HRP20020240B1 - Sustained release preparation comprising one or mo - Google Patents

Sustained release preparation comprising one or mo

Info

Publication number
HRP20020240B1
HRP20020240B1 HR20020240A HRP20020240A HRP20020240B1 HR P20020240 B1 HRP20020240 B1 HR P20020240B1 HR 20020240 A HR20020240 A HR 20020240A HR P20020240 A HRP20020240 A HR P20020240A HR P20020240 B1 HRP20020240 B1 HR P20020240B1
Authority
HR
Croatia
Prior art keywords
aryl
alkyl
cycloalkyl
alkylaryl
antibiotic
Prior art date
Application number
HR20020240A
Other languages
English (en)
Inventor
Vogt Sebastian
Schnabelrauch Matthias
K�hn Klaus-Dieter
Original Assignee
Heraeus Kulzer Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Kulzer Gmbh & Co. Kg filed Critical Heraeus Kulzer Gmbh & Co. Kg
Publication of HRP20020240A2 publication Critical patent/HRP20020240A2/hr
Publication of HRP20020240B1 publication Critical patent/HRP20020240B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
HR20020240A 2001-03-22 2002-03-21 Sustained release preparation comprising one or mo HRP20020240B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10114244A DE10114244A1 (de) 2001-03-22 2001-03-22 Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung

Publications (2)

Publication Number Publication Date
HRP20020240A2 HRP20020240A2 (en) 2002-12-31
HRP20020240B1 true HRP20020240B1 (en) 2005-04-30

Family

ID=7678691

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020240A HRP20020240B1 (en) 2001-03-22 2002-03-21 Sustained release preparation comprising one or mo

Country Status (32)

Country Link
US (1) US6913764B2 (ru)
EP (1) EP1243257B1 (ru)
JP (1) JP4181331B2 (ru)
CN (1) CN100486589C (ru)
AT (1) ATE258431T1 (ru)
AU (1) AU768962B2 (ru)
BG (1) BG65467B1 (ru)
BR (1) BR0200876A (ru)
CA (1) CA2378490C (ru)
CZ (1) CZ302690B6 (ru)
DE (2) DE10114244A1 (ru)
DK (1) DK1243257T3 (ru)
EE (1) EE200200153A (ru)
ES (1) ES2213717T3 (ru)
GE (1) GEP20053447B (ru)
HR (1) HRP20020240B1 (ru)
HU (1) HUP0201045A2 (ru)
IL (1) IL148703A (ru)
IS (2) IS2501B (ru)
MD (1) MD2550C2 (ru)
MX (1) MXPA02003007A (ru)
NO (1) NO331876B1 (ru)
NZ (1) NZ517922A (ru)
PL (1) PL204986B1 (ru)
PT (1) PT1243257E (ru)
RU (1) RU2264230C2 (ru)
SA (1) SA02230037B1 (ru)
SK (1) SK286493B6 (ru)
TR (1) TR200400244T4 (ru)
UA (1) UA71030C2 (ru)
YU (1) YU11802A (ru)
ZA (1) ZA200202254B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung
DE10114245A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung
DE10318991A1 (de) * 2003-04-25 2004-11-18 Heraeus Kulzer Gmbh & Co. Kg Poröser Körper mit antibiotischer Beschichtung, Verfahren zur Herstellung sowie Verwendung
EP1694712A1 (en) * 2003-12-04 2006-08-30 University of Utah Research Foundation Modified macromolecules and methods of making and using thereof
AU2005325213B2 (en) 2004-08-04 2010-10-07 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
DE102004060666B3 (de) 2004-12-15 2006-03-30 Heraeus Kulzer Gmbh Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung
DE102005002703C5 (de) * 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
JP5426168B2 (ja) * 2005-10-27 2014-02-26 トーメン メディカル アーゲー 歯科インプラント及びその製造方法
ES2507552T3 (es) * 2005-10-27 2014-10-15 Nexilis Ag Implante que contiene amino-bisfosfonatos y procedimiento para su producción
WO2007056667A2 (en) * 2005-11-04 2007-05-18 Rush University Medical Center Plastic implant impregnated with an antibiotic
DE102006007245A1 (de) 2006-02-15 2007-08-23 Heraeus Kulzer Gmbh Implantatmaterial
DE102006037362B3 (de) * 2006-08-09 2007-09-20 Heraeus Kulzer Gmbh Knochenersatzmaterial
WO2009015197A1 (en) * 2007-07-24 2009-01-29 University Of Memphis Research Foundation Local delivery method and composition
DE102007039871A1 (de) 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Weichgewebe-Implantat mit antibakterieller Wirkung
JP5502751B2 (ja) 2007-12-20 2014-05-28 エボニック コーポレイション 低残留溶媒濃度を有する微粒子を調製するためのプロセス
CN101758337B (zh) * 2009-12-03 2012-02-15 湖南阿斯达生化科技有限公司 一种助焊剂用非卤素活性剂
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
EA202090748A1 (ru) * 2017-06-16 2020-08-11 Борис Славинович ФАРБЕР Биологически активные комбинаторные производные полисахаридов
WO2019010447A1 (en) 2017-07-07 2019-01-10 Epicentrx, Inc. COMPOSITIONS FOR PARENTERAL ADMINISTRATION OF THERAPEUTIC AGENTS
IL256312A (en) * 2017-12-14 2018-01-31 Omrix Biopharmaceuticals Ltd Antibacterial preparations containing minocycline and oxidized cellulose

