HK17096A - Pertussis toxin mutants bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines - Google Patents
Pertussis toxin mutants bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccinesInfo
- Publication number
- HK17096A HK17096A HK17096A HK17096A HK17096A HK 17096 A HK17096 A HK 17096A HK 17096 A HK17096 A HK 17096A HK 17096 A HK17096 A HK 17096A HK 17096 A HK17096 A HK 17096A
- Authority
- HK
- Hong Kong
- Prior art keywords
- mutants
- bordetella strains
- pertussis toxin
- development
- producing
- Prior art date
Links
- 108010081690 Pertussis Toxin Proteins 0.000 title abstract 5
- 241000588807 Bordetella Species 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 102100021277 Beta-secretase 2 Human genes 0.000 abstract 1
- 101710150190 Beta-secretase 2 Proteins 0.000 abstract 1
- 101100083427 Mus musculus Pithd1 gene Proteins 0.000 abstract 1
- 101100109292 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) arg-13 gene Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8920341A IT1230139B (it) | 1989-04-28 | 1989-04-28 | Ceppi di bordetella utili come vaccini antipertosse |
IT01928690A IT1238007B (it) | 1990-02-07 | 1990-02-07 | Mutanti della tossina della pertosse, ceppi di bordetella capaci di produrre detti mutanti e loro impiego per lo sviluppo di vaccini antipertosse |
Publications (1)
Publication Number | Publication Date |
---|---|
HK17096A true HK17096A (en) | 1996-02-09 |
Family
ID=26327122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK17096A HK17096A (en) | 1989-04-28 | 1996-02-01 | Pertussis toxin mutants bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines |
Country Status (10)
Country | Link |
---|---|
US (2) | US7427404B1 (ja) |
EP (1) | EP0396964B1 (ja) |
JP (2) | JP2655583B2 (ja) |
AT (1) | ATE127347T1 (ja) |
CA (1) | CA2015677C (ja) |
DE (1) | DE69022106T2 (ja) |
DK (1) | DK0396964T3 (ja) |
ES (1) | ES2078258T3 (ja) |
GR (1) | GR3018285T3 (ja) |
HK (1) | HK17096A (ja) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP8900132A0 (en) * | 1988-07-22 | 1991-01-14 | Smithkline Biolog | Bordetella pertussis vaccine |
EP0396964B1 (en) * | 1989-04-28 | 1995-09-06 | SCLAVO S.p.A. | Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines |
US5786189A (en) * | 1989-11-29 | 1998-07-28 | Smithkline Beecham Biologicals (S.A.) | Vaccine |
IT1248735B (it) * | 1990-06-21 | 1995-01-26 | Sclavo Spa | Vaccini acellulari contro la pertosse |
DE4113385A1 (de) * | 1991-04-24 | 1992-10-29 | Biotechnolog Forschung Gmbh | Hybridtransposon mit pt-operon, plasmide und bakterienstaemme dafuer |
GB9115332D0 (en) * | 1991-07-16 | 1991-08-28 | Connaught Lab | Manipulation of gene copy number in bordetella |
GB9513371D0 (en) | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
DK0725653T3 (da) | 1993-10-05 | 2004-10-11 | Celltech Pharmaceuticals Ltd | Vaccinepræparater |
GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
FR2754543B1 (fr) * | 1996-10-11 | 1998-12-31 | Pasteur Institut | Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires |
GB9622660D0 (en) | 1996-10-31 | 1997-01-08 | Biocine Spa | Immunogenic detoxified mutant toxin |
US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
US7115730B1 (en) | 1999-04-27 | 2006-10-03 | Chiron Srl | Immunogenic detoxified mutant E. coli LT-A-toxin |
US7101558B2 (en) * | 2000-06-26 | 2006-09-05 | The United States Of America As Represented By The Department Of Health And Human Services | High yield pertussis vaccine production strain and method for making same |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
BRPI0402630B8 (pt) * | 2004-07-05 | 2021-05-25 | Fund Butantan | processo de obtenção de vacina pertussis celular menos reatogênica |
WO2010124281A2 (en) * | 2009-04-24 | 2010-10-28 | The Goverment Of The Usa, As Represented By The Secretary, Department Of Health And Human Services,Centres For Disease Control And Prevention | Selective detection of bordetella species |
US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
EP2553102B1 (en) | 2010-03-30 | 2015-12-09 | Pfenex Inc. | High level expression of recombinant toxin proteins |
