HK39192A - Improvements in or relating to a process for purifying proteins - Google Patents

Improvements in or relating to a process for purifying proteins

Info

Publication number
HK39192A
HK39192A HK391/92A HK39192A HK39192A HK 39192 A HK39192 A HK 39192A HK 391/92 A HK391/92 A HK 391/92A HK 39192 A HK39192 A HK 39192A HK 39192 A HK39192 A HK 39192A
Authority
HK
Hong Kong
Prior art keywords
relating
purifying proteins
purifying
proteins
Prior art date
Application number
HK391/92A
Other languages
English (en)
Inventor
Michele Ceceil Smith
Charles Pidgeon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK39192A publication Critical patent/HK39192A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/223—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material containing metals, e.g. organo-metallic compounds, coordination complexes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3265—Non-macromolecular compounds with an organic functional group containing a metal, e.g. a metal affinity ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/49—Materials comprising an indicator, e.g. colour indicator, pH-indicator
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK391/92A 1984-12-05 1992-05-28 Improvements in or relating to a process for purifying proteins HK39192A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/678,602 US4569794A (en) 1984-12-05 1984-12-05 Process for purifying proteins and compounds useful in such process

Publications (1)

Publication Number Publication Date
HK39192A true HK39192A (en) 1992-06-04

Family

ID=24723484

Family Applications (1)

Application Number Title Priority Date Filing Date
HK391/92A HK39192A (en) 1984-12-05 1992-05-28 Improvements in or relating to a process for purifying proteins

Country Status (12)

