HRP20040439A2 - Substituted benzopyrans as selective estrogen receptor-beta agonists - Google Patents
Substituted benzopyrans as selective estrogen receptor-beta agonists Download PDFInfo
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- HRP20040439A2 HRP20040439A2 HR20040439A HRP20040439A HRP20040439A2 HR P20040439 A2 HRP20040439 A2 HR P20040439A2 HR 20040439 A HR20040439 A HR 20040439A HR P20040439 A HRP20040439 A HR P20040439A HR P20040439 A2 HRP20040439 A2 HR P20040439A2
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- 150000001562 benzopyrans Chemical class 0.000 title abstract description 4
- 239000000900 selective estrogen receptor beta agonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 136
- 150000003839 salts Chemical class 0.000 claims abstract description 62
- 238000000034 method Methods 0.000 claims abstract description 43
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 29
- 108010041356 Estrogen Receptor beta Proteins 0.000 claims abstract description 26
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- 239000001257 hydrogen Substances 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- -1 -OH Chemical group 0.000 claims description 15
- 238000009739 binding Methods 0.000 claims description 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
- 230000027455 binding Effects 0.000 claims description 9
- 125000003368 amide group Chemical group 0.000 claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 8
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hematology (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33276601P | 2001-11-19 | 2001-11-19 | |
| US36362202P | 2002-03-11 | 2002-03-11 | |
| PCT/US2002/033622 WO2003044006A1 (en) | 2001-11-19 | 2002-11-07 | Substituted benzopyrans as selective estrogen receptor-beta agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040439A2 true HRP20040439A2 (en) | 2005-04-30 |
Family
ID=26988373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040439A HRP20040439A2 (en) | 2001-11-19 | 2004-05-18 | Substituted benzopyrans as selective estrogen receptor-beta agonists |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7217734B2 (de) |
| EP (1) | EP1448544B1 (de) |
| JP (1) | JP4381810B2 (de) |
| KR (1) | KR100950616B1 (de) |
| CN (1) | CN1312147C (de) |
| AT (1) | ATE362471T1 (de) |
| AU (1) | AU2002359283B2 (de) |
| CA (1) | CA2467013C (de) |
| CY (1) | CY1106726T1 (de) |
| DE (1) | DE60220179T2 (de) |
| DK (1) | DK1448544T3 (de) |
| EA (1) | EA007382B1 (de) |
| EC (1) | ECSP045113A (de) |
| ES (1) | ES2286322T3 (de) |
| HK (1) | HK1068349A1 (de) |
| HR (1) | HRP20040439A2 (de) |
| HU (1) | HU229351B1 (de) |
| IL (3) | IL161325A0 (de) |
| MX (1) | MXPA04004703A (de) |
| NO (1) | NO328563B1 (de) |
| NZ (1) | NZ531850A (de) |
| PL (1) | PL205733B1 (de) |
| PT (1) | PT1448544E (de) |
| WO (1) | WO2003044006A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1626974E (pt) | 2003-04-21 | 2008-11-14 | Lilly Co Eli | Benzopiranos substituídos como agonistas selectivos do receptor beta de estrogénio |
| EP1618102B1 (de) | 2003-04-21 | 2010-02-10 | Eli Lilly And Company | Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta |
| CA2578164A1 (en) | 2004-09-07 | 2006-03-16 | Wyeth | 6h-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents |
| EP1805160B1 (de) * | 2004-10-18 | 2011-04-06 | Eli Lilly And Company | Substituierte benzopyrane als selektive östrogenrezeptor-beta-agonisten |
| PL1812417T3 (pl) * | 2004-11-18 | 2009-04-30 | Janssen Pharmaceutica Nv | Nowe pochodne 2H-chromenu jako selektywne modulatory receptora estrogenu |
| US8093302B2 (en) | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| TW201043595A (en) | 2009-03-13 | 2010-12-16 | Organon Nv | Tetrahydronaphthalen-2-ol derivatives |
| US8063102B2 (en) | 2009-03-13 | 2011-11-22 | N.V. Organon | Tetrahydronaphthalen-2-ol derivatives |
| CN105960236A (zh) | 2013-12-05 | 2016-09-21 | 卡罗医药股份公司 | 用于治疗间皮瘤的雌激素受体β激动剂 |
| AU2016324495B2 (en) | 2015-09-17 | 2020-12-03 | Institute Of Molecular Genetics As Cr, V.V.I. | Carborane compounds and methods of use thereof |
| WO2021183760A1 (en) * | 2020-03-11 | 2021-09-16 | Ohio State Innovation Foundation | Methods of modulating t-cell activation using estrogen receptor beta (erβ) agonists |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3901926A (en) * | 1973-04-02 | 1975-08-26 | Abbott Lab | Alkylphenyl benzopyrans |
| US5958710A (en) | 1995-09-08 | 1999-09-28 | Karo Bio Ab | Orphan receptor |
| AU8102398A (en) * | 1997-07-09 | 1999-02-08 | Central Drug Research Institute | (dl)-2,3-diaryl-2h-1-benzopyrans |
| US6593322B1 (en) | 1999-03-17 | 2003-07-15 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| JP2003521468A (ja) | 1999-03-17 | 2003-07-15 | シグナル ファーマシューティカルズ， インコーポレイテッド | エストロゲンレセプタを変調させるための化合物及び方法 |
| SK14762001A3 (sk) | 1999-04-16 | 2002-10-08 | Astrazeneca Ab | Ligandy receptora estrogénu beta |
| AU781282B2 (en) | 1999-12-30 | 2005-05-12 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| WO2001064665A1 (en) * | 2000-03-01 | 2001-09-07 | Akzo Nobel N.V. | Chroman derivatives as estrogenic compounds |
| US6686371B2 (en) | 2000-03-27 | 2004-02-03 | Akzo Nobel N.V. | Non-steroidal, tetracylic compounds for estrogen-related treatments |
| GB2361642A (en) | 2000-10-24 | 2001-10-31 | Karobio Ab | Estrogen receptor beta (ERbeta) agonists for use in cancer treatment |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| TWI306450B (en) | 2001-12-13 | 2009-02-21 | Wyeth Corp | Substituted phenyl naphthalenes as estrogenic agents |
| US6630508B1 (en) * | 2002-02-11 | 2003-10-07 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor β agonists |
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