HRP20020647A2 - A method for maintaining or improving the synthesis of mucins - Google Patents
A method for maintaining or improving the synthesis of mucins Download PDFInfo
- Publication number
- HRP20020647A2 HRP20020647A2 HRP20020647A HRP20020647A2 HR P20020647 A2 HRP20020647 A2 HR P20020647A2 HR P20020647 A HRP20020647 A HR P20020647A HR P20020647 A2 HRP20020647 A2 HR P20020647A2
- Authority
- HR
- Croatia
- Prior art keywords
- threonine
- protein
- preparation
- amino acids
- use according
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 61
- 102000015728 Mucins Human genes 0.000 title abstract description 39
- 108010063954 Mucins Proteins 0.000 title abstract description 39
- 230000015572 biosynthetic process Effects 0.000 title abstract description 20
- 229940051875 mucins Drugs 0.000 title abstract description 5
- 238000003786 synthesis reaction Methods 0.000 title abstract description 3
- 239000004473 Threonine Substances 0.000 claims abstract description 126
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims abstract description 125
- 235000016709 nutrition Nutrition 0.000 claims abstract description 55
- 239000000203 mixture Substances 0.000 claims abstract description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 25
- 201000010099 disease Diseases 0.000 claims abstract description 23
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- 239000000828 canola oil Substances 0.000 description 1
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- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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- 229960002518 gentamicin Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
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- 235000021243 milk fat Nutrition 0.000 description 1
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- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
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- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
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- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 235000021476 total parenteral nutrition Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Obesity (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49890500A | 2000-02-04 | 2000-02-04 | |
US09/774,814 US6833350B2 (en) | 2000-02-04 | 2001-01-30 | Method for maintaining or improving the synthesis of mucins |
PCT/EP2001/001013 WO2001056405A2 (en) | 2000-02-04 | 2001-01-31 | A method for maintaining or improving the synthesis of mucins |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20020647A2 true HRP20020647A2 (en) | 2004-12-31 |
Family
ID=27052980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20020647 HRP20020647A2 (en) | 2000-02-04 | 2002-07-31 | A method for maintaining or improving the synthesis of mucins |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1255452B2 (hu) |
JP (1) | JP2003533436A (hu) |
CN (1) | CN1434681B (hu) |
AT (1) | ATE323422T1 (hu) |
AU (1) | AU784137B2 (hu) |
BG (1) | BG106967A (hu) |
BR (1) | BRPI0108096B1 (hu) |
CA (1) | CA2399063C (hu) |
CZ (1) | CZ20022978A3 (hu) |
DE (1) | DE60118888T3 (hu) |
DZ (1) | DZ3298A1 (hu) |
ES (1) | ES2261383T5 (hu) |
HR (1) | HRP20020647A2 (hu) |
HU (1) | HUP0204439A3 (hu) |
IL (1) | IL150977A (hu) |
MA (1) | MA25656A1 (hu) |
MX (1) | MXPA02007491A (hu) |
NO (1) | NO20023640L (hu) |
NZ (1) | NZ520605A (hu) |
PL (1) | PL357078A1 (hu) |
SK (1) | SK11212002A3 (hu) |
WO (1) | WO2001056405A2 (hu) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070036836A1 (en) | 2003-06-23 | 2007-02-15 | Magali Faure | Amino acid supplementation for a healthy microbiota ecosystem |
JPWO2007004613A1 (ja) * | 2005-07-01 | 2009-01-29 | 味の素株式会社 | 炎症性腸疾患治療薬及びTNF−α産生抑制剤 |
JP2009522334A (ja) * | 2006-01-09 | 2009-06-11 | ネステク ソシエテ アノニム | ストレス下にある患者の処置 |
WO2012133198A1 (ja) * | 2011-03-25 | 2012-10-04 | イーエヌ大塚製薬株式会社 | 炎症性疾患用栄養組成物 |
MY182335A (en) | 2011-07-22 | 2021-01-19 | Abbott Lab | Galactooligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract |
