HRP20080262T3 - Derivati 4-(2-feniloksifenil)-piperidin ili -1,2,3,6 tetrahidropiridin kao inhibitori ponovne apsorpcije serotonina - Google Patents

Derivati 4-(2-feniloksifenil)-piperidin ili -1,2,3,6 tetrahidropiridin kao inhibitori ponovne apsorpcije serotonina

Info

Publication number
HRP20080262T3
HRP20080262T3 HR20080262T HRP20080262T HRP20080262T3 HR P20080262 T3 HRP20080262 T3 HR P20080262T3 HR 20080262 T HR20080262 T HR 20080262T HR P20080262 T HRP20080262 T HR P20080262T HR P20080262 T3 HRP20080262 T3 HR P20080262T3
Authority
HR
Croatia
Prior art keywords
phenyloxyphenyl
piperidine
serotonin reuptake
reuptake inhibitors
disorder
Prior art date
Application number
HR20080262T
Other languages
English (en)
Inventor
Bang-Andersen Benny
Kroll Friedrich
Kehler Jan
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20080262T3 publication Critical patent/HRP20080262T3/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Spoj predstavljen općom formulom Inaznačen timeda točkasta crta-----ukazuje na jednostruku ili dvostruku svezu; R1, R2, R3, R4, R5 se nezavisno biraju iz vodika, halogena, cijana, C1-6-alk(en/in)il, C1-6-alk(en/in)iloksi, C1-6-alk(en/in)ilsulfanil, hidroksi, hidroksi-, halo- C1-6-alk(en/in)il ili NR R u kojem su Rx i Ry nezavisno izabrani iz vodika, C1-6-alk(en/in)il, ciano- C1-6-alk(en/in)il, C3-8-cikloalk/en)il, C3-8-cikloalk/en)il-C1-6-alk(en/in)il ili NRxRY-C1-6-alk(en/in)il gdje su Rz i Rw nezavisno izabrani iz vodika, C1-6-alk(en/in)il, C3-8-cikloalk/en)il ili C3-8-cikloalk/en)il- C1-6-alk(en/in)il i Rx i Ry zajedno s dušikom kojemu su pripojeni, tvore 3-7-člani prsten koji, opcionalno, sadrži još jedan heteroatom; iliR1 i R2 zajedno tvore heterociklus koji je spojen na fenilni prsten izabran iza R1, R4 i R5 su kako je to gore definirano; R6, R7, R8, R9 su nezavisno izabrani iz vodika, halogena, C1-6-alk(en/in)il, C1-6-alk(en/in)iloksi, C1-6-alk(en/in)ilsulfanil, hidroksi, hidroksi- C1-6-alk(en/in)il, halo-C1-6-alk(en/in)il, halo-C1-6-alk(en/in)iloksi ili NRXRY u kojem Rx i Ry su nezavisno izabrani iz vodika, C1-6-alk(en/in)il, ciano-C1-6-alk(en/in)il, C3-8-cikloalk(en)il, C3-8-cikloalk/en)il-C1-6-alk(en/in)il u kojem se Rz i Rw nezavisno biraju iz vodika, C1-6-alk(en/in)il, C3-8-cikloalk(en)il ili C3-8-cikloalk(en)il- C1-6-alk(en/in)il, ili RxiRy zajedno s dušikom kojemu su pripojeni tvore 3-7-člani prsten koji, opcionalno, sadrži još jedan heteroatom ;pod uvjetom da najmanje jedan od R1, R2, R3, R4, R5,R6, R7, R8, R9 nije vodik, ili njegova sol. Patent sadrži još 17 patentnih zahtjeva.
HR20080262T 2003-04-04 2008-06-12 Derivati 4-(2-feniloksifenil)-piperidin ili -1,2,3,6 tetrahidropiridin kao inhibitori ponovne apsorpcije serotonina HRP20080262T3 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46026503P 2003-04-04 2003-04-04
DKPA200300519 2003-04-04
PCT/DK2004/000241 WO2004087155A1 (en) 2003-04-04 2004-04-02 4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors

