BR9909867A - Composições estáveis contendo levosimendan e ácido algìnico - Google Patents

Composições estáveis contendo levosimendan e ácido algìnico

Info

Publication number
BR9909867A
BR9909867A BR9909867-9A BR9909867A BR9909867A BR 9909867 A BR9909867 A BR 9909867A BR 9909867 A BR9909867 A BR 9909867A BR 9909867 A BR9909867 A BR 9909867A
Authority
BR
Brazil
Prior art keywords
alginic acid
compositions containing
stable compositions
levosimendan
containing levosimendan
Prior art date
Application number
BR9909867-9A
Other languages
English (en)
Inventor
Ilkka Larma
Maarit Bockman
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of BR9909867A publication Critical patent/BR9909867A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

"COMPOSIçõES ESTáVEIS CONTENDO LEVOSIMENDAN E áCIDO ALGìNICO" A presente invenção se relaciona a composições de levosimendam que contêm ácido algínico para aprimorar a estabilidade do levosimendan nas composições. O Levosimendam é útil no tratamento da deficiência cardiáca congestiva.
BR9909867-9A 1998-04-23 1999-04-23 Composições estáveis contendo levosimendan e ácido algìnico BR9909867A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI980902A FI980902A (fi) 1998-04-23 1998-04-23 Levosimendaanin stabiileja koostumuksia
PCT/FI1999/000331 WO1999055337A1 (en) 1998-04-23 1999-04-23 Stabile compositions comprising levosimendan and alginic acid

Publications (1)

Publication Number Publication Date
BR9909867A true BR9909867A (pt) 2000-12-19

Family

ID=8551576

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909867-9A BR9909867A (pt) 1998-04-23 1999-04-23 Composições estáveis contendo levosimendan e ácido algìnico

Country Status (33)

Country Link
US (1) US6531458B1 (pt)
EP (1) EP1079834B1 (pt)
JP (1) JP4475809B2 (pt)
KR (1) KR100590622B1 (pt)
CN (1) CN1165309C (pt)
AT (1) ATE231395T1 (pt)
AU (1) AU756338B2 (pt)
BG (1) BG64766B1 (pt)
BR (1) BR9909867A (pt)
CA (1) CA2329232C (pt)
CZ (1) CZ290911B6 (pt)
DE (1) DE69905034T2 (pt)
DK (1) DK1079834T3 (pt)
EA (1) EA002428B1 (pt)
EE (1) EE04143B1 (pt)
ES (1) ES2191426T3 (pt)
FI (1) FI980902A (pt)
GE (1) GEP20032942B (pt)
HK (1) HK1031998A1 (pt)
HR (1) HRP20000703B1 (pt)
HU (1) HUP0105446A3 (pt)
ID (1) ID26650A (pt)
IL (2) IL138950A0 (pt)
MX (1) MXPA00010368A (pt)
NO (1) NO318575B1 (pt)
NZ (1) NZ507455A (pt)
PL (1) PL192274B1 (pt)
PT (1) PT1079834E (pt)
RS (1) RS49955B (pt)
SK (1) SK284600B6 (pt)
TR (1) TR200003101T2 (pt)
WO (1) WO1999055337A1 (pt)
ZA (1) ZA200005630B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI980901A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
WO2002064120A1 (fr) * 2001-02-13 2002-08-22 Taisho Pharmaceutical Co., Ltd. Preparations de gel a usage interne
EP1858518A1 (en) * 2005-03-14 2007-11-28 Orion Corporation A combination treatment for enhancing diuresis
EP3370693B1 (en) * 2015-11-06 2020-01-08 Carinopharm GmbH Improved formulations of levosimendan for intravenous administration as infusion or injection and of infusion concentrate
EP4076398A4 (en) 2019-12-16 2024-01-03 Tenax Therapeutics, Inc. LEVOSIMENDAN TO TREAT PULMONARY HYPERTENSION ACCOMPANIED BY HEART FAILURE BY MEANS OF PRESERVED EJECTION FRACTION (PH-HF-PEF)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1509866A (en) 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
PT76448B (en) * 1982-04-05 1986-03-20 Merck Sharp & Dohme Process for preparing stabilization of unstable drugs or food supplements containing antibiotics mainly ephrotomycin
EP0123291A2 (en) 1983-04-20 1984-10-31 Kyowa Hakko Kogyo Co., Ltd. Method for stabilizing interferon
US4906630A (en) * 1985-11-22 1990-03-06 Rorer Pharmaceutical Corporation Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
US4716042A (en) 1986-06-16 1987-12-29 American Home Products Corporation Stabilized coated aspirin tablets
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Also Published As

Publication number Publication date
BG64766B1 (bg) 2006-03-31
CN1165309C (zh) 2004-09-08
PL343722A1 (en) 2001-09-10
HRP20000703B1 (en) 2009-11-30
HUP0105446A3 (en) 2002-09-30
YU64000A (sh) 2002-12-10
NO20005312L (no) 2000-11-21
FI980902A (fi) 1999-10-24
CN1298303A (zh) 2001-06-06
DE69905034D1 (de) 2003-02-27
US6531458B1 (en) 2003-03-11
AU3524899A (en) 1999-11-16
MXPA00010368A (es) 2002-07-02
PL192274B1 (pl) 2006-09-29
FI980902A0 (fi) 1998-04-23
ES2191426T3 (es) 2003-09-01
HRP20000703A2 (en) 2001-04-30
CZ20003779A3 (en) 2001-05-16
JP2002512964A (ja) 2002-05-08
ZA200005630B (en) 2002-01-14
EE04143B1 (et) 2003-10-15
NO20005312D0 (no) 2000-10-20
EP1079834A1 (en) 2001-03-07
EP1079834B1 (en) 2003-01-22
IL138950A0 (en) 2001-11-25
ATE231395T1 (de) 2003-02-15
NO318575B1 (no) 2005-04-11
PT1079834E (pt) 2003-04-30
DE69905034T2 (de) 2003-09-04
RS49955B (sr) 2008-09-29
GEP20032942B (en) 2003-04-25
EA002428B1 (ru) 2002-04-25
IL138950A (en) 2006-08-20
SK15552000A3 (sk) 2001-05-10
AU756338B2 (en) 2003-01-09
WO1999055337A1 (en) 1999-11-04
BG104958A (en) 2001-07-31
JP4475809B2 (ja) 2010-06-09
CA2329232A1 (en) 1999-11-04
HK1031998A1 (en) 2001-07-06
CA2329232C (en) 2007-10-30
EE200000616A (et) 2002-06-17
TR200003101T2 (tr) 2001-01-22
SK284600B6 (sk) 2005-07-01
KR100590622B1 (ko) 2006-06-19
ID26650A (id) 2001-01-25
DK1079834T3 (da) 2003-04-07
KR20010072577A (ko) 2001-07-31
NZ507455A (en) 2002-02-01
CZ290911B6 (cs) 2002-11-13
EA200001097A1 (ru) 2001-04-23
HUP0105446A2 (hu) 2002-07-29

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: A61K 9/20, A61K 9/48, A61K 31/50, A61K 31/501, A61P 9/04

Ipc: A61K 9/20 (2009.01), A61K 9/48 (2009.01), A61K 31/

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE A MATERIA REIVINDICADA NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ART. 8O COMBINADO COM ART. 13 DA LPI )

B12B Appeal against refusal [chapter 12.2 patent gazette]