Country Link
US (1) US4569794A (fr)
EP (1) EP0184355B1 (fr)
JP (1) JPH0788400B2 (fr)
AU (1) AU588840B2 (fr)
CA (1) CA1252948A (fr)
DE (1) DE3585147D1 (fr)
DK (1) DK171917B1 (fr)
HK (1) HK39192A (fr)
HU (1) HU208025B (fr)
IE (1) IE58501B1 (fr)
IL (1) IL77104A (fr)
SG (1) SG25792G (fr)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279960A (en) * 1984-07-05 1994-01-18 Enzon Corp. 25 KD coccidial antigen of eimeria tenella
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US5047513A (en) * 1986-07-10 1991-09-10 Hoffmann-La Roche Inc. Metal chelate resins
CA1340522C (fr) * 1987-03-10 1999-05-04 Heinz Dobeli Proteins hybrides renfermant des histidines voisines pour une purification amelioree
GB8706599D0 (en) * 1987-03-19 1987-04-23 Hoffmann La Roche Plasmodium falciparum merozoite antigen peptides
US5780038A (en) * 1987-11-16 1998-07-14 Roche Diagnostic Systems, Inc. HIV-2 envelope polypeptides
DE3879881D1 (de) * 1987-11-16 1993-05-06 Hoffmann La Roche Rekombinante hiv-2 polypeptide.
JPH084519B2 (ja) * 1987-12-25 1996-01-24 エフ・ホフマン―ラ ロシュ アーゲー ハイブリッド形成用担体およびその調整方法
US4927879A (en) * 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
US4931498A (en) * 1988-02-25 1990-06-05 Purdue Research Foundation Immobilized artificial membranes
US4952321A (en) * 1988-10-07 1990-08-28 Brigham Young University Process of removing and concentrating desired ions from solutions
US5169936A (en) * 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
US5115102A (en) * 1989-07-21 1992-05-19 Monsanto Company Variant proteins and polypeptides possessing enhanced affinity for immobilized-metal affinity matrices
US6683046B1 (en) * 1989-12-22 2004-01-27 Hoffmann-La Roche Inc. Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers
US5136025A (en) * 1990-04-04 1992-08-04 California Biotechnology Inc. Method to purify basic fibroblast growth factor
US5594115A (en) * 1990-04-09 1997-01-14 Pharmacia & Upjohn Company Process of purifying recombinant proteins and compounds useful in such process
EP0527778B1 (fr) * 1990-04-09 1996-06-19 The Upjohn Company Procede ameliore de purification de proteines de recombinaison et procedes utiles dans ledit procede
US5972337A (en) * 1990-11-01 1999-10-26 Cancer Research Fund Of Contra Costa 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein
EP0561971A1 (fr) * 1990-12-13 1993-09-29 PHARMACIA & UPJOHN COMPANY Polypeptides de fusion
AU1332992A (en) * 1991-01-25 1992-08-27 Sloan-Kettering Institute For Cancer Research Antigen recognized by patients with antibody associated cerebellar degeneration, dna encoding same and uses thereof
US5439829A (en) * 1991-01-30 1995-08-08 Eli Lilly And Company Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion
EP0875578A3 (fr) * 1991-03-19 1999-05-12 Eli Lilly And Company Dérivés de la protéine 2A de liaison à la pénicilline de la souche de Staphylococcus aureus 27R à utilisation dans la purification de la même et analyse des composés effectifs contre des microorganismes résistants à la méthycilline
US6602861B1 (en) * 1992-04-16 2003-08-05 Research Corporation Technologies, Inc. Acylated phospholipid drugs
EP0583894A3 (en) * 1992-07-29 1995-09-06 Hybritech Inc Method of immobilizing and orienting molecules by use of metal chelating moieties to facilitate atomic force microscopy of proteins and molecular scale manipulation
US7105159B1 (en) 1992-11-05 2006-09-12 Sloan-Kettering Institute For Cancer Research Antibodies to prostate-specific membrane antigen
US7070782B1 (en) * 1992-11-05 2006-07-04 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen
US6569432B1 (en) 1995-02-24 2003-05-27 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
SE9303822D0 (sv) * 1993-11-18 1993-11-18 Kabi Pharmacia Ab Method for purification
US5449758A (en) * 1993-12-02 1995-09-12 Life Technologies, Inc. Protein size marker ladder
DE4433980C2 (de) * 1994-09-23 1996-08-22 Boehringer Ingelheim Int Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz
US5837520A (en) * 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
US20040253246A1 (en) * 1996-02-23 2004-12-16 Israeli Ron S. Prostate-specific membrane antigen and uses thereof
ES2108652B1 (es) * 1996-04-19 1998-07-16 Antibioticos Sa Un procedimiento para modificar la enzima 7/3-(4-carboxibutanamido) cefalosporinacilasa y purificarla en un solo paso cromatografico.
DE59711533D1 (de) 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulinderivate mit erhöhter Zinkbindung
US6271000B1 (en) * 1996-12-13 2001-08-07 Eli Lilly And Company Streptococcus pneumoniae gene sequence mraY
US20080261289A1 (en) * 1996-12-13 2008-10-23 Schering-Plough Corporation Compositions comprising viruses and methods for concentrating virus preparations
US6261823B1 (en) 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
US6544769B1 (en) * 1996-12-13 2003-04-08 Schering Corporation Compostions comprising viruses and methods for concentrating virus preparations
JP2001512306A (ja) 1997-01-08 2001-08-21 ライフ テクノロジーズ，インコーポレイテッド タンパク質の産生方法
US5932102A (en) * 1998-01-12 1999-08-03 Schering Corporation Immobilized metal, affinity chromatography
US7026456B1 (en) 1998-01-23 2006-04-11 Hoffman-La Roche, Inc. Antibodies against human IL-12
US6008329A (en) * 1998-03-06 1999-12-28 The United States Of America As Represented By The Secretary Of The Army Method for purifying cholera toxin
AU4187799A (en) * 1998-05-14 1999-11-29 Clontech Laboratories, Inc. Compositions and methods for protein purification based on metal ion affinity site
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
US7176298B2 (en) 1998-09-25 2007-02-13 Clontech Laboratories, Inc. Polynucleotides encoding metal ion affinity peptides and related products
US7449338B2 (en) * 1998-10-02 2008-11-11 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20050142613A1 (en) * 1998-10-02 2005-06-30 David Bar-Or Test for the rapid evaluation of ischemic states and kits
US20030215359A1 (en) * 1998-10-02 2003-11-20 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US7070937B1 (en) 1998-10-02 2006-07-04 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US6475743B1 (en) 1998-10-02 2002-11-05 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US7282369B2 (en) * 1998-10-02 2007-10-16 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US6479300B1 (en) 1999-03-15 2002-11-12 Millipore Corporation Metal loaded ligand bound membranes for metal ion affinity chromatography
US6379903B1 (en) 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
WO2001028569A1 (fr) * 1999-10-15 2001-04-26 Canji, Inc. Vecteurs cibles
US6521111B1 (en) * 2000-04-10 2003-02-18 Invitrogen Corporation Methods and articles for labeling polymer gels
US6623655B1 (en) 2000-04-24 2003-09-23 Sigma-Aldrich Co. Metal chelating compositions
EP1307490B1 (fr) * 2000-08-11 2007-04-18 Ruprecht-Karls-Universität Heidelberg Structure fv presentant une affinite influencable avec une substance a lier
