HRP20080533T3 - Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs) - Google Patents
Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs)Info
- Publication number
- HRP20080533T3 HRP20080533T3 HR20080533T HRP20080533T HRP20080533T3 HR P20080533 T3 HRP20080533 T3 HR P20080533T3 HR 20080533 T HR20080533 T HR 20080533T HR P20080533 T HRP20080533 T HR P20080533T HR P20080533 T3 HRP20080533 T3 HR P20080533T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- group
- nr12r12
- aryl
- arylalkyl
- Prior art date
Links
- XKLNOVWDVMWTOB-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1h-carbazole Chemical class N1C2=CC=CC=C2C2=C1CCCC2 XKLNOVWDVMWTOB-UHFFFAOYSA-N 0.000 title 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title 1
- 230000031018 biological processes and functions Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- -1 tetrahydrocarbazole compound Chemical class 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- AIDS & HIV (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58796904P | 2004-07-14 | 2004-07-14 | |
| DE102004033902A DE102004033902A1 (de) | 2004-07-14 | 2004-07-14 | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
| US68317805P | 2005-05-20 | 2005-05-20 | |
| PCT/EP2005/007255 WO2006005484A1 (fr) | 2004-07-14 | 2005-07-05 | Nouveaux derives de tetrahydrocarbazole a effet biologique et solubilite ameliores comme ligands pour des recepteurs couples aux proteines g (rcpgs) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080533T3 true HRP20080533T3 (en) | 2008-12-31 |
Family
ID=35045230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080533T HRP20080533T3 (en) | 2004-07-14 | 2008-11-06 | Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs) |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7375127B2 (fr) |
| EP (2) | EP1765776B1 (fr) |
| JP (1) | JP4746617B2 (fr) |
| KR (1) | KR100888895B1 (fr) |
| CN (1) | CN1997629B (fr) |
| AR (1) | AR050347A1 (fr) |
| AT (1) | ATE406352T1 (fr) |
| AU (1) | AU2005261930B2 (fr) |
| BR (1) | BRPI0513209A (fr) |
| CA (1) | CA2565850C (fr) |
| CY (1) | CY1110415T1 (fr) |
| DE (2) | DE102004033902A1 (fr) |
| DK (1) | DK1765776T3 (fr) |
| ES (1) | ES2315887T3 (fr) |
| HK (1) | HK1104295A1 (fr) |
| HR (1) | HRP20080533T3 (fr) |
| IL (1) | IL179067A (fr) |
| MX (1) | MXPA06014447A (fr) |
| NO (1) | NO20070688L (fr) |
| NZ (1) | NZ551314A (fr) |
| PL (1) | PL1765776T3 (fr) |
| PT (1) | PT1765776E (fr) |
| RS (1) | RS50684B (fr) |
| SI (1) | SI1765776T1 (fr) |
| TW (1) | TWI316933B (fr) |
| WO (1) | WO2006005484A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7371336B2 (en) | 2002-09-24 | 2008-05-13 | E.I. Du Pont Nemours And Company | Water dispersible polyanilines made with polymeric acid colloids for electronics applications |
| EP1967202A1 (fr) * | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Utilisation d'antagonistes LHTH pour le traitement des symptômes de tractus urinaires faibles, en particulier la vessie hyperactive et/ou hyperactivité du détrusor |
| EP1988098A1 (fr) * | 2007-04-27 | 2008-11-05 | AEterna Zentaris GmbH | Nouveaux dérivés de tétrahydrocarbazole en tant que ligands de récepteurs couplés à la protéine G |
| EP2095818A1 (fr) * | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration |
| US9175211B2 (en) * | 2010-03-03 | 2015-11-03 | Universal Display Corporation | Phosphorescent materials |
| BR112013020969A2 (pt) * | 2011-02-23 | 2018-07-10 | Massachusetts Inst Technology | proteínas de membrana solúvel em água e métodos para a sua preparação e uso. |
| RU2743206C2 (ru) | 2015-05-18 | 2021-02-16 | Кэнди Терапьютикс Лимитед | Двойные антагонисты рецептора нейрокинин-1/нейрокинин-3 для лечения заболеваний, зависимых от половых гормонов |
| AU2019233606A1 (en) | 2018-03-14 | 2020-09-17 | KaNDy Therapeutics Limited | Novel pharmaceutical formulation comprising dual NK-1/NK-3 receptor antagonists |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1418703A (en) * | 1973-06-02 | 1975-12-24 | Pfizer Ltd | 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles |
| DE3786030T2 (de) | 1986-03-27 | 1993-12-02 | Merck Frosst Canada Inc | Tetrahydrocarbazole Ester. |
