ATE115123T1 - Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte. - Google Patents

Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.

Info

Publication number
ATE115123T1
ATE115123T1 AT91920162T AT91920162T ATE115123T1 AT E115123 T1 ATE115123 T1 AT E115123T1 AT 91920162 T AT91920162 T AT 91920162T AT 91920162 T AT91920162 T AT 91920162T AT E115123 T1 ATE115123 T1 AT E115123T1
Authority
AT
Austria
Prior art keywords
formula
compound
oxazoline
oxazoline compound
pct
Prior art date
Application number
AT91920162T
Other languages
English (en)
Inventor
Jon E Clark
Doris P Schumacher
Guang-Zhong Wu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE115123T1 publication Critical patent/ATE115123T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
AT91920162T 1990-10-25 1991-10-23 Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte. ATE115123T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60357590A 1990-10-25 1990-10-25

Publications (1)

Publication Number Publication Date
ATE115123T1 true ATE115123T1 (de) 1994-12-15

Family

ID=24416027

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91920162T ATE115123T1 (de) 1990-10-25 1991-10-23 Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.

Country Status (19)

Country Link
US (1) US5382673A (de)
EP (1) EP0555340B1 (de)
JP (1) JPH0645580B2 (de)
KR (1) KR960008665B1 (de)
AT (1) ATE115123T1 (de)
AU (1) AU646910B2 (de)
CA (1) CA2094810C (de)
CZ (1) CZ286239B6 (de)
DE (1) DE69105752T2 (de)
DK (1) DK0555340T3 (de)
ES (1) ES2067958T3 (de)
GR (1) GR3015221T3 (de)
HK (1) HK185496A (de)
HU (2) HU9301182D0 (de)
NZ (2) NZ240319A (de)
PL (1) PL166385B1 (de)
RU (1) RU2071468C1 (de)
SK (1) SK281740B6 (de)
WO (1) WO1992007824A1 (de)

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CN1331849C (zh) * 2005-08-12 2007-08-15 中国科学院上海有机化学研究所 甲砜霉素和氟苯尼考的新合成方法及其关键中间体
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US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
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AR066265A1 (es) * 2007-04-27 2009-08-05 Schering Plough Ltd Compuestos y metodos para mejorar la solubilidad de florfenicol y antibioticos estructuralmente relacionados por medio del uso de ciclodextrinas. composicion. complejo. kit. metodo de tratamiento.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN101743000A (zh) 2007-06-27 2010-06-16 杜邦公司 动物虫害控制方法
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
KR20100085162A (ko) * 2007-11-09 2010-07-28 인터벳 인터내셔널 비.브이. 속방성 고체 제형, 제조 및 이의 용도
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
WO2010014566A2 (en) 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
AU2010279574A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
JP2013501063A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
ES2566402T3 (es) 2010-05-27 2016-04-12 E. I. Du Pont De Nemours And Company Forma cristalina de 4-[5-[3-cloro-5-(trifluorometil)fenil]-4,5-dihidro-5-(trifluorometil)-3-isoxazolil]-N-[2-oxo-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenocarboxamida
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103980167B (zh) * 2014-04-17 2016-06-08 天津大学 一种无定形氟苯尼考及其制备方法
CN105218474B (zh) * 2015-10-22 2017-12-05 山东国邦药业股份有限公司 (4r,5r)‑2‑二氯甲基‑4,5‑二氢‑5‑(4‑甲砜基苯基)‑4‑恶唑甲醇的合成方法
CN106278964B (zh) * 2016-07-31 2018-01-16 浙江润康药业有限公司 氟苯尼考的制备方法
CN109678811B (zh) * 2019-01-25 2020-12-29 湖北中牧安达药业有限公司 一种氟苯尼考中间体环合物的不对称制备方法
CN110330463B (zh) * 2019-08-02 2021-05-14 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法
CN113264892B (zh) * 2021-04-05 2022-12-20 复旦大学 一种使用微反应系统连续制备氟苯尼考关键中间体的方法
CN113185473B (zh) * 2021-06-30 2021-10-08 山东国邦药业有限公司 一种氟苯尼考中间体氟甲砜噁唑的制备方法
CN113185474B (zh) * 2021-07-02 2021-11-05 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法

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Also Published As

Publication number Publication date
DE69105752D1 (de) 1995-01-19
NZ250394A (en) 1994-10-26
HUT65402A (en) 1994-06-28
PL166385B1 (en) 1995-05-31
GR3015221T3 (en) 1995-05-31
CZ71093A3 (en) 1994-02-16
JPH05507289A (ja) 1993-10-21
DK0555340T3 (da) 1995-03-06
EP0555340B1 (de) 1994-12-07
HU212617B (en) 1996-09-30
NZ240319A (en) 1994-10-26
RU2071468C1 (ru) 1997-01-10
AU646910B2 (en) 1994-03-10
HK185496A (en) 1996-10-11
ES2067958T3 (es) 1995-04-01
EP0555340A1 (de) 1993-08-18
WO1992007824A1 (en) 1992-05-14
CA2094810A1 (en) 1992-04-26
US5382673A (en) 1995-01-17
SK37793A3 (en) 1993-10-06
DE69105752T2 (de) 1995-05-11
KR960008665B1 (en) 1996-06-28
SK281740B6 (sk) 2001-07-10
CA2094810C (en) 2002-06-04
JPH0645580B2 (ja) 1994-06-15
AU8927991A (en) 1992-05-26
HU9301182D0 (en) 1993-08-30
CZ286239B6 (cs) 2000-02-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time