HRP20030610B1 - Process for the preparation of mesylates of piperazine derivatives - Google Patents
Process for the preparation of mesylates of piperazine derivativesInfo
- Publication number
- HRP20030610B1 HRP20030610B1 HR20030610A HRP20030610A HRP20030610B1 HR P20030610 B1 HRP20030610 B1 HR P20030610B1 HR 20030610 A HR20030610 A HR 20030610A HR P20030610 A HRP20030610 A HR P20030610A HR P20030610 B1 HRP20030610 B1 HR P20030610B1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- group
- hydrogen
- alkoxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200534 | 2001-02-16 | ||
| PCT/EP2002/001666 WO2002066449A2 (en) | 2001-02-16 | 2002-02-14 | Process for the preparation of mesylates of piperazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20030610A2 HRP20030610A2 (en) | 2005-06-30 |
| HRP20030610B1 true HRP20030610B1 (en) | 2006-02-28 |
Family
ID=8179894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030610A HRP20030610B1 (en) | 2001-02-16 | 2002-02-14 | Process for the preparation of mesylates of piperazine derivatives |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US7030241B2 (cs) |
| EP (1) | EP1362040B1 (cs) |
| JP (1) | JP4328528B2 (cs) |
| KR (2) | KR100859106B1 (cs) |
| CN (1) | CN1176079C (cs) |
| AR (1) | AR034206A1 (cs) |
| AT (1) | ATE284875T1 (cs) |
| AU (1) | AU2002250962B2 (cs) |
| BG (1) | BG66101B1 (cs) |
| BR (1) | BR0205683A (cs) |
| CA (1) | CA2422703C (cs) |
| CZ (1) | CZ301780B6 (cs) |
| DE (1) | DE60202261T2 (cs) |
| DK (1) | DK1362040T3 (cs) |
| DZ (1) | DZ3489A1 (cs) |
| ES (1) | ES2230481T3 (cs) |
| HR (1) | HRP20030610B1 (cs) |
| HU (1) | HUP0400772A3 (cs) |
| IL (1) | IL153509A (cs) |
| IS (1) | IS2417B (cs) |
| ME (1) | MEP37508A (cs) |
| MX (1) | MXPA03002359A (cs) |
| MY (1) | MY130687A (cs) |
| NO (1) | NO324460B1 (cs) |
| NZ (1) | NZ524632A (cs) |
| PL (1) | PL208363B1 (cs) |
| PT (1) | PT1362040E (cs) |
| RS (1) | RS51126B (cs) |
| RU (1) | RU2272036C2 (cs) |
| SI (1) | SI1362040T1 (cs) |
| SK (1) | SK286143B6 (cs) |
| UA (1) | UA75390C2 (cs) |
| WO (1) | WO2002066449A2 (cs) |
| ZA (1) | ZA200301590B (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR045362A1 (es) * | 2003-08-18 | 2005-10-26 | Solvay Pharm Bv | Forma cristalina estable de mesilato de bifeprunox (monometansulfonato de 7-[4-([1,1- bifenil] -3- ilmetil) -1- piperazinil] - 2-(3h) -benzoxazolona |
| US7435738B2 (en) | 2003-08-18 | 2008-10-14 | Solvay Pharmaceuticals, Inc. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
| US7405216B2 (en) * | 2004-08-18 | 2008-07-29 | Solvay Pharmaceuticals, B.V. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
| US7964604B2 (en) * | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
| US7423040B2 (en) * | 2005-02-18 | 2008-09-09 | Irene Eijgendaal | Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same |
| US20070275977A1 (en) * | 2006-05-02 | 2007-11-29 | Van Aar Marcel P | N-oxides of pyridylmethyl -piperazine and -piperidine derivatives |
| US7786126B2 (en) * | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
| US8106056B2 (en) * | 2006-06-16 | 2012-01-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising bifeprunox and a dopamine agonist |
| EA200970239A1 (ru) | 2006-08-31 | 2009-08-28 | Солвей Фармасьютикалс Б.В. | Режим титрования бифепрунокса для лечения шизофрении и наборы для применения в этой области |
| US20080132520A1 (en) * | 2006-08-31 | 2008-06-05 | Winsemius Antje A | Compositions, kits and methods for administering a titration schedule comprising bifeprunox compounds |
| US20090068290A1 (en) * | 2006-08-31 | 2009-03-12 | Michel Bourin | Bifeprunox doses for treating schizophrenia |
| AU2009212314C1 (en) | 2008-02-05 | 2014-05-08 | Harbor Biosciences, Inc. | Pharmaceutical solid state forms |
