BR9909867A - Composições estáveis contendo levosimendan e ácido algìnico - Google Patents
Composições estáveis contendo levosimendan e ácido algìnicoInfo
- Publication number
- BR9909867A BR9909867A BR9909867-9A BR9909867A BR9909867A BR 9909867 A BR9909867 A BR 9909867A BR 9909867 A BR9909867 A BR 9909867A BR 9909867 A BR9909867 A BR 9909867A
- Authority
- BR
- Brazil
- Prior art keywords
- alginic acid
- compositions containing
- stable compositions
- levosimendan
- containing levosimendan
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229960001126 alginic acid Drugs 0.000 title abstract 3
- 235000010443 alginic acid Nutrition 0.000 title abstract 3
- 229920000615 alginic acid Polymers 0.000 title abstract 3
- 239000000783 alginic acid Substances 0.000 title abstract 3
- 150000004781 alginic acids Chemical class 0.000 title abstract 3
- WHXMKTBCFHIYNQ-SECBINFHSA-N levosimendan Chemical compound C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1 WHXMKTBCFHIYNQ-SECBINFHSA-N 0.000 title abstract 3
- 229960000692 levosimendan Drugs 0.000 title abstract 3
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
"COMPOSIçõES ESTáVEIS CONTENDO LEVOSIMENDAN E áCIDO ALGìNICO" A presente invenção se relaciona a composições de levosimendam que contêm ácido algínico para aprimorar a estabilidade do levosimendan nas composições. O Levosimendam é útil no tratamento da deficiência cardiáca congestiva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI980902A FI980902A (fi) | 1998-04-23 | 1998-04-23 | Levosimendaanin stabiileja koostumuksia |
PCT/FI1999/000331 WO1999055337A1 (en) | 1998-04-23 | 1999-04-23 | Stabile compositions comprising levosimendan and alginic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909867A true BR9909867A (pt) | 2000-12-19 |
Family
ID=8551576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909867-9A BR9909867A (pt) | 1998-04-23 | 1999-04-23 | Composições estáveis contendo levosimendan e ácido algìnico |
Country Status (33)
Country | Link |
---|---|
US (1) | US6531458B1 (pt) |
EP (1) | EP1079834B1 (pt) |
JP (1) | JP4475809B2 (pt) |
KR (1) | KR100590622B1 (pt) |
CN (1) | CN1165309C (pt) |
AT (1) | ATE231395T1 (pt) |
AU (1) | AU756338B2 (pt) |
BG (1) | BG64766B1 (pt) |
BR (1) | BR9909867A (pt) |
CA (1) | CA2329232C (pt) |
CZ (1) | CZ290911B6 (pt) |
DE (1) | DE69905034T2 (pt) |
DK (1) | DK1079834T3 (pt) |
EA (1) | EA002428B1 (pt) |
EE (1) | EE04143B1 (pt) |
ES (1) | ES2191426T3 (pt) |
FI (1) | FI980902A (pt) |
GE (1) | GEP20032942B (pt) |
HK (1) | HK1031998A1 (pt) |
HR (1) | HRP20000703B1 (pt) |
HU (1) | HUP0105446A3 (pt) |
ID (1) | ID26650A (pt) |
IL (2) | IL138950A0 (pt) |
MX (1) | MXPA00010368A (pt) |
NO (1) | NO318575B1 (pt) |
NZ (1) | NZ507455A (pt) |
PL (1) | PL192274B1 (pt) |
PT (1) | PT1079834E (pt) |
RS (1) | RS49955B (pt) |
SK (1) | SK284600B6 (pt) |
TR (1) | TR200003101T2 (pt) |
WO (1) | WO1999055337A1 (pt) |
ZA (1) | ZA200005630B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI980901A (fi) * | 1998-04-23 | 1999-10-24 | Orion Yhtymae Oyj | Levosimendaania säädellysti vapauttavia oraalisia koostumuksia |
FI109659B (fi) * | 1999-09-10 | 2002-09-30 | Orion Yhtymae Oyj | Levosimendaanin farmaseuttisia liuoksia |
FI20010233A0 (fi) * | 2001-02-08 | 2001-02-08 | Orion Corp | Menetelmä sydämen vajaatoiminnan hoitoon |
WO2002064120A1 (fr) * | 2001-02-13 | 2002-08-22 | Taisho Pharmaceutical Co., Ltd. | Preparations de gel a usage interne |
US20080194567A1 (en) * | 2005-03-14 | 2008-08-14 | Piero Pollesello | Combination Treatment for Enhancing Diuresis |
JP2023507626A (ja) | 2019-12-16 | 2023-02-24 | テナックス・セラピューティクス,インコーポレイテッド | 駆出率が保たれた心不全を伴う肺高血圧症(PH-HF-pEF)を治療するためのレボシメンダン |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1509866A (en) | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
