical composition comprising the same |
-
2005
- 2005-07-20 AT AT0122405A patent/AT502221A1/de not_active Application Discontinuation
-
2006
- 2006-07-20 KR KR1020087004014A patent/KR20080043312A/ko not_active Application Discontinuation
- 2006-07-20 AU AU2006272424A patent/AU2006272424A1/en not_active Abandoned
- 2006-07-20 ES ES06760795T patent/ES2328855T3/es active Active
- 2006-07-20 AT AT06760795T patent/ATE435868T1/de not_active IP Right Cessation
- 2006-07-20 DK DK06760795T patent/DK1904511T3/da active
- 2006-07-20 CA CA002615356A patent/CA2615356A1/fr not_active Abandoned
- 2006-07-20 RU RU2008106480/04A patent/RU2008106480A/ru not_active Application Discontinuation
- 2006-07-20 PL PL06760795T patent/PL1904511T3/pl unknown
- 2006-07-20 EP EP06760795A patent/EP1904511B1/fr active Active
- 2006-07-20 US US11/996,203 patent/US20080249119A1/en not_active Abandoned
- 2006-07-20 DE DE502006004194T patent/DE502006004194D1/de not_active Expired - Fee Related
- 2006-07-20 WO PCT/AT2006/000308 patent/WO2007009147A2/fr active Application Filing
- 2006-07-20 SI SI200630413T patent/SI1904511T1/sl unknown
- 2006-07-20 BR BRPI0614004-1A patent/BRPI0614004A2/pt not_active IP Right Cessation
- 2006-07-20 CN CNA2006800305003A patent/CN101243101A/zh active Pending
- 2006-07-20 PT PT06760795T patent/PT1904511E/pt unknown
-
2009
- 2009-09-23 HR HR20090505T patent/HRP20090505T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
EP1904511A2 (fr) | 2008-04-02 |
RU2008106480A (ru) | 2009-08-27 |
AT502221A1 (de) | 2007-02-15 |
CN101243101A (zh) | 2008-08-13 |
DK1904511T3 (da) | 2009-10-12 |
WO2007009147A2 (fr) | 2007-01-25 |
ATE435868T1 (de) | 2009-07-15 |
CA2615356A1 (fr) | 2007-01-25 |
SI1904511T1 (sl) | 2009-12-31 |
WO2007009147A3 (fr) | 2007-05-24 |
EP1904511B1 (fr) | 2009-07-08 |
US20080249119A1 (en) | 2008-10-09 |
ES2328855T3 (es) | 2009-11-18 |
PL1904511T3 (pl) | 2009-12-31 |
BRPI0614004A2 (pt) | 2011-03-01 |
DE502006004194D1 (de) | 2009-08-20 |
AU2006272424A1 (en) | 2007-01-25 |
PT1904511E (pt) | 2009-10-14 |
KR20080043312A (ko) | 2008-05-16 |
AU2006272424A8 (en) | 2008-05-29 |
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