US5159104A
(en)
*
|
1991-05-01 |
1992-10-27 |
Merck & Co., Inc. |
Process to simvastatin ester
|
GB9123933D0
(en)
*
|
1991-11-11 |
1992-01-02 |
British Bio Technology |
Compounds
|
US5393893A
(en)
*
|
1993-11-08 |
1995-02-28 |
Apotex, Inc. |
Process for producing simvastatin and analogs thereof
|
US5763653A
(en)
*
|
1997-03-13 |
1998-06-09 |
Ranbaxy Laboratories, Ltd. |
Key intermediates in the manufacture of simvastatin
|
CA2185961A1
(en)
*
|
1996-09-19 |
1998-03-20 |
K.S. Keshava Murthy |
Process for producing simvastatin
|
US5763646A
(en)
*
|
1997-03-13 |
1998-06-09 |
Ranbaxy Laboratories, Ltd. |
Process for manufacturing simvastatin from lovastatin or mevinolinic acid
|
EP0971913B1
(en)
*
|
1997-01-28 |
2003-04-16 |
Plus Chemicals B.V. |
Process for the production of semi synthetic statins via novel intermediates
|
IN186880B
(fi)
*
|
1997-10-28 |
2001-12-01 |
Ranbaxy Lab Ltd |
|
IN186879B
(fi)
*
|
1997-10-28 |
2001-12-01 |
Ranbaxy Lab Ltd |
|
SI9800057A
(sl)
|
1998-02-26 |
1999-08-31 |
Krka, Tovarna Zdravil, D.D. |
Postopek za pripravo simvastatina in njegovih derivatov
|
EP0940395A1
(en)
*
|
1998-03-05 |
1999-09-08 |
Synthon B.V. |
Process for producing simvastatin and/or its derivatives
|
NO991045L
(no)
*
|
1998-03-05 |
1999-09-06 |
Synthon Bv |
FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
|
ZA9810764B
(en)
*
|
1998-04-22 |
1999-08-13 |
Ranbaxy Lab Ltd |
An improved process of lactonization in the preparation of statins.
|
CA2240983A1
(en)
*
|
1998-06-18 |
1999-12-18 |
Yong Tao |
Process to manufacture simvastatin and intermediates
|
SI20116A
(sl)
|
1998-12-02 |
2000-06-30 |
LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. |
Nov postopek za pripravo simvastatina in njegovih analogov
|
CO5140104A1
(es)
|
1999-02-16 |
2002-03-22 |
Novartis Ag |
Derivados de mevinolina y preparacion farmaceuticas que los contienen
|
US6569461B1
(en)
*
|
1999-03-08 |
2003-05-27 |
Merck & Co., Inc. |
Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
|
WO2001030773A2
(en)
|
1999-10-27 |
2001-05-03 |
Merck & Co., Inc. |
Lactonization process
|
US6573385B1
(en)
|
1999-11-11 |
2003-06-03 |
Biocon India Limited |
Process for manufacturing simvastatin and novel intermediates thereof
|
US6573392B1
(en)
|
1999-11-11 |
2003-06-03 |
Biocon India Limited |
Process for manufacturing simvastatin and the novel intermediates
|
HUP0301214A2
(hu)
|
2000-03-03 |
2003-08-28 |
Plus Chemicals S.A. |
Tisztítási eljárás csökkentett dimer szennyező tartalmú lovastatin és simvastatin előállítására
|
YU101402A
(sh)
|
2000-07-27 |
2006-01-16 |
Plus Chemicals B.V. |
Visoko prečišćeni preparati simvastatina
|
WO2002024675A1
(en)
*
|
2000-09-13 |
2002-03-28 |
Biocon India Limited |
Process for manufacturing simvastatin and the novel intermediates
|
NL1017548C2
(nl)
|
2001-03-09 |
2002-09-10 |
Synthon Bv |
Een lactonisatie proces.
