HRP20010581A2 - Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy - Google Patents
Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy Download PDFInfo
- Publication number
- HRP20010581A2 HRP20010581A2 HR20010581A HRP20010581A HRP20010581A2 HR P20010581 A2 HRP20010581 A2 HR P20010581A2 HR 20010581 A HR20010581 A HR 20010581A HR P20010581 A HRP20010581 A HR P20010581A HR P20010581 A2 HRP20010581 A2 HR P20010581A2
- Authority
- HR
- Croatia
- Prior art keywords
- acetic acid
- cyclohexyl
- methyl
- acid hydrochloride
- dimethyl
- Prior art date
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- 206010012689 Diabetic retinopathy Diseases 0.000 title claims description 24
- 230000001419 dependent effect Effects 0.000 title claims description 11
- 238000011282 treatment Methods 0.000 title description 23
- 150000005693 branched-chain amino acids Chemical class 0.000 title description 10
- 239000002380 aminotransferase inhibitor Substances 0.000 title 1
- -1 alkoxyakanoyl Chemical group 0.000 claims description 217
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 130
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 71
- 150000001875 compounds Chemical class 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 57
- 125000000217 alkyl group Chemical group 0.000 claims description 55
- 239000001257 hydrogen Substances 0.000 claims description 54
- 229910052739 hydrogen Inorganic materials 0.000 claims description 54
- 150000003839 salts Chemical class 0.000 claims description 38
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 36
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 31
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 24
- MJEPQHYIBKJJGY-SCLLHFNJSA-N 2-[(3r,4r)-1-(aminomethyl)-3,4-dimethylcyclopentyl]acetic acid;hydrochloride Chemical compound Cl.C[C@@H]1CC(CN)(CC(O)=O)C[C@H]1C MJEPQHYIBKJJGY-SCLLHFNJSA-N 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 18
- 125000003545 alkoxy group Chemical group 0.000 claims description 18
- 150000002431 hydrogen Chemical group 0.000 claims description 18
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 15
- 239000000651 prodrug Substances 0.000 claims description 14
- 229940002612 prodrug Drugs 0.000 claims description 14
- 150000001408 amides Chemical class 0.000 claims description 11
- 150000002148 esters Chemical class 0.000 claims description 11
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 9
- 108090000340 Transaminases Proteins 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- BKJQWMWKPIBKSG-SATBOSKTSA-N 2-[(1r,3r)-1-[(benzylamino)methyl]-3-methylcyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C1[C@H](C)CCC[C@@]1(CC(O)=O)CNCC1=CC=CC=C1 BKJQWMWKPIBKSG-SATBOSKTSA-N 0.000 claims description 7
- UZUFIGDGZIJVDW-KQKCUOLZSA-N 2-[(1r,3r)-1-[[benzyl(methyl)amino]methyl]-3-methylcyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C1[C@H](C)CCC[C@@]1(CC(O)=O)CN(C)CC1=CC=CC=C1 UZUFIGDGZIJVDW-KQKCUOLZSA-N 0.000 claims description 7
