HRP20020988B1 - Compounds for treating impaired fundic relaxation - Google Patents

Compounds for treating impaired fundic relaxation

Info

Publication number
HRP20020988B1
HRP20020988B1 HR20020988A HRP20020988A HRP20020988B1 HR P20020988 B1 HRP20020988 B1 HR P20020988B1 HR 20020988 A HR20020988 A HR 20020988A HR P20020988 A HRP20020988 A HR P20020988A HR P20020988 B1 HRP20020988 B1 HR P20020988B1
Authority
HR
Croatia
Prior art keywords
alkyl
alkyloxy
hydroxy
alkyloxycarbonyloxy
aminocarbonyl
Prior art date
Application number
HR20020988A
Other languages
English (en)
Croatian (hr)
Inventor
Van Emelen Kristof
Frans Leopold De Bruyn Marcel
Jesus Alcazar-Vaca Manuel
Ignacio Andres-Gil Jose
Javier Fernandez-Gadea Francisco
Encarnacion Matesanz-Ballesteros Maria
Manuel Bartolome-Nebreda Jose
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HRP20020988A2 publication Critical patent/HRP20020988A2/hr
Publication of HRP20020988B1 publication Critical patent/HRP20020988B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20020988A 2000-06-22 2001-06-13 Compounds for treating impaired fundic relaxation HRP20020988B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00202180 2000-06-22
PCT/EP2001/006749 WO2001098306A1 (en) 2000-06-22 2001-06-13 Compounds for treating impaired fundic relaxation

Publications (2)

Publication Number Publication Date
HRP20020988A2 HRP20020988A2 (en) 2005-02-28
HRP20020988B1 true HRP20020988B1 (en) 2011-06-30

Family

ID=8171674

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020988A HRP20020988B1 (en) 2000-06-22 2001-06-13 Compounds for treating impaired fundic relaxation

Country Status (33)

Country Link
US (2) US7081453B2 (cs)
EP (1) EP1296987B1 (cs)
JP (1) JP4911860B2 (cs)
KR (1) KR100821107B1 (cs)
CN (2) CN1288157C (cs)
AR (1) AR032158A1 (cs)
AT (1) ATE312104T1 (cs)
AU (1) AU783292B2 (cs)
BG (1) BG65895B1 (cs)
BR (1) BR0111859B1 (cs)
CA (1) CA2410233C (cs)
CZ (1) CZ305005B6 (cs)
DE (1) DE60115647T2 (cs)
EA (1) EA005760B1 (cs)
EE (1) EE04878B1 (cs)
EG (1) EG24462A (cs)
ES (1) ES2254467T3 (cs)
HR (1) HRP20020988B1 (cs)
HU (1) HU227398B1 (cs)
IL (2) IL153559A0 (cs)
IS (1) IS2618B (cs)
JO (1) JO2352B1 (cs)
MX (1) MXPA02012844A (cs)
MY (1) MY155267A (cs)
NO (1) NO328547B1 (cs)
NZ (1) NZ522519A (cs)
PA (1) PA8519601A1 (cs)
PL (1) PL201656B1 (cs)
SA (1) SA01220442B1 (cs)
SK (1) SK287730B6 (cs)
UA (1) UA74576C2 (cs)
WO (1) WO2001098306A1 (cs)
ZA (1) ZA200210303B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075136A1 (en) 1999-06-02 2000-12-14 Janssen Pharmaceutica N.V. Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
BR0011247A (pt) 1999-06-02 2002-03-05 Janssen Pharmaceutica Nv Derivados (benzodioxano, benzofurano ou benzopirano) de pirrolidinila, piperidinila ou homopiperidinila substituìdos
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
KR101120414B1 (ko) 2003-04-24 2012-04-12 인사이트 코포레이션 메탈로프로테아제의 억제제로서의 아자 스피로 알칸 유도체
JP4896476B2 (ja) * 2005-09-16 2012-03-14 広栄化学工業株式会社 メチルオキシメチルアミノピリジン誘導体及びその製造方法
US7999107B2 (en) 2007-01-31 2011-08-16 Merck Sharp & Dohme Corp. Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
EA017249B8 (ru) * 2007-05-10 2013-01-30 Олбани Молекьюлар Рисерч, Инк. Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
EP2776405A1 (en) 2011-11-11 2014-09-17 Pfizer Inc 2-thiopyrimidinones
CN107531647A (zh) 2015-05-05 2018-01-02 辉瑞大药厂 2‑硫代嘧啶酮类
CN105481839B (zh) * 2015-11-23 2018-05-11 安徽千和新材料科技发展有限公司 一种光活性环氧啉对映体的制备方法
EP3229193A1 (en) 2016-04-07 2017-10-11 The Boeing Company A computer-implemented method and system for sharing information between passengers and air traffic management stakeholders

