HK185496A - Process for preparing florfenicaol its analogs and oxazoline intermediates thereto - Google Patents

Process for preparing florfenicaol its analogs and oxazoline intermediates thereto

Info

Publication number
HK185496A
HK185496A HK185496A HK185496A HK185496A HK 185496 A HK185496 A HK 185496A HK 185496 A HK185496 A HK 185496A HK 185496 A HK185496 A HK 185496A HK 185496 A HK185496 A HK 185496A
Authority
HK
Hong Kong
Prior art keywords
formula
compound
oxazoline
preparing
oxazoline compound
Prior art date
Application number
HK185496A
Other languages
English (en)
Inventor
Jon E Clark
Doris P Schumacher
Guang-Zhong Wu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK185496A publication Critical patent/HK185496A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
HK185496A 1990-10-25 1996-10-03 Process for preparing florfenicaol its analogs and oxazoline intermediates thereto HK185496A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60357590A 1990-10-25 1990-10-25

Publications (1)

Publication Number Publication Date
HK185496A true HK185496A (en) 1996-10-11

Family

ID=24416027

Family Applications (1)

Application Number Title Priority Date Filing Date
HK185496A HK185496A (en) 1990-10-25 1996-10-03 Process for preparing florfenicaol its analogs and oxazoline intermediates thereto

Country Status (19)

Country Link
US (1) US5382673A (da)
EP (1) EP0555340B1 (da)
JP (1) JPH0645580B2 (da)
KR (1) KR960008665B1 (da)
AT (1) ATE115123T1 (da)
AU (1) AU646910B2 (da)
CA (1) CA2094810C (da)
CZ (1) CZ286239B6 (da)
DE (1) DE69105752T2 (da)
DK (1) DK0555340T3 (da)
ES (1) ES2067958T3 (da)
GR (1) GR3015221T3 (da)
HK (1) HK185496A (da)
HU (2) HU9301182D0 (da)
NZ (2) NZ240319A (da)
PL (1) PL166385B1 (da)
RU (1) RU2071468C1 (da)
SK (1) SK281740B6 (da)
WO (1) WO1992007824A1 (da)

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US5663361A (en) * 1996-08-19 1997-09-02 Schering Corporation Process for preparing intermediates to florfenicol
US6348625B1 (en) * 2000-11-10 2002-02-19 Gloria Long Anderson Method for preparing some 1-adamantancecarboxamides
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KR20040091698A (ko) * 2002-03-08 2004-10-28 쉐링-플라우 리미티드. 신규한 플로르페니콜형 항생제
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
WO2006020689A1 (en) * 2004-08-13 2006-02-23 Schering-Plough Ltd. Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
ATE406348T1 (de) 2004-09-23 2008-09-15 Schering Plough Ltd Bekämpfung von parasiten in tieren durch verwendung neuer trifluormethansulfonanilidoximetherderivate
EP1811841B1 (en) * 2004-11-19 2009-10-28 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
US8680154B2 (en) * 2004-12-21 2014-03-25 Intervet International B.V. Injectable veterinary composition
EP1890547A2 (en) * 2005-06-09 2008-02-27 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
CN1331849C (zh) * 2005-08-12 2007-08-15 中国科学院上海有机化学研究所 甲砜霉素和氟苯尼考的新合成方法及其关键中间体
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
EP2102154A1 (en) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
CA2672586A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
AR066265A1 (es) * 2007-04-27 2009-08-05 Schering Plough Ltd Compuestos y metodos para mejorar la solubilidad de florfenicol y antibioticos estructuralmente relacionados por medio del uso de ciclodextrinas. composicion. complejo. kit. metodo de tratamiento.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
KR101714059B1 (ko) 2007-06-27 2017-03-08 이 아이 듀폰 디 네모아 앤드 캄파니 동물 해충 방제 방법
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
AU2008324852A1 (en) * 2007-11-09 2009-05-14 Intervet International B.V. Fast release solid formulation, preparation and use thereof
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
EP2321269B1 (en) * 2008-07-30 2018-09-19 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
EP2461684A2 (en) 2009-08-05 2012-06-13 E. I. du Pont de Nemours and Company Mesoionic pesticides
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
KR20120047996A (ko) 2009-08-05 2012-05-14 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
UY33397A (es) 2010-05-27 2011-12-01 Du Pont Forma sólida de un naftaleno carboxamida
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103980167B (zh) * 2014-04-17 2016-06-08 天津大学 一种无定形氟苯尼考及其制备方法
CN105218474B (zh) * 2015-10-22 2017-12-05 山东国邦药业股份有限公司 (4r,5r)‑2‑二氯甲基‑4,5‑二氢‑5‑(4‑甲砜基苯基)‑4‑恶唑甲醇的合成方法
CN106278964B (zh) * 2016-07-31 2018-01-16 浙江润康药业有限公司 氟苯尼考的制备方法
CN109678811B (zh) * 2019-01-25 2020-12-29 湖北中牧安达药业有限公司 一种氟苯尼考中间体环合物的不对称制备方法
CN110330463B (zh) * 2019-08-02 2021-05-14 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法
CN113264892B (zh) * 2021-04-05 2022-12-20 复旦大学 一种使用微反应系统连续制备氟苯尼考关键中间体的方法
CN113185473B (zh) * 2021-06-30 2021-10-08 山东国邦药业有限公司 一种氟苯尼考中间体氟甲砜噁唑的制备方法
CN113185474B (zh) * 2021-07-02 2021-11-05 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法