|
SK702003A3
(en)
*
|
2001-05-18 |
2003-12-02 |
Aurobindo Pharma Ltd |
A process for lactonization to produce simvastatin
|
US6797831B2
(en)
*
|
2001-05-18 |
2004-09-28 |
Aurobindo Pharma Limited |
Process for lactonization to produce simvastatin
|
KR100407758B1
(ko)
*
|
2001-08-27 |
2003-12-01 |
씨제이 주식회사 |
스타틴의 제조에 있어서 락톤화 방법
|
US6472542B1
(en)
|
2001-11-29 |
2002-10-29 |
Fermic S.A. De C.V. |
Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
|
KR100502834B1
(ko)
*
|
2002-03-25 |
2005-07-20 |
보령제약 주식회사 |
개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
|
SI21187A
(sl)
|
2002-03-26 |
2003-10-31 |
Krka, Tovarna Zdravil D.D., Novo Mesto |
Postopek za pripravo 4-oksitetrahidropiran-2-onov
|
CA2480879A1
(en)
|
2002-04-12 |
2003-10-23 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
US20050113577A1
(en)
*
|
2002-04-16 |
2005-05-26 |
Karki Shyam B. |
Solid forms of slats with tyrosine kinase activity
|
US6603022B1
(en)
|
2002-05-10 |
2003-08-05 |
Biocon India Limited |
Process for manufacturing Simvastatin and novel intermediates thereof
|
AR040588A1
(es)
|
2002-07-26 |
2005-04-13 |
Schering Corp |
Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
|
US20040198800A1
(en)
*
|
2002-12-19 |
2004-10-07 |
Geoffrey Allan |
Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
|
ATE407670T1
(de)
|
2002-12-20 |
2008-09-15 |
Pfizer Prod Inc |
Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer
|
US20040132771A1
(en)
*
|
2002-12-20 |
2004-07-08 |
Pfizer Inc |
Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
|
KR20050098313A
(ko)
*
|
2003-02-11 |
2005-10-11 |
플러스 케미칼스 비.브이. |
제어된 범위의 심바스타틴 이량체 함량을 갖는심바스타틴의 제조 방법
|
KR20040092790A
(ko)
*
|
2003-04-29 |
2004-11-04 |
씨제이 주식회사 |
심바스타틴 중간체 제조방법
|
AU2004266740B2
(en)
|
2003-08-21 |
2010-08-26 |
Merck Frosst Canada Ltd |
Cathepsin cysteine protease inhibitors
|
TW200529821A
(en)
*
|
2003-11-05 |
2005-09-16 |
Teva Pharma |
Simvastatin formulations and methods of making same
|
KR20060109926A
(ko)
|
2003-11-19 |
2006-10-23 |
메타베이시스 테라퓨틱스, 인크. |
새로운 인-함유 갑상선 호르몬 모방약들
|
BRPI0418644A
(pt)
*
|
2004-03-30 |
2007-05-29 |
Lupin Ltd |
processo para a preparação de um composto
|
DE602004023004D1
(de)
*
|
2004-09-08 |
2009-10-15 |
Jubilant Organosys Ltd |
Verbessertes verfahren zur lactonisierung bei der herstellung von statinen
|
CA2581596A1
(en)
*
|
2004-09-29 |
2006-04-13 |
Schering Corporation |
Combinations of substituted azetidonones and cb1 antagonists
|
RU2394820C2
(ru)
|
2004-12-09 |
2010-07-20 |
Мерк Шарп Энд Домэ Корп. |
Модуляторы рецептора эстрогена
|
DK1855674T3
(da)
|
2005-03-02 |
2014-10-20 |
Merck Sharp & Dohme |
Sammensætning til hæmning af cathepsin k
|
US8362075B2
(en)
|
2005-05-17 |
2013-01-29 |
Merck Sharp & Dohme Corp. |
Cyclohexyl sulphones for treatment of cancer
|
EP1741427A1
(en)
|
2005-07-06 |
2007-01-10 |
KRKA, D.D., Novo Mesto |
Pharmaceutical composition comprising simvastatin and ezetimibe
|
WO2007020079A2
(en)
*
|
2005-08-17 |
2007-02-22 |
Synthon B.V. |
Orally disintegratable simvastatin tablets
|
TW200804345A
(en)
*
|
2005-08-30 |
2008-01-16 |
Novartis Ag |
Substituted benzimidazoles and methods of preparation
|
KR20080034190A
(ko)
*
|
2005-09-13 |
2008-04-18 |
테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 |
심바스타틴 제조 방법 및 이의 중간체
|
US20070129437A1
(en)
*
|
2005-12-06 |
2007-06-07 |
Ferenc Korodi |
Process for preparing simvastatin and intermediates thereof
|
BRPI0620255A2
(pt)
*
|
2005-12-21 |
2011-11-08 |
Schering Corp |
uso de agentes redutores de colesterol e/ou antagonista/agonista inverso do receptor de h3
|
WO2007075555A2
(en)
*
|
2005-12-21 |
2007-07-05 |
Schering Corporation |
Combination of an h3 antagonist/inverse agonist and an appetite suppressant
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
PL2010528T3
(pl)
|
2006-04-19 |
2018-03-30 |
Novartis Ag |
6-0-podstawione związki benzoksazolowe i benzotiazolowe i sposoby hamowania sygnalizacji csf-1r
|
EP2059241A1
(en)
*
|
2006-09-05 |
2009-05-20 |
Schering Corporation |
Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
|
EP2083831B1
(en)
|
2006-09-22 |
2013-12-25 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
SI2805945T1
(sl)
|
2007-01-10 |
2019-09-30 |
Msd Italia S.R.L. |
Amid substituirani indazoli, kot inhibitorji poli(ADP-riboza)polimeraze(PARP)
|
EP2132177B1
(en)
|
2007-03-01 |
2013-07-17 |
Novartis AG |
Pim kinase inhibitors and methods of their use
|
KR20100017866A
(ko)
|
2007-05-21 |
2010-02-16 |
노파르티스 아게 |
Csf-1r 억제제, 조성물 및 사용 방법
|
EP2431043A1
(en)
|
2007-05-23 |
2012-03-21 |
Amcol International Corporation |
Cholesterol-interacting layered phyllosilicates for suppressing gastrointestinal cholesterol absorption
|
CA2690191C
(en)
|
2007-06-27 |
2015-07-28 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
WO2009078033A2
(en)
*
|
2007-12-18 |
2009-06-25 |
Themis Medicare Limited |
Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
|
WO2009082437A2
(en)
|
2007-12-21 |
2009-07-02 |
Ligand Pharmaceuticals Incorporated |
Selective androgen receptor modulators (sarms) and uses thereof
|
ES2343049B1
(es)
|
2008-10-15 |
2011-06-10 |
Neuron Biopharma, S.A. |
Biosintesis de derivados de monacolina j.
