HK59497A - Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-YL) benzenes - Google Patents

Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-YL) benzenes

Info

Publication number
HK59497A
HK59497A HK59497A HK59497A HK59497A HK 59497 A HK59497 A HK 59497A HK 59497 A HK59497 A HK 59497A HK 59497 A HK59497 A HK 59497A HK 59497 A HK59497 A HK 59497A
Authority
HK
Hong Kong
Prior art keywords
tetrazol
synthesis
substituted
ortho
benzenes
Prior art date
Application number
HK59497A
Other languages
English (en)
Inventor
Richard F Shuman
Anthony O King
Robert K Anderson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24061644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK59497(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK59497A publication Critical patent/HK59497A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
HK59497A 1990-05-02 1997-05-08 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-YL) benzenes HK59497A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/517,889 US5039814A (en) 1990-05-02 1990-05-02 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes

Publications (1)

Publication Number Publication Date
HK59497A true HK59497A (en) 1997-05-16

Family

ID=24061644

Family Applications (1)

Application Number Title Priority Date Filing Date
HK59497A HK59497A (en) 1990-05-02 1997-05-08 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-YL) benzenes

Country Status (15)

Country Link
US (1) US5039814A (fr)
EP (1) EP0455423B1 (fr)
JP (1) JPH0717619B2 (fr)
AT (1) ATE146461T1 (fr)
CA (1) CA2041620C (fr)
CY (1) CY1998A (fr)
DE (1) DE69123632T2 (fr)
DK (1) DK0455423T3 (fr)
ES (1) ES2095907T3 (fr)
GR (1) GR3022107T3 (fr)
HK (1) HK59497A (fr)
IE (1) IE911455A1 (fr)
LV (1) LV11893B (fr)
PT (1) PT97528B (fr)
RO (1) RO110339B1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
US5256654A (en) * 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
DE69233734D1 (de) * 1991-11-18 2008-06-26 Du Pont 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)phenylborsäure als Zwischenprodukt zur Synthese von A II Receptorenantagonisten
FR2688503B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2696745B1 (fr) * 1992-10-12 1995-05-12 Synthelabo Procédé de préparation de dérivés de phényltétrazole.
NO304429B1 (no) * 1992-12-17 1998-12-14 Sankyo Co Bifenylderivater, farmas°ytisk preparat og deres anvendelse for fremstilling av et medikament for behandling av hypertensjon og hjertesykdom
US5567815A (en) * 1994-07-18 1996-10-22 Bridgestone Corporation Teritary amine containing antonic initiators used in preparing polymers and process for the preparation thereof
DK0782996T3 (da) * 1994-09-20 1999-09-20 Wakunaga Seiyaku Kk Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af
KR100354802B1 (ko) * 1994-10-20 2002-12-26 한국화학연구원 테트라졸유도체의제조방법
US5760220A (en) * 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
HUP9900871A3 (en) * 1995-06-07 2000-07-28 Wyeth Corp Process for preparation of biphenyl derivatives
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
ES2264641B1 (es) * 2005-06-17 2008-03-01 Quimica Sintetica, S.A. Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios.
EP2081892A4 (fr) 2006-11-17 2014-03-05 Donald F Weaver Composés et procédés pour traiter des troubles de repliement de protéine
CN101903324B (zh) 2007-12-17 2013-07-03 联合治疗公司 一种制备Remodulin中的活性成分曲前列素的改良方法
JP6046034B2 (ja) 2010-06-03 2016-12-14 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの製造
KR101454571B1 (ko) * 2011-03-02 2014-10-23 유나이티드 세러퓨틱스 코오포레이션 트레프로스티닐 생산을 위한 중간체 합성
ES2778274T3 (es) 2014-10-20 2020-08-10 United Therapeutics Corp Síntesis de productos intermedios para producir derivados de prostaciclina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534113A (en) * 1968-02-08 1970-10-13 Lithium Corp Preparation of aryllithium compounds by metalation
CH531511A (de) * 1969-03-05 1972-12-15 Sandoz Ag Verfahren zur Herstellung des N,o-Dilithium-Derivats von 2-Phenyl-2-imidazolin
US4620025A (en) * 1984-08-01 1986-10-28 Merck & Co., Inc. Process for the preparation of biphenyl intermediates
US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (fr) * 1988-01-07 1996-04-09 David John Carini Imidazoles bloquant les recepteurs de l'angiotensine ii et combinaisons de ces imidazoles avec des diuretiques et des anti-inflammatoires non steroidiens

Also Published As

Publication number Publication date
LV11893A (en) 1997-12-20
EP0455423B1 (fr) 1996-12-18
CA2041620C (fr) 2003-03-11
RO110339B1 (ro) 1995-12-29
CA2041620A1 (fr) 1991-11-03
ATE146461T1 (de) 1997-01-15
US5039814A (en) 1991-08-13
IE911455A1 (en) 1991-11-06
ES2095907T3 (es) 1997-03-01
DE69123632T2 (de) 1997-05-15
EP0455423A2 (fr) 1991-11-06
JPH04225966A (ja) 1992-08-14
PT97528B (pt) 1998-08-31
CY1998A (en) 1997-12-05
EP0455423A3 (en) 1992-12-09
PT97528A (pt) 1992-01-31
DE69123632D1 (de) 1997-01-30
LV11893B (en) 1998-03-20
GR3022107T3 (en) 1997-03-31
DK0455423T3 (da) 1997-06-09
JPH0717619B2 (ja) 1995-03-01

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Effective date: 20110424