HRP20050213A2 - 2,4-substituted indoles and their use as 5-ht6 modulators - Google Patents
2,4-substituted indoles and their use as 5-ht6 modulatorsInfo
- Publication number
- HRP20050213A2 HRP20050213A2 HR20050213A HRP20050213A HRP20050213A2 HR P20050213 A2 HRP20050213 A2 HR P20050213A2 HR 20050213 A HR20050213 A HR 20050213A HR P20050213 A HRP20050213 A HR P20050213A HR P20050213 A2 HRP20050213 A2 HR P20050213A2
- Authority
- HR
- Croatia
- Prior art keywords
- modulators
- substituted indoles
- compound
- formula
- methods
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41148002P | 2002-09-17 | 2002-09-17 | |
| PCT/EP2003/009969 WO2004026831A1 (en) | 2002-09-17 | 2003-09-08 | 2,4-substituted indoles and their use as 5-ht6 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20050213A2 true HRP20050213A2 (en) | 2006-12-31 |
Family
ID=32030683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20050213A HRP20050213A2 (en) | 2002-09-17 | 2005-03-04 | 2,4-substituted indoles and their use as 5-ht6 modulators |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7381739B2 (de) |
| EP (1) | EP1542973B1 (de) |
| JP (1) | JP4267573B2 (de) |
| KR (1) | KR100686757B1 (de) |
| CN (1) | CN1301970C (de) |
| AR (1) | AR041256A1 (de) |
| AT (1) | ATE402923T1 (de) |
| AU (1) | AU2003267063B2 (de) |
| BR (1) | BR0314363A (de) |
| CA (1) | CA2498946A1 (de) |
| DE (1) | DE60322551D1 (de) |
| ES (1) | ES2311721T3 (de) |
| HK (1) | HK1083497A1 (de) |
| HR (1) | HRP20050213A2 (de) |
| MX (1) | MXPA05002836A (de) |
| NO (1) | NO20050664L (de) |
| NZ (1) | NZ538047A (de) |
| PA (1) | PA8582101A1 (de) |
| PL (1) | PL376022A1 (de) |
| RU (1) | RU2326112C2 (de) |
| TW (1) | TWI250150B (de) |
| UY (1) | UY27979A1 (de) |
| WO (1) | WO2004026831A1 (de) |
| ZA (1) | ZA200501175B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL209872B1 (pl) | 2002-03-27 | 2011-10-31 | Glaxo Group Ltd | Pochodna chinolinowa, sposób jej wytwarzania i jej zastosowanie oraz zawierająca ją farmaceutyczna kompozycja |
| PL376479A1 (en) * | 2002-10-18 | 2005-12-27 | F.Hoffmann-La Roche Ag | 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity |
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| PL1701940T3 (pl) * | 2003-12-23 | 2008-11-28 | H Lundbeck As | Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI |
| CA2563895C (en) * | 2004-04-13 | 2012-10-16 | Synta Pharmaceuticals Corp. | Disalt inhibitors of il-12 production |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| JP2010509259A (ja) * | 2006-11-09 | 2010-03-25 | エフ．ホフマン−ラ ロシュ アーゲー | インドール及びベンゾフラン２−カルボキサミド誘導体 |
| WO2008133867A1 (en) * | 2007-04-26 | 2008-11-06 | Merck & Co., Inc. | 2-substituted indole derivatives as calcium channel blockers |
| EP2508177A1 (de) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Kombinationen mit 3-phenylsulfonyl-8-piperazinyl-1yl-chinolin |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| EP2847165A2 (de) * | 2012-04-02 | 2015-03-18 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Indol, indolinderivate, zusammensetzungen damit und verwendungen davon |
| JP6454346B2 (ja) | 2013-12-20 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 芳香族複素環式化合物及び医薬におけるその応用 |
| CA2953004C (en) | 2014-07-08 | 2023-02-21 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
| RU2018103338A (ru) | 2015-07-15 | 2019-08-15 | Аксовант Сайенсиз Гмбх | Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2194984C (en) * | 1994-07-26 | 2002-07-02 | John Eugene Macor | 4-indole derivatives as serotonin agonists and antagonists |
| US6114532A (en) | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| EP0982304B1 (de) | 1998-06-30 | 2002-10-02 | Eli Lilly And Company | Auf serotonin-verwandte Systeme wirkende Piperidin-Derivate |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| EP1326830A1 (de) * | 2000-10-20 | 2003-07-16 | Biovitrum Ab | 2-,3-,4- oder 5-substituierte n1-(benzolsulfonyl)endole und deren verwendung in der therapie |