DE10040179A1 (de) * 2000-08-17 2002-02-28 Ipk Inst Fuer Pflanzengenetik Beeinflussung der Verteilung von Metallen in transgenen Pflanzen
US20040180415A1 (en) * 2001-05-15 2004-09-16 Tchaga Grigoriy S. Methods and compositions for protein purification
JP4283666B2 (ja) 2001-06-21 2009-06-24 クローンテック ラボラトリーズ インク． 水溶性ポリマー金属イオンアフィニティ組成物、およびその使用方法
US6902914B2 (en) * 2001-09-28 2005-06-07 Sigma-Aldrich, Co. Recombinant DNA processes using a dNTP mixture containing modified nucleotides
US7799561B2 (en) * 2002-06-12 2010-09-21 Sigma-Aldrich, Co. Affinity peptides and method for purification of recombinant proteins
US8025873B2 (en) 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8029803B2 (en) 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
AU2003297583B2 (en) * 2002-11-26 2010-01-14 Biocon, Ltd Modified naturetic compounds, conjugates, and uses thereof
ITMI20030755A1 (it) * 2003-04-11 2004-10-12 Bottega Verde S R L Peptidi e loro derivati quali inibitori di fenomeni degradativi e composizioni contenenti gli stessi.
CN1813059A (zh) * 2003-05-02 2006-08-02 西格玛-奥尔德利希公司 固相细胞裂解和捕获平台
JP4078247B2 (ja) * 2003-05-02 2008-04-23 キヤノン株式会社 磁性体−生体物質複合体型構造体、磁性体に対して結合能を有するアミノ酸配列を有するペプチド断片及びその遺伝子、ならびに磁性体−生体物質複合体型構造体の製造方法
US20040224425A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Biomolecule open channel solid phase extraction systems and methods
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US7187286B2 (en) 2004-03-19 2007-03-06 Applera Corporation Methods and systems for using RFID in biological field
WO2006026248A1 (fr) 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions et procedes faisant appel a des combinaisons de detergents zwitterioniques
US7294614B2 (en) * 2004-10-12 2007-11-13 Clontech Laboratories, Inc. Phosphoprotein affinity resins and methods for making and using the same
EP1831241A2 (fr) * 2004-11-24 2007-09-12 AplaGen GmbH Procede de synthese et purification de peptides en phase solide
NZ556635A (en) 2004-12-22 2010-11-26 Genentech Inc Method for producing soluble multi-membrane-spanning proteins
US20080207505A1 (en) * 2005-01-12 2008-08-28 James Kenneth D Bna Conjugates and Methods of Use
JP2006239661A (ja) * 2005-03-07 2006-09-14 Pentax Corp 吸着剤、吸着剤の製造方法、吸着装置および吸着装置の製造方法
US7229769B2 (en) * 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
US7741053B2 (en) * 2005-05-13 2010-06-22 Sigma-Aldrich Co. Processes for purification of recombinant proteins
US7265213B2 (en) * 2005-07-28 2007-09-04 Kpl, Inc. Methodology of conjugating chelators to biomolecules
ZA200804078B (en) * 2005-10-13 2009-09-30 Virexx Medical Corp Chimeric hepatitis C virus antigens for eliciting an immune response
WO2007096899A2 (fr) * 2006-02-08 2007-08-30 Usv Limited Polypeptide d'affinité pour la purification de protéines recombinantes
GB0604187D0 (en) * 2006-03-02 2006-04-12 Fusion Antibodies Ltd Peptide and uses thereof
WO2007120999A2 (fr) * 2006-03-06 2007-10-25 Bio-Rad Laboratories, Inc. Chélation de monomères et de polymères
EP1878739A1 (fr) * 2006-07-14 2008-01-16 LEK Pharmaceuticals D.D. Purification de protéines en une étape par IMAC (MCAC)
US20110053225A1 (en) * 2008-01-24 2011-03-03 Ge Healthcare Bio-Sciences Ab Multifunctional tags
KR101430627B1 (ko) 2008-05-13 2014-08-14 유니버시티 오브 캔사스 금속 추출 펩타이드(ｍａｐ) 태그 및 관련된 방법
SI2456786T2 (sl) 2009-07-24 2017-08-31 Immune Design Corp. Lentiviralni vektorji psevdo-tipizirani z glikoproteinom ovojnice virusa Sindbis
BR112013020875A2 (pt) 2011-02-15 2019-09-24 Immune Design Corp método para indução de uma resposta imune específica para um imunógeno em um indivíduo.
AU2012243039B2 (en) 2011-04-08 2017-07-13 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
US10100092B2 (en) 2011-11-03 2018-10-16 Vca, Inc. Compositions and methods to detect various infectious organisms
NZ700340A (en) 2012-03-30 2017-02-24 Immune Design Corp Lentiviral vector particles having improved transduction efficiency for cells expressing dc- sign
HU230585B1 (hu) 2012-05-30 2017-01-30 Budapesti Műszaki és Gazdaságtudományi Egyetem Fehérjék megkötésére és elválasztására alkalmas lantanida fémionokkal komplexált hordozók
WO2013181461A2 (fr) 2012-06-01 2013-12-05 University Of Kansas Peptide de capture de métal avec une activité superoxyde dismutase
EP3104878B1 (fr) 2014-02-14 2019-05-22 Immune Design Corp. Immunothérapie du cancer par combinaison de stimulation immunitaire locale et systémique
WO2016011083A1 (fr) 2014-07-15 2016-01-21 Immune Design Corp. Régimes de primo-vaccination/rappel avec un adjuvant d'agoniste tlr4 et un vecteur lentiviral
US11135283B2 (en) 2015-11-09 2021-10-05 Immune Design Corp. Retroviral vector for the administration and expression of replicon RNA expressing heterologous nucleic acids
AU2016354000A1 (en) 2015-11-09 2018-05-17 Immune Design Corp. Compositions comprising lentiviral vectors expressing IL-12 and methods of use thereof
US11112416B2 (en) 2018-01-30 2021-09-07 Life Technologies Corporation Instruments, devices and consumables for use in a workflow of a smart molecular analysis system
WO2020254540A1 (fr) 2019-06-18 2020-12-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Conjugaison spécifique à un site et cinétiquement inerte de marqueurs et/ou supports à des molécules cibles, telles que des protéines marquées par his, par l'intermédiaire de réactifs de type complexes métalliques
AU2021207901A1 (en) 2020-01-14 2022-09-08 Synthekine, Inc. IL2 orthologs and methods of use
EP4192863A2 (fr) 2020-08-05 2023-06-14 Synthekine, Inc. Molécules de liaison à il2rg et procédés d'utilisation
CA3190463A1 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Molecules de liaison a il27r.alpha. et procedes d'utilisation
AU2021320233A1 (en) 2020-08-05 2023-03-23 Synthekine, Inc. IL10Ra binding molecules and methods of use
WO2022032022A2 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Molécules de liaison au récepteur il10 et leurs procédés d'utilisation
WO2022032040A1 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Cytokines synthétiques il2rb/il2rg
CN116323669A (zh) 2020-08-05 2023-06-23 辛德凯因股份有限公司 受体配对相关的组合物和方法
AU2021320327A1 (en) 2020-08-05 2023-03-23 Synthekine, Inc. IL10Rb binding molecules and methods of use
WO2022032006A2 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Molécules de liaison à l'il2rb et leurs procédés d'utilisation
WO2022031869A2 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Molécules de liaison à la gp130 et procédés d'utilisation
JP2024504923A (ja) 2021-01-11 2024-02-02 シンセカイン インコーポレイテッド 受容体ペア形成に関する組成物および方法
CA3226163A1 (fr) 2021-07-14 2023-01-19 Synthekine, Inc. Methodes et compositions destinees a etre utilisees dans la therapie cellulaire contre la maladie neoplasique
WO2024086739A1 (fr) 2022-10-20 2024-04-25 Synthekine, Inc. Procédés et compositions de mutéines il12 et de mutéines il2

