HRP20080431T3 - Novi derivati dikarboksilnih kiselina - Google Patents

Novi derivati dikarboksilnih kiselina

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Publication number
HRP20080431T3
HRP20080431T3 HR20080431T HRP20080431T HRP20080431T3 HR P20080431 T3 HRP20080431 T3 HR P20080431T3 HR 20080431 T HR20080431 T HR 20080431T HR P20080431 T HRP20080431 T HR P20080431T HR P20080431 T3 HRP20080431 T3 HR P20080431T3
Authority
HR
Croatia
Prior art keywords
alkyl
group
optionally substituted
defined above
aryl
Prior art date
Application number
HR20080431T
Other languages
English (en)
Inventor
Capet Marc
Levoin Nicolas
Berrebi-Bertrand Isabelle
Poupardin Olivia
Robert Philippe
Schwartz Jean-Charles
Lecomte Jeanne-Marie
Rajamannar Thennati
Kumar Pal Ranjan
Samanta Biswajit
K Jivani Jignesh
M. Panchal Bhavesh
H. Bhatt Isha
D. Aradhye Jayraj
Original Assignee
Bioprojet
Sun Pharmaceutical Industries Ltd
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Publication date
Application filed by Bioprojet, Sun Pharmaceutical Industries Ltd filed Critical Bioprojet
Publication of HRP20080431T3 publication Critical patent/HRP20080431T3/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Spoj formule (I): ,gdje¦ Ar1 predstavlja Arilnu skupinu izborno supstituiranu s 1 do 5 R skupina, gdje, svakog R, istog ili različitog, se bira iz skupine koju čine Halogeni atom, -Alkil, -OAlkil, -OH, ?COOR7, -CONR7R8, -Alkil-Hal, -OAlkil-Hal, NO2,-CN, -NR7R8, -AlkilAril, -Aril, -S(O)lR7, ?Alkenil, -Si(Alkil)3;gdje R7 i R8, iste ili različite, se bira iz skupine koju čine H; Alkil izborno supstituiran s Halogenim atomom, polifluoralkil, Aril; Heteroaril; ili R7 i R8 tvore zajedno s N atomom na kojeg su vezani Heterocikl; ¦ l je 0, 1 ili 2; ¦ Y1 predstavlja -Alkil- lanac, izborno supstituiran s jednim ili više R, kao što je definirano gore,a izborno sadrži jedno ili više nezasićenja i/iliheteroatoma i/ili ostataka koje se bira iz skupine koju čine -Alken-, -Alkin-, -CH=N-, -N=CH-, -CH=N-O-, -O-N=CH-, -C(=O)-, -C(=O)(OR7)-, ?C(=O)(NR7)-, -N=N-, -S(O)l-;¦ m je 0 ili 1; ¦ X predstavlja heteroatom; ¦ n je 0 ili 1; ¦ -Ar2- predstavlja -Aril- skupinu izborno supstituiranu s jednim ili više R skupina, kao što je definirano gore, ili gdje2 R mogu tvoriti zajedno s atomima na koje su vezani kondenzirani ciklički, arilni ili heteroarilniprsten; ¦ p je 0 ili 1; ¦ -Y2- predstavlja -Alkil- lanac, izborno supstituiran s jednim ili više R,kao što je definirano gore, a izborno sadrži jedno ili više nezasićenja ili heteroatoma i/ili ostataka koje se bira iz skupine koju čine -Alken-, -Alkin-, -CH=N-, -N=CH-, -CH=N-O-, -O-N=CH-, -C(=O)-,-C(=O)O-, -C(=O)(NR7), ?N=N-, -S(O)l-;¦ -R' predstavlja vodikov atom, ili -Alkilni lanac, izborno supstituiran s jednim ili više R, kao što je definirano gore, a izborno sadrži jedno ili više nezasićenja ili heteroatoma i/ili ostataka koje se bira iz skupine koju čine -Alken-, -Alkin-, -CH=N-, -N=CH-, -CH=N-O-, -O-N=CH-, -C(=O)O-, ?C(=O)(NR7)-, -N=N-, -S(O)l-;¦ -Y3- predstavlja -Alkil- lanac, izborno supstituiran s jednim ili više R, kao što je definirano gore, a izborno sadrži jedno ili više nezasićenja ili heteroatoma i/ili ostataka koje se bira iz skupine koju čine -Alken-, -Alkin-, -CH=N-, -N=CH-, -CH=N-O-, -O-N=CH-, -C(=O)-, -C(=O)O-, -C(=O)(NR7)--N=N-, -S(O)l-;¦ q je 0 ili 1; ¦ Z predstavlja -Cikloalkil gdje (CO2R") i (COR"') mogu biti vezani na isti atom ili dva susjedna atoma; ¦ -R" predstavlja vodikov atom ili Alkilni lanac, izborno supstituiran s jednim ili više R, kao što je definirano gore, a izborno sadrži jedno ili više nezasićenja; -R'" predstavlja -OH, -OAlkil, H, -NR7OR8, -NR7R8, prirodni ili sintetski aminokiseline,gdje R7 i R8 su definirani kao gore; ili R" i R'"tvore zajedno prsten s jednim ili više atoma na koje su vezani kako bi tvorili cikličku unutarmolekulsku biskarbonilnu skupinu, uključujući derivate Meldrum kiseline; kao i njegovi enantiomeri, dijastereoizomeri, njihove smjese, slobodni oblici i farmaceutski prihvatljive soli, hidrati, te solvatisizuzetkom spojeva gdje:- m = n = p = 0, q = 0 ili1, R' = H ili Alkil, Y2 = -Alkil-, Y3 = -Alkil-, Z = -C(Alkil)- m = n = p = 0, q = 1, R' = H, Y2 = -CH2-, Y3 =
HR20080431T 2004-10-22 2008-09-03 Novi derivati dikarboksilnih kiselina HRP20080431T3 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04292517A EP1650186B1 (en) 2004-10-22 2004-10-22 Novel dicarboxylic acid derivatives

