HRP20080533T3 - Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs) - Google Patents

Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs)

Info

Publication number
HRP20080533T3
HRP20080533T3 HR20080533T HRP20080533T HRP20080533T3 HR P20080533 T3 HRP20080533 T3 HR P20080533T3 HR 20080533 T HR20080533 T HR 20080533T HR P20080533 T HRP20080533 T HR P20080533T HR P20080533 T3 HRP20080533 T3 HR P20080533T3
Authority
HR
Croatia
Prior art keywords
alkyl
group
nr12r12
aryl
arylalkyl
Prior art date
Application number
HR20080533T
Other languages
English (en)
Croatian (hr)
Inventor
Paulini Klaus
Gerlach Matthias
G�Nther Eckhard
Polymeropoulos Emmanuel
Baasner Silke
Schmidt Peter
K�hne Ronald
S�derh�ll Arvid
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of HRP20080533T3 publication Critical patent/HRP20080533T3/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20080533T 2004-07-14 2008-11-06 Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs) HRP20080533T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58796904P 2004-07-14 2004-07-14
DE102004033902A DE102004033902A1 (de) 2004-07-14 2004-07-14 Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
US68317805P 2005-05-20 2005-05-20
PCT/EP2005/007255 WO2006005484A1 (fr) 2004-07-14 2005-07-05 Nouveaux derives de tetrahydrocarbazole a effet biologique et solubilite ameliores comme ligands pour des recepteurs couples aux proteines g (rcpgs)

Publications (1)

Publication Number Publication Date
HRP20080533T3 true HRP20080533T3 (en) 2008-12-31

Family

ID=35045230

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080533T HRP20080533T3 (en) 2004-07-14 2008-11-06 Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs)

Country Status (26)

Country Link
US (2) US7375127B2 (fr)
EP (2) EP1765776B1 (fr)
JP (1) JP4746617B2 (fr)
KR (1) KR100888895B1 (fr)
CN (1) CN1997629B (fr)
AR (1) AR050347A1 (fr)
AT (1) ATE406352T1 (fr)
AU (1) AU2005261930B2 (fr)
BR (1) BRPI0513209A (fr)
CA (1) CA2565850C (fr)
CY (1) CY1110415T1 (fr)
DE (2) DE102004033902A1 (fr)
DK (1) DK1765776T3 (fr)
ES (1) ES2315887T3 (fr)
HK (1) HK1104295A1 (fr)
HR (1) HRP20080533T3 (fr)
IL (1) IL179067A (fr)
MX (1) MXPA06014447A (fr)
NO (1) NO20070688L (fr)
NZ (1) NZ551314A (fr)
PL (1) PL1765776T3 (fr)
PT (1) PT1765776E (fr)
RS (1) RS50684B (fr)
SI (1) SI1765776T1 (fr)
TW (1) TWI316933B (fr)
WO (1) WO2006005484A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7371336B2 (en) 2002-09-24 2008-05-13 E.I. Du Pont Nemours And Company Water dispersible polyanilines made with polymeric acid colloids for electronics applications
EP1967202A1 (fr) * 2007-03-05 2008-09-10 AEterna Zentaris GmbH Utilisation d'antagonistes LHTH pour le traitement des symptômes de tractus urinaires faibles, en particulier la vessie hyperactive et/ou hyperactivité du détrusor
EP1988098A1 (fr) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Nouveaux dérivés de tétrahydrocarbazole en tant que ligands de récepteurs couplés à la protéine G
EP2095818A1 (fr) * 2008-02-29 2009-09-02 AEterna Zentaris GmbH Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration
US9175211B2 (en) * 2010-03-03 2015-11-03 Universal Display Corporation Phosphorescent materials
BR112013020969A2 (pt) * 2011-02-23 2018-07-10 Massachusetts Inst Technology proteínas de membrana solúvel em água e métodos para a sua preparação e uso.
RU2743206C2 (ru) 2015-05-18 2021-02-16 Кэнди Терапьютикс Лимитед Двойные антагонисты рецептора нейрокинин-1/нейрокинин-3 для лечения заболеваний, зависимых от половых гормонов
AU2019233606A1 (en) 2018-03-14 2020-09-17 KaNDy Therapeutics Limited Novel pharmaceutical formulation comprising dual NK-1/NK-3 receptor antagonists