- ICGWGQBMEQWUFY-UHFFFAOYSA-N 2-[1-[[benzyl(methyl)amino]methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C1CCCCC1(CC(O)=O)CN(C)CC1=CC=CC=C1 ICGWGQBMEQWUFY-UHFFFAOYSA-N 0.000 claims description 7
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 7
- 229910052717 sulfur Inorganic materials 0.000 claims description 7
- JRQZCSUTLFGVDN-FOKYBFFNSA-N 2-[(1r,3r)-3-methyl-1-(methylaminomethyl)cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.CNC[C@]1(CC(O)=O)CCC[C@@H](C)C1 JRQZCSUTLFGVDN-FOKYBFFNSA-N 0.000 claims description 6
- HXXUCJKOJLEMTF-LBFSWCQCSA-N 2-[(3s,5r)-1-[(1-hydroxypropan-2-ylamino)methyl]-3,5-dimethylcyclohexyl]acetic acid;hydrochloride Chemical compound Cl.OCC(C)NCC1(CC(O)=O)C[C@@H](C)C[C@@H](C)C1 HXXUCJKOJLEMTF-LBFSWCQCSA-N 0.000 claims description 6
- NQVMYZRNWLBULH-OWYYFDEQSA-N 2-[(3s,5r)-1-[(2,2-dimethoxyethylamino)methyl]-3,5-dimethylcyclohexyl]acetic acid;hydrochloride Chemical compound Cl.COC(OC)CNCC1(CC(O)=O)C[C@@H](C)C[C@@H](C)C1 NQVMYZRNWLBULH-OWYYFDEQSA-N 0.000 claims description 6
- KBKKSZPQSOQSMA-FHNZKSGLSA-N 2-[(3s,5r)-1-[(cyclohexylmethylamino)methyl]-3,5-dimethylcyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C1[C@@H](C)C[C@@H](C)CC1(CC(O)=O)CNCC1CCCCC1 KBKKSZPQSOQSMA-FHNZKSGLSA-N 0.000 claims description 6
- KQQKWYFMLOGLLF-VPJPYYBTSA-N 2-[(3s,5r)-1-[(cyclopentylmethylamino)methyl]-3,5-dimethylcyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C1[C@@H](C)C[C@@H](C)CC1(CC(O)=O)CNCC1CCCC1 KQQKWYFMLOGLLF-VPJPYYBTSA-N 0.000 claims description 6
- YOQXGAFDZDLYSI-OEVGOWPCSA-N 2-[(3s,5r)-3,5-dimethyl-1-[(2-methylbutylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.CCC(C)CNCC1(CC(O)=O)C[C@@H](C)C[C@@H](C)C1 YOQXGAFDZDLYSI-OEVGOWPCSA-N 0.000 claims description 6
- FNUJAQMRFKOBKB-UHFFFAOYSA-N 2-[1-(acetamidomethyl)cyclohexyl]acetic acid Chemical compound CC(=O)NCC1(CC(O)=O)CCCCC1 FNUJAQMRFKOBKB-UHFFFAOYSA-N 0.000 claims description 6
- VBNXHSMULMVTGY-UHFFFAOYSA-N 2-[1-(aminomethyl)-4-ethylcyclohexyl]acetic acid;hydrochloride Chemical compound [Cl-].CCC1CCC(C[NH3+])(CC(O)=O)CC1 VBNXHSMULMVTGY-UHFFFAOYSA-N 0.000 claims description 6
- CCVRKZXBOLVGEO-UHFFFAOYSA-N 2-[1-(aminomethyl)-4-propylcyclohexyl]acetic acid hydrochloride Chemical compound Cl.NCC1(CCC(CC1)CCC)CC(=O)O CCVRKZXBOLVGEO-UHFFFAOYSA-N 0.000 claims description 6
- YCXOQRUZIRXNMS-UHFFFAOYSA-N 2-[1-(butylaminomethyl)cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.CCCCNCC1(CC(O)=O)CCCCC1 YCXOQRUZIRXNMS-UHFFFAOYSA-N 0.000 claims description 6
- GOFLBJHIYWXDGM-UHFFFAOYSA-N 2-[1-(ethylaminomethyl)cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.CCNCC1(CC(O)=O)CCCCC1 GOFLBJHIYWXDGM-UHFFFAOYSA-N 0.000 claims description 6
- LVFFKDSXOQLRSU-UHFFFAOYSA-N 2-[1-(methylaminomethyl)cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.CNCC1(CC(O)=O)CCCCC1 LVFFKDSXOQLRSU-UHFFFAOYSA-N 0.000 claims description 6
- RWNNSDSOAUSDGI-UHFFFAOYSA-N 2-[1-[(1-hydroxypropan-2-ylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.OCC(C)NCC1(CC(O)=O)CCCCC1 RWNNSDSOAUSDGI-UHFFFAOYSA-N 0.000 claims description 6
- DSPSOTCZFLZQQB-UHFFFAOYSA-N 2-[1-[(2,2-dimethoxyethylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.COC(OC)CNCC1(CC(O)=O)CCCCC1 DSPSOTCZFLZQQB-UHFFFAOYSA-N 0.000 claims description 6
