HRP20070283T3 - Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs - Google Patents
Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugsInfo
- Publication number
- HRP20070283T3 HRP20070283T3 HR20070283T HRP20070283T HRP20070283T3 HR P20070283 T3 HRP20070283 T3 HR P20070283T3 HR 20070283 T HR20070283 T HR 20070283T HR P20070283 T HRP20070283 T HR P20070283T HR P20070283 T3 HRP20070283 T3 HR P20070283T3
- Authority
- HR
- Croatia
- Prior art keywords
- group
- integer
- ono2
- radical
- branched
- Prior art date
Links
- 239000002876 beta blocker Substances 0.000 title abstract 2
- 239000002220 antihypertensive agent Substances 0.000 title 1
- 229940127088 antihypertensive drug Drugs 0.000 title 1
- 229940097320 beta blocking agent Drugs 0.000 title 1
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical class COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 title 1
- 229910004679 ONO2 Inorganic materials 0.000 abstract 6
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 239000011593 sulfur Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104484 | 2003-12-02 | ||
| PCT/EP2004/013683 WO2005053685A1 (en) | 2003-12-02 | 2004-12-01 | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070283T3 true HRP20070283T3 (en) | 2007-11-30 |
Family
ID=34639309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070283T HRP20070283T3 (en) | 2003-12-02 | 2007-06-27 | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7825263B2 (pt) |
| EP (1) | EP1691804B1 (pt) |
| JP (1) | JP2007513114A (pt) |
| KR (1) | KR20060120677A (pt) |
| CN (1) | CN1886132A (pt) |
| AR (1) | AR047732A1 (pt) |
| AT (1) | ATE358478T1 (pt) |
| AU (1) | AU2004294297A1 (pt) |
| BR (1) | BRPI0416584A (pt) |
| CA (1) | CA2548129A1 (pt) |
| DE (1) | DE602004005748T2 (pt) |
| DK (1) | DK1691804T3 (pt) |
| ES (1) | ES2285549T3 (pt) |
| HR (1) | HRP20070283T3 (pt) |
| IL (1) | IL174959A0 (pt) |
| NO (1) | NO20063057L (pt) |
| PL (2) | PL1691804T3 (pt) |
| PT (1) | PT1691804E (pt) |
| RU (1) | RU2006119528A (pt) |
| SI (1) | SI1691804T1 (pt) |
| WO (1) | WO2005053685A1 (pt) |
| ZA (1) | ZA200604458B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004528337A (ja) | 2001-05-02 | 2004-09-16 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化ネビボロール、ならびにその代謝産物、組成物、および使用方法 |
| JP2009525970A (ja) | 2006-02-06 | 2009-07-16 | ニコックス エス エイ | α２−アドレナリン受容体アゴニストとしてのアプラクロニジンおよびブリモドニジンのニトロオキシ含有誘導体 |
| WO2007090733A1 (en) * | 2006-02-06 | 2007-08-16 | Nicox S.A. | Nitrooxy derivatives suitable as alpha2 adrenergic receptor agonists |
| WO2008112287A1 (en) | 2007-03-12 | 2008-09-18 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
| US8425972B2 (en) | 2007-05-14 | 2013-04-23 | Covidien Lp | Antimicrobial materials and coatings |
| US8062653B2 (en) * | 2009-02-18 | 2011-11-22 | Bezwada Biomedical, Llc | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers |
| EP3589327A4 (en) * | 2017-03-03 | 2022-04-06 | Synovo GmbH | NOVEL ANTI-INFECTION AND ANTI-INFLAMMATORY COMPOUNDS |
| CN115246774A (zh) * | 2021-04-27 | 2022-10-28 | 南昌弘益科技有限公司 | 一类新型双羰基类阿魏酸衍生物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2805404A1 (de) * | 1978-02-09 | 1979-08-16 | Merck Patent Gmbh | 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung |
| DE3443998A1 (de) * | 1984-12-01 | 1986-06-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE3512627A1 (de) * | 1985-04-06 | 1986-10-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel |
