ZA200501175B - 2,4-substituted indoles and their use as 5-HT6 modulators - Google Patents
2,4-substituted indoles and their use as 5-HT6 modulatorsInfo
- Publication number
- ZA200501175B ZA200501175B ZA200501175A ZA200501175A ZA200501175B ZA 200501175 B ZA200501175 B ZA 200501175B ZA 200501175 A ZA200501175 A ZA 200501175A ZA 200501175 A ZA200501175 A ZA 200501175A ZA 200501175 B ZA200501175 B ZA 200501175B
- Authority
- ZA
- South Africa
- Prior art keywords
- modulators
- substituted indoles
- indoles
- substituted
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41148002P | 2002-09-17 | 2002-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200501175B true ZA200501175B (en) | 2007-03-28 |
Family
ID=32030683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200501175A ZA200501175B (en) | 2002-09-17 | 2005-02-09 | 2,4-substituted indoles and their use as 5-HT6 modulators |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7381739B2 (hr) |
| EP (1) | EP1542973B1 (hr) |
| JP (1) | JP4267573B2 (hr) |
| KR (1) | KR100686757B1 (hr) |
| CN (1) | CN1301970C (hr) |
| AR (1) | AR041256A1 (hr) |
| AT (1) | ATE402923T1 (hr) |
| AU (1) | AU2003267063B2 (hr) |
| BR (1) | BR0314363A (hr) |
| CA (1) | CA2498946A1 (hr) |
| DE (1) | DE60322551D1 (hr) |
| ES (1) | ES2311721T3 (hr) |
| HK (1) | HK1083497A1 (hr) |
| HR (1) | HRP20050213A2 (hr) |
| MX (1) | MXPA05002836A (hr) |
| NO (1) | NO20050664L (hr) |
| NZ (1) | NZ538047A (hr) |
| PA (1) | PA8582101A1 (hr) |
| PL (1) | PL376022A1 (hr) |
| RU (1) | RU2326112C2 (hr) |
| TW (1) | TWI250150B (hr) |
| UY (1) | UY27979A1 (hr) |
| WO (1) | WO2004026831A1 (hr) |
| ZA (1) | ZA200501175B (hr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1497266E (pt) | 2002-03-27 | 2008-09-10 | Glaxo Group Ltd | Derivados de quinolina e sua utilização como ligandos 5-ht6 |
| WO2004035047A1 (en) * | 2002-10-18 | 2004-04-29 | F. Hoffmann-La Roche Ag | 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity |
| MXPA06000795A (es) | 2003-07-22 | 2006-08-23 | Arena Pharm Inc | Derivados de diaril y arilheteroaril urea como moduladores del receptor 5-ht2a de serotonina utiles para la profilaxis y tratamiento de desordenes relacionados con el mismo. |
| PL1701940T3 (pl) * | 2003-12-23 | 2008-11-28 | H Lundbeck As | Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI |
| TWI380816B (zh) * | 2004-04-13 | 2013-01-01 | Synta Pharmaceuticals Corp | 抑制介白素-１２（ｉｌ-１２）生成之二鹽抑制劑 |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| MX2009004898A (es) * | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Derivados de indol y de benzofurano-2-carboxamida. |
| EP2150112A1 (en) * | 2007-04-26 | 2010-02-10 | Merck & Co., Inc. | 2-substituted indole derivatives as calcium channel blockers |
| EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| US9499484B2 (en) * | 2012-04-02 | 2016-11-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Indole, indoline derivatives, compositions comprising them and uses thereof |
| WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| CN105541693B (zh) | 2014-07-08 | 2018-10-16 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
| EP4119141A1 (en) | 2015-06-12 | 2023-01-18 | Axovant Sciences GmbH | Nelotanserin for the prophylaxis and treatment of rem sleep behavior disorder |
| CA2992518A1 (en) | 2015-07-15 | 2017-01-19 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2194984C (en) * | 1994-07-26 | 2002-07-02 | John Eugene Macor | 4-indole derivatives as serotonin agonists and antagonists |
| US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| CO5080791A1 (es) | 1998-06-30 | 2001-09-25 | Lilly Co Eli | Derivados de la piperidina que tienen efectos sobre sistemas con serotonina |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| PL361887A1 (en) * | 2000-10-20 | 2004-10-04 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