EP3167895A1 (en) * | 2015-11-10 | 2017-05-17 | University College Dublin | A dietary supplement comprising beta-glucan and casein hydrolysate for improving health and growth performance in a mammal |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2459620B1 (fr) * | 1979-06-26 | 1983-08-05 | Agronomique Inst Nat Rech | Hydrolisat enzymatique total de proteines de lactoserum, obtention et application |
US5162373A (en) * | 1986-01-17 | 1992-11-10 | Board Of Regents, The University Of Texas System | Methods and improved formulations for the determination and treatment of malignant disease in patients |
JP2631470B2 (ja) * | 1987-05-15 | 1997-07-16 | 雪印乳業株式会社 | 感染防御剤 |
CA1338682C (en) * | 1988-12-23 | 1996-10-29 | Gustavo Bounous | Biologically active undenatured whey protein concentrate as food supplement |
JP2805490B2 (ja) * | 1989-02-07 | 1998-09-30 | 雪印乳業株式会社 | 細菌毒素中和剤 |
JP3007694B2 (ja) * | 1990-12-14 | 2000-02-07 | 雪印乳業株式会社 | 胃潰瘍予防または治療のための医薬及び飲食品 |
ES2173109T3 (es) * | 1992-12-23 | 2002-10-16 | Abbott Lab | Alimentos de unso medico destinados parael sostenimiento nutricional de recien nacidos/de bebes que padecen enfermedades metabolicas. |
NZ248605A (en) * | 1993-05-28 | 1994-12-22 | Abbott Lab | Enteral nutritional product comprising protein and fat |
FR2711529B1 (fr) * | 1993-10-28 | 1996-07-05 | Clintec Nutrition Cy | Composition à base d'acides aminés destinée au traitement d'une infection ou d'une agression engendrant une réaction inflammatoire, chez les animaux et chez l'homme. |
JPH07267855A (ja) * | 1994-03-30 | 1995-10-17 | Taiho Yakuhin Kogyo Kk | グルタミン産生剤 |
US5952314A (en) * | 1994-04-01 | 1999-09-14 | Demichele; Stephen Joseph | Nutritional product for a person having ulcerative colitis |
US5728678A (en) * | 1995-06-06 | 1998-03-17 | Nestec Ltd. | Method and composition for providing nutrition to a renal failure patient |
US5670157A (en) * | 1995-12-11 | 1997-09-23 | Nestec Ltd. | Method for reducing and controlling immunoglobulin concentrations |
US5922766A (en) * | 1997-07-02 | 1999-07-13 | Acosta; Phyllis J. B. | Palatable elemental medical food |
ATE329500T1 (de) * | 1997-09-16 | 2006-07-15 | Nestle Sa | Verwendung eines organspezifischen ernährungmittels |
CA2331921A1 (en) * | 1998-06-24 | 1999-12-29 | Boyce Thompson Institute For Plant Research, Inc. | A novel invertebrate intestinal mucin cdna and related products and methods |
EP1034704A1 (en) * | 1999-03-12 | 2000-09-13 | Societe Des Produits Nestle S.A. | Nutritional composition intended for specific gastro-intestinal maturation in premature mammals |
NZ518319A (en) * | 1999-10-22 | 2004-04-30 | Univ Nebraska | Nucleic acid molecules encoding serum amyloid A isoforms from mammalian colostrum used to treat and prevent enteric infections |
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- 2001-01-31 DZ DZ013298A patent/DZ3298A1/fr active
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Also Published As
Publication number | Publication date |
---|---|
ES2261383T3 (es) | 2010-06-14 |
WO2001056405A2 (en) | 2001-08-09 |
CN1434681B (zh) | 2010-12-08 |
BRPI0108096B1 (pt) | 2017-05-09 |
DE60118888T2 (de) | 2007-01-18 |
NZ520605A (en) | 2004-06-25 |
CA2399063A1 (en) | 2001-08-09 |
MA25656A1 (fr) | 2002-12-31 |
BG106967A (bg) | 2003-04-30 |
SK11212002A3 (sk) | 2003-01-09 |
CN1434681A (zh) | 2003-08-06 |
EP1255452B1 (en) | 2006-04-19 |
HUP0204439A3 (en) | 2004-12-28 |
JP2003533436A (ja) | 2003-11-11 |
DE60118888D1 (de) | 2006-05-24 |
NO20023640L (no) | 2002-09-19 |
NO20023640D0 (no) | 2002-07-31 |
CA2399063C (en) | 2014-01-28 |
WO2001056405A3 (en) | 2002-01-24 |
AU784137B2 (en) | 2006-02-09 |
EP1255452A2 (en) | 2002-11-13 |
PL357078A1 (en) | 2004-07-12 |
IL150977A (en) | 2005-09-25 |
DZ3298A1 (fr) | 2001-08-09 |
ATE323422T1 (de) | 2006-05-15 |
AU4056401A (en) | 2001-08-14 |
IL150977A0 (en) | 2003-02-12 |
CZ20022978A3 (cs) | 2003-02-12 |
ES2261383T5 (es) | 2010-06-18 |
EP1255452B2 (en) | 2010-03-03 |
MXPA02007491A (es) | 2002-12-13 |
BR0108096A (pt) | 2002-10-29 |
DE60118888T3 (de) | 2010-09-23 |
HUP0204439A2 (hu) | 2003-04-28 |
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