Publications (1)

Publication Number Publication Date
HRP20080431T3 true HRP20080431T3 (hr) 2008-11-30

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HR20080431T HRP20080431T3 (hr) 2004-10-22 2008-09-03 Novi derivati dikarboksilnih kiselina

Country Status (22)

Country Link
US (1) US20090264469A1 (hr)
EP (1) EP1650186B1 (hr)
JP (1) JP2008517897A (hr)
KR (1) KR20070097418A (hr)
CN (1) CN101107218A (hr)
AP (1) AP2007004001A0 (hr)
AT (1) ATE397582T1 (hr)
AU (1) AU2005297138A1 (hr)
BR (1) BRPI0516988A (hr)
CA (1) CA2584610A1 (hr)
CY (1) CY1108321T1 (hr)
DE (1) DE602004014277D1 (hr)
DK (1) DK1650186T3 (hr)
EA (1) EA200700931A1 (hr)
ES (1) ES2308127T3 (hr)
HR (1) HRP20080431T3 (hr)
IL (1) IL182678A0 (hr)
MX (1) MX2007004847A (hr)
PL (1) PL1650186T3 (hr)
PT (1) PT1650186E (hr)
SI (1) SI1650186T1 (hr)
WO (1) WO2006043149A2 (hr)

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CA2584610A1 (en) 2006-04-27
EP1650186B1 (en) 2008-06-04
BRPI0516988A (pt) 2008-09-30
EA200700931A1 (ru) 2008-06-30
CY1108321T1 (el) 2014-02-12
WO2006043149A9 (en) 2006-08-10
ATE397582T1 (de) 2008-06-15
EP1650186A1 (en) 2006-04-26
DK1650186T3 (da) 2008-10-13
IL182678A0 (en) 2007-09-20
PT1650186E (pt) 2008-09-16
DE602004014277D1 (de) 2008-07-17
SI1650186T1 (sl) 2008-12-31
WO2006043149A2 (en) 2006-04-27
PL1650186T3 (pl) 2008-11-28
US20090264469A1 (en) 2009-10-22
ES2308127T3 (es) 2008-12-01
AP2007004001A0 (en) 2007-06-30
MX2007004847A (es) 2007-09-27
AU2005297138A1 (en) 2006-04-27
JP2008517897A (ja) 2008-05-29
WO2006043149A3 (en) 2006-07-13
KR20070097418A (ko) 2007-10-04
CN101107218A (zh) 2008-01-16

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