HRP20000297A2 - 5-ht1f agonists - Google Patents
5-ht1f agonists Download PDFInfo
- Publication number
- HRP20000297A2 HRP20000297A2 HR20000297A HRP20000297A HRP20000297A2 HR P20000297 A2 HRP20000297 A2 HR P20000297A2 HR 20000297 A HR20000297 A HR 20000297A HR P20000297 A HRP20000297 A HR P20000297A HR P20000297 A2 HRP20000297 A2 HR P20000297A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- pyridine
- pyrrolo
- hydroxy
- compound
- Prior art date
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- 238000011321 prophylaxis Methods 0.000 description 1
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
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- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 description 1
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- PORMUFZNYQJOEI-UHFFFAOYSA-N sumatriptan succinate Chemical compound OC(=O)CCC(O)=O.CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 PORMUFZNYQJOEI-UHFFFAOYSA-N 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
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- Psychiatry (AREA)
- Addiction (AREA)
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- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Battery Electrode And Active Subsutance (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/970,637 US5905084A (en) | 1997-11-14 | 1997-11-14 | 5-HTIF -agonists effective in treating migraine |
| PCT/US1998/024256 WO1999025348A1 (en) | 1997-11-14 | 1998-11-13 | 5-ht1f agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20000297A2 true HRP20000297A2 (en) | 2000-12-31 |
Family
ID=25517243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20000297A HRP20000297A2 (en) | 1997-11-14 | 2000-05-12 | 5-ht1f agonists |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5905084A (xx) |
| EP (1) | EP0916670B1 (xx) |
| JP (1) | JP2001522887A (xx) |
| KR (1) | KR20010032085A (xx) |
| CN (1) | CN1284874A (xx) |
| AT (1) | ATE240326T1 (xx) |
| AU (1) | AU1407299A (xx) |
| BR (1) | BR9814188A (xx) |
| CA (1) | CA2310248A1 (xx) |
| DE (1) | DE69814563T2 (xx) |
| DK (1) | DK0916670T3 (xx) |
| EA (1) | EA200000522A1 (xx) |
| ES (1) | ES2198657T3 (xx) |
| HR (1) | HRP20000297A2 (xx) |
| HU (1) | HUP0004317A3 (xx) |
| ID (1) | ID25478A (xx) |
| IL (1) | IL135634A0 (xx) |
| NO (1) | NO20002408L (xx) |
| PL (1) | PL340459A1 (xx) |
| PT (1) | PT916670E (xx) |
| TR (1) | TR200001724T2 (xx) |
| WO (1) | WO1999025348A1 (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60011269T2 (de) * | 1999-08-12 | 2005-06-23 | Nps Allelix Corp., Mississauga | Azaidole mit serotonin rezeptor affinität |
| WO2001029263A1 (en) * | 1999-10-19 | 2001-04-26 | Genaissance Pharmaceuticals, Inc. | Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1e gene |
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| BRPI0409211A (pt) | 2003-04-18 | 2006-03-28 | Lilly Co Eli | composto, composição farmacêutica, métodos para ativar receptores 5-ht1f, para inibir extravasão de proteìna neuronial, e para o tratamento ou prevenção de enxaqueca em um mamìfero, e, uso de um composto |
| UA82711C2 (xx) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Заміщені 2-карбоніламіно-6-піперидинамінопіридини та заміщені 1-карбоніламіно-3-піперидинамінобензоли як агоністи 5-ht1f$замещенные 2-карбониламино-6-пиперидинаминопиридины и замещенные 1-карбониламино-3-пиперидинаминобензолы как агонисты 5-ht1f |
| EP1697305B1 (en) | 2003-12-17 | 2007-08-15 | Eli Lilly And Company | Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists |
| US8030344B2 (en) * | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
