HRP20070146B1 - Novi derivati fenilaminopiridina kao inhibitori bcr-abl kinaze - Google Patents

Novi derivati fenilaminopiridina kao inhibitori bcr-abl kinaze

Info

Publication number
HRP20070146B1
HRP20070146B1 HRP20070146AA HRP20070146A HRP20070146B1 HR P20070146 B1 HRP20070146 B1 HR P20070146B1 HR P20070146A A HRP20070146A A HR P20070146AA HR P20070146 A HRP20070146 A HR P20070146A HR P20070146 B1 HRP20070146 B1 HR P20070146B1
Authority
HR
Croatia
Prior art keywords
novel
bcr
inhibitors
abl kinase
aminopyrimidine derivatives
Prior art date
Application number
HRP20070146AA
Other languages
English (en)
Croatian (hr)
Inventor
Amala Kishan Kompella
Bhujanga Rao Adibhatla Kali Satya
Sreenivas Rachakonda
Khadgapathi Podili
Nannapaneni Venkaiah Chowdary
Original Assignee
Natco Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Limited filed Critical Natco Pharma Limited
Publication of HRP20070146A2 publication Critical patent/HRP20070146A2/xx
Publication of HRP20070146B1 publication Critical patent/HRP20070146B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HRP20070146AA 2004-09-09 2005-07-19 Novi derivati fenilaminopiridina kao inhibitori bcr-abl kinaze HRP20070146B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN908CH2004 2004-09-09
PCT/IN2005/000243 WO2006027795A1 (en) 2004-09-09 2005-07-19 Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase

Publications (2)

Publication Number Publication Date
HRP20070146A2 HRP20070146A2 (en) 2007-08-31
HRP20070146B1 true HRP20070146B1 (hr) 2015-12-04

Family

ID=35395645

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20070146AA HRP20070146B1 (hr) 2004-09-09 2005-07-19 Novi derivati fenilaminopiridina kao inhibitori bcr-abl kinaze

Country Status (25)

Country Link
US (2) US7910598B2 (https=)
EP (2) EP1786799B1 (https=)
JP (1) JP5184887B2 (https=)
KR (1) KR100948453B1 (https=)
CN (1) CN101068805B (https=)
AP (1) AP2470A (https=)
AU (1) AU2005281299B2 (https=)
BR (1) BRPI0515081B8 (https=)
CA (1) CA2591321C (https=)
CY (1) CY1113617T1 (https=)
DK (1) DK1786799T3 (https=)
EA (1) EA013328B1 (https=)
ES (1) ES2390227T3 (https=)
HR (1) HRP20070146B1 (https=)
IL (1) IL181811A (https=)
MA (1) MA28922B1 (https=)
MX (1) MX2007002819A (https=)
NO (1) NO337598B1 (https=)
NZ (1) NZ554361A (https=)
PL (1) PL1786799T3 (https=)
PT (1) PT1786799E (https=)
SI (1) SI1786799T1 (https=)
UA (1) UA94570C2 (https=)
WO (1) WO2006027795A1 (https=)
ZA (2) ZA200701942B (https=)