Publications (1)

Publication Number Publication Date
HRP20080262T3 true HRP20080262T3 (hr) 2009-04-30

Family

ID=33132908

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080262T HRP20080262T3 (hr) 2003-04-04 2008-06-12 Derivati 4-(2-feniloksifenil)-piperidin ili -1,2,3,6 tetrahidropiridin kao inhibitori ponovne apsorpcije serotonina

Country Status (18)

Country Link
US (1) US20060293360A1 (hr)
EP (1) EP1635828B1 (hr)
JP (1) JP2006522027A (hr)
AT (1) ATE392896T1 (hr)
AU (1) AU2004226837A1 (hr)
BR (1) BRPI0408320A (hr)
CO (1) CO5640133A2 (hr)
DE (1) DE602004013314T2 (hr)
DK (1) DK1635828T3 (hr)
ES (1) ES2303062T3 (hr)
HR (1) HRP20080262T3 (hr)
MX (1) MXPA05010627A (hr)
NO (1) NO20055206L (hr)
NZ (1) NZ540891A (hr)
PL (1) PL1635828T3 (hr)
PT (1) PT1635828E (hr)
SI (1) SI1635828T1 (hr)
WO (1) WO2004087155A1 (hr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732463B2 (en) 2003-04-04 2010-06-08 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
CA2656057C (en) * 2006-06-16 2012-10-02 H. Lundbeck A/S Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
TWI432194B (zh) * 2007-03-20 2014-04-01 Lundbeck & Co As H ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途
AR074343A1 (es) 2008-11-14 2011-01-12 Amgen Inc Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10
DK2358675T3 (da) 2008-11-14 2013-01-14 Theravance Inc 4-[2-(2-Fluorphenoxymethyl)phenyl]piperidinforbindelser
TWI396689B (zh) 2008-11-14 2013-05-21 Amgen Inc 作為磷酸二酯酶１０抑制劑之吡衍生物
ES2397934T3 (es) 2008-12-17 2013-03-12 Amgen Inc. Compuestos de aminopiridina y carboxipiridina como inhibidores de fosfodiesterasa 10
EP2523945A1 (en) * 2010-01-11 2012-11-21 Theravance, Inc. 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
JP5769348B2 (ja) * 2010-03-22 2015-08-26 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー １−（２−フェノキシメチルヘテロアリール）ピペリジン化合物および１−（２−フェノキシメチルヘテロアリール）ピペラジン化合物
JP5774091B2 (ja) * 2010-04-22 2015-09-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 疼痛治療のためのセロトニン・ノルエピネフリン再取り込みインヒビターとオピオイド作動物質との組み合わせ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
US4198417A (en) * 1979-01-10 1980-04-15 American Hoechst Corporation Phenoxyphenylpiperidines
NZ512910A (en) * 1999-02-23 2003-11-28 Pfizer Prod Inc Monoamine reuptake inhibitors for treatment of CNS disorders
PL355289A1 (en) * 1999-10-13 2004-04-05 Pfizer Products Inc. Biaryl ether derivatives useful as monoamine reuptake inhibitors
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну

Also Published As

Publication number Publication date
SI1635828T1 (sl) 2008-08-31
PT1635828E (pt) 2008-07-01
NZ540891A (en) 2008-07-31
WO2004087155A1 (en) 2004-10-14
DK1635828T3 (da) 2008-08-11
US20060293360A1 (en) 2006-12-28
BRPI0408320A (pt) 2006-03-07
ATE392896T1 (de) 2008-05-15
PL1635828T3 (pl) 2008-10-31
MXPA05010627A (es) 2005-12-12
DE602004013314T2 (de) 2008-08-07
EP1635828B1 (en) 2008-04-23
DE602004013314D1 (de) 2008-06-05
EP1635828A1 (en) 2006-03-22
CO5640133A2 (es) 2006-05-31
ES2303062T3 (es) 2008-08-01
NO20055206L (no) 2005-11-04
JP2006522027A (ja) 2006-09-28
AU2004226837A1 (en) 2004-10-14

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