| EA006205B1 (ru) * | 2000-11-02 | 2005-10-27 | Уайт | 1-арил- или 1-алкилсульфонилгетероциклилбензазолы в качестве лигандов 5-гидрокситриптамина-6 |
| US20050176705A1 (en) * | 2000-11-24 | 2005-08-11 | Bromidge Steven M. | Compounds useful in the treatment of cns disorders |
| US6787568B1 (en) * | 2000-11-27 | 2004-09-07 | Phoenix Scientific, Inc. | Antibiotic/analgesic formulation and a method of making this formulation |
| JP4754821B2 (ja) | 2002-06-20 | 2011-08-24 | プロキシマゲン・リミテッド | 肥満症、ｉｉ型糖尿病およびｃｎｓ障害の治療に有用な新規化合物 |
-
2003
- 2003-09-08 MX MXPA05002836A patent/MXPA05002836A/es active IP Right Grant
- 2003-09-08 NZ NZ538047A patent/NZ538047A/en unknown
- 2003-09-08 WO PCT/EP2003/009969 patent/WO2004026831A1/en active IP Right Grant
- 2003-09-08 CN CNB03822044XA patent/CN1301970C/zh not_active Expired - Fee Related
- 2003-09-08 RU RU2005111590/04A patent/RU2326112C2/ru not_active IP Right Cessation
- 2003-09-08 AT AT03747986T patent/ATE402923T1/de not_active IP Right Cessation
- 2003-09-08 AU AU2003267063A patent/AU2003267063B2/en not_active Ceased
- 2003-09-08 PL PL03376022A patent/PL376022A1/xx not_active Application Discontinuation
- 2003-09-08 BR BR0314363-5A patent/BR0314363A/pt not_active IP Right Cessation
- 2003-09-08 CA CA002498946A patent/CA2498946A1/en not_active Abandoned
- 2003-09-08 EP EP03747986A patent/EP1542973B1/de not_active Expired - Lifetime
- 2003-09-08 JP JP2004537019A patent/JP4267573B2/ja not_active Expired - Fee Related
- 2003-09-08 DE DE60322551T patent/DE60322551D1/de not_active Expired - Lifetime
- 2003-09-08 ES ES03747986T patent/ES2311721T3/es not_active Expired - Lifetime
- 2003-09-08 KR KR1020057004479A patent/KR100686757B1/ko not_active IP Right Cessation
- 2003-09-12 PA PA20038582101A patent/PA8582101A1/es unknown
- 2003-09-12 TW TW092125224A patent/TWI250150B/zh not_active IP Right Cessation
- 2003-09-15 AR ARP030103332A patent/AR041256A1/es not_active Application Discontinuation
- 2003-09-15 UY UY27979A patent/UY27979A1/es not_active Application Discontinuation
- 2003-09-16 US US10/663,335 patent/US7381739B2/en not_active Expired - Fee Related
-
2005
- 2005-02-08 NO NO20050664A patent/NO20050664L/no not_active Application Discontinuation
- 2005-02-09 ZA ZA200501175A patent/ZA200501175B/xx unknown
- 2005-03-04 HR HR20050213A patent/HRP20050213A2/xx not_active Application Discontinuation
-
2006
- 2006-03-20 HK HK06103474A patent/HK1083497A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL376022A1 (en) | 2005-12-12 |
| EP1542973B1 (de) | 2008-07-30 |
| US7381739B2 (en) | 2008-06-03 |
| DE60322551D1 (de) | 2008-09-11 |
| EP1542973A1 (de) | 2005-06-22 |
| UY27979A1 (es) | 2004-03-31 |
| ATE402923T1 (de) | 2008-08-15 |
| NZ538047A (en) | 2007-10-26 |
| KR20050057356A (ko) | 2005-06-16 |
| NO20050664L (no) | 2005-04-15 |
| CN1681783A (zh) | 2005-10-12 |
| AR041256A1 (es) | 2005-05-11 |
| CA2498946A1 (en) | 2004-04-01 |
| KR100686757B1 (ko) | 2007-02-26 |
| ZA200501175B (en) | 2007-03-28 |
| ES2311721T3 (es) | 2009-02-16 |
| TW200413313A (en) | 2004-08-01 |
| PA8582101A1 (es) | 2004-04-23 |
| RU2005111590A (ru) | 2005-11-20 |
| RU2326112C2 (ru) | 2008-06-10 |
| US20040072844A1 (en) | 2004-04-15 |
| CN1301970C (zh) | 2007-02-28 |
| HK1083497A1 (en) | 2006-07-07 |
| BR0314363A (pt) | 2005-07-19 |
| AU2003267063A1 (en) | 2004-04-08 |
| JP4267573B2 (ja) | 2009-05-27 |
| WO2004026831A1 (en) | 2004-04-01 |
| AU2003267063B2 (en) | 2009-08-06 |
| MXPA05002836A (es) | 2005-05-27 |
| TWI250150B (en) | 2006-03-01 |
| JP2006502177A (ja) | 2006-01-19 |
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| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20080822 Year of fee payment: 6 |
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| OBST | Application withdrawn |