HK65193A - Nicorandil-containing preparation for injection - Google Patents

Nicorandil-containing preparation for injection

Info

Publication number
HK65193A
HK65193A HK651/93A HK65193A HK65193A HK 65193 A HK65193 A HK 65193A HK 651/93 A HK651/93 A HK 651/93A HK 65193 A HK65193 A HK 65193A HK 65193 A HK65193 A HK 65193A
Authority
HK
Hong Kong
Prior art keywords
nicorandil
injection
freeze
dissolved
dried
Prior art date
Application number
HK651/93A
Other languages
English (en)
Inventor
Kouji Ishihara
Mika Sanada
Naoki Matsuo
Yoshimitsu Iida
Yoshinori Matsuoka
Junko Matsuo
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of HK65193A publication Critical patent/HK65193A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK651/93A 1986-01-14 1993-07-08 Nicorandil-containing preparation for injection HK65193A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP574286 1986-01-14

Publications (1)

Publication Number Publication Date
HK65193A true HK65193A (en) 1993-07-16

Family

ID=11619552

Family Applications (1)

Application Number Title Priority Date Filing Date
HK651/93A HK65193A (en) 1986-01-14 1993-07-08 Nicorandil-containing preparation for injection

Country Status (12)

Country Link
US (1) US4769381A (fr)
EP (1) EP0236679B1 (fr)
JP (1) JPH0713018B2 (fr)
KR (1) KR950010150B1 (fr)
AT (1) ATE67406T1 (fr)
AU (1) AU594266B2 (fr)
CA (1) CA1285485C (fr)
DE (1) DE3773017D1 (fr)
ES (1) ES2038605T3 (fr)
GR (1) GR3003355T3 (fr)
HK (1) HK65193A (fr)
SG (1) SG64693G (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6351326A (ja) * 1986-08-22 1988-03-04 Nisshin Flour Milling Co Ltd ニコランジル外用剤
CA1336963C (fr) * 1988-07-18 1995-09-12 Gary James Grover Methode d'inhibition de la necrose des cellules du myocarde et de conservation de la fonction cardiaque pendant une ischemie myocardique et (ou) une perfusion repetee
DE69720602T2 (de) * 1996-06-24 2004-02-12 Tosoh Corp., Shinnanyo Enzymsubstrat
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
WO2000067754A1 (fr) 1999-05-12 2000-11-16 Nitromed, Inc. Activateurs nitroses et nitrosyles du canal potassique, compositions et utilisations
US20040235163A1 (en) * 2001-08-22 2004-11-25 Mitsuhiro Yokota Myocardial cell apoptosis inhibitors
CN100417381C (zh) * 2006-02-09 2008-09-10 西安力邦医药科技有限责任公司 尼可地尔冻干粉的制备方法
CN101474161B (zh) * 2009-01-14 2011-11-16 北京四环科宝制药有限公司 尼可地尔冻干粉针剂及其制备方法
KR20140053907A (ko) * 2011-06-30 2014-05-08 모찌다 세이야쿠 가부시끼가이샤 니코란딜 함유 의약 조성물
CN110123749B (zh) * 2019-06-03 2022-01-25 太阳升(亳州)生物医药科技有限公司 尼可地尔脂微球制剂及其制备方法
CN111606847B (zh) * 2020-05-26 2021-12-31 中国科学院上海药物研究所 尼可地尔与1-羟基-2-萘甲酸的共晶及其制备方法和应用
CN111574441B (zh) * 2020-05-26 2021-12-31 中国科学院上海药物研究所 一种尼可地尔与水杨酸的共晶及其制备方法和应用
CN115624527A (zh) * 2022-09-20 2023-01-20 朗天药业(湖北)有限公司 一种尼可地尔冻干粉针剂及其制备方法和用途
CN115487156A (zh) * 2022-10-17 2022-12-20 南京正科医药股份有限公司 一种注射用尼可地尔粉针剂及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168438A (en) * 1962-08-09 1965-02-02 Synergistics Inc Vasodilation by nitric acid ester derivatives of nicotinic acid
US3332848A (en) * 1963-07-10 1967-07-25 Hoffmann La Roche Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
JPS599539B2 (ja) * 1979-11-13 1984-03-03 日本化薬株式会社 ニトログリセリン水溶液及びその製造法
JPS56139414A (en) * 1980-04-01 1981-10-30 Dai Ichi Seiyaku Co Ltd Stabilizing method of aqueous solution
JPS5727087A (en) * 1980-07-25 1982-02-13 Toshiba Corp Wavelength sweeping laser
ATE22530T1 (de) * 1980-07-29 1986-10-15 Sanofi Sa Durch saeure stabilisierte mischungen von thienopyridinderivaten und verfahren zum verhindern der zersetzung solcher verbindungen.
US4490377A (en) * 1980-07-29 1984-12-25 Syntex (U.S.A.) Inc. Acid stabilized compositions of thieno-pyridine derived compounds
JPS5762284A (en) * 1980-10-01 1982-04-15 Sumitomo Chem Co Ltd Stabilizing method
US4382091A (en) * 1981-04-30 1983-05-03 Syntex (U.S.A.) Inc. Stabilization of 1-substituted imidazole derivatives in talc
JPS5839618A (ja) * 1981-09-04 1983-03-08 Chugai Pharmaceut Co Ltd 持続性積層錠剤
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JPS60185727A (ja) * 1984-03-05 1985-09-21 Sumitomo Chem Co Ltd 4−カルバモイルイミダゾリウム−5−オレ−ト製剤の安定化法
JPH0653658B2 (ja) * 1984-12-17 1994-07-20 中外製薬株式会社 安定な錠剤の製造法

