HRP20010969B1 - Novel piperazinylalkylthiopyrimidine derivatives, - Google Patents
Novel piperazinylalkylthiopyrimidine derivatives,Info
- Publication number
- HRP20010969B1 HRP20010969B1 HR20010969A HRP20010969A HRP20010969B1 HR P20010969 B1 HRP20010969 B1 HR P20010969B1 HR 20010969 A HR20010969 A HR 20010969A HR P20010969 A HRP20010969 A HR P20010969A HR P20010969 B1 HRP20010969 B1 HR P20010969B1
- Authority
- HR
- Croatia
- Prior art keywords
- derivatives
- piperazinylalkylthiopyrimidine derivatives
- novel
- novel piperazinylalkylthiopyrimidine
- preparing
- Prior art date
Links
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902214A HU9902214D0 (en) | 1999-06-29 | 1999-06-29 | Novel piperazinyl-alkyl-thio-pyrimidine-derivatives, process for producing them and medicaments containing the same |
| HU0002156A HU227402B1 (en) | 2000-06-06 | 2000-06-06 | Novel piperazinyl alkylthio pyrimidinyl derivatives, pharmaceutical compositions containing such active ingredients and process for producing the active ingredients |
| PCT/HU2000/000064 WO2001000617A2 (en) | 1999-06-29 | 2000-06-29 | Novel piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20010969A2 HRP20010969A2 (en) | 2003-04-30 |
| HRP20010969B1 true HRP20010969B1 (en) | 2005-04-30 |
Family
ID=89998587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010969A HRP20010969B1 (en) | 1999-06-29 | 2001-12-28 | Novel piperazinylalkylthiopyrimidine derivatives, |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6469168B1 (sk) |
| EP (1) | EP1194415B1 (sk) |
| JP (1) | JP2003503404A (sk) |
| KR (1) | KR20020016872A (sk) |
| CN (1) | CN1173956C (sk) |
| AT (1) | ATE247645T1 (sk) |
| AU (1) | AU5835400A (sk) |
| CA (1) | CA2376307A1 (sk) |
| CZ (1) | CZ20014575A3 (sk) |
| DE (1) | DE60004671T2 (sk) |
| DK (1) | DK1194415T3 (sk) |
| ES (1) | ES2204643T3 (sk) |
| HK (1) | HK1046902A1 (sk) |
| HR (1) | HRP20010969B1 (sk) |
| PL (1) | PL352476A1 (sk) |
| PT (1) | PT1194415E (sk) |
| RU (1) | RU2245334C2 (sk) |
| SK (1) | SK285670B6 (sk) |
| WO (1) | WO2001000617A2 (sk) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006502107A (ja) | 2002-07-02 | 2006-01-19 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｃｒ−３レセプターアンタゴニストｉｘとしての２，５−置換ピリミジン誘導体 |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| EP3549934A1 (en) | 2008-06-27 | 2019-10-09 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
| BR112013003388A2 (pt) * | 2010-08-10 | 2016-07-12 | Celgene Avilomics Res Inc | sal de besilato de um inibidor de btk |
| WO2012061303A1 (en) | 2010-11-01 | 2012-05-10 | Avila Therapeutics, Inc. | Heteroaryl compounds and uses thereof |
| JP5957460B2 (ja) | 2010-11-01 | 2016-07-27 | セルジーン アヴィロミクス リサーチ， インコーポレイテッド | 複素環式化合物またはその使用 |
| US8796255B2 (en) | 2010-11-10 | 2014-08-05 | Celgene Avilomics Research, Inc | Mutant-selective EGFR inhibitors and uses thereof |
| AR088570A1 (es) | 2011-10-28 | 2014-06-18 | Celgene Avilomics Res Inc | Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton |
| WO2013138495A1 (en) | 2012-03-15 | 2013-09-19 | Celgene Avilomics Research, Inc. | Solid forms of an epidermal growth factor receptor kinase inhibitor |