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US6667300B2 (en) * 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
SI2612862T1 (sl) 2004-05-13 2017-04-26 Icos Corporation Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta
US20110190328A1 (en) * 2004-09-09 2011-08-04 Natco Pharma Limited Acid addition salts of (3,5-bis trifluoromethyl)-n-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
US8735415B2 (en) 2004-09-09 2014-05-27 Natco Pharma Limited Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
UA94570C2 (en) 2004-09-09 2011-05-25 Натко Фарма Лимитед Phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase
US7939541B2 (en) * 2004-09-09 2011-05-10 Natco Pharma Limited Intermediates and a process employing the intermediates for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
WO2008031534A1 (en) * 2006-09-11 2008-03-20 Syngenta Participations Ag Insecticidal compounds
WO2008058037A1 (en) * 2006-11-03 2008-05-15 Irm Llc Compounds and compositions as protein kinase inhibitors
ES2396160T3 (es) * 2006-12-14 2013-02-19 Bayer Intellectual Property Gmbh Derivados de DIHIDROPIRIDINA que utiliza como inhibidores de la proteina quinasa
EP2152688A1 (en) * 2007-05-04 2010-02-17 Irm Llc Compounds and compositions as c-kit and pdgfr kinase inhibitors
EP2148874B1 (en) * 2007-05-04 2012-02-08 Irm Llc Pyrimidine derivatives and compositions as c-kit and pdgfr kinase inhibitors
CA2697077C (en) 2007-08-22 2012-10-16 Irm Llc 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors
CA2697081C (en) 2007-08-22 2013-04-23 Irm Llc 5-(4-(haloalkoxy)phenyl)pyrimidine-2-amine compounds and compositions as kinase inhibitors
US8067422B2 (en) 2008-03-04 2011-11-29 Natco Pharma Limited Crystal form of phenylamino pyrimidine derivatives
MY183331A (en) * 2008-03-04 2021-02-18 Natco Pharma Ltd Crystal form of phenylamino pyrimidine derivatives
WO2012004801A1 (en) * 2010-07-07 2012-01-12 Hetero Research Foundation Process for imatinib mesylate
GB2488788B (en) 2011-03-07 2013-07-10 Natco Pharma Ltd Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response
CN103797011B (zh) 2011-09-01 2016-03-30 诺华股份有限公司 作为c-Kit激酶抑制剂的化合物和组合物
US9061028B2 (en) 2012-02-15 2015-06-23 Natco Pharma Limited Process for the preparation of Nilotinib
CN104379582A (zh) * 2012-06-15 2015-02-25 巴斯夫欧洲公司 包含达沙替尼和所选择的共晶体形成剂的多组分晶体
PT3389633T (pt) 2015-12-18 2021-08-05 Natco Pharma Ltd Composições farmacêuticas compreendendo derivados de fenilaminopirimidina
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
JP2023534963A (ja) 2020-07-15 2023-08-15 サード ハーモニック バイオ， インコーポレイテッド 選択的ｃ－ｋｉｔキナーゼ阻害剤の結晶質形態
US11744823B2 (en) 2020-11-19 2023-09-05 Third Harmonic Bio, Inc. Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same
CN113125689B (zh) * 2021-03-29 2022-02-22 创芯国际生物科技(广州)有限公司 一种新型mtt细胞活力检测试剂盒及其应用

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WO1999015164A1 (en) * 1997-09-23 1999-04-01 Zeneca Limited Amide derivatives for the treatment of diseases mediated by cytokines
WO2004029038A1 (en) * 2002-09-27 2004-04-08 Novartis Ag Novel pyrimidineamide derivatives and the use thereof
WO2004110452A1 (en) * 2003-06-13 2004-12-23 Novartis Ag 2-aminopyrimidine derivatives as raf kinase inhibitors

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Also Published As

Publication number Publication date
EP1786799B1 (en) 2012-07-04
CY1113617T1 (el) 2016-06-22
ZA200701942B (en) 2008-10-29
US20070232633A1 (en) 2007-10-04
MA28922B1 (fr) 2007-10-01
SI1786799T1 (sl) 2012-12-31
JP5184887B2 (ja) 2013-04-17
PL1786799T3 (pl) 2012-12-31
IL181811A (en) 2013-07-31
NZ554361A (en) 2009-03-31
ES2390227T3 (es) 2012-11-07
MX2007002819A (es) 2007-08-14
AP2007003944A0 (en) 2007-04-30
UA94570C2 (en) 2011-05-25
EA013328B1 (ru) 2010-04-30
AU2005281299A1 (en) 2006-03-16
IL181811A0 (en) 2007-07-04
KR100948453B1 (ko) 2010-03-17
NO337598B1 (no) 2016-05-09
DK1786799T3 (da) 2012-10-01
JP2008512448A (ja) 2008-04-24
HRP20070146A2 (en) 2007-08-31
EP2295424B1 (en) 2015-10-14
NO20071521L (no) 2007-06-11
US7910598B2 (en) 2011-03-22
US8183253B2 (en) 2012-05-22
WO2006027795A1 (en) 2006-03-16
PT1786799E (pt) 2012-09-18
CN101068805A (zh) 2007-11-07
AU2005281299B2 (en) 2012-03-15
ZA200703123B (en) 2008-10-29
EA200700601A1 (ru) 2008-02-28
EP2295424A1 (en) 2011-03-16
CA2591321A1 (en) 2006-03-16
HK1110588A1 (en) 2008-07-18
CN101068805B (zh) 2013-04-03
KR20070106681A (ko) 2007-11-05
BRPI0515081A (pt) 2008-07-08
BRPI0515081B8 (pt) 2021-05-25
AP2470A (en) 2012-09-17
BRPI0515081B1 (pt) 2021-05-04
US20080306100A1 (en) 2008-12-11
CA2591321C (en) 2013-09-24
EP1786799A1 (en) 2007-05-23

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