HRP20000703B1 - Stabile compositions levosimendan and alginic acid - Google Patents

Stabile compositions levosimendan and alginic acid

Info

Publication number
HRP20000703B1
HRP20000703B1 HR20000703A HRP20000703A HRP20000703B1 HR P20000703 B1 HRP20000703 B1 HR P20000703B1 HR 20000703 A HR20000703 A HR 20000703A HR P20000703 A HRP20000703 A HR P20000703A HR P20000703 B1 HRP20000703 B1 HR P20000703B1
Authority
HR
Croatia
Prior art keywords
levosimendan
alginic acid
stabile
compositions
stabile compositions
Prior art date
Application number
HR20000703A
Other languages
English (en)
Croatian (hr)
Inventor
Larma Ilkka
Backman Maarit
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of HRP20000703A2 publication Critical patent/HRP20000703A2/hr
Publication of HRP20000703B1 publication Critical patent/HRP20000703B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
HR20000703A 1998-04-23 2000-10-19 Stabile compositions levosimendan and alginic acid HRP20000703B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI980902A FI980902A (fi) 1998-04-23 1998-04-23 Levosimendaanin stabiileja koostumuksia
PCT/FI1999/000331 WO1999055337A1 (en) 1998-04-23 1999-04-23 Stabile compositions comprising levosimendan and alginic acid

Publications (2)

Publication Number Publication Date
HRP20000703A2 HRP20000703A2 (en) 2001-04-30
HRP20000703B1 true HRP20000703B1 (en) 2009-11-30

Family

ID=8551576

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000703A HRP20000703B1 (en) 1998-04-23 2000-10-19 Stabile compositions levosimendan and alginic acid

Country Status (33)

Country Link
US (1) US6531458B1 (zh)
EP (1) EP1079834B1 (zh)
JP (1) JP4475809B2 (zh)
KR (1) KR100590622B1 (zh)
CN (1) CN1165309C (zh)
AT (1) ATE231395T1 (zh)
AU (1) AU756338B2 (zh)
BG (1) BG64766B1 (zh)
BR (1) BR9909867A (zh)
CA (1) CA2329232C (zh)
CZ (1) CZ290911B6 (zh)
DE (1) DE69905034T2 (zh)
DK (1) DK1079834T3 (zh)
EA (1) EA002428B1 (zh)
EE (1) EE04143B1 (zh)
ES (1) ES2191426T3 (zh)
FI (1) FI980902A (zh)
GE (1) GEP20032942B (zh)
HK (1) HK1031998A1 (zh)
HR (1) HRP20000703B1 (zh)
HU (1) HUP0105446A3 (zh)
ID (1) ID26650A (zh)
IL (2) IL138950A0 (zh)
MX (1) MXPA00010368A (zh)
NO (1) NO318575B1 (zh)
NZ (1) NZ507455A (zh)
PL (1) PL192274B1 (zh)
PT (1) PT1079834E (zh)
RS (1) RS49955B (zh)
SK (1) SK284600B6 (zh)
TR (1) TR200003101T2 (zh)
WO (1) WO1999055337A1 (zh)
ZA (1) ZA200005630B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI980901A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
JPWO2002064120A1 (ja) * 2001-02-13 2004-06-10 大正製薬株式会社 内服ゲル製剤
US20080194567A1 (en) * 2005-03-14 2008-08-14 Piero Pollesello Combination Treatment for Enhancing Diuresis
PL3370693T3 (pl) * 2015-11-06 2020-07-13 Carinopharm Gmbh Ulepszone preparaty lewosimendanu do podawania dożylnego w postaci roztworów do wlewów lub wstrzykiwań i koncentratu do wlewów
AU2020408323A1 (en) 2019-12-16 2022-08-11 Tenax Therapeutics, Inc. Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HF-pEF)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091767A2 (en) * 1982-04-05 1983-10-19 Merck Sharp & Dohme Ltd. Stabilization of unstable drugs or food supplements
US4716042A (en) * 1986-06-16 1987-12-29 American Home Products Corporation Stabilized coated aspirin tablets
WO1992012135A1 (en) * 1991-01-03 1992-07-23 Orion-Yhtymä Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
WO1998001111A1 (en) * 1996-07-05 1998-01-15 Orion-Yhtymä Oy Transdermal compositions containing levosimendan
WO1999016443A1 (en) * 1997-09-26 1999-04-08 Orion Corporation Oral compositions of levosimendan

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1509866A (en) 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
EP0123291A2 (en) 1983-04-20 1984-10-31 Kyowa Hakko Kogyo Co., Ltd. Method for stabilizing interferon
US4906630A (en) * 1985-11-22 1990-03-06 Rorer Pharmaceutical Corporation Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2266841A (en) 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091767A2 (en) * 1982-04-05 1983-10-19 Merck Sharp & Dohme Ltd. Stabilization of unstable drugs or food supplements
US4716042A (en) * 1986-06-16 1987-12-29 American Home Products Corporation Stabilized coated aspirin tablets
WO1992012135A1 (en) * 1991-01-03 1992-07-23 Orion-Yhtymä Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
WO1998001111A1 (en) * 1996-07-05 1998-01-15 Orion-Yhtymä Oy Transdermal compositions containing levosimendan
WO1999016443A1 (en) * 1997-09-26 1999-04-08 Orion Corporation Oral compositions of levosimendan