AU555304B2 (en) * | 1982-04-05 | 1986-09-18 | Merck Sharp & Dohme Limited | Stabilization of drugs in alginic acid and magnesium hydroxide granules |
EP0123291A2 (en) | 1983-04-20 | 1984-10-31 | Kyowa Hakko Kogyo Co., Ltd. | Method for stabilizing interferon |
US4906630A (en) * | 1985-11-22 | 1990-03-06 | Rorer Pharmaceutical Corporation | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds |
US4716042A (en) * | 1986-06-16 | 1987-12-29 | American Home Products Corporation | Stabilized coated aspirin tablets |
GB8903130D0 (en) | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
GB2251615B (en) * | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
GB2266841A (en) | 1992-05-06 | 1993-11-17 | Orion Yhtymae Oy | Compounds for use as anti-ischemic medicaments |
GB9614098D0 (en) | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
FI973804A (fi) * | 1997-09-26 | 1999-03-27 | Orion Yhtymae Oy | Levosimendaanin oraalisia koostumuksia |
-
1998
- 1998-04-23 FI FI980902A patent/FI980902A/fi unknown
-
1999
- 1999-04-23 US US09/673,793 patent/US6531458B1/en not_active Expired - Fee Related
- 1999-04-23 KR KR1020007011789A patent/KR100590622B1/ko not_active IP Right Cessation
- 1999-04-23 IL IL13895099A patent/IL138950A0/xx active IP Right Grant
- 1999-04-23 BR BR9909867-9A patent/BR9909867A/pt not_active Application Discontinuation
- 1999-04-23 PL PL343722A patent/PL192274B1/pl not_active IP Right Cessation
- 1999-04-23 SK SK1555-2000A patent/SK284600B6/sk not_active IP Right Cessation
- 1999-04-23 ES ES99916943T patent/ES2191426T3/es not_active Expired - Lifetime
- 1999-04-23 DE DE69905034T patent/DE69905034T2/de not_active Expired - Lifetime
- 1999-04-23 EP EP99916943A patent/EP1079834B1/en not_active Expired - Lifetime
- 1999-04-23 HU HU0105446A patent/HUP0105446A3/hu unknown
- 1999-04-23 ID IDW20002368A patent/ID26650A/id unknown
- 1999-04-23 CN CNB998053805A patent/CN1165309C/zh not_active Expired - Fee Related
- 1999-04-23 CZ CZ20003779A patent/CZ290911B6/cs not_active IP Right Cessation
- 1999-04-23 CA CA002329232A patent/CA2329232C/en not_active Expired - Fee Related
- 1999-04-23 WO PCT/FI1999/000331 patent/WO1999055337A1/en active IP Right Grant
- 1999-04-23 MX MXPA00010368A patent/MXPA00010368A/es active IP Right Grant
- 1999-04-23 EE EEP200000616A patent/EE04143B1/xx not_active IP Right Cessation
- 1999-04-23 TR TR2000/03101T patent/TR200003101T2/xx unknown
- 1999-04-23 AT AT99916943T patent/ATE231395T1/de not_active IP Right Cessation
- 1999-04-23 NZ NZ507455A patent/NZ507455A/en unknown
- 1999-04-23 AU AU35248/99A patent/AU756338B2/en not_active Ceased
- 1999-04-23 EA EA200001097A patent/EA002428B1/ru not_active IP Right Cessation
- 1999-04-23 PT PT99916943T patent/PT1079834E/pt unknown
- 1999-04-23 RS YUP-640/00A patent/RS49955B/sr unknown
- 1999-04-23 JP JP2000545535A patent/JP4475809B2/ja not_active Expired - Lifetime
- 1999-04-23 GE GEAP19995638A patent/GEP20032942B/en unknown
- 1999-04-23 DK DK99916943T patent/DK1079834T3/da active
-
2000
- 2000-10-11 IL IL138950A patent/IL138950A/en not_active IP Right Cessation
- 2000-10-12 ZA ZA200005630A patent/ZA200005630B/en unknown
- 2000-10-19 HR HR20000703A patent/HRP20000703B1/xx not_active IP Right Cessation
- 2000-10-20 NO NO20005312A patent/NO318575B1/no not_active IP Right Cessation
- 2000-11-17 BG BG104958A patent/BG64766B1/bg unknown
-
2001
- 2001-03-26 HK HK01102147A patent/HK1031998A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT.CL: A61K 9/20, A61K 9/48, A61K 31/50, A61K 31/501, A61P 9/04 Ipc: A61K 9/20 (2009.01), A61K 9/48 (2009.01), A61K 31/ |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE A MATERIA REIVINDICADA NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ART. 8O COMBINADO COM ART. 13 DA LPI ) |
|
B12B | Appeal against refusal [chapter 12.2 patent gazette] |