|
CN101381356B
(zh)
*
|
2008-10-23 |
2012-05-23 |
河北科技大学 |
辛伐他汀的制备方法
|
EP2204170A1
(en)
|
2008-12-01 |
2010-07-07 |
LEK Pharmaceuticals D.D. |
Pharmaceutical composition comprising ezetimibe and simvastatin
|
EP2216016A1
(en)
|
2009-02-06 |
2010-08-11 |
LEK Pharmaceuticals d.d. |
Process for the preparation of a pharmaceutical composition comprising ezetimibe
|
US20120046364A1
(en)
|
2009-02-10 |
2012-02-23 |
Metabasis Therapeutics, Inc. |
Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
|
EP2413932A4
(en)
|
2009-04-01 |
2012-09-19 |
Merck Sharp & Dohme |
INHIBITORS OF AKT ACTIVITY
|
US9057085B2
(en)
|
2009-09-30 |
2015-06-16 |
Codexis, Inc. |
Lov-D acyltransferase mediated acylation
|
SG10201504099WA
(en)
|
2009-10-08 |
2015-06-29 |
Univ California |
LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS
|
CA2777043C
(en)
|
2009-10-14 |
2015-12-15 |
Schering Corporation |
Substituted piperidines that increase p53 activity and the uses thereof
|
CN101704808A
(zh)
|
2009-11-20 |
2010-05-12 |
西南合成制药股份有限公司 |
制备他汀类化合物的内酯化方法
|
EP2368543A1
(en)
|
2010-03-25 |
2011-09-28 |
KRKA, tovarna zdravil, d.d., Novo mesto |
Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe
|
US8999957B2
(en)
|
2010-06-24 |
2015-04-07 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as ERK inhibitors
|
US8518907B2
(en)
|
2010-08-02 |
2013-08-27 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
|
EP2606134B1
(en)
|
2010-08-17 |
2019-04-10 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
WO2012036997A1
(en)
|
2010-09-16 |
2012-03-22 |
Schering Corporation |
Fused pyrazole derivatives as novel erk inhibitors
|
EP3766975A1
(en)
|
2010-10-29 |
2021-01-20 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
US9351965B2
(en)
|
2010-12-21 |
2016-05-31 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as ERK inhibitors
|
US8791162B2
(en)
|
2011-02-14 |
2014-07-29 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
WO2012143879A1
(en)
|
2011-04-21 |
2012-10-26 |
Piramal Healthcare Limited |
A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
|
EP2770987B1
(en)
|
2011-10-27 |
2018-04-04 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
WO2013165816A2
(en)
|
2012-05-02 |
2013-11-07 |
Merck Sharp & Dohme Corp. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
AU2013323508B2
(en)
|
2012-09-28 |
2017-11-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are ERK inhibitors
|
ES2651347T3
(es)
|
2012-11-28 |
2018-01-25 |
Merck Sharp & Dohme Corp. |
Composiciones y métodos para el tratamiento del cáncer
|
CA2895504A1
(en)
|
2012-12-20 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Substituted imidazopyridines as hdm2 inhibitors
|
US9540377B2
(en)
|
2013-01-30 |
2017-01-10 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as HDM2 inhibitors
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
WO2015051479A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
CA2923272A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
EP3094323A4
(en)
|
2014-01-17 |
2017-10-11 |
Ligand Pharmaceuticals Incorporated |
Methods and compositions for modulating hormone levels
|
WO2015120580A1
(en)
|
2014-02-11 |
2015-08-20 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
JO3589B1
(ar)
|
2014-08-06 |
2020-07-05 |
Novartis Ag |
مثبطات كيناز البروتين c وطرق استخداماتها
|
CN106831424B
(zh)
*
|
2015-12-04 |
2019-08-02 |
浙江京新药业股份有限公司 |
由洛伐他汀制备辛伐他汀铵盐的方法
|
EP3525785A4
(en)
|
2016-10-12 |
2020-03-25 |
Merck Sharp & Dohme Corp. |
KDM5 INHIBITORS
|
WO2019094311A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
EP3833667B1
(en)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
WO2021126731A1
(en)
|
2019-12-17 |
2021-06-24 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
WO2024180169A1
(en)
|
2023-03-02 |
2024-09-06 |
Carcimun Biotech Gmbh |
Means and methods for diagnosing cancer and/or an acute inflammatory disease
|