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GB1418703A (en) * 1973-06-02 1975-12-24 Pfizer Ltd 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles
DE3786030T2 (de) 1986-03-27 1993-12-02 Merck Frosst Canada Inc Tetrahydrocarbazole Ester.
ES2122982T3 (es) 1992-12-18 1999-01-01 Smithkline Beecham Plc Derivados de tetrahidrocarbazol para la fabricacion de un medicamento para el tratamiento de una enfermedad en la que esta indicado un agonista similar a 5-ht1.
TW449600B (en) 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
US5607939A (en) 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
US5576317A (en) * 1994-12-09 1996-11-19 Pfizer Inc. NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
UY23948A1 (es) 1995-02-08 2001-10-25 Takeda Chemical Industries Ltd Derivados de anillos condensados de tiofeno su producción y uso.
WO1997014697A1 (fr) 1995-10-19 1997-04-24 Takeda Chemical Industries, Ltd. DERIVES DE THIENOPYRIDINE ANTAGONISTES DE LA gn-RH
ATE223902T1 (de) 1995-10-19 2002-09-15 Takeda Chemical Industries Ltd Chinolinderivate als gnrh antagonisten
CZ183298A3 (cs) 1995-12-14 1998-09-16 Merck And Co., Inc. Nepeptidové deriváty, antagonizující hormon, uvolňující gonadotropin
AU704937B2 (en) 1995-12-14 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU2406597A (en) 1996-04-26 1997-11-19 Takeda Chemical Industries Ltd. Thienopyridine derivatives, their production and use
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
EP0882736A1 (fr) * 1997-06-02 1998-12-09 Laboratoire Theramex S.A. Analogues peptidiques du LH-RH, leurs utilisations et compositions pharmaceutiques les contenant
CA2291647A1 (fr) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonistes de la gonadoliberine
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Also Published As

Publication number Publication date
KR20070035036A (ko) 2007-03-29
AU2005261930A1 (en) 2006-01-19
SI1765776T1 (sl) 2008-12-31
WO2006005484A1 (fr) 2006-01-19
CA2565850A1 (fr) 2006-01-19
US20080280965A1 (en) 2008-11-13
AU2005261930B2 (en) 2008-12-11
IL179067A (en) 2013-08-29
TW200616955A (en) 2006-06-01
BRPI0513209A (pt) 2008-04-29
PT1765776E (pt) 2008-11-04
ATE406352T1 (de) 2008-09-15
ES2315887T3 (es) 2009-04-01
CN1997629A (zh) 2007-07-11
DE102004033902A1 (de) 2006-02-16
CN1997629B (zh) 2011-08-03
CY1110415T1 (el) 2015-04-29
EP1995238A3 (fr) 2009-09-02
DE502005005206D1 (de) 2008-10-09
EP1995238A2 (fr) 2008-11-26
IL179067A0 (en) 2007-03-08
RS50684B (sr) 2010-06-30
CA2565850C (fr) 2011-05-10
TWI316933B (en) 2009-11-11
US20060014818A1 (en) 2006-01-19
JP4746617B2 (ja) 2011-08-10
EP1765776B1 (fr) 2008-08-27
AR050347A1 (es) 2006-10-18
US7375127B2 (en) 2008-05-20
NO20070688L (no) 2007-03-26
EP1765776A1 (fr) 2007-03-28
DK1765776T3 (da) 2008-12-15
US8067456B2 (en) 2011-11-29
NZ551314A (en) 2009-09-25
JP2008505947A (ja) 2008-02-28
PL1765776T3 (pl) 2009-01-30
HK1104295A1 (en) 2008-01-11
MXPA06014447A (es) 2007-03-01
KR100888895B1 (ko) 2009-03-17

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