HRP20030447A2 - Guanidine and amidine derivatives as factor xa inhibitors - Google Patents

Guanidine and amidine derivatives as factor xa inhibitors Download PDF

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Publication number
HRP20030447A2
HRP20030447A2 HR20030447A HRP20030447A HRP20030447A2 HR P20030447 A2 HRP20030447 A2 HR P20030447A2 HR 20030447 A HR20030447 A HR 20030447A HR P20030447 A HRP20030447 A HR P20030447A HR P20030447 A2 HRP20030447 A2 HR P20030447A2
Authority
HR
Croatia
Prior art keywords
alkyl
mono
unsubstituted
tri
substituted
Prior art date
Application number
HR20030447A
Other languages
English (en)
Croatian (hr)
Inventor
Peyman Anuschirvan
William Will David
Gerlach Uwe
Nazar Marc
Zoller Gerhard
Nestler Hans-Peter
Matter Hans
Al-Obeidi Fahad
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of HRP20030447A2 publication Critical patent/HRP20030447A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20030447A 2000-12-06 2001-11-28 Guanidine and amidine derivatives as factor xa inhibitors HRP20030447A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00126750 2000-12-06
PCT/EP2001/013874 WO2002046159A1 (en) 2000-12-06 2001-11-28 Guanidine and amidine derivatives as factor xa inhibitors

Publications (1)

Publication Number Publication Date
HRP20030447A2 true HRP20030447A2 (en) 2005-04-30

Family

ID=8170585

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030447A HRP20030447A2 (en) 2000-12-06 2001-11-28 Guanidine and amidine derivatives as factor xa inhibitors

Country Status (26)

Country Link
US (2) US20020173656A1 (cs)
EP (1) EP1345900B1 (cs)
JP (1) JP4274522B2 (cs)
KR (1) KR20040015036A (cs)
CN (1) CN1479722A (cs)
AR (1) AR033684A1 (cs)
AU (2) AU3320602A (cs)
BR (1) BR0115938A (cs)
CA (1) CA2430518C (cs)
CZ (1) CZ20031554A3 (cs)
DE (1) DE60126143T2 (cs)
DK (1) DK1345900T3 (cs)
EE (1) EE200300192A (cs)
ES (1) ES2278798T3 (cs)
HR (1) HRP20030447A2 (cs)
HU (1) HUP0302604A3 (cs)
IL (2) IL156214A0 (cs)
MX (1) MXPA03004848A (cs)
NO (1) NO20032489L (cs)
NZ (1) NZ526269A (cs)
PL (1) PL362320A1 (cs)
PT (1) PT1345900E (cs)
RU (1) RU2003120070A (cs)
SK (1) SK6862003A3 (cs)
WO (1) WO2002046159A1 (cs)
ZA (1) ZA200303847B (cs)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1703395A (zh) * 2002-08-09 2005-11-30 特兰斯泰克制药公司 芳基和杂芳基化合物以及调节凝血的方法
US7405210B2 (en) 2003-05-21 2008-07-29 Osi Pharmaceuticals, Inc. Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
EP1660439A2 (en) * 2003-08-08 2006-05-31 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014532A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
WO2005034994A1 (ja) * 2003-10-10 2005-04-21 Chugai Seiyaku Kabushiki Kaisha 固形腫瘍治療剤
ATE483708T1 (de) 2004-03-08 2010-10-15 Prosidion Ltd Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase
ATE424821T1 (de) 2004-12-02 2009-03-15 Prosidion Ltd Pyrrolopyridin-2-karbonsäureamide
DE102006048300A1 (de) 2006-01-26 2007-08-02 Hellstern, Peter, Prof. Dr.med. Inhibitoren des Blutgerinnungsfaktors Xa zur Verwendung als Antikoagulans
TW201035088A (en) 2009-02-27 2010-10-01 Supergen Inc Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
US8507640B2 (en) 2010-08-19 2013-08-13 International Business Machines Corporation Methods of ring opening polymerization and catalysts therefor
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US10647661B2 (en) 2017-07-11 2020-05-12 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
JP2020536863A (ja) 2017-10-06 2020-12-17 フォーマ セラピューティクス，インコーポレイテッド ユビキチン特異的ペプチダーゼ３０の阻害
MX2020012180A (es) 2018-05-17 2021-01-29 Forma Therapeutics Inc Compuestos biciclicos fusionados utiles como inhibidores de la peptidasa 30 especifica de ubiquitina.
KR20210072791A (ko) 2018-10-05 2021-06-17 포르마 세라퓨틱스 인크. 유비퀴틴-특이적 프로테아제 30 (usp30)의 억제제로서 작용하는 융합된 피롤린
US12440481B2 (en) 2019-01-10 2025-10-14 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
WO2020146682A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201303B (cs) * 1990-07-05 1993-03-01 Hoffmann La Roche
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
ES2103181B1 (es) * 1994-08-01 1998-04-01 Menarini Lab Amidas naftalenicas con accion antagonista de los leucotrienos.
RU2152954C1 (ru) * 1994-04-26 2000-07-20 Селектид Корпорейшн Ингибиторы фактора ха
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
TW542822B (en) * 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
CA2294126A1 (en) * 1997-06-26 1999-01-07 Douglas Wade Beight Antithrombotic agents
BR9909086A (pt) 1998-03-23 2001-09-04 Aventis Pharm Prod Inc Derivados de piperidinila e n-amidinopiperidinila
US20020016339A1 (en) * 1998-03-23 2002-02-07 Klein Scott I. Piperididinyl and N-amidinopiperidinyl derivatives
EP0987274A1 (en) 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
EP1216228B1 (en) * 1999-09-17 2008-10-29 Millennium Pharmaceuticals, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa

Also Published As

Publication number Publication date
IL156214A (en) 2010-05-31
CA2430518A1 (en) 2002-06-13
NO20032489D0 (no) 2003-06-02
AU3320602A (en) 2002-06-18
CA2430518C (en) 2010-06-15
ZA200303847B (en) 2004-04-15
CN1479722A (zh) 2004-03-03
RU2003120070A (ru) 2004-12-27
EP1345900A1 (en) 2003-09-24
US20050143419A1 (en) 2005-06-30
AU2002233206B2 (en) 2006-06-22
DE60126143D1 (de) 2007-03-08
US20020173656A1 (en) 2002-11-21
JP2004515492A (ja) 2004-05-27
WO2002046159A1 (en) 2002-06-13
KR20040015036A (ko) 2004-02-18
BR0115938A (pt) 2003-12-23
PL362320A1 (en) 2004-10-18
CZ20031554A3 (cs) 2003-08-13
HUP0302604A2 (hu) 2003-11-28
IL156214A0 (en) 2003-12-23
ES2278798T3 (es) 2007-08-16
SK6862003A3 (en) 2004-02-03
EE200300192A (et) 2003-08-15
PT1345900E (pt) 2007-03-30
AR033684A1 (es) 2004-01-07
EP1345900B1 (en) 2007-01-17
NZ526269A (en) 2004-11-26
JP4274522B2 (ja) 2009-06-10
NO20032489L (no) 2003-07-25
MXPA03004848A (es) 2003-08-19
DE60126143T2 (de) 2007-11-15
HUP0302604A3 (en) 2005-09-28
US7435747B2 (en) 2008-10-14
DK1345900T3 (da) 2007-05-21

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HRP20030447A2 (en) Guanidine and amidine derivatives as factor xa inhibitors
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