| WO2011023796A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Healthcare Products B.V. | Bifeprunox for treating addiction |
| UY32934A (es) | 2009-10-12 | 2011-05-31 | Abbott Healthcare Products Bv | Monohidrato de pardoprunox |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3571436D1 (en) | 1984-12-21 | 1989-08-17 | Duphar Int Res | New pharmaceutical compositions having anti-psychotic properties |
| DE3586794T2 (de) | 1984-12-21 | 1993-05-27 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| JPH0344383A (ja) * | 1989-07-12 | 1991-02-26 | Ihara Chem Ind Co Ltd | ５―トリフルオロメチル―２―ハロメチルベンゾチアゾール類の製造法 |
| JP3044383B2 (ja) * | 1990-05-22 | 2000-05-22 | コニカ株式会社 | 含窒素６員環化合物の製造方法 |
| GB9200293D0 (en) * | 1992-01-08 | 1992-02-26 | Wyeth John & Brother Ltd | Piperazine derivatives |
| DK0889889T3 (da) * | 1996-03-29 | 2007-01-29 | Duphar Int Res | Piperazin- og piperidinforbindelser |
| SE9702799D0 (sv) * | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| US7435738B2 (en) | 2003-08-18 | 2008-10-14 | Solvay Pharmaceuticals, Inc. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
-
2002
- 2002-02-12 AR ARP020100460A patent/AR034206A1/es active IP Right Grant
- 2002-02-14 ME MEP-375/08A patent/MEP37508A/xx unknown
- 2002-02-14 SI SI200230061T patent/SI1362040T1/xx unknown
- 2002-02-14 PL PL369330A patent/PL208363B1/pl unknown
- 2002-02-14 MY MYPI20020505A patent/MY130687A/en unknown
- 2002-02-14 US US10/468,098 patent/US7030241B2/en not_active Expired - Fee Related
- 2002-02-14 IL IL153509A patent/IL153509A/en not_active IP Right Cessation
- 2002-02-14 ES ES02719858T patent/ES2230481T3/es not_active Expired - Lifetime
- 2002-02-14 CZ CZ20030697A patent/CZ301780B6/cs not_active IP Right Cessation
- 2002-02-14 NZ NZ524632A patent/NZ524632A/en not_active IP Right Cessation
- 2002-02-14 SK SK309-2003A patent/SK286143B6/sk not_active IP Right Cessation
- 2002-02-14 PT PT02719858T patent/PT1362040E/pt unknown
- 2002-02-14 JP JP2002565965A patent/JP4328528B2/ja not_active Expired - Fee Related
- 2002-02-14 KR KR1020037000026A patent/KR100859106B1/ko not_active Expired - Fee Related
- 2002-02-14 AU AU2002250962A patent/AU2002250962B2/en not_active Ceased
- 2002-02-14 BR BR0205683-6A patent/BR0205683A/pt not_active Application Discontinuation
- 2002-02-14 CN CNB028016858A patent/CN1176079C/zh not_active Expired - Fee Related
- 2002-02-14 MX MXPA03002359A patent/MXPA03002359A/es active IP Right Grant
- 2002-02-14 EP EP02719858A patent/EP1362040B1/en not_active Expired - Lifetime
- 2002-02-14 HR HR20030610A patent/HRP20030610B1/xx not_active IP Right Cessation
- 2002-02-14 WO PCT/EP2002/001666 patent/WO2002066449A2/en active IP Right Grant
- 2002-02-14 DK DK02719858T patent/DK1362040T3/da active
- 2002-02-14 UA UA2003098528A patent/UA75390C2/uk unknown
- 2002-02-14 RU RU2003105902/04A patent/RU2272036C2/ru not_active IP Right Cessation
- 2002-02-14 HU HU0400772A patent/HUP0400772A3/hu unknown
- 2002-02-14 RS YUP-644/03A patent/RS51126B/sr unknown
- 2002-02-14 CA CA2422703A patent/CA2422703C/en not_active Expired - Fee Related
- 2002-02-14 AT AT02719858T patent/ATE284875T1/de active
- 2002-02-14 KR KR1020087015071A patent/KR101000733B1/ko not_active Expired - Fee Related
- 2002-02-14 DE DE60202261T patent/DE60202261T2/de not_active Expired - Lifetime
- 2002-02-14 DZ DZ023489A patent/DZ3489A1/fr active
-
2003
- 2003-02-26 ZA ZA200301590A patent/ZA200301590B/en unknown
- 2003-04-15 NO NO20031754A patent/NO324460B1/no not_active IP Right Cessation
- 2003-07-17 IS IS6876A patent/IS2417B/is unknown
- 2003-08-13 BG BG108090A patent/BG66101B1/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| A1OB | Publication of a patent application | ||
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20120209 Year of fee payment: 11 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20130215 |