| ES2122982T3 (es) | 1992-12-18 | 1999-01-01 | Smithkline Beecham Plc | Derivados de tetrahidrocarbazol para la fabricacion de un medicamento para el tratamiento de una enfermedad en la que esta indicado un agonista similar a 5-ht1. |
| TW449600B (en) | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
| US5607939A (en) | 1994-04-28 | 1997-03-04 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| US5576317A (en) * | 1994-12-09 | 1996-11-19 | Pfizer Inc. | NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis |
| UY23948A1 (es) | 1995-02-08 | 2001-10-25 | Takeda Chemical Industries Ltd | Derivados de anillos condensados de tiofeno su producción y uso. |
| WO1997014697A1 (fr) | 1995-10-19 | 1997-04-24 | Takeda Chemical Industries, Ltd. | DERIVES DE THIENOPYRIDINE ANTAGONISTES DE LA gn-RH |
| ATE223902T1 (de) | 1995-10-19 | 2002-09-15 | Takeda Chemical Industries Ltd | Chinolinderivate als gnrh antagonisten |
| CZ183298A3 (cs) | 1995-12-14 | 1998-09-16 | Merck And Co., Inc. | Nepeptidové deriváty, antagonizující hormon, uvolňující gonadotropin |
| AU704937B2 (en) | 1995-12-14 | 1999-05-06 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6200957B1 (en) | 1995-12-14 | 2001-03-13 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| AU2406597A (en) | 1996-04-26 | 1997-11-19 | Takeda Chemical Industries Ltd. | Thienopyridine derivatives, their production and use |
| US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
| EP0882736A1 (fr) * | 1997-06-02 | 1998-12-09 | Laboratoire Theramex S.A. | Analogues peptidiques du LH-RH, leurs utilisations et compositions pharmaceutiques les contenant |
| CA2291647A1 (fr) | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonistes de la gonadoliberine |
| AU729752B2 (en) | 1997-06-05 | 2001-02-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2002502427A (ja) | 1997-06-05 | 2002-01-22 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモンの拮抗薬 |
| DE19728737C1 (de) | 1997-07-04 | 1999-02-11 | Johannes Christian Groeninghen | Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten |
| CA2308454A1 (fr) | 1997-10-28 | 1999-05-06 | Merck & Co., Inc. | Antagonistes de l'hormone de liberation de la gonadothrophine |
| CA2325995A1 (fr) | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonistes de l'hormone liberant la gonadotropine (gnrh) |
| JP2002510685A (ja) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
| CA2367113A1 (fr) | 1999-03-10 | 2000-09-14 | Merck & Co., Inc. | Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine |
| AU3868500A (en) | 1999-03-10 | 2000-09-28 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
| US20020065309A1 (en) | 1999-08-04 | 2002-05-30 | Ge Peng | Novel Bicyclic and tricyclic pyrrolidine derivatives as GnRH antagonists |
| AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
| US6939883B2 (en) | 2001-08-02 | 2005-09-06 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| DE10164564B4 (de) * | 2001-12-14 | 2007-05-16 | Zentaris Gmbh | Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR) |
| EP1453803A2 (fr) | 2001-12-14 | 2004-09-08 | Zentaris GmbH | Derives tetrahydrocarbazol servant de ligands de recepteurs couples aux proteines g (gpcr) |
| GB0206219D0 (en) | 2002-03-15 | 2002-05-01 | Ferring Bv | Non-Peptide GnRH antagonists |
| WO2005033099A2 (fr) | 2003-10-03 | 2005-04-14 | Glenmark Pharmaceuticals Ltd. | Nouveaux inhibiteurs de dipeptidylpeptidase iv, leurs procedes de preparation et compositions les contenant |
-
2004
- 2004-07-14 DE DE102004033902A patent/DE102004033902A1/de not_active Withdrawn
-
2005
- 2005-06-30 US US11/172,142 patent/US7375127B2/en not_active Expired - Fee Related
- 2005-07-05 AU AU2005261930A patent/AU2005261930B2/en not_active Ceased
- 2005-07-05 PT PT05764033T patent/PT1765776E/pt unknown
- 2005-07-05 WO PCT/EP2005/007255 patent/WO2006005484A1/fr active Application Filing
- 2005-07-05 MX MXPA06014447A patent/MXPA06014447A/es active IP Right Grant
- 2005-07-05 EP EP05764033A patent/EP1765776B1/fr active Active
- 2005-07-05 PL PL05764033T patent/PL1765776T3/pl unknown
- 2005-07-05 DE DE502005005206T patent/DE502005005206D1/de active Active
- 2005-07-05 BR BRPI0513209-6A patent/BRPI0513209A/pt not_active IP Right Cessation