| ES2065291B1 (es) * | 1993-07-30 | 1995-10-01 | Prodesfarma Sa | "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente" |
| US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
| IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| PE20001302A1 (es) * | 1998-11-27 | 2000-11-30 | Hoffmann La Roche | Preparaciones de una combinacion farmaceutica que contiene carvedilol e hidroclorotiazida |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1311923B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1314184B1 (it) * | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| EP1385509A4 (en) * | 2001-04-02 | 2004-06-30 | Smithkline Beecham Corp | TREATMENT METHOD |
| US7119229B2 (en) * | 2001-05-28 | 2006-10-10 | Chemtech Research Incorporation | Alkaloid derivative and a pharmaceutical composition containing the same |
| ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
-
2004
- 2004-12-01 ES ES04803434T patent/ES2285549T3/es active Active
- 2004-12-01 CA CA002548129A patent/CA2548129A1/en not_active Abandoned
- 2004-12-01 SI SI200430328T patent/SI1691804T1/sl unknown
- 2004-12-01 RU RU2006119528/04A patent/RU2006119528A/ru not_active Application Discontinuation
- 2004-12-01 WO PCT/EP2004/013683 patent/WO2005053685A1/en active Application Filing
- 2004-12-01 AU AU2004294297A patent/AU2004294297A1/en not_active Abandoned
- 2004-12-01 KR KR1020067010491A patent/KR20060120677A/ko not_active Application Discontinuation
- 2004-12-01 BR BRPI0416584-5A patent/BRPI0416584A/pt not_active IP Right Cessation
- 2004-12-01 DE DE602004005748T patent/DE602004005748T2/de active Active
- 2004-12-01 JP JP2006541892A patent/JP2007513114A/ja active Pending
- 2004-12-01 AT AT04803434T patent/ATE358478T1/de not_active IP Right Cessation
- 2004-12-01 AR ARP040104485A patent/AR047732A1/es not_active Application Discontinuation
- 2004-12-01 EP EP04803434A patent/EP1691804B1/en active Active
- 2004-12-01 PL PL04803434T patent/PL1691804T3/pl unknown
- 2004-12-01 DK DK04803434T patent/DK1691804T3/da active
- 2004-12-01 CN CNA200480035459XA patent/CN1886132A/zh active Pending
- 2004-12-01 PT PT04803434T patent/PT1691804E/pt unknown
- 2004-12-01 US US10/577,912 patent/US7825263B2/en not_active Expired - Fee Related
- 2004-12-01 PL PL380065A patent/PL380065A1/pl not_active Application Discontinuation
-
2006
- 2006-03-31 ZA ZA200604458A patent/ZA200604458B/xx unknown
- 2006-04-11 IL IL174959A patent/IL174959A0/en unknown
- 2006-06-30 NO NO20063057A patent/NO20063057L/no not_active Application Discontinuation
-
2007
- 2007-06-27 HR HR20070283T patent/HRP20070283T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004294297A1 (en) | 2005-06-16 |
| CA2548129A1 (en) | 2005-06-16 |
| DE602004005748D1 (de) | 2007-05-16 |
| PL380065A1 (pl) | 2006-12-11 |
| SI1691804T1 (sl) | 2007-10-31 |
| BRPI0416584A (pt) | 2007-01-30 |
| ES2285549T3 (es) | 2007-11-16 |
| DK1691804T3 (da) | 2007-07-16 |
| NO20063057L (no) | 2006-06-30 |
| CN1886132A (zh) | 2006-12-27 |
| RU2006119528A (ru) | 2008-01-10 |
| JP2007513114A (ja) | 2007-05-24 |
| EP1691804B1 (en) | 2007-04-04 |
| ZA200604458B (en) | 2007-04-25 |
| DE602004005748T2 (de) | 2007-12-27 |
| US7825263B2 (en) | 2010-11-02 |
| ATE358478T1 (de) | 2007-04-15 |
| US20070072854A1 (en) | 2007-03-29 |
| PL1691804T3 (pl) | 2007-08-31 |
| KR20060120677A (ko) | 2006-11-27 |
| EP1691804A1 (en) | 2006-08-23 |
| WO2005053685A1 (en) | 2005-06-16 |
| PT1691804E (pt) | 2007-07-04 |
| AR047732A1 (es) | 2006-02-15 |
| IL174959A0 (en) | 2006-08-20 |
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