HRP20050213A2 - 2,4-substituted indoles and their use as 5-ht6 modulators - Google Patents
2,4-substituted indoles and their use as 5-ht6 modulatorsInfo
- Publication number
- HRP20050213A2 HRP20050213A2 HR20050213A HRP20050213A HRP20050213A2 HR P20050213 A2 HRP20050213 A2 HR P20050213A2 HR 20050213 A HR20050213 A HR 20050213A HR P20050213 A HRP20050213 A HR P20050213A HR P20050213 A2 HRP20050213 A2 HR P20050213A2
- Authority
- HR
- Croatia
- Prior art keywords
- modulators
- substituted indoles
- compound
- formula
- methods
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ovaj izum donosi spoj formule (I): njegovu farmaceutski prihvatljivu sol ili predlijek, pri čemu suR1, R2, R3, R4, p i n oni ovdje definirani. Ovaj izum također donosi pripravke koji sadrže, postupke za uporabu i postupke za pripravljanje spoja Formule (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41148002P | 2002-09-17 | 2002-09-17 | |
PCT/EP2003/009969 WO2004026831A1 (en) | 2002-09-17 | 2003-09-08 | 2,4-substituted indoles and their use as 5-ht6 modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20050213A2 true HRP20050213A2 (en) | 2006-12-31 |
Family
ID=32030683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20050213A HRP20050213A2 (en) | 2002-09-17 | 2005-03-04 | 2,4-substituted indoles and their use as 5-ht6 modulators |
Country Status (24)
Country | Link |
---|---|
US (1) | US7381739B2 (hr) |
EP (1) | EP1542973B1 (hr) |
JP (1) | JP4267573B2 (hr) |
KR (1) | KR100686757B1 (hr) |
CN (1) | CN1301970C (hr) |
AR (1) | AR041256A1 (hr) |
AT (1) | ATE402923T1 (hr) |
AU (1) | AU2003267063B2 (hr) |
BR (1) | BR0314363A (hr) |
CA (1) | CA2498946A1 (hr) |
DE (1) | DE60322551D1 (hr) |
ES (1) | ES2311721T3 (hr) |
HK (1) | HK1083497A1 (hr) |
HR (1) | HRP20050213A2 (hr) |
MX (1) | MXPA05002836A (hr) |
NO (1) | NO20050664L (hr) |
NZ (1) | NZ538047A (hr) |
PA (1) | PA8582101A1 (hr) |
PL (1) | PL376022A1 (hr) |
RU (1) | RU2326112C2 (hr) |
TW (1) | TWI250150B (hr) |
UY (1) | UY27979A1 (hr) |
WO (1) | WO2004026831A1 (hr) |
ZA (1) | ZA200501175B (hr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7452888B2 (en) | 2002-03-27 | 2008-11-18 | Glaxo Group Limited | Quinoline derivatives and their use as 5-ht6 ligands |
JP2006505559A (ja) * | 2002-10-18 | 2006-02-16 | エフ.ホフマン−ラ ロシュ アーゲー | 5−ht6受容体親和性を持つ4−ピペラジニルベンゼンスルホニルインドール |
KR101157272B1 (ko) | 2003-07-22 | 2012-06-15 | 아레나 파마슈티칼스, 인크. | 5?ht2a 세로토닌 수용체의 조절자로서 이와 관련된질환의 예방 및 치료에 유용한 디아릴 및 아릴헤테로아릴우레아 유도체 |
BRPI0417858B1 (pt) * | 2003-12-23 | 2017-10-10 | H. Lundbeck A/S | Derivative compounds of aniline and pharmaceutical composition that understand it |
JP4926943B2 (ja) * | 2004-04-13 | 2012-05-09 | シンタ ファーマシューティカルズ コーポレーション | Il−12産生を阻害する二塩 |
AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
BRPI0718776A2 (pt) * | 2006-11-09 | 2013-12-03 | Hoffmann La Roche | Derivados de indol e benzofurano 2-carboxamida |
JP2010532748A (ja) * | 2007-04-26 | 2010-10-14 | メルク・シャープ・エンド・ドーム・コーポレイション | カルシウムチャネル遮断薬としての2−置換インドール誘導体 |
EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
WO2013150529A2 (en) * | 2012-04-02 | 2013-10-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Indole, indoline derivatives, compositions comprising them and uses thereof |
US9663498B2 (en) | 2013-12-20 | 2017-05-30 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
WO2016004882A1 (en) | 2014-07-08 | 2016-01-14 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
EP4119141A1 (en) | 2015-06-12 | 2023-01-18 | Axovant Sciences GmbH | Nelotanserin for the prophylaxis and treatment of rem sleep behavior disorder |
JP2018520187A (ja) | 2015-07-15 | 2018-07-26 | アクソヴァント サイエンシーズ ゲゼルシャフト ミット ベシュレンクテル ハフツングAxovant Sciences GmbH | 神経変性疾患と関連する幻覚の予防および処置のために有用な5−ht2aセロトニン受容体のモジュレーターとしてのジアリールおよびアリールヘテロアリール尿素誘導体 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3155008B2 (ja) * | 1994-07-26 | 2001-04-09 | ファイザー・インコーポレーテッド | セロトニンアゴニストおよびアンタゴニストとしての4−インドール誘導体 |