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910930A (en) * 1973-01-04 1975-10-07 Janssen Pharmaceutica Nv 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones
EP0004358A1 (de) * 1978-03-20 1979-10-03 Ciba-Geigy Ag N-Oxacyclyl-alkyl-piperidine, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen
WO1993017017A1 (en) * 1992-02-27 1993-09-02 Janssen Pharmaceutica N.V. [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors
WO1997028157A1 (fr) * 1996-02-01 1997-08-07 Pierre Fabre Medicament Nouveaux derives de la piperidine substitues en position 4 par un groupe imidazolidin-2-on-1-yl-ethyl, tetrahydropyrimidin-2-on-1-yl-ethyl, et 1,3-dia-zepin-2-on-1-yl-ethyl, et leurs applications comme antagonistes des recepteurs alpha-2 adrenergiques
WO1999029687A1 (en) * 1997-12-05 1999-06-17 Janssen Pharmaceutica N.V. (benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
WO2000075136A1 (en) * 1999-06-02 2000-12-14 Janssen Pharmaceutica N.V. Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
WO2000075137A1 (en) * 1999-06-02 2000-12-14 Janssen Pharmaceutica N.V. Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2400049A1 (de) * 1974-01-02 1975-07-10 Spumalit Anstalt Transportkasten aus kunststoff, insbesondere fuer flaschen
US4329348A (en) * 1979-02-26 1982-05-11 Ciba-Geigy Corporation N-Oxacyclic-alkylpiperidines as psychostimulants
DE3484096D1 (de) * 1983-11-30 1991-03-14 Janssen Pharmaceutica Nv Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
ZA931343B (en) 1992-03-06 1993-09-24 Akzo Nv 1,4-dioxino(2,3-b)pyridine derivatives.
US6403103B1 (en) * 1994-08-12 2002-06-11 Bio Merieux Trypanosoma cruzi antigen, gene encoding therefore, and methods of detecting and treating chagas disease
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910930A (en) * 1973-01-04 1975-10-07 Janssen Pharmaceutica Nv 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones
EP0004358A1 (de) * 1978-03-20 1979-10-03 Ciba-Geigy Ag N-Oxacyclyl-alkyl-piperidine, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen
WO1993017017A1 (en) * 1992-02-27 1993-09-02 Janssen Pharmaceutica N.V. [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors
WO1997028157A1 (fr) * 1996-02-01 1997-08-07 Pierre Fabre Medicament Nouveaux derives de la piperidine substitues en position 4 par un groupe imidazolidin-2-on-1-yl-ethyl, tetrahydropyrimidin-2-on-1-yl-ethyl, et 1,3-dia-zepin-2-on-1-yl-ethyl, et leurs applications comme antagonistes des recepteurs alpha-2 adrenergiques
WO1999029687A1 (en) * 1997-12-05 1999-06-17 Janssen Pharmaceutica N.V. (benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
WO2000075136A1 (en) * 1999-06-02 2000-12-14 Janssen Pharmaceutica N.V. Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
WO2000075137A1 (en) * 1999-06-02 2000-12-14 Janssen Pharmaceutica N.V. Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

Also Published As

Publication number Publication date
CN1437602A (zh) 2003-08-20
EA005760B1 (ru) 2005-06-30
US7081453B2 (en) 2006-07-25
JP2004501157A (ja) 2004-01-15
BR0111859B1 (pt) 2015-01-06
US20040019051A1 (en) 2004-01-29
EP1296987B1 (en) 2005-12-07
IL153559A0 (en) 2003-07-06
BG65895B1 (bg) 2010-04-30
KR20030007566A (ko) 2003-01-23
ATE312104T1 (de) 2005-12-15
ZA200210303B (en) 2004-03-19
JO2352B1 (en) 2006-12-12
CZ2003115A3 (cs) 2003-06-18
HU227398B1 (hu) 2011-05-30
EE200200694A (et) 2004-06-15
SK287730B6 (en) 2011-07-06
CN100516066C (zh) 2009-07-22
IL153559A (en) 2008-03-20
MY155267A (en) 2015-09-30
NZ522519A (en) 2003-09-26
WO2001098306A1 (en) 2001-12-27
UA74576C2 (en) 2006-01-16
IS2618B (is) 2010-04-15
IS6591A (is) 2002-10-25
BG107313A (bg) 2003-06-30
DE60115647T2 (de) 2006-08-24
SA01220442B1 (ar) 2008-05-21
CN1288157C (zh) 2006-12-06
CA2410233C (en) 2011-01-25
HRP20020988A2 (en) 2005-02-28
AU783292B2 (en) 2005-10-13
PA8519601A1 (es) 2002-08-26
HUP0301185A2 (hu) 2003-08-28
HUP0301185A3 (en) 2009-03-30
EE04878B1 (et) 2007-08-15
KR100821107B1 (ko) 2008-04-14
AR032158A1 (es) 2003-10-29
SK492003A3 (en) 2003-07-01
NO20026219L (no) 2003-02-17
NO328547B1 (no) 2010-03-15
JP4911860B2 (ja) 2012-04-04
EA200300049A1 (ru) 2003-04-24
HK1057896A1 (en) 2004-04-23
US7423048B2 (en) 2008-09-09
EP1296987A1 (en) 2003-04-02
DE60115647D1 (de) 2006-01-12
CA2410233A1 (en) 2001-12-27
CZ305005B6 (cs) 2015-03-25
AU8386401A (en) 2002-01-02
US20060142318A1 (en) 2006-06-29
BR0111859A (pt) 2003-05-13
MXPA02012844A (es) 2003-05-15
NO20026219D0 (no) 2002-12-23
PL358886A1 (en) 2004-08-23
PL201656B1 (pl) 2009-04-30
CN1781921A (zh) 2006-06-07
ES2254467T3 (es) 2006-06-16
EG24462A (en) 2009-07-16

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Payment date: 20180524

Year of fee payment: 18

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Effective date: 20190613