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1048150B (it) * 1973-10-31 1980-11-20 O T I Officina Terapeutica Ita Metodo per l isolamento delle transferine da materiali biologici
US4216143A (en) * 1977-10-20 1980-08-05 Ashmead H H Soluble non-ferrous metal proteinates
US4216144A (en) * 1977-10-20 1980-08-05 Ashmead H H Soluble iron proteinates
US4172072A (en) * 1977-10-20 1979-10-23 Ashmead H H Buffered enzymatically produced metal proteinates
JPS5562902A (en) * 1978-11-07 1980-05-12 Toray Ind Inc Separation of endotoxin
JPS55148098A (en) * 1979-05-10 1980-11-18 Toray Ind Inc Concentration and purification of interferon
JPS5835157A (ja) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd ヒトリムホブラストイドインターフェロンのｎ末端ペプチド
US4431546A (en) * 1981-04-27 1984-02-14 The Public Health Laboratory Services Board Affinity chromatography using metal ions
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
JPS59130254A (ja) * 1982-10-18 1984-07-26 Mitsubishi Chem Ind Ltd ポリペプチド
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
GB8308483D0 (en) * 1983-03-28 1983-05-05 Health Lab Service Board Secretion of gene products
GB8311136D0 (en) * 1983-04-25 1983-06-02 Lepetit Spa Immobilised oligopeptides
JPS59206342A (ja) * 1983-05-10 1984-11-22 Mitsubishi Chem Ind Ltd ペプチド類