- AEXUIPUQQWBSPQ-UHFFFAOYSA-N 2-[1-[(2-methylbutylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.CCC(C)CNCC1(CC(O)=O)CCCCC1 AEXUIPUQQWBSPQ-UHFFFAOYSA-N 0.000 claims description 6
- AXYYQYGGFQFOAF-UHFFFAOYSA-N 2-[1-[(2-methylpropylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.CC(C)CNCC1(CC(O)=O)CCCCC1 AXYYQYGGFQFOAF-UHFFFAOYSA-N 0.000 claims description 6
- HODGFTBMXWIXAO-UHFFFAOYSA-N 2-[1-[(2-phenylethylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C=1C=CC=CC=1CCNCC1(CC(=O)O)CCCCC1 HODGFTBMXWIXAO-UHFFFAOYSA-N 0.000 claims description 6
- HEDVELUZJVNGHQ-UHFFFAOYSA-N 2-[1-[(3-phenylpropylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C=1C=CC=CC=1CCCNCC1(CC(=O)O)CCCCC1 HEDVELUZJVNGHQ-UHFFFAOYSA-N 0.000 claims description 6
- SJLGNGOOIJNHDH-UHFFFAOYSA-N 2-[1-[(4,4,4-trifluorobutylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.FC(F)(F)CCCNCC1(CC(=O)O)CCCCC1 SJLGNGOOIJNHDH-UHFFFAOYSA-N 0.000 claims description 6
- MVNINPHAJCAMTL-UHFFFAOYSA-N 2-[1-[(benzylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C=1C=CC=CC=1CNCC1(CC(=O)O)CCCCC1 MVNINPHAJCAMTL-UHFFFAOYSA-N 0.000 claims description 6
- UFJIPTKJUVSAQT-UHFFFAOYSA-N 2-[1-[(cyclobutylmethylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C1CCC1CNCC1(CC(=O)O)CCCCC1 UFJIPTKJUVSAQT-UHFFFAOYSA-N 0.000 claims description 6
- WTUQDYYGCCWDBW-UHFFFAOYSA-N 2-[1-[(cyclohexylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C1CCCCC1NCC1(CC(=O)O)CCCCC1 WTUQDYYGCCWDBW-UHFFFAOYSA-N 0.000 claims description 6
- OEAKKHOQGHHQIV-UHFFFAOYSA-N 2-[1-[(cyclohexylmethylamino)methyl]cyclohexyl]acetic acid hydrochloride Chemical compound Cl.C1(CCCCC1)CNCC1(CCCCC1)CC(=O)O OEAKKHOQGHHQIV-UHFFFAOYSA-N 0.000 claims description 6
- KBHTUCXAJTXPPO-UHFFFAOYSA-N 2-[1-[(cyclopropylmethylamino)methyl]cyclohexyl]acetic acid;hydrochloride Chemical compound Cl.C1CC1CNCC1(CC(=O)O)CCCCC1 KBHTUCXAJTXPPO-UHFFFAOYSA-N 0.000 claims description 6
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- WRJMVUCUIPZLCD-UHFFFAOYSA-N 2-[1-(aminomethyl)-3,3-dimethylcyclohexyl]acetic acid;hydrochloride Chemical compound Cl.CC1(C)CCCC(CN)(CC(O)=O)C1 WRJMVUCUIPZLCD-UHFFFAOYSA-N 0.000 claims description 5
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- BKTLFFVJGHKKSO-UHFFFAOYSA-N 2-[1-[(prop-2-ynylamino)methyl]cyclohexyl]acetic acid Chemical compound C#CCNCC1(CC(=O)O)CCCCC1 BKTLFFVJGHKKSO-UHFFFAOYSA-N 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
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- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/11—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16963599P | 1999-12-08 | 1999-12-08 | |
US17539900P | 2000-01-11 | 2000-01-11 | |
US23002000P | 2000-09-05 | 2000-09-05 | |
PCT/US2000/030769 WO2001042191A1 (fr) | 1999-12-08 | 2000-11-08 | Inhibiteurs d'aminotransferase acides amines-dependante a chaine ramifiee, et leur utilisation dans le cadre du traitement de la retinopathie diabetique |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20010581A2 true HRP20010581A2 (en) | 2002-08-31 |