US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
CA2336117A1 (en) | 1998-06-30 | 2000-01-06 | Sidney Xi Liang | Piperidine derivatives having effects on serotonin related systems |
GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
PL361887A1 (en) * | 2000-10-20 | 2004-10-04 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
NZ525592A (en) * | 2000-11-02 | 2004-07-30 | Wyeth Corp | 1-Aryl- or 1-alkylsufonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands |
JP2004517072A (ja) * | 2000-11-24 | 2004-06-10 | スミスクライン ビーチャム パブリック リミテッド カンパニー | Cns障害の治療において有用な化合物 |
US6787568B1 (en) * | 2000-11-27 | 2004-09-07 | Phoenix Scientific, Inc. | Antibiotic/analgesic formulation and a method of making this formulation |
US7943639B2 (en) * | 2002-06-20 | 2011-05-17 | Proximagen Limited | Compounds |
-
2003
- 2003-09-08 AT AT03747986T patent/ATE402923T1/de not_active IP Right Cessation
- 2003-09-08 BR BR0314363-5A patent/BR0314363A/pt not_active IP Right Cessation
- 2003-09-08 MX MXPA05002836A patent/MXPA05002836A/es active IP Right Grant
- 2003-09-08 EP EP03747986A patent/EP1542973B1/en not_active Expired - Lifetime
- 2003-09-08 JP JP2004537019A patent/JP4267573B2/ja not_active Expired - Fee Related
- 2003-09-08 PL PL03376022A patent/PL376022A1/xx not_active Application Discontinuation
- 2003-09-08 CA CA002498946A patent/CA2498946A1/en not_active Abandoned
- 2003-09-08 ES ES03747986T patent/ES2311721T3/es not_active Expired - Lifetime
- 2003-09-08 WO PCT/EP2003/009969 patent/WO2004026831A1/en active IP Right Grant
- 2003-09-08 KR KR1020057004479A patent/KR100686757B1/ko not_active IP Right Cessation
- 2003-09-08 CN CNB03822044XA patent/CN1301970C/zh not_active Expired - Fee Related
- 2003-09-08 NZ NZ538047A patent/NZ538047A/en unknown
- 2003-09-08 DE DE60322551T patent/DE60322551D1/de not_active Expired - Lifetime
- 2003-09-08 AU AU2003267063A patent/AU2003267063B2/en not_active Ceased
- 2003-09-08 RU RU2005111590/04A patent/RU2326112C2/ru not_active IP Right Cessation
- 2003-09-12 PA PA20038582101A patent/PA8582101A1/es unknown
- 2003-09-12 TW TW092125224A patent/TWI250150B/zh not_active IP Right Cessation
- 2003-09-15 AR ARP030103332A patent/AR041256A1/es not_active Application Discontinuation
- 2003-09-15 UY UY27979A patent/UY27979A1/es not_active Application Discontinuation
- 2003-09-16 US US10/663,335 patent/US7381739B2/en not_active Expired - Fee Related
-
2005
- 2005-02-08 NO NO20050664A patent/NO20050664L/no not_active Application Discontinuation
- 2005-02-09 ZA ZA200501175A patent/ZA200501175B/xx unknown
- 2005-03-04 HR HR20050213A patent/HRP20050213A2/xx not_active Application Discontinuation
-
2006
- 2006-03-20 HK HK06103474A patent/HK1083497A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL376022A1 (en) | 2005-12-12 |
RU2326112C2 (ru) | 2008-06-10 |
JP2006502177A (ja) | 2006-01-19 |
HK1083497A1 (en) | 2006-07-07 |
UY27979A1 (es) | 2004-03-31 |
US7381739B2 (en) | 2008-06-03 |
TWI250150B (en) | 2006-03-01 |
KR100686757B1 (ko) | 2007-02-26 |
ZA200501175B (en) | 2007-03-28 |
ATE402923T1 (de) | 2008-08-15 |
JP4267573B2 (ja) | 2009-05-27 |
AU2003267063A1 (en) | 2004-04-08 |
CN1681783A (zh) | 2005-10-12 |
AR041256A1 (es) | 2005-05-11 |
EP1542973B1 (en) | 2008-07-30 |
KR20050057356A (ko) | 2005-06-16 |
EP1542973A1 (en) | 2005-06-22 |
ES2311721T3 (es) | 2009-02-16 |
WO2004026831A1 (en) | 2004-04-01 |
US20040072844A1 (en) | 2004-04-15 |
MXPA05002836A (es) | 2005-05-27 |
DE60322551D1 (de) | 2008-09-11 |
PA8582101A1 (es) | 2004-04-23 |
RU2005111590A (ru) | 2005-11-20 |
CA2498946A1 (en) | 2004-04-01 |
AU2003267063B2 (en) | 2009-08-06 |
NZ538047A (en) | 2007-10-26 |
TW200413313A (en) | 2004-08-01 |
NO20050664L (no) | 2005-04-15 |
BR0314363A (pt) | 2005-07-19 |
CN1301970C (zh) | 2007-02-28 |
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