HRP20031063A2 - New derivatives of oxazolidinones as antibacterial agents - Google Patents
New derivatives of oxazolidinones as antibacterial agentsInfo
- Publication number
- HRP20031063A2 HRP20031063A2 HR20031063A HRP20031063A HRP20031063A2 HR P20031063 A2 HRP20031063 A2 HR P20031063A2 HR 20031063 A HR20031063 A HR 20031063A HR P20031063 A HRP20031063 A HR P20031063A HR P20031063 A2 HRP20031063 A2 HR P20031063A2
- Authority
- HR
- Croatia
- Prior art keywords
- oxazolidinones
- antibacterial agents
- new derivatives
- derivatives
- new
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200101559A ES2186550B2 (es) | 2001-06-27 | 2001-06-27 | Nuevos derivados de oxazolidinonas como antibacterianos. |
| PCT/IB2002/002408 WO2003002560A1 (en) | 2001-06-27 | 2002-06-24 | New derivatives of oxazolidinones as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20031063A2 true HRP20031063A2 (en) | 2004-04-30 |
Family
ID=8498288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20031063A HRP20031063A2 (en) | 2001-06-27 | 2003-12-19 | New derivatives of oxazolidinones as antibacterial agents |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20040147545A1 (es) |
| EP (1) | EP1401834A1 (es) |
| JP (1) | JP2004521147A (es) |
| KR (1) | KR20040030712A (es) |
| CN (1) | CN1520412A (es) |
| AP (1) | AP2003002942A0 (es) |
| AR (1) | AR035254A1 (es) |
| BG (1) | BG108498A (es) |
| BR (1) | BR0210667A (es) |
| CA (1) | CA2450982A1 (es) |
| CO (1) | CO5540387A2 (es) |
| CR (1) | CR7195A (es) |
| CZ (1) | CZ2004101A3 (es) |
| EA (1) | EA200400086A1 (es) |
| EE (1) | EE200400004A (es) |
| ES (1) | ES2186550B2 (es) |
| HR (1) | HRP20031063A2 (es) |
| HU (1) | HUP0400370A2 (es) |
| IL (1) | IL159434A0 (es) |
| IS (1) | IS7088A (es) |
| MA (1) | MA27046A1 (es) |
| MX (1) | MXPA04000185A (es) |
| NO (1) | NO20035791L (es) |
| NZ (1) | NZ530206A (es) |
| OA (1) | OA12639A (es) |
| PE (1) | PE20030134A1 (es) |
| PL (1) | PL365476A1 (es) |
| SK (1) | SK572004A3 (es) |
| WO (1) | WO2003002560A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| ES2308171T3 (es) * | 2003-04-30 | 2008-12-01 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones. |
| DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| WO2005051933A1 (en) * | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| EP1557416A1 (en) * | 2004-01-23 | 2005-07-27 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| RU2371443C2 (ru) | 2003-12-18 | 2009-10-27 | Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми | Оксазолидинон-хинолонгибридные антибиотики |
| US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
| WO2007114326A1 (ja) | 2006-03-31 | 2007-10-11 | Research Foundation Itsuu Laboratory | ヘテロ環を有する新規化合物 |
| CN101883768A (zh) | 2007-10-02 | 2010-11-10 | 财团法人乙卯研究所 | 具有7元杂环的噁唑烷酮衍生物 |
| DK2296651T3 (da) * | 2008-05-09 | 2012-09-24 | Actelion Pharmaceuticals Ltd | 5-hydroxymethyl-oxazolidin-2-on-derivater til behandling af bakterielle intestinale sygdomme |
| AU2014273510B2 (en) | 2013-05-28 | 2019-10-10 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases |
| AU2014273471B2 (en) | 2013-05-28 | 2019-10-03 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections |
| CN107286111B (zh) * | 2016-03-30 | 2020-06-19 | 广东赛法洛药业有限公司 | 一种噁唑烷酮化合物的制备方法 |
| CN107286182A (zh) * | 2016-04-12 | 2017-10-24 | 李靖 | 新型噁唑烷酮‑氟喹诺酮衍生物及用途 |
| US10087171B2 (en) | 2016-12-19 | 2018-10-02 | Actelion Pharmaceuticals Ltd | Crystalline forms of cadazolid |
| GB201708606D0 (en) | 2017-05-30 | 2017-07-12 | King's College London | Antibiotic resistance breakers |
| ES2952989T3 (es) * | 2017-11-29 | 2023-11-07 | Bugworks Res Inc | Compuestos heterocíclicos antibacterianos y su síntesis |
| CN111087409B (zh) * | 2018-10-24 | 2021-06-08 | 江阴安博生物医药有限公司 | 一种喹诺酮类化合物及其制备方法和应用 |
| CN112940038A (zh) * | 2019-12-11 | 2021-06-11 | 华创合成制药股份有限公司 | 新型噁唑烷酮类化合物及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE444566B (sv) * | 1977-09-20 | 1986-04-21 | Bellon Labor Sa Roger | 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav |
| EP0390215B1 (en) * | 1989-03-30 | 1995-06-07 | Wakunaga Seiyaku Kabushiki Kaisha | Quinolone derivatives and salts thereof, preparation process es thereof, and antibacterial agents containing the same |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| RU2134692C1 (ru) * | 1994-10-26 | 1999-08-20 | Фармация Энд Апджон Компани | Антимикробные фенилоксазолидиноны |
| CN1214632A (zh) * | 1996-01-31 | 1999-04-21 | 三共株式会社 | 艾滋病治疗剂或预防剂 |
| RU2176643C2 (ru) * | 1996-04-11 | 2001-12-10 | Фармация Энд Апджон Компани | Способ получения 5-гидроксиметил замещенных оксазолидинонов, способ получения 5-аминометил замещенных оксазолидиноновых аминов, оксазолидинонсульфонат |
| GB9614236D0 (en) * | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
-
2001
- 2001-06-27 ES ES200101559A patent/ES2186550B2/es not_active Expired - Fee Related
-
2002
- 2002-06-24 NZ NZ530206A patent/NZ530206A/en unknown
- 2002-06-24 BR BR0210667-1A patent/BR0210667A/pt not_active Application Discontinuation
- 2002-06-24 HU HU0400370A patent/HUP0400370A2/hu unknown
- 2002-06-24 KR KR10-2003-7017038A patent/KR20040030712A/ko not_active Application Discontinuation
- 2002-06-24 AP APAP/P/2003/002942A patent/AP2003002942A0/en unknown
- 2002-06-24 US US10/469,283 patent/US20040147545A1/en not_active Abandoned
- 2002-06-24 JP JP2003508941A patent/JP2004521147A/ja active Pending
- 2002-06-24 EA EA200400086A patent/EA200400086A1/ru unknown
- 2002-06-24 SK SK57-2004A patent/SK572004A3/sk unknown
- 2002-06-24 CA CA002450982A patent/CA2450982A1/en not_active Abandoned
- 2002-06-24 EE EEP200400004A patent/EE200400004A/xx unknown
- 2002-06-24 CN CNA028128524A patent/CN1520412A/zh active Pending
- 2002-06-24 CZ CZ2004101A patent/CZ2004101A3/cs unknown
- 2002-06-24 EP EP02738497A patent/EP1401834A1/en not_active Withdrawn
- 2002-06-24 MX MXPA04000185A patent/MXPA04000185A/es unknown
- 2002-06-24 WO PCT/IB2002/002408 patent/WO2003002560A1/en active IP Right Grant
- 2002-06-24 PL PL02365476A patent/PL365476A1/xx not_active Application Discontinuation
- 2002-06-24 IL IL15943402A patent/IL159434A0/xx unknown
- 2002-06-24 OA OA1200300345A patent/OA12639A/en unknown
- 2002-06-26 AR ARP020102399A patent/AR035254A1/es not_active Application Discontinuation
- 2002-06-26 PE PE2002000572A patent/PE20030134A1/es not_active Application Discontinuation
-
2003
- 2003-12-10 CR CR7195A patent/CR7195A/es not_active Application Discontinuation
- 2003-12-19 HR HR20031063A patent/HRP20031063A2/xx not_active Application Discontinuation
- 2003-12-22 IS IS7088A patent/IS7088A/is unknown
- 2003-12-22 BG BG108498A patent/BG108498A/xx unknown
- 2003-12-22 NO NO20035791A patent/NO20035791L/no not_active Application Discontinuation
- 2003-12-23 MA MA27460A patent/MA27046A1/fr unknown
- 2003-12-26 CO CO03112619A patent/CO5540387A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR035254A1 (es) | 2004-05-05 |
| ES2186550A1 (es) | 2003-05-01 |
| PL365476A1 (en) | 2005-01-10 |
| CZ2004101A3 (cs) | 2004-07-14 |
| EA200400086A1 (ru) | 2004-06-24 |
| BR0210667A (pt) | 2004-10-05 |
| EP1401834A1 (en) | 2004-03-31 |
| JP2004521147A (ja) | 2004-07-15 |
| NO20035791L (no) | 2004-02-19 |
| PE20030134A1 (es) | 2003-04-04 |
| EE200400004A (et) | 2004-02-16 |
| CO5540387A2 (es) | 2005-07-29 |
| NZ530206A (en) | 2005-07-29 |
| IS7088A (is) | 2003-12-22 |
| KR20040030712A (ko) | 2004-04-09 |
| HUP0400370A2 (hu) | 2004-08-30 |
| CN1520412A (zh) | 2004-08-11 |
| CR7195A (es) | 2004-03-05 |
| ES2186550B2 (es) | 2003-11-16 |
| WO2003002560A1 (en) | 2003-01-09 |
| IL159434A0 (en) | 2004-06-01 |
| AP2003002942A0 (en) | 2003-12-24 |
| CA2450982A1 (en) | 2003-01-09 |
| US20040147545A1 (en) | 2004-07-29 |
| MA27046A1 (fr) | 2004-12-20 |
| BG108498A (en) | 2005-03-31 |
| SK572004A3 (en) | 2004-08-03 |
| MXPA04000185A (es) | 2004-03-18 |
| OA12639A (en) | 2006-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| OBST | Application withdrawn |