Also Published As

Publication number Publication date
DE3585147D1 (de) 1992-02-20
DK171917B1 (da) 1997-08-11
IE58501B1 (en) 1993-10-06
US4569794A (en) 1986-02-11
AU588840B2 (en) 1989-09-28
IL77104A (en) 1990-03-19
DK535285D0 (da) 1985-11-20
AU5024085A (en) 1986-06-12
EP0184355B1 (fr) 1992-01-08
CA1252948A (fr) 1989-04-18
JPH0788400B2 (ja) 1995-09-27
HUT39462A (en) 1986-09-29
IE852913L (en) 1986-06-05
HU208025B (en) 1993-07-28
JPS61148197A (ja) 1986-07-05
EP0184355A2 (fr) 1986-06-11
IL77104A0 (en) 1986-04-29
DK535285A (da) 1986-06-06
EP0184355A3 (en) 1987-04-08
SG25792G (en) 1992-05-15

Similar Documents

Publication Publication Date Title
IL77104A0 (en) Improvements in or relating to a process for purifying proteins
EP0169997A3 (en) Process for purifying smoke
EP0201983A3 (en) Improvements relating to microtomes
GB8521744D0 (en) Purifying process
GB2161843B (en) Improvements in or relating to walls
DE3563308D1 (en) Improvements in or relating to wrist supports
IL75615A0 (en) Improvements in or relating to a crystallization process for ceftazidime
ZA868274B (en) Purification method for proteins
GB2176420B (en) Improvements relating to filters
GB2166453B (en) Purification process
GB8510109D0 (en) Purification process
PT85956A (en) Process for protein purification
GB2160167B (en) Improvements in or relating to tractors
YU45459B (en) Process for purifying aluminium-trioxide
GB2167643B (en) Improvements in or relating to a clamp
GB8815715D0 (en) Improvements in & relating to vehicles
ZW4084A1 (en) Improvements in or relating to hydro-cyclones
GB8427744D0 (en) Improvements in or relating to hydrophones
GB2166424B (en) Improvements in or relating to materials
GB2160494B (en) Improvements in or relating to pallets
GB2156708B (en) Improvements in or relating to separation
AU4784985A (en) Improvements in or relating to filters
GB2184957B (en) Improvements in or relating to a chromatographic system
GB2168026B (en) Improvements relating to containers
DE3565978D1 (en) Process for hydroxymethylation

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20051120