| CN104284584B (zh) | 2012-03-15 | 2019-06-04 | 西建卡尔有限责任公司 | 表皮生长因子受体激酶抑制剂的盐 |
| US9126950B2 (en) | 2012-12-21 | 2015-09-08 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US9145387B2 (en) | 2013-02-08 | 2015-09-29 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP3179858B1 (en) | 2014-08-13 | 2019-05-15 | Celgene Car Llc | Forms and compositions of an erk inhibitor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT76266A (en) * | 1995-10-31 | 1997-07-28 | Egyt Gyogyszervegyeszeti Gyar | New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components |
-
2000
- 2000-06-29 US US10/009,675 patent/US6469168B1/en not_active Expired - Fee Related
- 2000-06-29 PL PL00352476A patent/PL352476A1/xx unknown
- 2000-06-29 DK DK00944119T patent/DK1194415T3/da active
- 2000-06-29 EP EP00944119A patent/EP1194415B1/en not_active Expired - Lifetime
- 2000-06-29 KR KR1020017016917A patent/KR20020016872A/ko not_active Application Discontinuation
- 2000-06-29 CZ CZ20014575A patent/CZ20014575A3/cs unknown
- 2000-06-29 WO PCT/HU2000/000064 patent/WO2001000617A2/en not_active Application Discontinuation
- 2000-06-29 RU RU2002102551/04A patent/RU2245334C2/ru not_active IP Right Cessation
- 2000-06-29 CN CNB008096635A patent/CN1173956C/zh not_active Expired - Fee Related
- 2000-06-29 SK SK1927-2001A patent/SK285670B6/sk unknown
- 2000-06-29 AT AT00944119T patent/ATE247645T1/de not_active IP Right Cessation
- 2000-06-29 ES ES00944119T patent/ES2204643T3/es not_active Expired - Lifetime
- 2000-06-29 PT PT00944119T patent/PT1194415E/pt unknown
- 2000-06-29 JP JP2001507025A patent/JP2003503404A/ja active Pending
- 2000-06-29 CA CA002376307A patent/CA2376307A1/en not_active Abandoned
- 2000-06-29 DE DE60004671T patent/DE60004671T2/de not_active Expired - Fee Related
- 2000-06-29 AU AU58354/00A patent/AU5835400A/en not_active Abandoned
-
2001
- 2001-12-28 HR HR20010969A patent/HRP20010969B1/xx not_active IP Right Cessation
-
2002
- 2002-10-10 HK HK02107406.1A patent/HK1046902A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1046902A1 (zh) | 2003-01-30 |
| CN1359375A (zh) | 2002-07-17 |
| EP1194415A2 (en) | 2002-04-10 |
| CZ20014575A3 (cs) | 2002-04-17 |
| DK1194415T3 (da) | 2003-12-08 |
| RU2245334C2 (ru) | 2005-01-27 |
| EP1194415B1 (en) | 2003-08-20 |
| JP2003503404A (ja) | 2003-01-28 |
| WO2001000617A3 (en) | 2001-03-01 |
| KR20020016872A (ko) | 2002-03-06 |
| ES2204643T3 (es) | 2004-05-01 |
| WO2001000617A2 (en) | 2001-01-04 |
| DE60004671T2 (de) | 2004-07-29 |
| PL352476A1 (en) | 2003-08-25 |
| CN1173956C (zh) | 2004-11-03 |
| ATE247645T1 (de) | 2003-09-15 |
| SK285670B6 (sk) | 2007-06-07 |
| PT1194415E (pt) | 2004-01-30 |
| AU5835400A (en) | 2001-01-31 |
| DE60004671D1 (de) | 2003-09-25 |
| HRP20010969A2 (en) | 2003-04-30 |
| CA2376307A1 (en) | 2001-01-04 |
| US6469168B1 (en) | 2002-10-22 |
| SK19272001A3 (sk) | 2002-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20070608 Year of fee payment: 8 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20080630 |