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US2694071A (en) * 1954-11-09 Process for the preparation of tech
US2820041A (en) * 1958-01-14 Preparation of nitrophenyloxazolines
US2686787A (en) * 1954-08-17 x xx xx - -
US2718520A (en) * 1955-09-20 Nitrophenyl-oxazolines and processes
US2402198A (en) * 1944-09-06 1946-06-18 Du Pont Preparation of oxazolines
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FR1071077A (fr) * 1952-03-01 1954-08-24 Parke Davis & Co Procédé de production de delta 2-oxazolines
US2692897A (en) * 1952-03-01 1954-10-26 Parke Davis & Co Process for the production of acylamido diol compounds
US2786870A (en) * 1954-04-19 1957-03-26 Parke Davis & Co Synthesis of chloramphenicol and related acylamidodiols
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DE2732213A1 (de) * 1977-07-16 1979-01-25 Bayer Ag Derivate der cyclopropancarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte zur herstellung von insektiziden
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IT1173213B (it) * 1984-02-03 1987-06-18 Zambon Spa Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi
ATE143953T1 (de) * 1983-06-02 1996-10-15 Zambon Spa Verfahren zur herstellung von 1-(phenyl)-1- hydroxy-2-amino-3-fluor-propan-derivaten
US5105009A (en) * 1983-06-02 1992-04-14 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives
HU215919B (hu) * 1988-09-14 1999-03-29 Schering Corp. Új eljárás oxazolinvegyületek előállítására
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US5227494A (en) * 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
IT1237798B (it) * 1989-10-20 1993-06-17 Zambon Spa Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
US5243050A (en) * 1990-12-20 1993-09-07 North Carolina State University Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs

Also Published As

Publication number Publication date
AU646910B2 (en) 1994-03-10
CA2094810C (en) 2002-06-04
NZ250394A (en) 1994-10-26
DE69105752D1 (de) 1995-01-19
JPH05507289A (ja) 1993-10-21
AU8927991A (en) 1992-05-26
GR3015221T3 (en) 1995-05-31
EP0555340B1 (en) 1994-12-07
DK0555340T3 (da) 1995-03-06
DE69105752T2 (de) 1995-05-11
NZ240319A (en) 1994-10-26
HUT65402A (en) 1994-06-28
RU2071468C1 (ru) 1997-01-10
ATE115123T1 (de) 1994-12-15
JPH0645580B2 (ja) 1994-06-15
ES2067958T3 (es) 1995-04-01
PL166385B1 (en) 1995-05-31
SK37793A3 (en) 1993-10-06
CZ286239B6 (cs) 2000-02-16
WO1992007824A1 (en) 1992-05-14
SK281740B6 (sk) 2001-07-10
KR960008665B1 (en) 1996-06-28
HU212617B (en) 1996-09-30
CZ71093A3 (en) 1994-02-16
US5382673A (en) 1995-01-17
CA2094810A1 (en) 1992-04-26
EP0555340A1 (en) 1993-08-18
HU9301182D0 (en) 1993-08-30

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Effective date: 20111022