- 2005-07-05 CN CN2005800220208A patent/CN1997629B/zh not_active Expired - Fee Related
- 2005-07-05 RS RSP-2008/0561A patent/RS50684B/sr unknown
- 2005-07-05 ES ES05764033T patent/ES2315887T3/es active Active
- 2005-07-05 NZ NZ551314A patent/NZ551314A/en unknown
- 2005-07-05 KR KR1020077000903A patent/KR100888895B1/ko not_active IP Right Cessation
- 2005-07-05 JP JP2007520710A patent/JP4746617B2/ja not_active Expired - Fee Related
- 2005-07-05 DK DK05764033T patent/DK1765776T3/da active
- 2005-07-05 CA CA2565850A patent/CA2565850C/fr not_active Expired - Fee Related
- 2005-07-05 SI SI200530418T patent/SI1765776T1/sl unknown
- 2005-07-05 AT AT05764033T patent/ATE406352T1/de active
- 2005-07-05 EP EP08162452A patent/EP1995238A3/fr not_active Withdrawn
- 2005-07-08 TW TW094123208A patent/TWI316933B/zh active
- 2005-07-13 AR ARP050102900A patent/AR050347A1/es unknown
-
2006
- 2006-11-06 IL IL179067A patent/IL179067A/en not_active IP Right Cessation
-
2007
- 2007-02-06 NO NO20070688A patent/NO20070688L/no not_active Application Discontinuation
- 2007-09-04 HK HK07109577.5A patent/HK1104295A1/xx not_active IP Right Cessation
-
2008
- 2008-02-14 US US12/070,214 patent/US8067456B2/en not_active Expired - Fee Related
- 2008-11-06 HR HR20080533T patent/HRP20080533T3/xx unknown
- 2008-11-19 CY CY20081101329T patent/CY1110415T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20080533T3 (en) | Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (gpcrs) | |
| EA200901379A1 (ru) | Производные никотиновой кислоты как модуляторы метаботропных глутаматных рецепторов 5 подтипа | |
| RS52100B (en) | PROCEDURES AND UNITS FOR PREPARING ANALOG CC-1065 | |
| RS50537B (sr) | Derivati benzimidazola i njihovo korišćenje kao antagonista receptora a ii | |
| MY139750A (en) | Cyclohexylamides as dopamine d3, d2 and 5ht1a antagonists | |
| NO331165B1 (no) | Derivater av dioksan-2-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse av de samme for fremstilling av medikamenter | |
| ME00615B (fr) | DERIVES DE 2-ARYL-6-PHENYL-IMIDAZO[1,2-α]PYRIDINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE | |
| HRP20080542T3 (en) | (poly) aminoacetamide derivatives of epipodophyllotoxin, their process of preparation and their applications in therapeutics as anticancer agents | |
| UY29312A1 (es) | Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones | |
| MA32246B1 (fr) | Dérivés polysubstitues de 2-aryl-6-phenyl-imidazo[1,2- a]pyridines, leur préparation et leur application en thérapeutique | |
| HRP20070194T3 (en) | N-thiazol-2-yl-benzamide derivatives | |
| EA201071012A1 (ru) | Производные азетидинов, способ их получения и применение их в терапии | |
| HRP20080510T3 (en) | Process for the preparation of optically active derivatives of 2-(2-pyridylmethylsulfinyl)-benzimidazole via inclusion complex with 1,1'-binaphthalene-2, 2'diol | |
| RS53246B (en) | DERIVATI IMIDAZOLA KAO INHIBITORI KAZEIN KINAZE | |
| RS49906B (sr) | Benzociklohepteni, postupak za njihovo dobijanje, farmaceutski preparati koji ove sadrže kao i njihova primena za izradu lekova | |
| MX2009003927A (es) | Derivado espirocetal de tioglucosa y uso del mismo como un agente terapeutico para la diabetes. | |
| WO2008136444A1 (fr) | Dérivé hétérocyclique fusionné | |
| MY146939A (en) | Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics | |
| RS51557B (en) | 4H-1,2,4-TRIAZIN-5-ONE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS ALFA 7 NICOTINE ACETYLHOLINE RECEPTORS | |
| HRP20080097T3 (en) | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | |
| AR045548A1 (es) | Derivados de imidazol | |
| NO20065323L (no) | 6-substituerte pyridoindolonderivater, fremstilling og anvendelse derav | |
| ATE452636T1 (de) | 3-azabicycloä4.1.0üheptan-derivate zur behandlung von depressionen | |
| AR125138A1 (es) | Nuevos derivados de 5,6,7,8-tetrahidropirido[4,3:4,5]tieno[2,3-d]pirimidin-4(3h)-ona como ligandos de sigma | |
| ECSP055546A (es) | Derivados novedosos de piridiletanol (feniletil) aminas como inhibidores de la biosíntesis de colesterol, procesos para su preparación, y composiciones farmaceuticas que los contienen |