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US356759A (en) * 1887-02-01 Paul gmehlikt
US3091572A (en) * 1962-07-16 1963-05-28 Schering Corp Gentamycin and method of production
GB1120992A (en) * 1965-04-24 1968-07-24 Fisons Pharmaceuticals Ltd Aerosol compositions
ES315101A1 (es) 1965-07-08 1966-01-01 Folch Vazquez Conrado Procedimiento de preparaciën de nuevos derivados de tetraciclina
FR6476M (ru) 1967-06-06 1968-11-18
DE2320373B2 (de) * 1973-04-21 1978-04-06 Merck Patent Gmbh, 6100 Darmstadt Antibioticahaltiges Mittel und seine Verwendung als chirurgisches Kunststoffmaterial
FR2272680B1 (ru) * 1974-05-29 1978-07-21 Hosbon Sa Lab
DE2511122B2 (de) * 1975-03-14 1977-06-08 Vorprodukt fuer die zubereitung von knochenzement
AR216922A1 (es) * 1976-11-11 1980-02-15 Merck Patent Gmbh Procedimiento para la fabricacion de un medio quirurgico
JPS5391113A (en) * 1977-01-21 1978-08-10 Meiji Seika Kaisha Ltd Preparation of suppository of antibiotics
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
DE3168032D1 (en) * 1980-11-10 1985-02-14 Alza Corp Erodible polymer containing erosion rate modifier
DE3206725A1 (de) * 1981-05-13 1982-12-02 Merck Patent Gmbh, 6100 Darmstadt Schwer loesliche salze von aminoglykosidantibiotika
DE3248328A1 (de) * 1982-12-28 1984-06-28 Bayer Ag, 5090 Leverkusen Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe
US5035891A (en) * 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
US5709875A (en) * 1990-10-26 1998-01-20 Centre National De La Rechierche Scientifique (C.N.R.S) Implantable biodegradable material and process for its production
FR2668367B1 (fr) * 1990-10-26 1994-05-13 Centre Nal Recherc Scientifique Medicament implantable a effet prolonge.
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DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung

Also Published As

Publication number Publication date
NO20021390L (no) 2002-09-23
JP2002322097A (ja) 2002-11-08
AU2755402A (en) 2002-09-26
SA02230037B1 (ar) 2007-04-15
US20020182251A1 (en) 2002-12-05
ES2213717T3 (es) 2004-09-01
DE50200223D1 (de) 2004-03-04
BG106454A (en) 2002-10-31
ZA200202254B (en) 2002-10-10
IS6270A (is) 2002-09-22
IL148703A0 (en) 2002-11-10
BR0200876A (pt) 2003-03-11
CN100486589C (zh) 2009-05-13
DE10114244A1 (de) 2002-10-02
SK3892002A3 (en) 2002-10-08
MXPA02003007A (es) 2003-08-20
CZ302690B6 (cs) 2011-09-07
MD20020075A (en) 2002-11-30
RU2264230C2 (ru) 2005-11-20
CZ2002871A3 (cs) 2002-11-13
HUP0201045A2 (hu) 2003-02-28
NO331876B1 (no) 2012-04-23
EE200200153A (et) 2002-12-16
HU0201045D0 (ru) 2002-05-29
SK286493B6 (sk) 2008-11-06
CA2378490A1 (en) 2002-09-22
US6913764B2 (en) 2005-07-05
AU768962B2 (en) 2004-01-08
HRP20020240A2 (en) 2002-12-31
YU11802A (sh) 2004-12-31
DK1243257T3 (da) 2004-05-10
UA71030C2 (ru) 2004-11-15
EP1243257B1 (de) 2004-01-28
NO20021390D0 (no) 2002-03-20
ATE258431T1 (de) 2004-02-15
TR200400244T4 (tr) 2004-04-21
PT1243257E (pt) 2004-06-30
PL352920A1 (en) 2002-09-23
BG65467B1 (bg) 2008-09-30
CN1376469A (zh) 2002-10-30
PL204986B1 (pl) 2010-02-26
EP1243257A1 (de) 2002-09-25
NZ517922A (en) 2003-08-29
IL148703A (en) 2006-07-05
IS2501B (is) 2009-03-15
IS6269A (is) 2002-09-22
GEP20053447B (en) 2005-02-25
MD2550C2 (ru) 2005-04-30
CA2378490C (en) 2008-05-13
MD2550B2 (en) 2004-09-30
JP4181331B2 (ja) 2008-11-12

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