Also Published As

Publication number Publication date
GR3003355T3 (en) 1993-02-17
KR950010150B1 (ko) 1995-09-11
CA1285485C (fr) 1991-07-02
EP0236679A1 (fr) 1987-09-16
EP0236679B1 (fr) 1991-09-18
JPS62252722A (ja) 1987-11-04
AU594266B2 (en) 1990-03-01
ES2038605T3 (es) 1993-08-01
SG64693G (en) 1993-08-06
ATE67406T1 (de) 1991-10-15
JPH0713018B2 (ja) 1995-02-15
KR870006892A (ko) 1987-08-13
AU6756287A (en) 1987-07-16
DE3773017D1 (de) 1991-10-24
US4769381A (en) 1988-09-06

Similar Documents

Publication Publication Date Title
EP0221041A3 (fr) Dérivés de benzimidazole, leur préparation et leur application comme médicaments
MY121908A (en) 3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them.
GR3003355T3 (en) Nicorandil-containing preparation for injection
IL95691A0 (en) Thienylcarboxylates of amino alcohols,their preparation and pharmaceutical compositions containing them
PT86186A (en) Process for the preparation of benzimidazol derivatives and of pharmaceutical compositions containing the same
ES8402560A1 (es) Procedimiento para la obtencion de nuevos derivados de omega-ciano-1,omega-difenil-aza-alcano.
IL102814A0 (en) Pyrazine derivatives,their preparation and pharmaceutical compositions comprising them
ES483894A1 (es) Un procedimiento para la preparacion de una sal de adicion -de acido de un derivado de androstano.
IE780180L (en) Ethoxyquin derivatives
HUT57204A (en) Process for producing 4-fluoro-2-///4-methoxy-2-pyridinyl/-methyl/-sulfinyl/-1h-benzimidazol with gastric acid secration-diminishing activity and pharmaceutical compositions containing them
IT1197516B (it) Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
ES8200363A1 (es) Procedimiento para la obtencion de esteres 4,5-dialquil-3- hidroxi-pirrol-2-carboxilicos
MY101266A (en) Pharmaceutical formulations
GB1449404A (en) N-arylsulphonyl urea derivatives
DE3065087D1 (en) Piperidine derivatives of 3-hydroxy-thiophene-2-carboxylic acid esters, their preparation, and pharmaceutical preparations containing them
JPS5251362A (en) Preparation of optically active pyrrolidine derivatives
EP0321967A3 (en) Compounds active on the cardiovascular system
IE43848L (en) Pharmaceutical compositions
EP0389773A3 (fr) Procédé de préparation d'une composition pharmaceutique de phénonoxime-2-hydroxy-5-méthyllauro avec de la biodisponibilité optimale
JO1531B1 (en) New near-compounds
JO1664B1 (en) The compound has the effect of immobilizing gastric acid and the process of preparing it

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20070112