| HUP0303756A3 (en) * | 2000-11-02 | 2009-08-28 | Wyeth Corp | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands and process for their preparation and pharmaceutical compositions containing them |
| US20050176705A1 (en) * | 2000-11-24 | 2005-08-11 | Bromidge Steven M. | Compounds useful in the treatment of cns disorders |
| US6787568B1 (en) * | 2000-11-27 | 2004-09-07 | Phoenix Scientific, Inc. | Antibiotic/analgesic formulation and a method of making this formulation |
| JP4754821B2 (ja) * | 2002-06-20 | 2011-08-24 | プロキシマゲン・リミテッド | 肥満症、ｉｉ型糖尿病およびｃｎｓ障害の治療に有用な新規化合物 |
-
2003
- 2003-09-08 DE DE60322551T patent/DE60322551D1/de not_active Expired - Lifetime
- 2003-09-08 CA CA002498946A patent/CA2498946A1/en not_active Abandoned
- 2003-09-08 EP EP03747986A patent/EP1542973B1/en not_active Expired - Lifetime
- 2003-09-08 NZ NZ538047A patent/NZ538047A/en unknown
- 2003-09-08 ES ES03747986T patent/ES2311721T3/es not_active Expired - Lifetime
- 2003-09-08 WO PCT/EP2003/009969 patent/WO2004026831A1/en active IP Right Grant
- 2003-09-08 RU RU2005111590/04A patent/RU2326112C2/ru not_active IP Right Cessation
- 2003-09-08 KR KR1020057004479A patent/KR100686757B1/ko not_active IP Right Cessation
- 2003-09-08 AT AT03747986T patent/ATE402923T1/de not_active IP Right Cessation
- 2003-09-08 AU AU2003267063A patent/AU2003267063B2/en not_active Ceased
- 2003-09-08 MX MXPA05002836A patent/MXPA05002836A/es active IP Right Grant
- 2003-09-08 PL PL03376022A patent/PL376022A1/xx not_active Application Discontinuation
- 2003-09-08 CN CNB03822044XA patent/CN1301970C/zh not_active Expired - Fee Related
- 2003-09-08 JP JP2004537019A patent/JP4267573B2/ja not_active Expired - Fee Related
- 2003-09-08 BR BR0314363-5A patent/BR0314363A/pt not_active IP Right Cessation
- 2003-09-12 TW TW092125224A patent/TWI250150B/zh not_active IP Right Cessation
- 2003-09-12 PA PA20038582101A patent/PA8582101A1/es unknown
- 2003-09-15 UY UY27979A patent/UY27979A1/es not_active Application Discontinuation
- 2003-09-15 AR ARP030103332A patent/AR041256A1/es not_active Application Discontinuation
- 2003-09-16 US US10/663,335 patent/US7381739B2/en not_active Expired - Fee Related
-
2005
- 2005-02-08 NO NO20050664A patent/NO20050664L/no not_active Application Discontinuation
- 2005-02-09 ZA ZA200501175A patent/ZA200501175B/xx unknown
- 2005-03-04 HR HR20050213A patent/HRP20050213A2/xx not_active Application Discontinuation
-
2006
- 2006-03-20 HK HK06103474A patent/HK1083497A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05002836A (es) | 2005-05-27 |
| UY27979A1 (es) | 2004-03-31 |
| BR0314363A (pt) | 2005-07-19 |
| TW200413313A (en) | 2004-08-01 |
| EP1542973B1 (en) | 2008-07-30 |
| JP4267573B2 (ja) | 2009-05-27 |
| ATE402923T1 (de) | 2008-08-15 |
| HRP20050213A2 (en) | 2006-12-31 |
| HK1083497A1 (en) | 2006-07-07 |
| AU2003267063A1 (en) | 2004-04-08 |
| KR100686757B1 (ko) | 2007-02-26 |
| AU2003267063B2 (en) | 2009-08-06 |
| CA2498946A1 (en) | 2004-04-01 |
| TWI250150B (en) | 2006-03-01 |
| US7381739B2 (en) | 2008-06-03 |
| CN1681783A (zh) | 2005-10-12 |
| NO20050664L (no) | 2005-04-15 |
| PA8582101A1 (es) | 2004-04-23 |
| RU2005111590A (ru) | 2005-11-20 |
| ES2311721T3 (es) | 2009-02-16 |
| EP1542973A1 (en) | 2005-06-22 |
| CN1301970C (zh) | 2007-02-28 |
| US20040072844A1 (en) | 2004-04-15 |
| KR20050057356A (ko) | 2005-06-16 |
| PL376022A1 (en) | 2005-12-12 |
| NZ538047A (en) | 2007-10-26 |
| RU2326112C2 (ru) | 2008-06-10 |
| AR041256A1 (es) | 2005-05-11 |
| JP2006502177A (ja) | 2006-01-19 |
| DE60322551D1 (de) | 2008-09-11 |
| WO2004026831A1 (en) | 2004-04-01 |
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