BR112014014950B1 (pt) * | 2011-12-21 | 2022-03-29 | Bionet-Asia, Co. Ltd | Cepa de bordetella pertussis geneticamente modificada, e, métodos para produzir uma cepa de bordetella pertussis modificada e para produzir antígenos de bordetella pertussis |
US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
AU2013301312A1 (en) | 2012-08-06 | 2015-03-19 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against RSV and B. pertussis |
US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
KR20150065878A (ko) | 2012-10-12 | 2015-06-15 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 조합 백신에서 사용하기 위한 가교되지 않은 무세포 백일해 항원 |
ES2597832T3 (es) | 2013-03-08 | 2017-01-23 | Janssen Vaccines & Prevention B.V. | Vacuna acelular contra la tosferina |
AU2014304545A1 (en) | 2013-08-05 | 2016-02-25 | Glaxosmithkline Biologicals S.A. | Combination immunogenic compositions |
CN108025053A (zh) | 2015-04-16 | 2018-05-11 | 创赏有限公司 | 百日咳杆菌免疫原性的疫苗组合物 |
JP7469302B2 (ja) | 2018-11-06 | 2024-04-16 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
EP3799884A1 (en) | 2019-10-01 | 2021-04-07 | GlaxoSmithKline Biologicals S.A. | Immunogenic compositions |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5750925A (en) * | 1980-09-12 | 1982-03-25 | Takeda Chem Ind Ltd | Preparation of pertussis toxoid |
CA1340373C (en) * | 1986-01-28 | 1999-02-02 | Rino Rappuoli | Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin |
US4883761A (en) * | 1986-03-25 | 1989-11-28 | The United States Of America As Represented By The Department Of Health And Human Services | Pertussis toxin gene: cloning and expression of protective antigen |
JP2918895B2 (ja) * | 1987-09-04 | 1999-07-12 | アムジエン・インコーポレーテツド | 組換え型dna由来ボルデテラ毒素サブユニット類似体 |
US6713072B1 (en) * | 1987-11-02 | 2004-03-30 | Chiron S.R.L. | Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine |
IT1223334B (it) * | 1987-11-02 | 1990-09-19 | Sclavo Spa | Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse |
GB8727489D0 (en) * | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
US5221618A (en) | 1987-11-24 | 1993-06-22 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
IT1223529B (it) * | 1987-12-18 | 1990-09-19 | Sclavo Spa | Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse |
AP8900132A0 (en) * | 1988-07-22 | 1991-01-14 | Smithkline Biolog | Bordetella pertussis vaccine |
US5000952A (en) * | 1988-08-02 | 1991-03-19 | The Board Of Trustees Of The Leland Stanford, Jr. University | Polypeptide pertussis toxin vaccine |
EP0396964B1 (en) * | 1989-04-28 | 1995-09-06 | SCLAVO S.p.A. | Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines |
-
1990
- 1990-04-25 EP EP90107892A patent/EP0396964B1/en not_active Expired - Lifetime
- 1990-04-25 DE DE69022106T patent/DE69022106T2/de not_active Expired - Lifetime
- 1990-04-25 AT AT90107892T patent/ATE127347T1/de not_active IP Right Cessation
- 1990-04-25 DK DK90107892.3T patent/DK0396964T3/da active
- 1990-04-25 ES ES90107892T patent/ES2078258T3/es not_active Expired - Lifetime
- 1990-04-27 CA CA002015677A patent/CA2015677C/en not_active Expired - Lifetime
- 1990-05-01 JP JP2111865A patent/JP2655583B2/ja not_active Expired - Lifetime
-
1994
- 1994-06-17 US US08/261,691 patent/US7427404B1/en active Active
-
1995
- 1995-05-02 US US08/431,673 patent/US7666436B1/en active Active
- 1995-12-05 GR GR950403403T patent/GR3018285T3/el unknown
-
1996
- 1996-02-01 HK HK17096A patent/HK17096A/xx not_active IP Right Cessation
- 1996-07-19 JP JP8191142A patent/JP2852025B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH03169825A (ja) | 1991-07-23 |
DE69022106D1 (de) | 1995-10-12 |
ATE127347T1 (de) | 1995-09-15 |
EP0396964B1 (en) | 1995-09-06 |
DK0396964T3 (da) | 1995-10-30 |
CA2015677A1 (en) | 1990-10-28 |
EP0396964A1 (en) | 1990-11-14 |
CA2015677C (en) | 2005-06-21 |
JP2655583B2 (ja) | 1997-09-24 |
DE69022106T2 (de) | 1996-02-15 |
ES2078258T3 (es) | 1995-12-16 |
JPH09163978A (ja) | 1997-06-24 |
US7427404B1 (en) | 2008-09-23 |
US7666436B1 (en) | 2010-02-23 |
GR3018285T3 (en) | 1996-03-31 |
JP2852025B2 (ja) | 1999-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PE | Patent expired |
Effective date: 20100424 |