Family
ID=27389690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20010581A HRP20010581A2 (en) | 1999-12-08 | 2001-08-03 | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy |
Country Status (33)
Country | Link |
---|---|
EP (1) | EP1157000B1 (fr) |
JP (1) | JP2003516379A (fr) |
KR (1) | KR20010101811A (fr) |
CN (2) | CN1626069A (fr) |
AP (1) | AP2001002242A0 (fr) |
AR (1) | AR037738A1 (fr) |
AT (1) | ATE308510T1 (fr) |
AU (1) | AU784553B2 (fr) |
BG (1) | BG105875A (fr) |
BR (1) | BR0008443A (fr) |
CA (1) | CA2361647A1 (fr) |
CO (1) | CO5280055A1 (fr) |
CZ (1) | CZ20012758A3 (fr) |
DE (1) | DE60023657T2 (fr) |
DZ (1) | DZ3141A1 (fr) |
EA (1) | EA006597B1 (fr) |
EE (1) | EE200100416A (fr) |
ES (1) | ES2252075T3 (fr) |
GE (1) | GEP20043298B (fr) |
HK (1) | HK1044933B (fr) |
HR (1) | HRP20010581A2 (fr) |
HU (1) | HUP0200570A3 (fr) |
IS (1) | IS6033A (fr) |
MA (1) | MA26777A1 (fr) |
MX (1) | MXPA01008085A (fr) |
NO (1) | NO20013844L (fr) |
OA (1) | OA11759A (fr) |
PE (1) | PE20010929A1 (fr) |
PL (1) | PL349193A1 (fr) |
SK (1) | SK11022001A3 (fr) |
UY (1) | UY26474A1 (fr) |
WO (1) | WO2001042191A1 (fr) |
YU (1) | YU57401A (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
AU2002310409C1 (en) * | 2001-06-11 | 2008-04-17 | Xenoport, Inc. | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
MXPA02010430A (es) * | 2001-11-27 | 2003-06-02 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
DE602004010135T2 (de) * | 2004-09-20 | 2008-09-04 | Kao Corp. | Verfahren zur Herstellung von Lactonen und deren Verwendung als Geruchsstoffe |
EP1811986B1 (fr) | 2004-11-04 | 2014-03-26 | XenoPort, Inc. | Formes posologiques orales a liberation prolongee d'un promedicament de la gabapentine |
WO2008103319A2 (fr) * | 2007-02-16 | 2008-08-28 | Ark Diagnostics, Inc. | Composés et procédés destinés à être utilisés dans la détection de la gabapentine |
WO2008155619A2 (fr) * | 2007-06-21 | 2008-12-24 | Pfizer Inc. | Préparation d'acides aminés cycliques optiquement actifs |
EP2383255A1 (fr) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | Nouveaux composés, synthèse et utilisation dans le traitement de la douleur |
EP2481801A1 (fr) | 2011-01-28 | 2012-08-01 | Deutsches Krebsforschungszentrum | Inhibiteurs d'aminotransférase-1 (BCAT1) à chaîne branchée pour le traitement de la néoplasie |
US10941109B2 (en) | 2011-06-13 | 2021-03-09 | Ergon Pharmaceuticals Llc | Compositions and methods of treatment using a BCAT1 inhibitor |
JP6053768B2 (ja) * | 2011-06-13 | 2016-12-27 | エルゴン ファーマシューティカルズ エルエルシー | Bcat1阻害剤を使用する治療方法 |
CN113694202B (zh) * | 2020-06-29 | 2023-03-31 | 江苏省中医院 | Ass1或bckdk抑制剂在制备治疗溃疡性结肠炎的药物中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2167717T3 (es) * | 1996-03-14 | 2002-05-16 | Warner Lambert Co | Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos. |
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- 2000-11-08 EP EP00977094A patent/EP1157000B1/fr not_active Expired - Lifetime
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2001
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