| CA2795062A1 (en) | 2010-04-02 | 2011-10-06 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists |
| AR119319A1 (es) | 2019-07-09 | 2021-12-09 | Lilly Co Eli | Procesos e intermediario para la preparación a gran escala de hemisuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida y preparación de acetato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990007926A1 (en) * | 1989-01-20 | 1990-07-26 | Pfizer Inc. | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| GB9423460D0 (en) * | 1994-11-21 | 1995-01-11 | Merck Sharp & Dohme | Therapeutic agents |
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| KR19980703048A (ko) * | 1995-03-20 | 1998-09-05 | 피터쥐.스트링거 | 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트 |
| CA2234166A1 (en) * | 1995-10-10 | 1997-04-17 | Patric James Hahn | N-¬2-substituted-3-(2-aminoethyl)-1h-indol-5-yl|-amides: new 5-ht1f agonists |
| ZA979961B (en) * | 1996-11-15 | 1999-05-05 | Lilly Co Eli | 5-HT1F agonists |
-
1997
- 1997-11-14 US US08/970,637 patent/US5905084A/en not_active Expired - Fee Related
-
1998
- 1998-11-13 HU HU0004317A patent/HUP0004317A3/hu unknown
- 1998-11-13 DK DK98309321T patent/DK0916670T3/da active
- 1998-11-13 JP JP2000520781A patent/JP2001522887A/ja not_active Withdrawn
- 1998-11-13 AU AU14072/99A patent/AU1407299A/en not_active Abandoned
- 1998-11-13 KR KR1020007005209A patent/KR20010032085A/ko not_active Application Discontinuation
- 1998-11-13 DE DE69814563T patent/DE69814563T2/de not_active Expired - Fee Related
- 1998-11-13 WO PCT/US1998/024256 patent/WO1999025348A1/en not_active Application Discontinuation
- 1998-11-13 EA EA200000522A patent/EA200000522A1/ru unknown
- 1998-11-13 IL IL13563498A patent/IL135634A0/xx unknown
- 1998-11-13 BR BR9814188-0A patent/BR9814188A/pt not_active Application Discontinuation
- 1998-11-13 AT AT98309321T patent/ATE240326T1/de not_active IP Right Cessation
- 1998-11-13 CN CN98812914A patent/CN1284874A/zh active Pending
- 1998-11-13 PT PT98309321T patent/PT916670E/pt unknown
- 1998-11-13 ID IDW20000837A patent/ID25478A/id unknown
- 1998-11-13 ES ES98309321T patent/ES2198657T3/es not_active Expired - Lifetime
- 1998-11-13 CA CA002310248A patent/CA2310248A1/en not_active Abandoned
- 1998-11-13 TR TR2000/01724T patent/TR200001724T2/xx unknown
- 1998-11-13 PL PL98340459A patent/PL340459A1/xx unknown
- 1998-11-13 EP EP98309321A patent/EP0916670B1/en not_active Expired - Lifetime
-
2000
- 2000-05-09 NO NO20002408A patent/NO20002408L/no not_active Application Discontinuation
- 2000-05-12 HR HR20000297A patent/HRP20000297A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ID25478A (id) | 2000-10-05 |
| EP0916670A3 (en) | 2001-05-23 |
| DK0916670T3 (da) | 2003-09-15 |
| ES2198657T3 (es) | 2004-02-01 |
| PL340459A1 (en) | 2001-02-12 |
| DE69814563T2 (de) | 2004-04-08 |
| DE69814563D1 (de) | 2003-06-18 |
| KR20010032085A (ko) | 2001-04-16 |
| EP0916670B1 (en) | 2003-05-14 |
| JP2001522887A (ja) | 2001-11-20 |
| EA200000522A1 (ru) | 2000-10-30 |
| NO20002408D0 (no) | 2000-05-09 |
| EP0916670A2 (en) | 1999-05-19 |
| US5905084A (en) | 1999-05-18 |
| NO20002408L (no) | 2000-07-12 |
| CA2310248A1 (en) | 1999-05-27 |
| TR200001724T2 (tr) | 2000-11-21 |
| HUP0004317A3 (en) | 2002-03-28 |
| ATE240326T1 (de) | 2003-05-15 |
| AU1407299A (en) | 1999-06-07 |
| HUP0004317A2 (hu) | 2001-10-28 |
| IL135634A0 (en) | 2001-05-20 |
| CN1284874A (zh) | 2001-02-21 |
| PT916670E (pt) | 2003-09-30 |
| BR9814188A (pt) | 2000-10-03 |
| WO1999025348A1 (en) | 1999-05-27 |
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