Also Published As

Publication number Publication date
CN1165309C (zh) 2004-09-08
RS49955B (sr) 2008-09-29
ATE231395T1 (de) 2003-02-15
HUP0105446A2 (hu) 2002-07-29
FI980902A (fi) 1999-10-24
WO1999055337A1 (en) 1999-11-04
SK284600B6 (sk) 2005-07-01
NO20005312L (no) 2000-11-21
EP1079834A1 (en) 2001-03-07
KR20010072577A (ko) 2001-07-31
BG64766B1 (bg) 2006-03-31
FI980902A0 (fi) 1998-04-23
TR200003101T2 (tr) 2001-01-22
HUP0105446A3 (en) 2002-09-30
JP4475809B2 (ja) 2010-06-09
EA002428B1 (ru) 2002-04-25
DE69905034D1 (de) 2003-02-27
IL138950A (en) 2006-08-20
AU756338B2 (en) 2003-01-09
HK1031998A1 (en) 2001-07-06
BR9909867A (pt) 2000-12-19
HRP20000703A2 (en) 2001-04-30
CZ290911B6 (cs) 2002-11-13
NZ507455A (en) 2002-02-01
PL192274B1 (pl) 2006-09-29
YU64000A (sh) 2002-12-10
DK1079834T3 (da) 2003-04-07
MXPA00010368A (es) 2002-07-02
CZ20003779A3 (en) 2001-05-16
CA2329232A1 (en) 1999-11-04
CN1298303A (zh) 2001-06-06
EP1079834B1 (en) 2003-01-22
EA200001097A1 (ru) 2001-04-23
DE69905034T2 (de) 2003-09-04
PT1079834E (pt) 2003-04-30
NO20005312D0 (no) 2000-10-20
EE200000616A (et) 2002-06-17
BG104958A (en) 2001-07-31
ES2191426T3 (es) 2003-09-01
GEP20032942B (en) 2003-04-25
JP2002512964A (ja) 2002-05-08
US6531458B1 (en) 2003-03-11
SK15552000A3 (sk) 2001-05-10
NO318575B1 (no) 2005-04-11
IL138950A0 (en) 2001-11-25
PL343722A1 (en) 2001-09-10
CA2329232C (en) 2007-10-30
ZA200005630B (en) 2002-01-14
AU3524899A (en) 1999-11-16
ID26650A (id) 2001-01-25
KR100590622B1 (ko) 2006-06-19
EE04143B1 (et) 2003-10-15

Similar Documents

Publication Publication Date Title
ES2184149T3 (es) Paclitaxeles 6-tio sustituidos.
DE69928938D1 (de) Neues cyclosporin mit verbesserter wirkung
DE69817208D1 (de) Saure, verdickte reinigungs- bzw. desinfektionszusammensetzung
EE04450B1 (et) Farmatseutilised kompositsioonid kahe või enama toimeainega aerosoolidele
EA199900373A2 (ru) Фармацевтические композиции
BR0112969A (pt) Método de utilização de dicetopiperazinas e composições contendo-as
HK1044349A1 (en) Compositions comprising 1,1,1,3,3-pentafluorobutane and use of said compositions.
RS50485B (sr) Terapeutske kombinacije koje sadrže amplodipin i atorvastatin
BR9710372B1 (pt) composto, e, composiÇço farmacÊutica.
ATE231872T1 (de) Thiazolopyrimidinderivate
HRP20010277B1 (en) Pharmaceutical composition comprising entacapone or nitecapone as well as a cross-linked cellulose derivative
DE69300694D1 (de) Desinfizierende Zusammensetzungen.
PT1121127E (pt) Composicoes farmaceuticas orais contendo buprenorfina
ES2180319T3 (es) Utilizacion de derivados de metilenbisoxazolidina y composiciones de los mismos.
HRP20000703B1 (en) Stabile compositions levosimendan and alginic acid
ES2132539T3 (es) Composiciones insecticidas sinergicas.
MXPA03011128A (es) Composicion de sabor y fragancia.
BR0116205A (pt) 2-piridonas antimicrobianas, suas composições e usos
BR9916537B1 (pt) composição de fragráncia, e, produto.
ES2192789T3 (es) Derivados de hidrazono-benzazuleno, composiciones farmaceuticas y compuestos intermedios.
ITTO20000371A0 (it) Composizioni pesticide.
RS50355B (sr) Formulacije eritropoietina sa više doza
MA26604A1 (fr) Compositions pharmaceutiques.
IT1307264B1 (it) Composizioni insetticide.
DK1011329T3 (da) 7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20100412

Year of fee payment: 12

PBON Lapse due to non-payment of renewal fee

Effective date: 20110424